Hetong decoction(和通汤)relieves loperamide-induced constipation in rats by regulating expression of aquaporins

OBJECTIVE:To investigate whether Hetong decoction(和通汤,HTT)alleviates constipation via regulating AQPs expression.METHODS:Constipation in rats was induced by loperamide,and rats were randomly assigned into model(saline),HHT-low(95 g/kg),HTT-medium(190 g/kg),HTT-high(380 g/kg)and positive control(mosapride)groups.Then the defecation function,the concentration of serum arginine vasopressin(AVP)and cyclic adenosine monophosphate(cAMP),and the expression of AQP3 and AQP8 in colon tissues were assessed.NCM460 colon cells with AQP3 and AQP8 knockdown or overexpression were exposed to serum from rats that received low or high dose of HTT,followed by detection of AQP3 and AQP8 expression.RESULTS:The model group showed lower fecal weight and water content,weaker intestinal transit,higher serum concentration of AVP and cAMP,increased proximal and distal AQP8 expression,increased proximal but decreased distal AQP3 expression.However,these trends were reversed in both the HTT group(low,medium and high dose)and the positive control group.In NCM460 cells,HTT dose-dependently stabilized AQP3 and AQP8 expression under AQP3/8 plasmid interference or overexpression.CONCLUSIONS:HTT relieves constipation in rats through regulating AQP3 and AQP8 expression.

脉斑灵胶囊治疗高脂血症肝功能异常临床疗效

目的探讨中药脉斑灵胶囊治疗高脂血症肝功能异常的临床疗效。方法选择在佳木斯医学院第一附属医院、佳木斯市中心医院进行健康体检,经实验室检查确定血脂四项以及肝功异常的高脂血症患者。口服中药脉斑灵胶囊,规格0. 5g/粒,5粒/次,3次/日,饭后即服,连续服用1个病程,120天为1个疗程。观察治疗前后的临床疗效。结果 31例中显效22例,70. 97%;有效7例,23%;无效2例,6. 03%;总有效率93. 97%。治疗后TC与TG的变化较治疗前降低,有显著性差异。23例肝功能异常者临床治愈12例,52. 17%;有效5例,21. 74%;无效6例,26. 09%;总有效率73. 91%。治疗后ALT、AST、γ-GT、TBIL较治疗前显著降低,两组比较有显著性差异。结论中药脉斑灵胶囊治疗高脂血症肝功异常患者疗效显著,该药具有降血脂、升高高密度脂蛋白胆固醇、降肝功血清酶、胆红素,对肝细胞具有保护、修复、延缓衰老作用。

应用CTA评价鹤童草中药胶囊治疗冠状动脉狭窄的效果

目的探讨应用冠状动脉CT血管成像技术评价鹤童草中药胶囊治疗冠状动脉狭窄的效果。方法收集2018年6月至2020年7月符合纳入条件的门诊患者65例,口服鹤童草中药胶囊12个月,服药前后分别进行冠状动脉CT血管成像检查并对比分析。结果65例研究对象中,非钙化斑块48处,混合斑块98处,钙化斑块56处;斑块引起的冠状动脉狭窄共202处,其中轻度狭窄82处,占40.59%;中度狭窄73处,占36.14%;重度狭窄47处,占23.27%。65例患者202处冠状动脉狭窄:治愈84处,占41.59%(84/202);有效68处,占33.66%(68/202);无效50处,占24.75%(50/202)。结论鹤童草中药胶囊治疗冠状动脉狭窄性冠心病能使硬化斑块缩小或消失,狭窄、闭塞的血管再通,从而减缓动脉粥样硬化进程,改善症状,提高生活质量。