Background:The patients with Langya henipavirus(LayV)infection are managed mainly with symptomatic treatment and supportive care.Objective:This review article focuses on the beneficial effects of black seeds(Nigella s...Background:The patients with Langya henipavirus(LayV)infection are managed mainly with symptomatic treatment and supportive care.Objective:This review article focuses on the beneficial effects of black seeds(Nigella sativa)in the management of Langya henipavirus(LayV)infection.Methods:The literature was searched in online databases,including Medline/Pubmed/PMC,Google Scholar,Science Direct,Ebsco,Scopus,Web of Science,Embase,and reference lists,to identify published studies,which established beneficial effects of black seeds(N.sativa)related to signs and symptoms of LayV infection.Results:Black seeds(N.sativa)have shown potential antiviral,bronchodilatory,antihistaminic,antitussive,hepatoprotective,renoprotective,anti-inflammatory,antioxidant,and immunomodulatory properties in various clinical,animal,in-vitro,in-vivo,and in-silico studies,which would help the patients with LayV infection.Conclusion:N.sativa would be a potential herbal candidate in the management of LayV infection along with symptomatic treatment and supportive care,to prevent further deterioration,and hospitalization.The safety and efficacy of N.sativa in patients with LayV infection would further be established by future randomized controlled clinical trials.展开更多
Due to their inability to generate a complete immune response, mice knockout for type I interferon （IFN） receptors （Ifnar-/-） are more susceptible to viral infections, and are thus commonly used for pathogenesis s...Due to their inability to generate a complete immune response, mice knockout for type I interferon （IFN） receptors （Ifnar-/-） are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.展开更多
文摘Background:The patients with Langya henipavirus(LayV)infection are managed mainly with symptomatic treatment and supportive care.Objective:This review article focuses on the beneficial effects of black seeds(Nigella sativa)in the management of Langya henipavirus(LayV)infection.Methods:The literature was searched in online databases,including Medline/Pubmed/PMC,Google Scholar,Science Direct,Ebsco,Scopus,Web of Science,Embase,and reference lists,to identify published studies,which established beneficial effects of black seeds(N.sativa)related to signs and symptoms of LayV infection.Results:Black seeds(N.sativa)have shown potential antiviral,bronchodilatory,antihistaminic,antitussive,hepatoprotective,renoprotective,anti-inflammatory,antioxidant,and immunomodulatory properties in various clinical,animal,in-vitro,in-vivo,and in-silico studies,which would help the patients with LayV infection.Conclusion:N.sativa would be a potential herbal candidate in the management of LayV infection along with symptomatic treatment and supportive care,to prevent further deterioration,and hospitalization.The safety and efficacy of N.sativa in patients with LayV infection would further be established by future randomized controlled clinical trials.
基金supported by the National Natural Science Foundation of China International Cooperation and Exchange Program(8161101193)the National Science and Technology Major Project(2016ZX10004222)to G.Wong
文摘Due to their inability to generate a complete immune response, mice knockout for type I interferon （IFN） receptors （Ifnar-/-） are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.
