Prediction of high-embankment settlement combining joint denoising technique and enhanced GWO-v-SVR method

Reliable long-term settlement prediction of a high embankment relates to mountain infrastructure safety.This study developed a novel hybrid model(NHM)that combines a joint denoising technique with an enhanced gray wolf optimizer(EGWO)-n-support vector regression(n-SVR)method.High-embankment field measurements were preprocessed using the joint denoising technique,which in-cludes complete ensemble empirical mode decomposition,singular value decomposition,and wavelet packet transform.Furthermore,high-embankment settlements were predicted using the EGWO-n-SVR method.In this method,the standard gray wolf optimizer(GWO)was improved to obtain the EGWO to better tune the n-SVR model hyperparameters.The proposed NHM was then tested in two case studies.Finally,the influences of the data division ratio and kernel function on the EGWO-n-SVR forecasting performance and prediction efficiency were investigated.The results indicate that the NHM suppresses noise and restores details in high-embankment field measurements.Simultaneously,the NHM out-performs other alternative prediction methods in prediction accuracy and robustness.This demonstrates that the proposed NHM is effective in predicting high-embankment settlements with noisy field mea-surements.Moreover,the appropriate data division ratio and kernel function for EGWO-n-SVR are 7:3 and radial basis function,respectively.

Settlement Control Technology of High Filled Soil-Rock Embankment in Alpine and High-Altitude Areas

China's infrastructure has gradually achieved large-scale development,and transportation construction has also shifted from east to west,transitioning from plains to mountainous areas.High-fill embankments of different sizes in mountainous areas are unavoidable,and the settlement of high-fill embankments is usually the most concerned issue in high-fill projects.According to the current research of highway projects,most of the high embankments in mountainous areas are soil-rock mixed embankments or rock-filled embankments,and their post-construction settlements are directly related to construction technology and the type of filler used.In this paper,the problems in the settlement control of earth-filled embankment and related factors are analyzed in detail.The settlement control technology of high-fill embankment in high-cold and high-altitude areas is also discussed,so as to ensure the overall quality of high-fill embankment.

Model tests on XCC-piled embankment under dynamic train load of high-speed railways

Piled embankments,which offer many advantages,are increasingly popular in construction of high-speed railways in China.Although the performance of piled embankment under static loading is well-known,the behavior under the dynamic train load of a high-speed railway is not yet understood.In light of this,a heavily instrumented piled embankment model was set up,and a model test was carried out,in which a servo-hydraulic actuator outputting M-shaped waves was adopted to simulate the process of a running train.Earth pressure,settlement,strain in the geogrid and pile and excess pore water pressure were measured.The results show that the soil arching height under the dynamic train load of a high-speed railway is shorter than under static loading.The growth trend for accumulated settlement slowed down after long-term vibration although there was still a tendency for it to increase.Accumulated geogrid strain has an increasing tendency after long-term vibration.The closer the embankment edge,the greater the geogrid strain over the subsoil.Strains in the pile were smaller under dynamic train loads,and their distribution was different from that under static loading.At the same elevation,excess pore water pressure under the track slab was greater than that under the embankment shoulder.

Dynamic responses of bridge-approach embankment transition section of high-speed rail

Based on the vehicle track coupling dynamics theory, a new spatial dynamic numerical model of vehicle track subgrade coupling system was established considering the interaction among different structural layers in the subgrade system. The dynamic responses of the coupled system were analyzed when the speed of train was 350 km/h and the transition was filled with graded broken stones mixed with 5% cement. The results indicate that the setting form of bridge-approach embankment section has little effect on the dynamic responses, thus designers can choose it on account of the practical circumstances. Because the location about 5 m from the bridge abutment has the greatest deformation, the stiffness within 0 5 m zone behind the abutment should be specially designed. The results of the study from vehicle track dynamics show that the maximum allowable track deflection angle should be 0.09% and the coefficient of subgrade reaction(K30) is greater than 190 MPa within the 0 5 m zone behind the abutment and greater than 150 MPa in other zones.

Mechanism and calculation method of rheological settlement of high-filled embankment

The characteristics of high-filled embankment rheological settlement were analyzed;mechanical calculation model of high-filled embankment rheological settlement during constructing and running period was also put forward.Combining the macroscopic and microscopic deformation properties of the engineering soil grain,its constitutive model was set up and its characters were fully revealed,at the same time,its practical calculation formula under the action of dead-weight load was derived,which is feasible by analysis and comparison.

基于协同降噪与IGWO-SVR的高填方路基沉降预测

高填方路基沉降影响山岭重丘区重载铁路运营安全。为克服实测沉降数据掺杂随机噪声、现有预测模型适用性差的不足,提出基于协同降噪算法与IGWO-SVR模型的沉降预测方法。运用互补集合经验模态分解法(CEEMD)与小波包变换法(WPT)对含噪沉降数据进行协同降噪处理;提出基于佳点集初始化均布、非线性收敛控制与自身历史最优记忆位置更新的改进灰狼优化(IGWO)算法,并结合支持向量回归模型(SVR),构建IGWO-SVR沉降预测模型。进一步地,利用大准铁路工点及现有文献研究成果,验证IGWO-SVR模型的优越性。结果表明:协同降噪法可有效消除原数据中噪声项的干扰波动;在小样本数据集上,IGWO-SVR模型较传统沉降预测模型与现有文献所述预测模型,具有更高的预测精度与稳定性。研究成果为重载铁路高填方路基沉降预测提供了新途径。

Dual-doping for enhancing chemical stability of functional anionic units in sulfide for high-performance all-solid-state lithium batteries

The sulfide-based solid-state electrolytes(SEs)reactivity toward moisture and Li-metal are huge barriers that impede their large-scale manufactu ring and applications in all-solid-state lithium batteries(ASSLBs).Herein,we proposed an Al and O dual-doped strategy for Li_(3)PS_(4)SE to regulate the chemical/electrochemical stability of anionic PS_(4)^(3-)tetrahedra to mitigate structural hydrolysis and parasitic reactions at the SE/Li interface.The optimized Li_(3.08)A_(10.04)P_(0.96)S_(3.92)O_(0.08)SE presents the highestσLi+of 3.27 mS cm^(-1),which is~6.8 times higher than the pristine Li_(3)PS_(4)and excellently inhibits the structural hydrolysis for~25 min@25%humidity at RT.DFT calculations confirmed that the enhanced chemical stability was revealed to the intrinsically stable entities,e.g.,POS33-units.Moreover,Li_(3.08)Al_(0.04)P_(0.96)S_(3.92)O_(0.08)SE cycled stably in Li//Li symmetric cell over 1000 h@0.1 mA cm^(-2)/0.1 mA h cm^(-2),could be revealed to Li-Al alloy and Li_(2)Oat SE/Li interface impeding the growth of Li-dendrites during cycling.Resultantly,LNO@LCO/Li_(3.08)Al_(0.04)P_(0.96)S_(3.92)O_(0.08)/Li-In cell delivered initial discharge capacities of 129.8 mA h g^(-1)and 83.74%capacity retention over 300 cycles@0.2 C at RT.Moreover,the Li_(3.08)Al_(0.04)P_(0.96)S_(3.92)O_(0.08)SE presented>90%capacity retention over 200 and 300 cycles when the cell was tested with LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2)(NCA)cathode material vs.5 and 10 mg cm^(-2)@RT.

Analysis of the Influence Factors of Differential Settlement of High Embankment in Mountain Area

This paper reveals and analyses various influence factors which cause differential settlement of high embankment in mountain area using indoor consolidation test and field loading test. In this research, the actual stress characteristics of high embankment are simplified, stability compression value of stuffing with loads under lateral restricted conditions can be measured, e-p curves and p-s curves are drawn, we can calculate compression modulus as computation criteria to estimate the settlement of high embankment. The results indicate that unconsolidated flow of high embankment is the main factor to cause differential settlement of high embankment in mountain area. As the soil consolidated, compressive deformation and the strength gradually increase, the bearing capacity of the foundation is enhanced to reduce differential settlement of the post-construction of high embankment.

MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss

Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related diseases.Furthermore,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling pathway.This study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling pathway.Methods Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different groups.The targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were investigated.In addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,ELISA,and RT-PCR,respectively.Furthermore,changes of the NF-κB signaling pathway in ILC1s were examined in the different groups.For the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling pathway.Results The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all P<0.05).In addition,miR-142-3p was found to drastically inhibit the activation of the NF-κB signaling pathway(P<0.05).The number of ILC1s and the levels of pro-inflammatory cytokines were significantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all P<0.05).Conclusion miR-142-3p can regulate ILC1s by targeting HMGB1 via the NF-κB signaling pathway,and attenuate the inflammation at the maternal-fetal interface in abortive mice.

前列腺癌患者外周血中CD4^+CD25^(high)调节性T细胞及调节因子TGF-β1和COX-2的表达

目的:通过检测前列腺癌患者以及健康志愿者外周血中CD4+CD25high调节性T细胞、TGF-β1及COX-2的表达,初步探讨CD4+CD25high调节性T细胞在前列腺癌发病机制中的作用及其与TGF-β1和COX-2的相关性。方法:应用流式细胞术检测30例前列腺癌患者治疗前后(其中前列腺癌局限组11例,非局限组19例)及20例健康志愿者外周血单个核细胞(PBMC)中CD4+CD25high调节性T细胞占CD4+T细胞的比例;应用酶联免疫吸附试验(ELISA)检测其外周血清中TGF-β1和COX-2的表达。对前列腺癌患者上述指标进行术前术后对比分析,另对CD4+CD25high调节性T细胞与TGF-β1及COX-2的相关性进行分析;并探讨上述指标在前列腺癌患者局限组和非局限组间是否存在差异性。结果:流式细胞术检测显示,前列腺癌患者治疗前PBMC中CD4+CD25high调节性T细胞占CD4+T细胞的比例为(18.32±7.49)%,高于健康志愿者对照组(7.77±1.86)%(P<0.05)。前列腺癌患者治疗后其比值为(17.34±5.87)%,较治疗前稍减低,但两者相比无显著差异(P>0.05)。ELISA检测外周血清中TGF-β1和COX-2显示,前列腺癌组分别为(215.97±55.16)ng/ml和(6.88±5.14)ng/ml,对照组分别为(149.75±47.11)ng/ml和(5.65±2.69)ng/ml;前列腺癌患者外周血清中TGF-β1的表达水平高于健康志愿者对照组(P<0.05),COX-2的表达水平与对照组无显著差异(P>0.05)。通过多重线性回归分析表明,前列腺癌患者PBMC中CD4+CD25high调节性T细胞的表达与血清中TGF-β1和COX-2的表达无显著相关。前列腺癌局限组和非局限组外周血中CD4+CD25high调节性T细胞、TGF-β1及COX-2的表达均无显著性差异(P>0.05)。结论:前列腺癌患者PBMC中CD4+CD25high调节性T细胞可能参与前列腺癌的发生,其增殖机制与血清中TGF-β1和COX-2的表达无关,可能与肿瘤本身及肿瘤局部微环境相关。

Future Changes in Extreme High Temperature over China at 1.5℃-5℃ Global Warming Based on CMIP6 Simulations

Extreme high temperature(EHT)events are among the most impact-related consequences related to climate change,especially for China,a nation with a large population that is vulnerable to the climate warming.Based on the latest Coupled Model Intercomparison Project Phase 6(CMIP6),this study assesses future EHT changes across China at five specific global warming thresholds(1.5℃-5℃).The results indicate that global mean temperature will increase by 1.5℃/2℃ before 2030/2050 relative to pre-industrial levels(1861-1900)under three future scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5),and warming will occur faster under SSP5-8.5 compared to SSP1-2.6 and SSP2-4.5.Under SSP5-8.5,global warming will eventually exceed 5℃ by 2100,while under SSP1-2.6,it will stabilize around 2℃ after 2050.In China,most of the areas where warming exceeds global average levels will be located in Tibet and northern China(Northwest China,North China and Northeast China),covering 50%-70%of the country.Furthermore,about 0.19-0.44 billion people(accounting for 16%-41%of the national population)will experience warming above the global average.Compared to present-day(1995-2014),the warmest day(TXx)will increase most notably in northern China,while the number of warm days(TX90p)and warm spell duration indicator(WSDI)will increase most profoundly in southern China.For example,relative to the present-day,TXx will increase by 1℃-5℃ in northern China,and TX90p(WSDI)will increase by 25-150(10-80)days in southern China at 1.5℃-5℃ global warming.Compared to 2℃-5℃,limiting global warming to 1.5℃ will help avoid about 36%-87%of the EHT increases in China.

LaSrNiO_(4-λ) with K_2NiF_4 Strcture──A Highly Active Catalyst for Direct Decomposition of Nitrogen Monoxide

A series of perovskite-like mixed oxides La2-xSrxMO4±λ(M =Cu, Co,Ni; x=0,1 ) was prepared and characterized using X-ray powder diffraction. The catalytic properties of these catalysts in NO decompositiori were tested. The results showed that LaSrNiO4-λ with K2NiF4 structure is very active and stable for the decomposition of NO.

Process for improving the ladle free- opening rate for high aluminum steel in continuous casting

Steel 20Mn23AlV is a type of high aluminum steel with a very low ladle free-opening rate. The aluminum composition of 20Mn23AlV ranges from 1.6% to 2.45% ,which is significantly higher than other types of steel. According to the real condition of 40 t ladle in steel-making plant of Baosteel Special Steel Company, previous works show that the key factors affecting the ladle free-opening rate of high aluminum steel in continuous casting are：sand material, accessories baking, ladle nozzle cleaning, the process and amount of adding sand, and the rate of argon stirring during refining. Therefore, improving the ladle filler sand quality, baking all of the raw materials, controlling the addition of ladle filler sand, cleaning the ladle nozzle, and optimizing argon stirring during the refining process can resolve the problem of a low ladle free-opening rate of high aluminum steel caused by the long ladle time of liquid steel.

Seismic stability evaluation of embankment slope based on catastrophe theory

An evaluation method for the seismic stability of embankment slope was presented based on catastrophe theory. Seven control factors, including internal frictional angle, cohesion force, slope height, slope angle, surface gradients, peak acceleration, and distance to fault were selected for analysis of multi-level objective decomposition. According to the normalization formula and the fuzzy subject function produced by combination of catastrophe theory and fuzzy math, a recursive calculation was carried out to obtain a catastrophic affiliated functional value, which can be used to evaluate the seismic stability of embankment slope. Fifteen samples were used to verify the effectiveness of this method. The results show that compared with the traditional quantitative method, the catastrophe progression owns higher accuracy and good application potential in predicting the seismic stability of embankment slope.

Layer regrouping for water-flooded commingled reservoirs at a high water-cut stage

Layer regrouping is to divide all the layers into several sets of production series according to the physical properties and recovery percent of layers at high water-cut stage, which is an important technique to improve oil recovery for high water-cut multilayered reservoirs. Dif- ferent regroup scenarios may lead to different production performances. Based on unstable oil-water flow theory, a multilayer commingled reservoir simulator is established by modifying the production split method. Taking into account the differences of layer properties, including per- meability, oil viscosity, and remaining oil saturation, the pseudo flow resistance contrast is proposed to serve as a characteristic index of layer regrouping for high water-cut multilayered reservoirs. The production indices of multi- layered reservoirs with different pseudo flow resistances are predicted with the established model in which the data are taken from the Shengtuo Oilfield. Simulation results show that the pseudo flow resistance contrast should be less than 4 when the layer regrouping is implemented. The K-means clustering method, which is based on the objec- tive function, is used to automatically carry out the layer regrouping process according to pseudo flow resistances. The research result is applied to the IV-VI sand groups of the second member of the Shahejie Formation in the Shengtuo Oilfield, a favorable development performance is obtained, and the oil recovery is enhanced by 6.08 %.

A Simple and Highly Efficient Enantioselective Synthesis of (<i>S</i>)-Rivastigmine

A highly efficient and convenient procedure for the enantioselective synthesis of (S)-Rivastigmine, a cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parkinson’s disease, is accomplished by the treatment of versatile, readily accessible (S)-(-)-2-methyl-2-propanesulfinamide with 3-hydroxyacetophenone. This protocol provides high yield and excellent enantiomeric excess in short step synthesis.

Plastic Flow Modeling of Ti-5 Al-2 Sn-2 Zr-4 Mo-4 Cr Alloy at Elevated Temperatures and High Strain Rates

The true stress-sWain relationships of Ti-5A1-2Sn-2Zr-4Mo-4Cr（TC17） alloy with a wide range of strain rates were investigated by tmiaxial quasi-static and dynamic compression tests, respectively. Quasi- static compression tests were carried out with Instron 8874 test machine, while dynamic compression tests were performed with the split Hopkinson pressure bar （SHPB） which was installed with heating device and synchro- assembly system. The dynamic mechanical behaviors tests of TC17 were carded out from room temperature to 800 ℃ at intervals of 200 ℃ and at high sWain rates （5 500-1 9200 s-l）. The stress-strain curves considering temperature-sWain rate coupling actions were obtained. The Johnson-Cook constitutive model was developed through data fitting of the stress-sWain curves. The material constants in the developed constitutive model can be determined using isothermal and adiabatic stress-strain curves at different strain rates. The Johnson-Cook constitutive model provided satisfied prediction of the plastic flow stress for TC17 alloy.

Dynamic compaction treatment technology research of red clay soil embankment in southern mountains

High liquid limit soil generally adopted in expressway embankment construction of southern mountains, which often expresses some characteristics including high moisture content, high porosity ratio, low permeability, high compressibility, certain disintegration, and so on. Spring soil phenomenon and inhomogeneous compaction have effects on the quality of embankment construction, just because the water in soil is difficult to evaporate. Based on the study of reinforcement mechanism for high liquid limit soil, in situ tests for dynamic compaction treatment in Yizhang-Fengtouling expressway embankment were developed. The reliable and economical dynamic compaction treatment methods and the construction technology for large range high liquid limit soil embankment in southern mountains expressway were discussed. In the process, convenient measurement methods were adopted to evaluate the treatment effects. The test results show that the dynamic compaction method has good treatment effects on the local red clay embankment. The embankment compaction degree is improved with compactness coming to 90% around tamping pits and compactness over 95% in tamping pits interior after tamping. The bearing capacity, the physical mechanic-property and the shear strength for soil are obviously improved, which are enhanced with cohesive strength increasing over 10 kPa and compression modulus increasing over 3 MPa.

Probabilistic analysis of embankment slope stability in frozen ground regions based on random finite element method

Prediction on the coupled thermal-hydraulic fields of embankment and cutting slopes is essential to the assessment on evolution of melting zone and natural permafrost table, which is usually a key factor for permafrost embankment design in frozen ground regions. The prediction may be further complicated due to the inherent uncertainties of material properties. Hence, stochastic analyses should be conducted. Firstly, Karhunen-Loeve expansion is applied to attain the random fields for hydraulic and thermal conductions. Next, the mixed-form modified Richards equation for mass transfer （i.e., mass equation） and the heat transport equation for heat transient flow in a variably saturated frozen soil are combined into one equation with temperature unknown. Furthermore, the finite element formulation for the coupled thermal-hydraulic fields is derived. Based on the random fields, the stochastic finite element analyses on stability of embankment are carried out. Numerical results show that stochastic analyses of embankment stability may provide a more rational picture for the distribution of factors of safety （FOS）, which is definitely useful for embankment design in frozen ground regions.

A COMPUTER SIMULATION OF HIGH-DOSE ION IMPLANTATION INTO AMORPHOUS MATERIALS

A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, so that the radial distribution function will characterize the short - range order and long - range disorder of amorphous targets. A simulation example is given.