Scallop culture is an important way of bottom-seeding marine ranching,which is of great significance to improve the current situation of fishery resources.However,there are some problems in site-selection evaluation o...Scallop culture is an important way of bottom-seeding marine ranching,which is of great significance to improve the current situation of fishery resources.However,there are some problems in site-selection evaluation of marine ranching,such as imperfect criteria system,complex structure,untargeted criteria quantification,etc.In addition,no site-selection evaluation method of bottom-seeding culture areas for scallops is available.Therefore,we established a hierarchy structure model according to the analytic hierarchy process(AHP)theory,in which social,physical,chemical,and biological environments are used as main criteria,and marine functional zonation,water depth,current,water temperature,salinity,substrate type,water quality,sediment quality,red tide,phytoplankton,and zooplankton are used as sub-criteria,on which a multi-parameter evaluation system is set up.Meanwhile,the dualism method,assignment method,and membership function method were used to quantify sub-criteria,and a quantitative evaluation for the entire criteria was added,including the evaluation and analysis of two types of unsuitable environmental situations.By overall consideration in scallop yield,quality,and marine ranching construction objectives,the weight of the main criteria could be determined.Five grades in the suitability corresponding to the evaluation result were divided,and the Python language was used to create an evaluation system for efficient calculation and intuitive presentation of the evaluation outcome.Eight marine cases were simulated based on existing survey data,and the results prove that the method is feasible for evaluating and analyzing the site selection of bottom-seeding culture areas for scallops under various environmental situations.The proposed evaluation method can be promoted for the site selection of bottom-seeding marine ranching.This study provided theoretical and methodological references for the site selection evaluation of other types of marine ranching.展开更多
For an arbitrary solution to the Volterra lattice hierarchy,the logarithmic derivatives of the tau-function of the solution can be computed by the matrix-resolvent method.In this paper,we define a pair of wave functio...For an arbitrary solution to the Volterra lattice hierarchy,the logarithmic derivatives of the tau-function of the solution can be computed by the matrix-resolvent method.In this paper,we define a pair of wave functions of the solution and use them to give an expression of the matrix resolvent;based on this we obtain a new formula for the k-point functions for the Volterra lattice hierarchy in terms of wave functions.As an application,we give an explicit formula of k-point functions for the even GUE(Gaussian Unitary Ensemble)correlators.展开更多
Hydrogen is the new age alternative energy source to combat energy demand and climate change.Storage of hydrogen is vital for a nation’s growth.Works of literature provide different methods for storing the produced h...Hydrogen is the new age alternative energy source to combat energy demand and climate change.Storage of hydrogen is vital for a nation’s growth.Works of literature provide different methods for storing the produced hydrogen,and the rational selection of a viable method is crucial for promoting sustainability and green practices.Typically,hydrogen storage is associated with diverse sustainable and circular economy(SCE)criteria.As a result,the authors consider the situation a multi-criteria decision-making(MCDM)problem.Studies infer that previous models for hydrogen storage method(HSM)selection(i)do not consider preferences in the natural language form;(ii)weights of experts are not methodically determined;(iii)hesitation of experts during criteria weight assessment is not effectively explored;and(iv)three-stage solution of a suitable selection of HSM is unexplored.Driven by these gaps,in this paper,authors put forward a new integrated framework,which considers double hierarchy linguistic information for rating,criteria importance through inter-criteria correlation(CRITIC)for expert weight calculation,evidence-based Bayesian method for criteria weight estimation,and combined compromise solution(CoCoSo)for ranking HSMs.The applicability of the developed framework is testified by using a case example of HSM selection in India.Sensitivity and comparative analysis reveal the merits and limitations of the developed framework.展开更多
This paper builds a binary tree for the target based on the bounding volume hierarchy technology,thereby achieving strict acceleration of the shadow judgment process and reducing the computational complexity from the ...This paper builds a binary tree for the target based on the bounding volume hierarchy technology,thereby achieving strict acceleration of the shadow judgment process and reducing the computational complexity from the original O(N^(3))to O(N^(2)logN).Numerical results show that the proposed method is more efficient than the traditional method.It is verified in multiple examples that the proposed method can complete the convergence of the current.Moreover,the proposed method avoids the error of judging the lit-shadow relationship based on the normal vector,which is beneficial to current iteration and convergence.Compared with the brute force method,the current method can improve the simulation efficiency by 2 orders of magnitude.The proposed method is more suitable for scattering problems in electrically large cavities and complex scenarios.展开更多
A dissertation is a research report or scientific paper written by an author to obtain a certain degree. It reflects postgraduates’ research achievements and the educational quality of an institute, even a country. T...A dissertation is a research report or scientific paper written by an author to obtain a certain degree. It reflects postgraduates’ research achievements and the educational quality of an institute, even a country. To construct an optimized quality evaluation system for postgraduate dissertation (QESPD), we summarized the influencing factors and invited 10 experienced specialists to rate and prioritize them based on fuzzy analytic hierarchy process. Four primary indicators (innovation, integrity, scientificity and normativity) and 16 sub-indicators were selected to form the evaluation system. The order of primary indicators by weight, was innovation (0.4269), scientificity (0.2807), integrity (0.1728) and normativity (0.1196). The top five sub-dimensions were theoretical originality, scientific value, data reliability, design rationality and evidence credibility. To demonstrate the effectiveness of the proposed system, a case study was performed. In the case study, it was demonstrated that the established two-index-hierarchy QESPD in this study was a more scientific and reasonable evaluation system worthy of promotion and application.展开更多
We present an eight component integrable Hamiltonian hierarchy, based on a reduced seventh order matrix spectral problem, with the aim of aiding the study and classification of multicomponent integrable models and the...We present an eight component integrable Hamiltonian hierarchy, based on a reduced seventh order matrix spectral problem, with the aim of aiding the study and classification of multicomponent integrable models and their underlying mathematical structures. The zero-curvature formulation is the tool to construct a recursion operator from the spatial matrix problem. The second and third set of integrable equations present integrable nonlinear Schrödinger and modified Korteweg-de Vries type equations, respectively. The trace identity is used to construct Hamiltonian structures, and the first three Hamiltonian functionals so generated are computed.展开更多
Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Method...Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.展开更多
Terahertz time-domain spectroscopy is a kind of far-infrared spectroscopy technology,and its spectrum reflects the internal properties of substances with rich physical and chemical information,so the use of terahertz ...Terahertz time-domain spectroscopy is a kind of far-infrared spectroscopy technology,and its spectrum reflects the internal properties of substances with rich physical and chemical information,so the use of terahertz waves can be used to qualitatively identify food additives containing nitrogen elements.Analytic hierarchy process(AHP)was originally used to solve evaluation-type problems,and this paper introduces it into the field of terahertz spectral qualitative analysis,proposes a terahertz time-domain spectral qualitative identification method combined with analytic hierarchy process,and verifies the feasibility of the method by taking four common food additives(xylitol,L-alanine,sorbic acid,and benzoic acid)and two illegal additives(melamine,and Sudan Red No.I)as the objects of study.Firstly,the collected terahertz time-domain spectral data were pre-processed and transformed into a data set consisting of peaks,peak positions,peak numbers and overall trends;then,the data were divided into comparison and test sets,and a qualitative additive identification model incorporating analytic hierarchy process was constructed and parameter optimisation was performed.The results showed that the qualitative identification accuracies of additives based on single factors,i.e.,overall trend,peak value,peak position,and peak number,were 80.23%,70.93%,67.44%,and 40.70%,respectively,whereas the identification accuracy of the analytic hierarchy process qualitative identification method based on multi-factors could be improved to 92.44%.In addition,the fuzzy characterisation of the absorption spectrum data was binarised in the data pre-processing stage and used as the base data for the overall trend,and the recognition accuracy was improved to 94.19%by combining the fuzzy characterisation method of such data with the hierarchical analysis qualitative recognition model.The results show that it is feasible to use terahertz technology to identify different varieties of additives,and this paper constructs a hierarchical analytical qualitative model with better effect,which provides a new means for food additives detection,and the method is simple in steps,with a small demand for samples,which is suitable for the rapid detection of small samples.展开更多
Floods are phenomenon with significant socio-economic implications mainly for human loss, agriculture, livestock, soil loss and land degradation, for which many researchers try to identify the most appropriate methodo...Floods are phenomenon with significant socio-economic implications mainly for human loss, agriculture, livestock, soil loss and land degradation, for which many researchers try to identify the most appropriate methodologies by analyzing their temporal and spatial development. This study therefore attempts to employ the GIS-based multi-criteria decision analysis and analytical hierarchy process techniques to derive the flood risks management on rice productivity in the Gishari Agricultural Marshland in Rwamagana district, Rwanda. Here, six influencing potential factors to flooding, including river slope, soil texture, Land Use Land Cover through Land Sat 8, rainfall, river distance and Digital Elevation Model are considered for the delineation of flood risk zones. Data acquisition like Landsat 8 images, DEM, land use land cover, slope, and soil class in the study area were considered. Results showed that if the DEM is outdated or inaccurate due to changes in the terrain, such as construction, excavation, or erosion, the predicted flood patterns might not reflect the actual water flow. This could result unexpected flood extents and depths, potentially inundating rice fields that were not previously at risk and this, expectedly explained that the increase 1 m in elevation would reduce the rice productivity by 0.17% due to unplanned flood risks in marshland. It was found that the change in rainfall distribution in Gishari agricultural marshland would also decrease the rice productivity by 0.0018%, which is a sign that rainfall is a major factor of flooding in rice scheme. Rainfall distribution plays a crucial role in flooding analysis and can directly impact rice productivity. Oppositely, another causal factor was Land Use Land Cover (LULC), where the Multivariate Logistic Regression Model Analysis findings showed that the increase of one unit in Land Use Land Cover would increase rice productivity by 0.17% of the total rice productivity from the Gishari Agricultural Marshland. Based on findings from these techniques, the Gishari Agricultural Marshlands having steeped land with grassland is classified into five classes of flooding namely very low, low, moderate, high, and very high which include 430%, 361%, 292%, 223%, and 154%. Government of Rwanda and other implementing agencies and major key actors have to contribute on soil and water conservation strategies to reduce the runoff and soil erosion as major contributors of flooding.展开更多
The whole-beach quality assessment is the basis of building and preserving beautiful beaches.The beach quality assessment index system and assessment standard have been established based on the attributes of beaches(i...The whole-beach quality assessment is the basis of building and preserving beautiful beaches.The beach quality assessment index system and assessment standard have been established based on the attributes of beaches(including the width,slope,landform,and types),sorting coefficient,and softness degree of surface sediment.The assessment weight of each index for quality evaluation was analyzed using the analytic hierarchy process,and comprehensive scores of selected beach profiles were calculated in accordance with the light assessment standard.A beach quality evaluation model based on index weight and scores was established in this paper.The factors of 12 profiles of Yangkou Beach in Qingdao City were surveyed to carry out a quality assessment,and the comprehensive scores of each profile were calculated in accordance with the evaluation model.The results showed that the quality of Yangkou Beach can be divided into four ratings:excellent,good,medium,and poor.The excellent-quality area includes a wide and flat dry beach zone and soft,flat,and clean intertidal and subtidal zones covered with well-sorted fine sand,and leisure sports,such as volleyball,running,and swimming,are suitable for tourists.The good-quality area features a slightly narrow and dry beach zone,moderately soft and uneven intertidal and subtidal zones covered with fine sand and a small tidal gully,and a small amount of foreign matter;leisure sports,such as walking and running,are suitable for tourists.This study recommends the building of fixed drainage ditches or underground culverts to reduce the tidal gully.The medium-quality area consisted of a narrow and dry beach zone,moderately soft and uneven intertidal and subtidal zones covered by poorly sorted medium sand,a tide ditch,and a small amount of foreign matter.In this area,walking is suitable for tourists.Sand should be supplemented in the intertidal zone.The poor-quality area contained a very narrow and dry beach zone covered with poor-sorted gravel,a very chaotic intertidal zone with a considerable amount of foreign matters,such as bricks and rocks,wide tidal ditches,and an uneven subtidal zone with some reefs;leisure sports are unsuitable here.Thus,foreign matter and reefs should be removed,and the dry beach zone should be supplemented with sand.Therefore,the beach quality assessment is a very useful tool for building beautiful beaches.展开更多
Smart cities depend highly on an intelligent electrical networks to provide a reliable,safe,and clean power supplies.A smart grid achieves such aforementioned power supply by ensuring resilient energy delivery,which p...Smart cities depend highly on an intelligent electrical networks to provide a reliable,safe,and clean power supplies.A smart grid achieves such aforementioned power supply by ensuring resilient energy delivery,which presents opportunities to improve the cost-effectiveness of power supply and minimize environmental impacts.A systematic evaluation of the comprehensive benefits brought by smart grid to smart cities can provide necessary theoretical fundamentals for urban planning and construction towards a sustainable energy future.However,most of the present methods of assessing smart cities do not fully take into account the benefits expected from the smart grid.To comprehensively evaluate the development levels of smart cities while revealing the supporting roles of smart grids,this article proposes a model of smart city development needs from the perspective of residents’needs based on Maslow’s Hierarchy of Needs theory,which serves the primary purpose of building a smart city.By classifying and reintegrating the needs,an evaluation index system of smart grids supporting smart cities was further constructed.A case analysis concluded that smart grids,as an essential foundation and objective requirement for smart cities,are important in promoting scientific urban management,intelligent infrastructure,refined public services,efficient energy utilization,and industrial development and modernization.Further optimization suggestions were given to the city analyzed in the case include strengthening urban management and infrastructure constructions,such as electric vehicle charging facilities and wireless coverage.展开更多
The hydrogeological situation of the study area requires the identification of groundwater potential.Remote sensing and satellite data have proven to be reliable tools for understanding various factors that affect gro...The hydrogeological situation of the study area requires the identification of groundwater potential.Remote sensing and satellite data have proven to be reliable tools for understanding various factors that affect groundwater occurrence and movement.This study employed weighted overlay analysis based on satellite imagery and secondary data to create a thematic map for characterizing groundwater potentials in the study area located within Abbay Basin,Ethiopia.Remote sensing(RS)and GIS-based Fuzzy-Analytical Hierarchy Process methods were utilized to classify groundwater potential(GWP)zones into five categories:Very good,good,moderate,poor,and very poor.The central and eastern parts of the study area were identified as having high(33.186%)and very high(2.351%)groundwater potentials,while the western part exhibited poor and very poor potential areas.The groundwater potential map delineated higher and moderate potentials,suitable for installing shallow and production bores.This research demonstrates the effectiveness of RS and GIS techniques for delineating groundwater potential zones,which can aid in the planning and management of groundwater resources.The research findings have the potential to contribute to the formulation of improved groundwater management programs in the study area.展开更多
Most research works nowadays deal with real-time Internetof Things (IoT) data. However, with exponential data volume increases,organizations need help storing such humongous amounts of IoT data incloud storage systems...Most research works nowadays deal with real-time Internetof Things (IoT) data. However, with exponential data volume increases,organizations need help storing such humongous amounts of IoT data incloud storage systems. Moreover, such systems create security issues whileefficiently using IoT and Cloud Computing technologies. Ciphertext-Policy Attribute-Based Encryption (CP-ABE) has the potential to make IoT datamore secure and reliable in various cloud storage services. Cloud-assisted IoTssuffer from two privacy issues: access policies (public) and super polynomialdecryption times (attributed mainly to complex access structures). We havedeveloped a CP-ABE scheme in alignment with a Hidden HierarchyCiphertext-Policy Attribute-Based Encryption (HH-CP-ABE) access structure embedded within two policies, i.e., public policy and sensitive policy.In this proposed scheme, information is only revealed when the user’sinformation is satisfactory to the public policy. Furthermore, the proposedscheme applies to resource-constrained devices already contracted tasks totrusted servers (especially encryption/decryption/searching). Implementingthe method and keywords search resulted in higher access policy privacy andincreased security. The new scheme introduces superior storage in comparisonto existing systems (CP-ABE, H-CP-ABE), while also decreasing storage costsin HH-CP-ABE. Furthermore, a reduction in time for key generation canalso be noted.Moreover, the scheme proved secure, even in handling IoT datathreats in the Decisional Bilinear Diffie-Hellman (DBDH) case.展开更多
Currently, the comprehensive assessment of the communication troops’ camp planning project is primarily qualitative, with limited quantitative evaluation. Drawing upon the relevant spirit of the Military Commission’...Currently, the comprehensive assessment of the communication troops’ camp planning project is primarily qualitative, with limited quantitative evaluation. Drawing upon the relevant spirit of the Military Commission’s documents and leveraging the author’s own work experience in branch offices, this article thoroughly explores the factors influencing the comprehensive assessment of the project and proposes quantitative representation methods for these factors. Utilizing the Analytic Hierarchy Process (AHP), a hierarchical structure model and judgment matrix for the evaluation factors of the communication troops’ camp construction planning project are constructed, enabling the determination of the weightage of each factor. This provides a certain level of support and reference for the project approval and management by branch offices, while also offering valuable insights for the approval and management of camp planning and construction projects in other types of troops and battlefield projects.展开更多
Landfilling is one of the most effective and responsible ways to dispose of municipal solid waste(MSW).Identifying landfill sites,however,is a challenging and complex undertaking because it depends on social,environme...Landfilling is one of the most effective and responsible ways to dispose of municipal solid waste(MSW).Identifying landfill sites,however,is a challenging and complex undertaking because it depends on social,environmental,technical,economic,and legal issues.This study aims to map the optimal sites that were environmentally suitable for locating a landfill site in Butuan City,Philippines.With reference to the policy requirements from DENR Section I,Landfill Site Identification Criteria and Screening Guidelines of National Solid Waste Management Commission,the integration of a Geographic Information System(GIS)model builder and Analytical Hierarchy Process(AHP)has been used in this study to address the aforementioned challenges related to the landfill site suitability analysis.Based on the generated sanitary landfill suitability map,results showed that Barangay Tungao(1131.42967 ha)and Florida(518.48 ha)were able to meet and consider the three(3)main components,namely economic,environmental,and physical criteria,and are highly suitable as landfill site locations in Butuan City.It is recommended that there will conduct a geotechnical evaluation,involving rigorous geological and hydrogeological assessment employing a combination of site investigation and laboratory techniques.In addition,additional specific social,ecological,climatic,and economic factors need to be considered(i.e.including impact on humans,flora,fauna,soil,water,air,climate,and landscape).展开更多
基金Supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB 42010203)the National Natural Science Foundation of China(No.42176090)。
文摘Scallop culture is an important way of bottom-seeding marine ranching,which is of great significance to improve the current situation of fishery resources.However,there are some problems in site-selection evaluation of marine ranching,such as imperfect criteria system,complex structure,untargeted criteria quantification,etc.In addition,no site-selection evaluation method of bottom-seeding culture areas for scallops is available.Therefore,we established a hierarchy structure model according to the analytic hierarchy process(AHP)theory,in which social,physical,chemical,and biological environments are used as main criteria,and marine functional zonation,water depth,current,water temperature,salinity,substrate type,water quality,sediment quality,red tide,phytoplankton,and zooplankton are used as sub-criteria,on which a multi-parameter evaluation system is set up.Meanwhile,the dualism method,assignment method,and membership function method were used to quantify sub-criteria,and a quantitative evaluation for the entire criteria was added,including the evaluation and analysis of two types of unsuitable environmental situations.By overall consideration in scallop yield,quality,and marine ranching construction objectives,the weight of the main criteria could be determined.Five grades in the suitability corresponding to the evaluation result were divided,and the Python language was used to create an evaluation system for efficient calculation and intuitive presentation of the evaluation outcome.Eight marine cases were simulated based on existing survey data,and the results prove that the method is feasible for evaluating and analyzing the site selection of bottom-seeding culture areas for scallops under various environmental situations.The proposed evaluation method can be promoted for the site selection of bottom-seeding marine ranching.This study provided theoretical and methodological references for the site selection evaluation of other types of marine ranching.
基金supported by the National Key R and D Program of China(2020YFA0713100).
文摘For an arbitrary solution to the Volterra lattice hierarchy,the logarithmic derivatives of the tau-function of the solution can be computed by the matrix-resolvent method.In this paper,we define a pair of wave functions of the solution and use them to give an expression of the matrix resolvent;based on this we obtain a new formula for the k-point functions for the Volterra lattice hierarchy in terms of wave functions.As an application,we give an explicit formula of k-point functions for the even GUE(Gaussian Unitary Ensemble)correlators.
文摘Hydrogen is the new age alternative energy source to combat energy demand and climate change.Storage of hydrogen is vital for a nation’s growth.Works of literature provide different methods for storing the produced hydrogen,and the rational selection of a viable method is crucial for promoting sustainability and green practices.Typically,hydrogen storage is associated with diverse sustainable and circular economy(SCE)criteria.As a result,the authors consider the situation a multi-criteria decision-making(MCDM)problem.Studies infer that previous models for hydrogen storage method(HSM)selection(i)do not consider preferences in the natural language form;(ii)weights of experts are not methodically determined;(iii)hesitation of experts during criteria weight assessment is not effectively explored;and(iv)three-stage solution of a suitable selection of HSM is unexplored.Driven by these gaps,in this paper,authors put forward a new integrated framework,which considers double hierarchy linguistic information for rating,criteria importance through inter-criteria correlation(CRITIC)for expert weight calculation,evidence-based Bayesian method for criteria weight estimation,and combined compromise solution(CoCoSo)for ranking HSMs.The applicability of the developed framework is testified by using a case example of HSM selection in India.Sensitivity and comparative analysis reveal the merits and limitations of the developed framework.
基金the National Natural Science Foundation of China under Grants No.62231021 and No.92373201.
文摘This paper builds a binary tree for the target based on the bounding volume hierarchy technology,thereby achieving strict acceleration of the shadow judgment process and reducing the computational complexity from the original O(N^(3))to O(N^(2)logN).Numerical results show that the proposed method is more efficient than the traditional method.It is verified in multiple examples that the proposed method can complete the convergence of the current.Moreover,the proposed method avoids the error of judging the lit-shadow relationship based on the normal vector,which is beneficial to current iteration and convergence.Compared with the brute force method,the current method can improve the simulation efficiency by 2 orders of magnitude.The proposed method is more suitable for scattering problems in electrically large cavities and complex scenarios.
文摘A dissertation is a research report or scientific paper written by an author to obtain a certain degree. It reflects postgraduates’ research achievements and the educational quality of an institute, even a country. To construct an optimized quality evaluation system for postgraduate dissertation (QESPD), we summarized the influencing factors and invited 10 experienced specialists to rate and prioritize them based on fuzzy analytic hierarchy process. Four primary indicators (innovation, integrity, scientificity and normativity) and 16 sub-indicators were selected to form the evaluation system. The order of primary indicators by weight, was innovation (0.4269), scientificity (0.2807), integrity (0.1728) and normativity (0.1196). The top five sub-dimensions were theoretical originality, scientific value, data reliability, design rationality and evidence credibility. To demonstrate the effectiveness of the proposed system, a case study was performed. In the case study, it was demonstrated that the established two-index-hierarchy QESPD in this study was a more scientific and reasonable evaluation system worthy of promotion and application.
文摘We present an eight component integrable Hamiltonian hierarchy, based on a reduced seventh order matrix spectral problem, with the aim of aiding the study and classification of multicomponent integrable models and their underlying mathematical structures. The zero-curvature formulation is the tool to construct a recursion operator from the spatial matrix problem. The second and third set of integrable equations present integrable nonlinear Schrödinger and modified Korteweg-de Vries type equations, respectively. The trace identity is used to construct Hamiltonian structures, and the first three Hamiltonian functionals so generated are computed.
文摘Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.
基金funded by Key Technology Tackling Programme of Inner Mongolia,grant number2021GG0361funded by Basic Research Operating Costs of Colleges and Universities Directly Under the Inner Mongolia Autonomous Region Project。
文摘Terahertz time-domain spectroscopy is a kind of far-infrared spectroscopy technology,and its spectrum reflects the internal properties of substances with rich physical and chemical information,so the use of terahertz waves can be used to qualitatively identify food additives containing nitrogen elements.Analytic hierarchy process(AHP)was originally used to solve evaluation-type problems,and this paper introduces it into the field of terahertz spectral qualitative analysis,proposes a terahertz time-domain spectral qualitative identification method combined with analytic hierarchy process,and verifies the feasibility of the method by taking four common food additives(xylitol,L-alanine,sorbic acid,and benzoic acid)and two illegal additives(melamine,and Sudan Red No.I)as the objects of study.Firstly,the collected terahertz time-domain spectral data were pre-processed and transformed into a data set consisting of peaks,peak positions,peak numbers and overall trends;then,the data were divided into comparison and test sets,and a qualitative additive identification model incorporating analytic hierarchy process was constructed and parameter optimisation was performed.The results showed that the qualitative identification accuracies of additives based on single factors,i.e.,overall trend,peak value,peak position,and peak number,were 80.23%,70.93%,67.44%,and 40.70%,respectively,whereas the identification accuracy of the analytic hierarchy process qualitative identification method based on multi-factors could be improved to 92.44%.In addition,the fuzzy characterisation of the absorption spectrum data was binarised in the data pre-processing stage and used as the base data for the overall trend,and the recognition accuracy was improved to 94.19%by combining the fuzzy characterisation method of such data with the hierarchical analysis qualitative recognition model.The results show that it is feasible to use terahertz technology to identify different varieties of additives,and this paper constructs a hierarchical analytical qualitative model with better effect,which provides a new means for food additives detection,and the method is simple in steps,with a small demand for samples,which is suitable for the rapid detection of small samples.
文摘Floods are phenomenon with significant socio-economic implications mainly for human loss, agriculture, livestock, soil loss and land degradation, for which many researchers try to identify the most appropriate methodologies by analyzing their temporal and spatial development. This study therefore attempts to employ the GIS-based multi-criteria decision analysis and analytical hierarchy process techniques to derive the flood risks management on rice productivity in the Gishari Agricultural Marshland in Rwamagana district, Rwanda. Here, six influencing potential factors to flooding, including river slope, soil texture, Land Use Land Cover through Land Sat 8, rainfall, river distance and Digital Elevation Model are considered for the delineation of flood risk zones. Data acquisition like Landsat 8 images, DEM, land use land cover, slope, and soil class in the study area were considered. Results showed that if the DEM is outdated or inaccurate due to changes in the terrain, such as construction, excavation, or erosion, the predicted flood patterns might not reflect the actual water flow. This could result unexpected flood extents and depths, potentially inundating rice fields that were not previously at risk and this, expectedly explained that the increase 1 m in elevation would reduce the rice productivity by 0.17% due to unplanned flood risks in marshland. It was found that the change in rainfall distribution in Gishari agricultural marshland would also decrease the rice productivity by 0.0018%, which is a sign that rainfall is a major factor of flooding in rice scheme. Rainfall distribution plays a crucial role in flooding analysis and can directly impact rice productivity. Oppositely, another causal factor was Land Use Land Cover (LULC), where the Multivariate Logistic Regression Model Analysis findings showed that the increase of one unit in Land Use Land Cover would increase rice productivity by 0.17% of the total rice productivity from the Gishari Agricultural Marshland. Based on findings from these techniques, the Gishari Agricultural Marshlands having steeped land with grassland is classified into five classes of flooding namely very low, low, moderate, high, and very high which include 430%, 361%, 292%, 223%, and 154%. Government of Rwanda and other implementing agencies and major key actors have to contribute on soil and water conservation strategies to reduce the runoff and soil erosion as major contributors of flooding.
基金supported by the Intercollegiate Cooperation Plan of Innovation and Entrepreneurship Training Program for College Students of Beijing City(No.202211012).
文摘The whole-beach quality assessment is the basis of building and preserving beautiful beaches.The beach quality assessment index system and assessment standard have been established based on the attributes of beaches(including the width,slope,landform,and types),sorting coefficient,and softness degree of surface sediment.The assessment weight of each index for quality evaluation was analyzed using the analytic hierarchy process,and comprehensive scores of selected beach profiles were calculated in accordance with the light assessment standard.A beach quality evaluation model based on index weight and scores was established in this paper.The factors of 12 profiles of Yangkou Beach in Qingdao City were surveyed to carry out a quality assessment,and the comprehensive scores of each profile were calculated in accordance with the evaluation model.The results showed that the quality of Yangkou Beach can be divided into four ratings:excellent,good,medium,and poor.The excellent-quality area includes a wide and flat dry beach zone and soft,flat,and clean intertidal and subtidal zones covered with well-sorted fine sand,and leisure sports,such as volleyball,running,and swimming,are suitable for tourists.The good-quality area features a slightly narrow and dry beach zone,moderately soft and uneven intertidal and subtidal zones covered with fine sand and a small tidal gully,and a small amount of foreign matter;leisure sports,such as walking and running,are suitable for tourists.This study recommends the building of fixed drainage ditches or underground culverts to reduce the tidal gully.The medium-quality area consisted of a narrow and dry beach zone,moderately soft and uneven intertidal and subtidal zones covered by poorly sorted medium sand,a tide ditch,and a small amount of foreign matter.In this area,walking is suitable for tourists.Sand should be supplemented in the intertidal zone.The poor-quality area contained a very narrow and dry beach zone covered with poor-sorted gravel,a very chaotic intertidal zone with a considerable amount of foreign matters,such as bricks and rocks,wide tidal ditches,and an uneven subtidal zone with some reefs;leisure sports are unsuitable here.Thus,foreign matter and reefs should be removed,and the dry beach zone should be supplemented with sand.Therefore,the beach quality assessment is a very useful tool for building beautiful beaches.
文摘Smart cities depend highly on an intelligent electrical networks to provide a reliable,safe,and clean power supplies.A smart grid achieves such aforementioned power supply by ensuring resilient energy delivery,which presents opportunities to improve the cost-effectiveness of power supply and minimize environmental impacts.A systematic evaluation of the comprehensive benefits brought by smart grid to smart cities can provide necessary theoretical fundamentals for urban planning and construction towards a sustainable energy future.However,most of the present methods of assessing smart cities do not fully take into account the benefits expected from the smart grid.To comprehensively evaluate the development levels of smart cities while revealing the supporting roles of smart grids,this article proposes a model of smart city development needs from the perspective of residents’needs based on Maslow’s Hierarchy of Needs theory,which serves the primary purpose of building a smart city.By classifying and reintegrating the needs,an evaluation index system of smart grids supporting smart cities was further constructed.A case analysis concluded that smart grids,as an essential foundation and objective requirement for smart cities,are important in promoting scientific urban management,intelligent infrastructure,refined public services,efficient energy utilization,and industrial development and modernization.Further optimization suggestions were given to the city analyzed in the case include strengthening urban management and infrastructure constructions,such as electric vehicle charging facilities and wireless coverage.
文摘The hydrogeological situation of the study area requires the identification of groundwater potential.Remote sensing and satellite data have proven to be reliable tools for understanding various factors that affect groundwater occurrence and movement.This study employed weighted overlay analysis based on satellite imagery and secondary data to create a thematic map for characterizing groundwater potentials in the study area located within Abbay Basin,Ethiopia.Remote sensing(RS)and GIS-based Fuzzy-Analytical Hierarchy Process methods were utilized to classify groundwater potential(GWP)zones into five categories:Very good,good,moderate,poor,and very poor.The central and eastern parts of the study area were identified as having high(33.186%)and very high(2.351%)groundwater potentials,while the western part exhibited poor and very poor potential areas.The groundwater potential map delineated higher and moderate potentials,suitable for installing shallow and production bores.This research demonstrates the effectiveness of RS and GIS techniques for delineating groundwater potential zones,which can aid in the planning and management of groundwater resources.The research findings have the potential to contribute to the formulation of improved groundwater management programs in the study area.
文摘Most research works nowadays deal with real-time Internetof Things (IoT) data. However, with exponential data volume increases,organizations need help storing such humongous amounts of IoT data incloud storage systems. Moreover, such systems create security issues whileefficiently using IoT and Cloud Computing technologies. Ciphertext-Policy Attribute-Based Encryption (CP-ABE) has the potential to make IoT datamore secure and reliable in various cloud storage services. Cloud-assisted IoTssuffer from two privacy issues: access policies (public) and super polynomialdecryption times (attributed mainly to complex access structures). We havedeveloped a CP-ABE scheme in alignment with a Hidden HierarchyCiphertext-Policy Attribute-Based Encryption (HH-CP-ABE) access structure embedded within two policies, i.e., public policy and sensitive policy.In this proposed scheme, information is only revealed when the user’sinformation is satisfactory to the public policy. Furthermore, the proposedscheme applies to resource-constrained devices already contracted tasks totrusted servers (especially encryption/decryption/searching). Implementingthe method and keywords search resulted in higher access policy privacy andincreased security. The new scheme introduces superior storage in comparisonto existing systems (CP-ABE, H-CP-ABE), while also decreasing storage costsin HH-CP-ABE. Furthermore, a reduction in time for key generation canalso be noted.Moreover, the scheme proved secure, even in handling IoT datathreats in the Decisional Bilinear Diffie-Hellman (DBDH) case.
文摘Currently, the comprehensive assessment of the communication troops’ camp planning project is primarily qualitative, with limited quantitative evaluation. Drawing upon the relevant spirit of the Military Commission’s documents and leveraging the author’s own work experience in branch offices, this article thoroughly explores the factors influencing the comprehensive assessment of the project and proposes quantitative representation methods for these factors. Utilizing the Analytic Hierarchy Process (AHP), a hierarchical structure model and judgment matrix for the evaluation factors of the communication troops’ camp construction planning project are constructed, enabling the determination of the weightage of each factor. This provides a certain level of support and reference for the project approval and management by branch offices, while also offering valuable insights for the approval and management of camp planning and construction projects in other types of troops and battlefield projects.
文摘Landfilling is one of the most effective and responsible ways to dispose of municipal solid waste(MSW).Identifying landfill sites,however,is a challenging and complex undertaking because it depends on social,environmental,technical,economic,and legal issues.This study aims to map the optimal sites that were environmentally suitable for locating a landfill site in Butuan City,Philippines.With reference to the policy requirements from DENR Section I,Landfill Site Identification Criteria and Screening Guidelines of National Solid Waste Management Commission,the integration of a Geographic Information System(GIS)model builder and Analytical Hierarchy Process(AHP)has been used in this study to address the aforementioned challenges related to the landfill site suitability analysis.Based on the generated sanitary landfill suitability map,results showed that Barangay Tungao(1131.42967 ha)and Florida(518.48 ha)were able to meet and consider the three(3)main components,namely economic,environmental,and physical criteria,and are highly suitable as landfill site locations in Butuan City.It is recommended that there will conduct a geotechnical evaluation,involving rigorous geological and hydrogeological assessment employing a combination of site investigation and laboratory techniques.In addition,additional specific social,ecological,climatic,and economic factors need to be considered(i.e.including impact on humans,flora,fauna,soil,water,air,climate,and landscape).