Great change,big attraction and high expectation Persistent overheating of ITMA ASIA +CITME 2018 registration

On June 19th,2017,the registration system of ITMA ASIA+CITME 2018 came online officially.In the past five months,the exhibition recruitment work has obtained the general concentration of the industry.What is the biggest difference of this exhibition with the previous ones?What will the audiences and exhibitors get from this exhibition?What is the working emphasis of the

A perspective on recent methods on testing predictability of asset returns

This paper highlights some recent developments in testing predictability of asset returns with focuses on linear mean regressions, quantile regressions and nonlinear regression models. For these models, when predictors are highly persistent and their innovations are contemporarily correlated with dependent variable, the ordinary least squares estimator has a finite-sample bias, and its limiting distribution relies on some unknown nuisance parameter, which is not consistently estimable. Without correcting these issues, conventional test statistics are subject to a serious size distortion and generate a misleading conclusion in testing pre- dictability of asset returns in real applications. In the past two decades, sequential studies have contributed to this subject and proposed various kinds of solutions, including, but not limit to, the bias-correction procedures, the linear projection approach, the IVX filtering idea, the variable addition approaches, the weighted empirical likelihood method, and the double-weight robust approach. Particularly, to catch up with the fast-growing literature in the recent decade, we offer a selective overview of these methods. Finally, some future research topics, such as the econometric theory for predictive regressions with structural changes, and nonparametric predictive models, and predictive models under a more general data setting, are also discussed.

Identification of HIV-1 specific T lymphocyte responses in highly exposed persistently seronegative Chinese

Background Studies of highly exposed persistently seronegative （HEPS） individuals may provide valuable information on mechanisms of protection and on vaccine design. Cellular immune responses play a critical role in containing human immunodeficiency virus. However, the cellular immune responses in HEPS individuals have not been thoroughly assessed at the entire viral genome level. Methods Ten HEPS Chinese with a history of frequent penetrative vaginal intercourse （mean frequency, at least once a week）, with some unprotected sexual contact occurring in the weeks or days immediately before enrollment, 25 HIV-1 seropositive individuals, 10 HIV-1-seronegative healthy individuals with low-risk sexual behavior and no history suggestive of exposure to HIV-1 infection were enrolled. HIV-1-specific T cell responses were comprehensively analyzed by an interferon- 7 Elispot assay against 770 overlapping peptides spanning all HIV-1 proteins. Results HIV-1-specific T-cell responses of interferon- 7 secretion were identified in 3 （30%） out of 10 HEPS individuals; the specific cytotoxic T lymphocytes were targeted at Pol （2/10）, Env （2/10）, and Tat （1/10）. HIV-1-specific T-cell responses of interferon- ~ secretion were identified in 20 （80%） out of 25 seropositive intravenous drug users （IDUs）, revealing that all HIV-1 proteins and protein subunits could serve as targets for HIV-1-specific CD8^＋ T cell responses with 85% recognizing Gag, 80% recognizing Nef, 75% recognizing Pol, 60% recognizing Env, 55% recognizing Vpu, 45% recognizing Vpr, 20% recognizing Vif, 20% recognizing Tat and 15% recognizing Rev in these seropositive individuals. None of the seronegative healthy individuals gave the positive T-cell responses. Conclusions About 30% of HEPS Chinese mounted HIV-1 specific T cell immune responses. Cell-mediated immunity against HIV-1 may be developed through non-productive infections.

Comparison of the Multi-Scale Features in Two Persistent Heavy Rainfall Events in the Middle and Lower Reaches of Yangtze River

Two persistent heavy rainfall（PHR） events in the middle and lower reaches of Yangtze River（MLYR）occurring in June 1982 and 1998 are studied in this paper.Though both events happened in the Meiyu season,their large-scale background and developing processes were quite different.During the PHR event in 1982,the Lake Baikal area was occupied by a strong westerly trough and the western Pacific subtropical high（WPSH） was stronger and more westward-extending than the normal years.Under such a condition,the cold dry air and warm moist air were continuously transported to the MLYR and favored the PHR there.For the event in 1998,the WPSH was similar to that in 1982,while the westerly trough in the Lake Baikal area was comparatively weak and a shortwave trough situating in East China contributed to advect cold dry air to the MLYR.It is found that the high-latitude trough was closely related to the 1030-day low-frequency oscillation while the anomaly of WPSH was linked with the combined effect of both30 60- and 10 30-day low-frequency oscillations in the PHR event in 1982.By contrast,the 60-day low-pass perturbation demonstrated positive impact on the westward extension of WPSH and development of the Baikal trough while the 30 60-day oscillation played a role in strengthening the shortwave trough in East China and the WPSH in the case of 1998.Though the low-latitude 30 60-day oscillations contributed to the intensification and westward extension of the WPSH in both PHR events,their evolution exhibited evident differences.In the 1982 case,the 30 60-day anomalies originated from the western Indian Ocean were much more like the Madden Julian Oscillation,while its counterpart in the 1998 case was much more similar to the first mode of the boreal summer intraseasonal oscillation.