COVID-19 Patients with Hepatic Complications During the Third Wave of Pandemic in Egypt

COVID-19 is a respiratory infection that has lately begun to affect other vital organs,including the heart,kidney,and liver.The purpose of this study was to investigate the hepatic complications in COVID-19 patients and the risk of being admitted to ICU or facing death.Methodology:Comorbidities(hypertension and diabetes),COVID-19 symptoms,laboratory findings(ALT level,AST level,and albumin),complications during hospitalization,treatment protocol used,and survival outcomes were all studied in 200 COVID-19 infected Egyptian patients who had virological symptoms and were followed up until they recovered or died.It was found that older people and those with higher blood glucose levels have a higher risk of developing liver-associated COVID-19 disorders.Also,the majority of patients who developed liver complications in the course of the infection had high mortality rates.Patients with diabetes,hypertension,or hepatic disease are at higher risk of ICU admission or death.Hence,it is important to pay attention to these problems in the diagnosis and treatment of COVID-19 to develop a suitable individualized treatment protocol.There was also a correlation between the mortality in COVID-19 patients and both,high blood glucose and liver enzyme levels.It can be attributed to the correlation between diabetes and liver disease as every disease may be a complication to the other;moreover,COVID-19 may lead to increased blood sugar levels in addition to ALT and AST levels.Another theory is that COVID-19 may afiect the liver and hence people with chronic liver disease.

Effect of SARS-CoV-2 infection on the liver

There have been numerous concerns about the disease and how it affects the human body since the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic began in December 2019.The impact of SARS-CoV-2 on the liver is being carefully investigated due to an increase in individuals with hepatitis and other liver illnesses,such as alcoholic liver disease.Additionally,the liver is involved in the metabolism of numerous drugs used to treat comorbidities and coronavirus disease 2019(COVID-19).Determining how SARS-CoV-2 affects the liver and what factors place individuals with COVID-19 at a higher risk of developing liver problems are the two main objectives of this study.This evaluation of the literature included research from three major scientific databases.To provide an update on the current impact of COVID-19 on the liver,data was collected and relevant information was incorporated into the review.With more knowledge about the effect of the disease on the liver,better management and therapeutics can be developed,and education can ultimately save lives and reduce the long-term impact of the pandemic on our population.

Sitagliptin in treatment of diabetes complicated by chronic hepatitis C

To the Editor: A high prevalence of glucose intolerance in patients with chronic hepatitis C has been reported, [1] and there is a significant association of chronic hepatitis C with diabetes mellitus (DM). [2] But DM has been suggested to be associated with the onset of hepatocellular carcinoma