Breaking and Characteristics of Ganoderma Lucidum Spores by High Speed Entrifugai Shearing Pulverizer

The spores of Ganoderma lucidum were ground and broken to ultrafine particles by high speed centrifugal shearing（HSCS） pulverizer. The characteristics of Ganoderma lucidum spores were analyzed by scanning electron microscope （SEM）, Fourier transform infrared spectrophotometry （FTIR）. Ultraviolet-visible pectrophotometer was used to determine the extraction ratio of aqueous solubility polysaccharide between the raw and broken spores. The immunological function on the mice before and after the breaking of spores wan investigated. The experimental results show that after being ground, the sporoderm-broken ratio reachs 100%, the original active ingredients of ganoderma lucidum spores do not change, and the extraction ratio of aqueous solubility polysaccharide is greatly increased by 40.08%. The broken spores show much higher immunological activity comparing with original spores of Ganoderma lucidum.

Hot Spot in Materials with Structural Defects under High Shear Loading Rates

The response of three-dimensional sample of Al, containing vacancy complex, under shear loading was simulated. The molecular dynamics method was used and interaction between atoms was described on the base of pseudopotential theory Solitary waves were generated in the sample under mechanical loading. Their interaction with the vacancy complexes was shown to be able to initiate hot spot in that local region of the complexes. Some parameters of the hot spot as well as solitary waves were calculated. The initiation of the hot spot is accompanied with sufficient local structural relaxation.

Analysis of Adiabatic Shearing Failure Mechanism for Aluminum Matrix Composites Based on Experimental and Numerical Simulation

Adiabatic shear behavior and the corresponding mechanism of TiB2/Al composites were researched by split Hopkinson pressure bar （SHPB）.Results show that the flow stresses of the TiB2/Al composites exhibit softening tendency with the increasing of strain rates. All the composites fail in splitting and cutting with a 45 degree, and the phase transformed bands of molten aluminum are found on the adiabatic shear layers. The deformation behavior and shear localization of the TiB2/Al composites specimens were simulated by finite element code MSC.Marc. The Johnson-Cook model was used to describe the thermo-viscoplastic response of the specimen material. There was unanimous between the numerical result and the experimental result on the location of the adiabatic shear band. From the numerical simulation and experiment, it was concluded that the instantaneous failure of the composite was ascribed due to the local low strength area where the formation of adiabatic shear band was, and the stress condition had significant effect on the initiation and propagation of adiabatic shear band （ASB）.

Study on Rheological Characteristics of a Grease Used in High Speed Bearing

On a self-made super-high shear strain rate rheometer, the rheological characteristics and apparent viscosity curves of a high-speed bearing grease were obtained under different working conditions. A new grease rheological model suited to a shear strain rate range of 0—3.5×10~6s^(-1) was presented. The results showed that the shear stress increased linearly at first and then increased nonlinearly with the increase in shear strain rate up to 1.5×10~6s^(-1), and finally the shear stress decreased slightly with the successive increase in shear strain rate. The shear stress increased with a decreasing rolling speed and an increasing contact pressure. The apparent viscosity decreased rapidly with the increase of shear strain rate at beginning and could approach the viscosity of the base oil if the shear strain rate surpassed 1.5×10~6s^(-1). The fits between the test data and the predicted values by the new model were fairly good.

Ni-Al mixed metal oxide with rich oxygen vacancies: CO methanation performance and density functional theory study

Ni-Al mixed metal oxides have been successfully prepared by high shear mixer(HSM)and coprecipitation(CP)methods for low temperature CO methanation.In this work,Ni-Al(HSM-CP)catalyst presented small Ni crystallite size and high surface area,which all contribute to the methanation reaction at low temperature conditions.The obtained Ni-Al(HSM-CP)sample exhibited a mass of defective oxygen,thereby accelerating the dissociation of CO and ultimately increasing the activity of the catalyst.Ni-Al(HSM-CP)catalyst offered the best activity with CO conversion=100%and CH_(4) selectivity=93%at 300℃,and the CH_(4) selectivity can reach 81.8%at 200℃.In situ Fourier transform infrared spectroscopy and density functional theory show that CHO and COH intermediates with lower activation energy barriers are produced during the reaction,and hydrogen-assisted carbon–oxygen bond scission is more favorable.

Controlled Release of Construction Chemicals by Encapsulation

Encapsulation and controlled release of active agents is a common practice to improve processing and properties of materials and final products in different industries. Today, a large variety of chemical admixtures are used in construction materials, the performance of which could be improved by a better dosage control. This work presents investigations on the controlled release of encapsulated construction chemicals for future applications in construction materials. The high shear mixing technology was used to produce matrix based encapsulations by agglomeration applied to commercially available construction materials. The agglomeration process was varied by the use of different agitator types, the variation of the agitator speed and the application of additional coating materials. The particle size distribution as well as the particle shape of the produced agglomerates was analyzed by automatic image evolution and scanning electron microscopy. The release behavior of the capsules in aqueous solutions was investigated by UV spectroscopy. The obtained results confirmed a theoretical model for the encapsulation and release of admixtures, which was derived from pharmaceutical drug release concepts and adapted to construction materials. The results indicate that the matrix based encapsulation is a promising technique for future applications in the field of construction materials.

Specific inhibiting effects of Ilexonin A on von Willebrand factor-dependent platelet aggregation under high shear rate

Background llexonin A (IA), purified from the Chinese herbal medicine Maodongqing (Ilex pubescens Hook, et Am) has been commonly used in south China to treat thrombotic disorders. In this study, we aimed to study the inhibiting effects and mechanism of IA on von Willebrand factor (vWF)-dependent high shear-induced platelet aggregation.Methods vWF-dependent high shear (10 800 s-1) induced aggregation of platelets obtained from normal donors in the presence or absence of IA was measured by a modified cone-plate viscometer and shear-induced vWF binding was measured by quantitative flowcytometry with monoclonal antibody known to bind exclusively to the C-terminal domain of vWF (LJ-C3) directly labeled with fluorescein isothiocyanate (FITC). P-selectin surface expression was also measured by a similar method with FITC conjugated anti-P-selectin monoclonal antibody (WGA1).Results Shear-induced platelet aggregation was inhibited by IA in a dose-dependent manner. The extent of aggregation decreased from (78. 6 ±4. 6)% in the absence of IA to (36. 5 ±2.1)% in the presence of IA (3. 3 mmol/L) (P<0. 0001, n =9) with a high shear rate of 10800 s-1. vWF binding and P-selectin expression were also inhibited by IA in a dose dependent manner. The number of binding FITC-LJ-C3 molecules increased after exposure of platelet-rich plasma to a high shear rate of 10800 s-1 for 6 minutes, but this shear-induced increased binding platelet surface vWF molecules and P-selectin expression can be decreased in the presence of IA.Conclusion vWF binding and vWF mediated platelet activation, aggregation occurring under high shear rate were inhibited by IA. IA may be a unique antithrombotic drug inhibiting the vWF-GP Ibα interaction, and may thus facilitate drug design targeting arterial thrombosis.

High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis

Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes.Inhibition of thrombosis is one of the important tasks developing biomedical materials such as intravascular stents and vascular grafts.Shear stress(SS)influences the formation and development of atherosclerosis.The current review focuses on the vulnerable plaques observed in the high shear stress(HSS)regions,which localizes at the proximal region of the plaque intruding into the lumen.The vascular outward remodelling occurs in the HSS region for vascular compensation and that angiogenesis is a critical factor for HSS which induces atherosclerotic vulnerable plaque formation.These results greatly challenge the established belief that low shear stress is important for expansive remodelling,which provides a new perspective for preventing the transition of stable plaques to high-risk atherosclerotic lesions.

Effects of rotor and stator geometry on dissolution process and power consumption in jet-flow high shear mixers

The jet-flow high shear mixer(JF-HSM)is a new type of intensified equipment with special configurations of the rotor and the stator.The mass transfer property and power consumption were studied in the solid-liquid system for a series of JF-HSMs involving different configuration parameters,such as rotor diameter,rotor blade inclination,rotor blade bending direction,stator diameter,and stator bottom opening diameter.The flow characteristics were examined by computational fluid dynamic simulations.Results indicate that the turbulent power consumption of the JF-HSM is affected by the change in rotor blade inclination and stator bottom opening.With the increase in the shear head size and the change in the rotor into a backward-curved blade,the solid-liquid mass transfer rate can be remarkably increased under the same input power.Dimensionless correlations for the mass transfer coefficient and power consumption were obtained to guide the scale-up design and selection of such a new type of equipment to intensify the overall mixing efficiency.

Scale-up of a high shear wet granulation process using a nucleation regime map approach

Scale-up of the high shear wet granulation （HSWG） process is considered a challenge because HSWG is complex and influenced by numerous factors, including equipment, formulation, and process variables. For a system of microcrystalline cellulose and water, HSWG experiments at three scales （1, 2, and 4 L working vessel） were conducted with a granulator. Scale-up was implemented on the basis of a nucleation regime map approach. To keep dimensionless spray flux and drop penetration time constant, water addition time at three processing scales were 300, 442, and 700 s, respectively. The other process parameters were kept unchanged. Granule size distributions were plotted and compared, and scanning electron microscopy was used to analyze granule surface morphology. Physical characterization was undertaken using a modified SeDeM method. At nearly all scales, granule yield was greater than 85% and all the cosine values were larger than 0.89. At the same experiment points, granules at all scales had similar surface morphology and similar physical characteristics. The results demonstrate that a rational scaling-up of the HSWG process is feasible using a regime map approach.

Morphology and Mechanical Properties of Immiscible Polyethylene/Polyamide12 Blends Prepared by High Shear Processing

In this work, completely immiscible polyethylene/polyamidel2 （PE/PA12） blends were prepared by high shear extruder. The morphology and mechanical properties of the blends were investigated as a function of rotation speed. It was found that the high shear processing is an effective method to improve the dispersion of the PAl2 phase in PE matrix when PA 12 contents are 5 wt% and 10 wt%, and the dispersed phase particle size is reduced with the increase of rotation speed from 100 r/min to 500 r/min. However, with further increase of PAl2 content to 20 wt%, high shear processing has no effect on the phase morphology of the blends. Accordingly, a largely increased elongation at break and impact strength are observed for PE/PAl2/95/5 and PE/PA12/90/10 blends obtained at high rotation speeds but no effect on the property of PE/PAI2/80/20. Annealing experiment demonstrated that the obtained phase morphology is not stable thus compatibilizer should be introduced in the future work. This work could provide a guideline for the application of high shear processing in the preparation of polymer blends with huge polarity difference.

Analysis on Shear Deformation for High Manganese Austenite Steel during Hot Asymmetrical Rolling Process Using Finite Element Method

Based on the rigid-plastic finite element method（FEM）, the shear stress field of deformation region for high manganese austenite steel during hot asymmetrical rolling process was analyzed. The influences of rolling parameters, such as the velocity ratio of upper to lower rolls, the initial temperature of workpiece and the reduction rate, on the shear deformation of three nodes in the upper, center and lower layers were discussed. As the rolling parameters change, distinct shear deformation appears in the upper and lower layers, but the shear deformation in the center layer appears only when the velocity ratio is more than 1.00, and the absolute value of the shear stress in this layer is changed with rolling parameters. A mathematical model which reflected the change of the maximal absolute shear stress for the center layer was established, by which the maximal absolute shear stress for the center layer can be easily calculated and the appropriate rolling technology can be designed.

Micromixing performance of the teethed high shear mixer under semi-batch operation

Semi-batch operated reaction processes are necessary for some competitive reaction systems to achieve a desirable process selectivity and productivity of fine chemical products.Herein the structural and operating parameters of the teethed high shear mixers were adjusted to study the micromixing performance in the semi-batch operated system,using the Villermaux/Dushman reaction system.The results indicate that the rising of the rotor speed and the number of rotor teeth,the decrease of the width of the shear gap and the radial distance between the feed position and the inner wall of stator can enhance the micromixing level and lead to the decrease of the segregation index.Additionally,computational fluid dynamics calculations were carried out to disclose the evolution of the flow pattern and turbulent energy dissipation rate of the semi-batch operated high shear mixer.Furthermore,the correlation was established with a mean relative error of 8.05%and R^(2)of 0.955 to fit the segregation index and the parameters studied in this work,which can provide valuable guidance on the design and optimization of the semi-batch operated high shear mixers in practical applications.

Investigation on the granulation behavior of iron ore fine in a horizontal high-shear granulator

High-shear granulation is widely used in many particulate industries for its good capability to improve the size,strength and composition uniformity of powder substances.This work conducted an experimental study to investigate the granulation behavior of iron ore fine in a horizontal high-shear granulator,such as granules size distribution,granules growth rate,and permeability of the granules bed.The results show that the granule size and permeability of packed granules bed increase gradually with increasing the granulation time,and the growth of granules can be divided into three stages:the rapid growth stage,the slow growth stage and the relatively stable stage.Both the higher rotational speed and larger number of impellers increase the kinetic energy and collision frequency of the particles,which causes the increase of average granule size,growth rate and permeability of granules packed bed.On the other hand,the shear damage effect of the impellers on the granules is also enhanced with the increase of rotational speed and impeller number,resulting in significant granule size segregation.

Further investigations on the influence of scale-up of a high shear granulator on the granule properties

This study focuses on the characterisation of strength, density, and size of granules produced in various scales of a high shear granulator. Calcium carbonate （Durca165） was used as the feed powder and aqueous polyethylene glycol （PEG 4000） as the binder. The dried granules were analysed for their strength, density, size distribution, and wall make-up. Granules were produced in granulators with four scales, 1, 5, 50, and 250 L under three scale-up rules of constant tip speed, constant shear stress, and constant Froude number. The results show that regardless of equipment scale, increasing the impeller speed has a great effect on crushing strength and stress. The underlying cause is an increase in granule density due to more consolidation at higher impeller speeds. Wall make-up is significantly reduced to less than 5% as the scale is increased from 1 to 250 L. The results of this study corroborate our previous findings that the constant tip speed rule is the best criterion for scale-up of high shear granulators.