Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood glucose.Due to its increased usage in clinics,the number of studies investigating its accuracy has increased.However,its accuracy has not been investigated in highland populations in China.AIM To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to plains.METHODS Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 d.Throughout the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three meals.Moreover,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 min.The accuracy of the FGM system was evaluated according to the CGM guidelines.Subsequently,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression method.RESULTS Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and B.According to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when the largest amplitude of glycemic excursion(LAGE)was<5.80 mmol/L but negatively correlated with blood glucose when the LAGE was≥5.80 mmol/L.CONCLUSION The FreeStyle Libre FGM system has good accuracy in patients with T2D who had recently migrated from highlands to plains.This system might be ideal for avoiding the effects of high hematocrit on blood glucose monitoring in populations that recently migrated to plains.MARD is mainly influenced by glucose levels and fluctuations,and the accuracy of the system is higher when the blood glucose fluctuation is small.In case of higher blood glucose level fluctuations,deviation in the scanned glucose levels is the highest at extremely low blood glucose levels.

基于Galileo HAS服务的全球PWV反演验证分析

基于实时精密单点定位PPP的大气可降水量PWV反演技术近年来受到广泛研究,但目前该技术大多需利用网络通讯接收改正信息,这使其在通讯网络不能覆盖及因灾通讯受限地区的使用受到限制。2023年1月开通服务的Galileo系统高精度定位服务HAS(High Accuracy Service)为实现不依赖额外通讯手段的实时PWV反演提供了新手段。本文首先分析验证了Galileo系统HAS服务的卫星轨道和钟差改正信息精度,并将基于武汉大学IGS分析中心产品的PWV反演结果作为内部对比参考值、将基于ERA5数据及探空数据结果作为PWV结果对比的外部参考值,验证了基于HAS服务的PWV反演精度。结果表明HAS服务反演得到的PWV与两类参考值均具有较高的一致性。其中HAS服务计算得出的结果与IGS事后产品PWV解算结果的两序列差的RMS为2.91 mm,与探空数据的序列差的RMS为2.51 mm。初步验证了HAS可用于降雨的短时预报可行性。

Benchmarking calculations of excitation energies and transition properties with spectroscopic accuracy of highly charged ions used for the fusion plasma and astrophysical plasma

Atomic radiative data such as excitation energies, transition wavelengths, radiative rates, and level lifetimes with high precision are the essential parameters for the abundance analysis, simulation, and diagnostics in fusion and astrophysical plasmas. In this work, we mainly focus on reviewing our two projects performed in the past decade. One is about the ions with Z■30 that are generally of astrophysical interest, and the other one is about the highly charged krypton(Z = 36)and tungsten(Z = 74) ions that are relevant in research of magnetic confinement fusion. Two different and independent methods, namely, multiconfiguration Dirac–Hartree–Fock(MCDHF) and the relativistic many-body perturbation theory(RMBPT) are usually used in our studies. As a complement/extension to our previous works for highly charged tungsten ions with open M-shell and open N-shell, we also mainly focus on presenting and discussing our complete RMBPT and MCDHF calculations for the excitation energies, wavelengths, electric dipole(E1), magnetic dipole(M1), electric quadrupole(E2), and magnetic quadrupole(M2) transition properties, and level lifetimes for the lowest 148 levels belonging to the 3l3configurations in Al-like W61+. We also summarize the uncertainties of our systematical theoretical calculations, by cross-checking/validating our datasets from our RMBPT and MCDHF calculations, and by detailed comparisons with available accurate observations and other theoretical calculations. The data are openly available in Science Data Bank at https://doi.org/10.57760/sciencedb.10569.

Performance validation of High Mountain Asia 8-meter Digital Elevation Model using ICESat-2 geolocated photons

High Mountain Asia(HMA),recognized as a third pole,needs regular and intense studies as it is susceptible to climate change.An accurate and high-resolution Digital Elevation Model(DEM)for this region enables us to analyze it in a 3D environment and understand its intricate role as the Water Tower of Asia.The science teams of NASA realized an 8-m DEM using satellite stereo imagery for HMA,termed HMA 8-m DEM.In this research,we assessed the vertical accuracy of HMA 8-m DEM using reference elevations from ICESat-2 geolocated photons at three test sites of varied topography and land covers.Inferences were made from statistical quantifiers and elevation profiles.For the world’s highest mountain,Mount Everest,and its surroundings,Root Mean Squared Error(RMSE)and Mean Absolute Error(MAE)resulted in 1.94 m and 1.66 m,respectively;however,a uniform positive bias observed in the elevation profiles indicates the seasonal snow cover change will dent the accurate estimation of the elevation in this sort of test sites.The second test site containing gentle slopes with forest patches has exhibited the Digital Surface Model(DSM)features with RMSE and MAE of 0.58 m and 0.52 m,respectively.The third test site,situated in the Zanda County of the Qinghai-Tibet,is a relatively flat terrain bed,mostly bare earth with sudden river cuts,and has minimal errors with RMSE and MAE of 0.32 m and 0.29 m,respectively,and with a negligible bias.Additionally,in one more test site,the feasibility of detecting the glacial lakes was tested,which resulted in exhibiting a flat surface over the surface of the lakes,indicating the potential of HMA 8-m DEM for deriving the hydrological parameters.The results accrued in this investigation confirm that the HMA 8-m DEM has the best vertical accuracy and should be of high use for analyzing natural hazards and monitoring glacier surfaces.

An Explicit Difference Scheme with High Accuracy and Branching Stability for Solving Parabolic Partial Differential Equation

This paper presents an explicit difference scheme with accuracy and branching stability for solving onedimensional parabolic type equation by the method of undetermined parameters and its truncation error is O(△t4+△x4). The stability condition is r=a△t/△x2<1/2.

High accuracy non-equidistant method for singular perturbation reaction-diffusion problem

Singular perturbation reaction-diffusion problem with Dirichlet boundary condition is considered. It is a multi-scale problem. Presence of small parameter leads to boundary layer phenomena in both sides of the region. A non-equidistant finite difference method is presented according to the property of boundary layer. The region is divided into an inner boundary layer region and an outer boundary layer region according to transition point of Shishkin. The steps sizes are equidistant in the outer boundary layer region. The step sizes are gradually increased in the inner boundary layer region such that half of the step sizes are different from each other. Truncation error is estimated. The proposed method is stable and uniformly convergent with the order higher than 2. Numerical results are given, which are in agreement with the theoretical result.

HIGH ACCURACY FINITE VOLUME ELEMENT METHOD FOR TWO-POINT BOUNDARY VALUE PROBLEM OF SECOND ORDER ORDINARY DIFFERENTIAL EQUATIONS

In this paper, a high accuracy finite volume element method is presented for two-point boundary value problem of second order ordinary differential equation, which differs from the high order generalized difference methods. It is proved that the method has optimal order error estimate O(h3) in H1 norm. Finally, two examples show that the method is effective.

Feasibility and Diagnostic Accuracy for Assessment of Coronary Artery Stenosis of Prospectively Electrocardiogram-gated High-pitch Spiral Acquisition Mode Dual-source CT Coronary Angiography in Patients with Relatively Higher Heart Rates: in Comparison wit

Objective To prospectively investigate the diagnostic accuracy for coronary artery stenosis of prospectively electrocardiogram-triggered spiral acquisition mode (high pitch mode) dual-source computed tomography coronary angiography (CTCA) in patients with relatively higher heart rates (HR) compared with catheter coronary angiography (CCA). Methods Forty-seven consecutive patients with relatively higher HR (>65 and <100 bpm) (20 male, 27 female; age 55±10 years) who both underwent dual-source CTCA and CCA were prospectively included in this study. All patients were performed CTCA using high pitch mode setting at 20%-30% of the R-R interval for the image acquisition. All coronary segments were evaluated by two blinded and independent observers with regard to image quality on a three-point scale (1: excellent to 3: non-diagnostic) and for the presence of significant coronary stenoses (defined as diameter narrowing exceeding 50%). Considered CCA as the standard of reference, the sensitivity, specificity, positive predictive value and negative predictive value were calculated. Radiation dose values were calculated using the dose-length product. Results Image quality was rated as being score 1 in 92.4% of segments, score 2 in 6.1% of segmentsand score 3 in 1.5% of segments. The average image quality score per segment was 1.064±0.306. The HR variability of patients with image score 1, 2 and 3 were 2.29±1.06 bpm, 5.17±1.37 bpm, 8.88±1.53 bpm, respectively. The average HR variability of patients with different image scores were significantly different (F=170.402, P=0.001). The sensitivity, specificity, positive and negative predictive values were 92.6%, 97.0%, 87.6%, 98.3%, respectively, per segment and 90.0%, 95.2%, 85.3%, 96.9%, respectively, per vessel and 100%, 63.6%, 90.0%, 100%, respectively, per patient. The effective radiation dose was on average 0.86±0.16 mSv. Conclusion In patients with HR more than 65 bpm and below 100 bpm without cardiac arrhythmia, the prospectively electrocardiogram-gated high-pitch spiral acquisition mode with image acquired timing set at 20%-30% of the R-R interval provides a high diagnostic accuracy for the assessment of coronary stenoses combined with a 1.5% of non-diagnostic coronary segments and a radiation dose below 1 mSv.

A SET OF 12-PARAMETER RECTANGULAR PLATE ELEMENT WITH HIGH ACCURACY

Using the method of undetermined function, a set of 12 parameter rectangular plate element with double set parameter and geometry symmetry is constructed. Their consistency error are O(h\+2) , one order higher than the usual 12 parameter rectangular plate elements.

High Accuracy Finite Volume Method for Solving Nonlinear Aeroacoustics Problems on Unstructured Meshes

The paper presents a finite volume numerical method universally applicable for solving both linear and nonlinear aeroacoustics problems on arbitrary unstructured meshes. It is based on the vertexcentered multi-parameter scheme offering up to the 6th accuracy order achieved on the Cartesian meshes. An adaptive dissipation is added for the numerical treatment of possible discontinuities. The scheme properties are studied on a series of test cases, its efficiency is demonstrated at simulating the noise suppression in resonance-type liners.

ADFE METHOD WITH HIGH ACCURACY FOR NONLINEAR PARABOLIC INTEGRO-DIFFERENTIAL SYSTEM WITH NONLINEAR BOUNDARY CONDITIONS

Alternating direction finite element (ADFE) scheme for d-dimensional nonlinear system of parabolic integro-differential equations is studied. By using a local approximation based on patches of finite elements to treat the capacity term qi(u), decomposition of the coefficient matrix is realized, by using alternating direction, the multi-dimensional problem is reduced to a family of single space variable problems, calculation work is simplified; by using finite element method, high accuracy for space variant is kept; by. using inductive hypothesis reasoning, the difficulty coming from the nonlinearity of the coefficients and boundary conditions is treated; by introducing Ritz-Volterra projection, the difficulty coming from the memory term is solved. Finally, by using various techniques for priori estimate for differential equations, the unique resolvability and convergence properties for both FE and ADFE schemes are rigorously demonstrated, and optimal H-1 and L-2 norm space estimates and O((Deltat)(2)) estimate for time variant are obtained.

HIGH ORDER ACCURACY SCHEME FOR 2-D TRANSONIC FLOWS

According to Taylor's expansion formula, a kind of derivatives computation method is presented, which can achieve arbitrary order of accuracy. Then it is combined with a flux difference splitting technique and a flux limiter to construct the desiredscheme that is suitable for non-oscillatory shock-capturing calculation. TVD typeRunge-Kutta method is used for temporal discretization. Several steady and unsteadynumerical experiments demonstrate that the scheme is a robust solver for transonicflows with high accuracy and high resolution of shock wave structures.

A new alternating group explicit-implicit algorithm with high accuracy for dispersive equation

In this paper, a new alternating group explicit-implicit （nAGEI） scheme for dispersive equations with a periodic boundary condition is derived. This new unconditionally stable scheme has a fourth-order truncation error in space and a convergence ratio faster than some known alternating methods such as ASEI and AGE. Comparison in accuracy with the AGEI and AGE methods is presented in the numerical experiment.

A COUPLING METHOD OF DIFFERENCE WITH HIGH ORDER ACCURACY AND BOUNDARY INTEGRAL EQUATION FOR EVOLUTIONARY EQUATION AND ITS ERROR ESTIMATES

In the present paper, a new numerical method for solving initial-boundary value problems of evolutionary equations is proposed and studied, combining difference method with high accuracy with boundary integral equation method. The numerical approximate schemes for both problems on a bounded or unbounded domain in R3 are proposed and their prior error estimates are obtained.

A Compact Explicit Difference Scheme of High Accuracy for Extended Boussinesq Equations

Presented here is a compact explicit difference scheme of high accuracy for solving the extended Boussinesq equations. For time discretization, a three-stage explicit Runge-Kutta method with TVD property is used at predicting stage, a cubic spline function is adopted at correcting stage, which made the time discretization accuracy up to fourth order; For spatial discretization, a three-point explicit compact difference scheme with arbitrary order accuracy is employed. The extended Boussinesq equations derived by Beji and Nadaoka are solved by the proposed scheme. The numerical results agree well with the experimental data. At the same time, the comparisons of the two numerical results between the present scheme and low accuracy difference method are made, which further show the necessity of using high accuracy scheme to solve the extended Boussinesq equations. As a valid sample, the wave propagation on the rectangular step is formulated by the present scheme, the modelled results are in better agreement with the experimental data than those of Kittitanasuan.

An online fast multi-track locating algorithm for high-resolution single-event effect test platform

To improve the efficiency and accuracy of single-event effect(SEE)research at the Heavy Ion Research Facility at Lanzhou,Hi’Beam-SEE must precisely localize the position at which each heavy ion hitting the integrated circuit(IC)causes SEE.In this study,we propose a fast multi-track location(FML)method based on deep learning to locate the position of each particle track with high speed and accuracy.FML can process a vast amount of data supplied by Hi’Beam-SEE online,revealing sensitive areas in real time.FML is a slot-based object-centric encoder-decoder structure in which each slot can learn the location information of each track in the image.To make the method more accurate for real data,we designed an algorithm to generate a simulated dataset with a distribution similar to that of the real data,which was then used to train the model.Extensive comparison experiments demonstrated that the FML method,which has the best performance on simulated datasets,has high accuracy on real datasets as well.In particular,FML can reach 238 fps and a standard error of 1.6237μm.This study discusses the design and performance of FML.

Analysis on a Set of 12-parameter Rectangular Plate Element with High Accuracy

It is proved that the so-called a set of 12-parameter rectangular plate elements with high accuracy constructed by using double set parameter method and undetermined method are, in fact, the same one; the real shape function space is nothing but the Adini＇s element＇s, which has nothing to do with the other high degree terms and leads to a new method for constructing the high accuracy plate elements. This fact has never been seen for other conventional and unconventional, conforming and nonconforming rectangular plate elements, such as Quasi-conforming elements, generalized conforming elements and other double set parameter finite elements. Moreover, such kind of rectangular elements can not be constructed by the conventional finite element methods.

Methodology of High Accuracy and Resolution 3D Geological Model Generation and Application

By generating a high accuracy and high resolution geological model in Liuchu oil field, the technique of geological modeling is expanded and involved in primary geological study, making the sand bodies and reservoir be easily described in detail. The 3D visualization and 3D interactive editing of geological structure model are the key for modeling procedure. And a high accuracy and resolution geological model has been well applied in optimizing the production scheme.

Model of Rotation Accuracy of High-Speed Spindles on Ball Bearings

For the purpose to improve a design quality of high-speed spindle units, we have developed mathematical models and software to simulate a rotation accuracy of spindles running on ball bearings. In order to better understand the mechanics of ball bearings, the dynamic interaction of ball bearings and spindle unit, and the influence of the bearing imperfections on the spindle rotation accuracy, we have carried out computer aided analysis and experimental studies. When doing this, we have found that the spindle rotation accuracy can vary drastically with rotational speed. The influence of bearing preload has a secondary importance. Comparison of the results of these studies has demonstrated adequacy of the models developed to the real spindle units.

A HIGH ACCURACY DIFFERENCE SCHEME FOR THE SINGULAR PERTURBATION PROBLEM OF THE SECOND-ORDER LINEAR ORDINARY DIFFERENTIAL EQUATION IN CONSERVATION FORM

In this paper, combining the idea of difference method and finite element method, we construct a difference scheme for a self-adjoint problem in conservation form. Its solution uniformly converges to that of the original differential equation problem with order h3.