Diagnostic and prognostic implications of non-high-density lipoprotein cholesterol and homocysteine levels for cognitive impairment in thalamic infarction

BACKGROUND Patients with thalamic infarction experience abnormal blockages of multinuc-leated vessels,affecting the body and thereby the thalamus.Most patients with thalamic infarction have an adverse prognosis,which seriously affects their safety.Therefore,it is essential to analyze the independent risk factors that influence the prognosis of patients with thalamic infarction and develop corresponding preventive measures.AIM To explore the effect of non-high-density lipoprotein cholesterol(non-HDL-C)and Homocysteine(Hcy)levels in cognitive impairment in thalamic infarction.METHODS From March 2019 to March 2022,80 patients with thalamic infarction were divided into a group with cognitive impairment[Montreal Cognitive Assessment(MoCA)score<26;35 patients]and a group with normal cognitive function(MoCA score of 26-30;45 patients)according to the MoCA score.In addition,50 healthy people in the same period were selected as the control group.A correlation between the non-HDL-C and Hcy levels and the MoCA score and receiver operating characteristic curve was observed,and the serum non-HDL-C and Hcy levels were analyzed for the diagnosis of cognitive impairment in patients with thalamic infarction.According to the Modified Rankin Scale(MRS)score,80 patients with thalamic infarction were divided into a good prognosis group(MRS score≤2)and a poor prognosis group(MRS score>2).RESULTS The non-HDL-C and Hcy levels were significantly higher in the group with cognitive impairment than in the group with normal cognitive function(P<0.05).There was no significant difference in the non-HDL-C level between the control group and the group with normal cognitive function(P>0.05).The MoCA scores of the group with cognitive impairment were significantly lower than those of the group with normal cognitive function and the control group(P<0.05).There was a significant difference between the control group and the group with normal cognitive function(P<0.05).The non-HDL-C and Hcy levels were correlated with the MoCA score(P<0.05),cognitive impairment[areas under the curve(AUC)=0.709,95%confidence interval(95%CI):0.599-0.816],the non-HDL-C level,and could predict cognitive impairment in patients with thalamic infarction(AUC=0.738,95%CI:0.618-0.859).Hcy combined with non-HDL-C levels can predict cognitive impairment in patients with thalamic infarction(AUC=0.769,95%CI:0.721-0.895).RESULTS There were 50 patients in the good prognosis group and 30 patients in the poor prognosis group.Compared with the good prognosis group,in the poor prognosis group,the National Institutes of Health Stroke Scale(NIHSS)score,non-HDL-C level,Hcy level,large-area cerebral infarction,atrial fibrillation,and activated partial prothrombin time were statistically significant(P<0.05).The non-HDL-C level,the Hcy level,the NIHSS score,extensive cerebral serum,and atrial fibrillation may all be independent risk factors for poor prognosis in patients with thalamic infarction(P<0.05).CONCLUSION Non-HDL-C and Hcy levels are positively correlated with cognitive impairment in patients with thalamic infarction.Non-HDL-C and Hcy levels can be used in the diagnosis of cognitive impairment in patients with thalamic infarction,and the combined detection effect is better.The main factors affecting the prognosis of patients with thalamic infarction are the non-HDL-C level,the Hcy level,the NIHSS score,large-area cerebral infarction,and atrial fibrillation.Clinically,corresponding preventive measures can be formulated based on the above factors to prevent poor prognosis and reduce mortality.

Theory and Practice of High-Level Sprint Training Based on Accurate Sectional Timing

There is an obvious gap in sprint level at home and abroad,and there are different opinions on the reasons.According to the analysis,physical energy and its distribution in each segment are the main factors restricting the sprint performance in China.Different from middle and long-distance running,we must rely on accurate sectional timing technology to master the law of speed-physical energy change in the process of sprint.Each stage is an integral part of the whole dash process,and each part restricts each other.Each stage has a relative best achievement.Simply pursuing the optimal state of segment is not only not helpful to the final result,but also counterproductive.

Coral Reef and High Sea Level at Luhuitou, Hainan Island during the Holocene

According to the field survey and ^14C dating at Luhuitou, southern Hainan Island, a subsiding area, the authors conclude the high sea level history recorded by coral reef in the Holocene. At least 4 sea level high-stands can be identified from the distribution of coral reef ages： 7300 - 6000 cal.aBP, 4800 - 4700 cal.aBP, 4300 - 4200 cal.aBP and 3100 - 2900 cal.aBP. The highest sea level occurred around 7300 - 6700 cal.aBP, and biological-morphological zones took their shape during the stage. The later coral reefs developed in ponds, depressions, and developed outwards on both sides of Luhuitou peninsula. The modern coral reefs are developing in out reef flat and reef-front slope. Moreover, the time of high sea levels in the northern South China Sea recorded by coral reefs in the Luhuitou peninsula can link up with that in other parts of South China Sea. That means the high sea levels in the South China Sea during the Holocene, which are relative to the warming climate, have the global background.

Individualized management of pregnant women with high hepatitis B virus DNA levels

Hepatitis B is a major health concern in the Asia-Pacific region, and is endemic in China, Southeast Asia, and Africa. Chronic hepatitis B virus (HBV) infection may cause hepatic cirrhosis and liver cancer. It is estimated that there are more than 350 million chronic HBV carriers worldwide, of whom approximately one quarter will die of chronic hepatitis B-related liver diseases. HBV is transmitted horizontally through blood and blood products or by sexual transmission, and vertically from mother to infant. Perinatal infection is the predominant mode of transmission in countries with a high prevalence of hepatitis B surface antigen (HBsAg) carriage, and perinatal transmission leads to high rates of chronic infection. Therefore, it is important to prevent the mother-to-child transmission (MTCT) of HBV. Research has shown that pregnant women with high HBV DNA levels have an increased risk of MTCT. However, most of the obstetrics guidelines do not make a distinction between pregnant women with high HBV DNA levels and those who are HBsAg positive only. This review addresses the management of pregnant women with high levels of HBV viremia, in terms of antiviral therapy, use of hepatitis B immunoglobulin (HBIG), the combined application of hepatitis B vaccine and HBIG, choice of delivery mode and feeding practices. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

High level architecture evolved modular federation object model

To improve the agility, dynamics, composability, reusability, and development efficiency restricted by monolithic federation object model （FOM）, a modular FOM is proposed by high level architecture （HLA） evolved product development group. This paper reviews the state-of-the-art of HLA evolved modular FOM. In particular, related concepts, the overall impact on HLA standards, extension principles, and merging processes are discussed. Also permitted and restricted combinations, and merging rules are provided, and the influence on HLA interface specification is given. The comparison between modular FOM and base object model （BOM） is performed to illustrate the importance of their combination. The applications of modular FOM are summarized. Finally, the significance to facilitate compoable simulation both in academia and practice is presented and future directions are pointed out.

The effects of high temperature level on square Bt protein concen-tration of Bt cotton

Higher boll worm survival rates were detected after high temperature presented during square period in Bt cotton. The objective of this study was to investigate the effects of high temperature level on the Bt efficacy of two different types of Bt cotton cultivars at squaring stage. During the 2011 to 2013 cotton growth seasons, high temperature treatments ranged from 34 to 44°C in climate chambers, and field experiments under high temperature weather with various temperature levels were conducted to investigate the effects of the high temperature level on square Bt protein concentration and nitrogen metabolism. The climate chamber experiments showed that the square insecticidal protein contents reduced after 24 h elevated temperature treatments for both cultivars, whereas significant declines of the square insecticidal protein contents were detected at temperature 〉38°C, and only slightly numerical reductions were observed when temperature below 38°C. Similar high temperature responses were also observed at the two field experimental sites in 2013. Correspondingly, high temperature below 38°C seems have little effect on the square amino acid concentrations, soluble protein contents, glutamic-pyruvic transaminase（GPT） and glutamic-oxalacetic transaminase（GOT） activities as well as protease and peptidase activities; however, when the temperature was above 38°C, reduced soluble protein contents, enhanced amino acid concentrations, decreased GPT and GOT activities, bolstered protease and peptidase activities in square were detected. In general, the higher the temperature is（〉38°C）, the larger the changes for the above compound contents and key enzymes activities of the square protein cycle. The findings indicated that the unstable insect resistance of the square was related to high temperature level during square stage.

Middle Holocene warm period and sea level high in coastal areas,North China

Relevant geological, geographical, archaeological data were collected to study the characteristics of middle Holocene warm period and sea level high on North China coast. Middle Holocene climate and sea level change on North China coast were correlated to warm marine environment events in about 8–3 ka B.P. The sea level in about 8 ka B.P. was higher than present mean sea level, then fluctuated for 5 000 years and after that it became even in 3 ka B.P. The highest sea level occurred in about 6–5 ka B.P.; the maximum was about 2–3 m and minimum was about 1–2 m.

Robust Synchronization in an E/I Network with Medium Synaptic Delay and High Level of Heterogeneity

It is known that both excitatory and inhibitory neuronal networks can achieve robust synchronization only under certain conditions, such as long synaptic delay or low level of heterogeneity. In this work, robust synchronization can be found in an excitatory/inhibitory （E/I） neuronal network with medium synaptie delay and high level of heterogeneity, which often occurs in real neuronal networks. Two effects of post-synaptic potentials （PSP） to network synchronization are presented, and the synaptic contribution of excitatory and inhibitory neurons to robust synchronization in this E/I network is investigated. It is found that both excitatory and inhibitory neurons may contribute to robust synchronization in E/I networks, especially the excitatory PSP has a more positive effect on synchronization in E/I networks than that in excitatory networks. This may explain the strong robustness of synchronization in Eli neuronal networks.

Observation of an Even-Odd Asymmetric Transport in High Landau Levels

Magnetotransport experiments including tilt fields are performed on ultrahigh mobility L-shaped Hall-bar samples of GaAs/AlGaAs quantum wells. The low-temperature longitudinal resistivity （ρxx） data demonstrate that a striking even-odd asymmetric transport exists along the [110] direction at half filling in N ≥ 2 high Landau levels. Although the origin for the peculiar even-odd asymmetry remains unclear, we propose that the coupling strength between electrons within the same Landau level and between the neighboring two Landau levels should be considered in future studies. The tilt field data show that the in-plane field can suppress the formation of both bubble and stripe phases.

REVIEW OF HIGH LEVEL FAULT MODELING APPROACHES FOR MIXED-SIGNAL SYSTEMS

In the modern analogue design, Transistor Level Fault Simulation (TLFS) plays the im-portant part since every fault in the whole circuit has to be simulated at that level. Unfortunately, it is a very CPU intensive task even though it maintains the high accuracy. Therefore, High Level Fault Modeling (HLFM) and High Level Fault Simulation (HLFS) are required in order to alleviate the efforts of simulation. In this paper, different HLFM approaches are reviewed at the device level during last two decades. We clarify their domains of application and evaluate their strengths and current limitations. We also analyze causes of faults and introduce various test approaches.

Analysis on the Physical Characteristics of High-level Football Players

This article uses the literature data method and literature review method to review and collect relevant literature,and summarizes and analyzes the representative views on domestic physical fitness research.After summarizing and summarizing,it is considered that:physical energy is the basic athletic ability of the human body expressed through physical qualities such as strength,speed,endurance,coordination,flexibility,and sensitivity,and is an important component of athletes'athletic ability.The level of physical fitness is closely related to the morphological characteristics of the human body and the functional characteristics of the human body.The morphological characteristics of the human body are the structural basis of its physical fitness,and the functional characteristics of the human body are its biological functional basis.As the basic ability of athletes,physical fitness is an important factor of athletes'competitive ability.Each competitive sport has its own specific physical characteristics and training rules and methods.Grasping these laws has very important guiding significance for the improvement of athletes'sports level.

Performance prediction of expressway pavement in high maintenance level areas based on cosine deterioration equation: A case study of Zhejiang Province in China

Accurate prediction of performance decay law is an important basis for long-term planning of maintenance strategy.The statistical regression prediction model is the most widely employed method to calculate pavement performance due to its advantages such as the small amount of calculation and good accuracy,but the traditional prediction model seems not applicable to the high maintenance level areas with excellent pavement conditions.In this paper,the service life and the cumulative number of the axle load were determined as the independent variables of prediction models of pavement performance.The pavement condition index(PCI)and rutting depth index(RDI)were selected as maintenance decision control indexes to establish the unified prediction model of PCI and RDI respectively by applying the cosine deterioration equation.Results reveal that the deterioration law of PCI presents an anti-S type or concave type and the deterioration law of RDI shows an obvious concave type.The prediction model proposed in this study added the pavement maintenance standard factor d,which brings the model parameterα(reflecting the road life)and the deterioration equations are more applicable than the traditional standard equations.It is found that the fitting effects of PCI and RDI prediction models with different traffic grades are relatively similar to the actual service state of the pavements.

The Application of Trenchless Piping in Sandbar Drainage Network Renovation Projects

In this study,the research progress of trenchless piping technology for pipes with a large diameter was reviewed.The geological conditions of the sandbar in Xiangyang were taken into account in this study.This paper highlights the construction process management of the pipeline network project in Yuliangzhou Starting Area of Xiangyang City.Research was carried out in the aspects of optimizing mud ratio,controlling pipeline elevations,pipeline welding,and trenchless pipeline construction in limited spaces,stable support during pit excavation,and controlling the spacing between the junctions of two pipe segments.The research resulted in excellent outcomes and ensured safe construction,and the quality requirements were also met.

Analysis of An Infrequent Regional Heavy Rainfall Weather Process in Heilongjiang Province in June of 2009

From June 18th to June 19th of 2009,Heilongjiang Province was hit by the regional rainstorm rarely paralleled in history.According to the findings based upon the conventional observation data,the precipitation occurred under the double-blocking situation of Ural Mountains and the Sea of Okhotsk.The main influencing systems were the upper vortex and northward low-pressure that came from Hetao area,accompanied by the delivery of high and low level jet stream.The results showed that the evolvement of blocking high,transfer of water vapor and configuration of high and low level jet stream were the key factors resulting in the rainfall process.

基于HLS的矩阵求逆算法设计优化

本文主要研究了HLS多层动态边界循环的优化策略。HLS利用C/C++语言完成算法设计和验证,通过高级综合工具自动生成RTL代码,显著缩短了算法FPGA设计复杂度及实现效率,在信号处理算法实现方面有着显著的优势。但对于具有多层动态循环边界的算法,由于各层循环的数据依赖性及循环边界的不可预知性,HLS难以实现理想的结果。本文以Cholesky分解矩阵求逆算法为例,通过对矩阵求逆计算过程数据计算顺序、数据依赖性、运算步骤进行了分析与理论计算,提出了一种将多层循环优化为单层、两层循环的方法,解决了流水线优化指令高效应用问题。实现结果表明,经过优化后,在资源增加较少的情况下,矩阵求逆延迟性能提升118倍。

Graph Clustering Algorithm for RT Level ALU Technology Mapping

Register transfer level mapping (RTLM) algorithm for technology mapping at RT level is presented,which supports current design methodologies using high level design and design reuse.The mapping rules implement a source ALU using target ALU.The source ALUs and the target ALUs are all represented by the general ALUs and the mapping rules are applied in the algorithm.The mapping rules are described in a table fashion.The graph clustering algorithm is a branch and bound algorithm based on the graph formulation of the mapping algorithm.The mapping algorithm suits well mapping of regularly structured data path.Comparisons are made between the experimental results generated by 1 greedy algorithm and graphclustering algorithm,showing the feasibility of presented algorithm.

Simultaneous Partitioning and Scheduling Algorithm for Clustered Architecture

Clustered architecture is selected for high level synthesis,and a simultaneous partitioning and scheduling algorithm are proposed.Compared with traditional methods,circuit performance can be improved.Experiments show the efficiency of the method.

Theory and Implementation of Distributed Visual Simulation

The development process as well as the core theory of distributed interactive simulation and high level architecture are discussed, and combined with graphics features, a system of real time distributed visual simulation is established. Based on computer network, simulation platform is built by installing related software and modeling object, and the interactive functions are extended by programming. A set of solutions for building a distributed visual simulation system that include both hardware and software are put forward, and a practical instance is also provided. The whole building process can be summarized into two steps that are scheme consideration and system realization.

Architecture of HLA Based Distributed Virtual Geographic Environment

Integrating the theory of distributed virtual geographic environment (DVGE) and high level architecture(HLA), the architecture of DVGE based on HLA is designed. The data flow and the object models of the architecture are also discussed. The architecture basically meets the need of DVGE in real-time communication, distribution, collaboration, reusing and interoperation, expansion, and standard.

ANALYSIS OF THE CHARACTERISTICS OF SUSTAINED TORRENTIAL RAINS IN JUNES DURING 1958-2000

Day-to-day precipitation data of Juries during the 43 years of 1958-2000 from stations to the south of Yangtze River are used to divide regions and run statistical analysis of sustained torrential rainfall processes. A preliminary analysis is then made based on it and the results show that June is the month in which torrential rains in the southern half of China take place frequently and sustained torrential rains occur at the same time in South China and the area to the south of Yangtze River. In addition, the analysis gives the basic features of sustained torrential rains of June in China and their interannual variability patterns, with the suggestion that the amount of these events increases significantly after the 1990s. Lastly, the sustained torrential rains occurring in Junes of 1994, 1998 and 2005 in the southern half of China are taken as examples in the research on the basic patterns and formation mechanisms of the evolution of double rain-bands during the rain season in South China and the area to the south of Yangtze River. The analysis shows that the large scale environment field in which sustained torrential rains occur is related to the stable sustaining of the South Asia High and upper level jet streams.