To study the high-fat-diet induced rat obesity and the of fect of endurance training on the body fat content of obese rats, we randomly divided 66 male weanling SD rats into control(16 rats) and high fat diet group(50...To study the high-fat-diet induced rat obesity and the of fect of endurance training on the body fat content of obese rats, we randomly divided 66 male weanling SD rats into control(16 rats) and high fat diet group(50 rats). After 10 weeks, we chose diet-induced obese rats(DIO, 26 rats) and divided them into endurance training group(DIO-T, 8 rats) and DIO groups(DIO, 18 rats) randomly. Aner 8 weeks, endurance training, all rats were killed. The results showed that nosignificant difference was found between groups in body weight, the feed efficiency of DIO groups was higher than control groups, tke carass fat con tent of DIO-T group was significantlylower than DIO group, and plasma insulin concentration of DIO group was higher than control and DIO-T groups. It was suggested that rats’ obesity was induced obesity by high fat diet, dietary obesity had relation to higher eding efficiency and hyperinsulinemia. Endurance training can effectively reduce the body fat content of high-fat-diet induced obese rats by improving its hyper-insulinemia. Plasma TCH and TG of all rats had no significant difference.展开更多
目的:研究植物甾醇酯(phytosterol ester,PSE)对高脂饮食大鼠结肠内容物短链脂肪酸的影响。方法:将30只6周龄雄性SD大鼠随机分为四组,其中正常对照组饲喂普通饲料,高脂组饲喂高脂饲料,PSE干预组分别灌胃低(0.05 g/100 g BW·d)、高...目的:研究植物甾醇酯(phytosterol ester,PSE)对高脂饮食大鼠结肠内容物短链脂肪酸的影响。方法:将30只6周龄雄性SD大鼠随机分为四组,其中正常对照组饲喂普通饲料,高脂组饲喂高脂饲料,PSE干预组分别灌胃低(0.05 g/100 g BW·d)、高剂量PSE(0.10 g/100 g BW·d)PSE强化牛奶;连续干预13周后,处死动物取结肠内容物,利用气相色谱法测定其SCFAs的含量。结果:与正常对照组相比,高脂饮食使大鼠结肠内容物中总SCFAs含量增加33.63%,其中丙酸含量显著升高(126.07%)(p<0.05),乙酸(26.05%)和异戊酸(42.11%)含量具有升高趋势(p>0.05),丁酸(33.21%)和戊酸(23.92%)含量则表现为降低趋势(p>0.05);而PSE干预可抑制高脂饮食所致大鼠结肠内容物中SCFAs水平的升高,其中低剂量PSE可显著降低丙酸(51.52%)、丁酸(59.59%)、异戊酸(60.66%)和戊酸(72.07%)的含量(p<0.05);高剂量PSE干预可降低丁酸(29.48%)的含量(p>0.05),并显著降低乙酸(48.64%)、丙酸(58.39%)、戊酸(69.12%)和异戊酸(58.59%)的含量(p<0.05)。结论:高脂饮食会引起大鼠结肠中SCFAs水平的升高,而PSE可能通过降低结肠内容物SCFAs的含量来调节大鼠肠道内环境。展开更多
目的探讨血管性血友病因子(von Willebrand Factor,vWF)对高脂饮食诱导的肥胖及内脏脂肪含量、组织炎症的影响。方法 16只8周大雄性WT小鼠随机分为普通饮食组(WTNC)、高脂饮食组(WT HFD),16只8周大vWF基因敲除小鼠随机分为普通饮食组(vW...目的探讨血管性血友病因子(von Willebrand Factor,vWF)对高脂饮食诱导的肥胖及内脏脂肪含量、组织炎症的影响。方法 16只8周大雄性WT小鼠随机分为普通饮食组(WTNC)、高脂饮食组(WT HFD),16只8周大vWF基因敲除小鼠随机分为普通饮食组(vWFKONC)、高脂饮食组(vWFKOHFD),一共四组,每组8只,普通饮食组给予普通饲料喂养,高脂饮食组给予60%高脂饲料喂养。12周后对比各组小鼠体重、附睾脂肪含量及附睾脂肪的病理形态和炎症表达水平。结果相较于普通饮食,高脂饮食可显著增加WT、vWF基因敲除小鼠的体重及附睾脂肪含量;而对比高脂饮食vWF基因敲除和高脂饮食WT小鼠,发现前者的体重、附睾脂肪含量均明显小于后者[体重:(30.44±0.60) g vs (43.74±0.78) g,附睾脂肪含量:(1.14±0.11) g vs (3.01±0.04) g,P值均<0.05],进一步对上述2组附睾脂肪组织进行HE病理分析,发现前者附睾脂肪中"王冠样结构"[1]的数量少于后者,且附睾脂肪RT-PCR分析显示前者MCP-1、TNF-α、IL-β和IL-6的表达均低于后者(P值均<0.05)。结论 vWF基因敲除可抑制高脂饮食小鼠的体重增长和附睾脂肪含量,同时可降低脂肪组织炎症水平。展开更多
文摘To study the high-fat-diet induced rat obesity and the of fect of endurance training on the body fat content of obese rats, we randomly divided 66 male weanling SD rats into control(16 rats) and high fat diet group(50 rats). After 10 weeks, we chose diet-induced obese rats(DIO, 26 rats) and divided them into endurance training group(DIO-T, 8 rats) and DIO groups(DIO, 18 rats) randomly. Aner 8 weeks, endurance training, all rats were killed. The results showed that nosignificant difference was found between groups in body weight, the feed efficiency of DIO groups was higher than control groups, tke carass fat con tent of DIO-T group was significantlylower than DIO group, and plasma insulin concentration of DIO group was higher than control and DIO-T groups. It was suggested that rats’ obesity was induced obesity by high fat diet, dietary obesity had relation to higher eding efficiency and hyperinsulinemia. Endurance training can effectively reduce the body fat content of high-fat-diet induced obese rats by improving its hyper-insulinemia. Plasma TCH and TG of all rats had no significant difference.
文摘目的:研究植物甾醇酯(phytosterol ester,PSE)对高脂饮食大鼠结肠内容物短链脂肪酸的影响。方法:将30只6周龄雄性SD大鼠随机分为四组,其中正常对照组饲喂普通饲料,高脂组饲喂高脂饲料,PSE干预组分别灌胃低(0.05 g/100 g BW·d)、高剂量PSE(0.10 g/100 g BW·d)PSE强化牛奶;连续干预13周后,处死动物取结肠内容物,利用气相色谱法测定其SCFAs的含量。结果:与正常对照组相比,高脂饮食使大鼠结肠内容物中总SCFAs含量增加33.63%,其中丙酸含量显著升高(126.07%)(p<0.05),乙酸(26.05%)和异戊酸(42.11%)含量具有升高趋势(p>0.05),丁酸(33.21%)和戊酸(23.92%)含量则表现为降低趋势(p>0.05);而PSE干预可抑制高脂饮食所致大鼠结肠内容物中SCFAs水平的升高,其中低剂量PSE可显著降低丙酸(51.52%)、丁酸(59.59%)、异戊酸(60.66%)和戊酸(72.07%)的含量(p<0.05);高剂量PSE干预可降低丁酸(29.48%)的含量(p>0.05),并显著降低乙酸(48.64%)、丙酸(58.39%)、戊酸(69.12%)和异戊酸(58.59%)的含量(p<0.05)。结论:高脂饮食会引起大鼠结肠中SCFAs水平的升高,而PSE可能通过降低结肠内容物SCFAs的含量来调节大鼠肠道内环境。
文摘目的探讨血管性血友病因子(von Willebrand Factor,vWF)对高脂饮食诱导的肥胖及内脏脂肪含量、组织炎症的影响。方法 16只8周大雄性WT小鼠随机分为普通饮食组(WTNC)、高脂饮食组(WT HFD),16只8周大vWF基因敲除小鼠随机分为普通饮食组(vWFKONC)、高脂饮食组(vWFKOHFD),一共四组,每组8只,普通饮食组给予普通饲料喂养,高脂饮食组给予60%高脂饲料喂养。12周后对比各组小鼠体重、附睾脂肪含量及附睾脂肪的病理形态和炎症表达水平。结果相较于普通饮食,高脂饮食可显著增加WT、vWF基因敲除小鼠的体重及附睾脂肪含量;而对比高脂饮食vWF基因敲除和高脂饮食WT小鼠,发现前者的体重、附睾脂肪含量均明显小于后者[体重:(30.44±0.60) g vs (43.74±0.78) g,附睾脂肪含量:(1.14±0.11) g vs (3.01±0.04) g,P值均<0.05],进一步对上述2组附睾脂肪组织进行HE病理分析,发现前者附睾脂肪中"王冠样结构"[1]的数量少于后者,且附睾脂肪RT-PCR分析显示前者MCP-1、TNF-α、IL-β和IL-6的表达均低于后者(P值均<0.05)。结论 vWF基因敲除可抑制高脂饮食小鼠的体重增长和附睾脂肪含量,同时可降低脂肪组织炎症水平。