Screening and early detection of pancreatic cancer in high risk population

Pancreatic cancer is a serious growing health issue in developed countries.For patients diagnosed with pancreatic cancer,the five year survival rate is below 5%.One major important reason leads to the poor survival rate is lack of early detection of pancreatic cancer.Over 80% of the patients are diagnosed in advanced disease stages.Screening for pancreatic cancer is a desirable option for high risk individuals to allow early detection and treatment of curable pancreatic neoplasms at a pre-invasive stage.This article highlights the need,endpoint,population,method,diagnostic yield,and the problems of current screening programs.

ESTABLISHMENT OF HIGH RISK POPULATION AND PRECANCEROUS LESION OF NASOPHARYNGEAL CARCINOMA(NPC)

A prospective study was done by the examination of nasopharyngoscope, reaction of EB virus's antigens and antibodies, nasopharyngofibroscope, pathological and EB virus's DNA, EBERs, etc. of about 100000 persons in high risk area of NPC in Guangdong Province, China from 1986 to 1995. If any one of the following four conditions is present in some persons, i.e., (1) EBV VCA/IgA titer>1:80, (2) EBV EDAb>60%, (3) Dual or triple positiveness in VCA/IgA, EA/IgA and EDAb, (4) Any one of VCA/IgA, EA/IgA and EDAb keeps high titer or going up, they should be regarded as in precancerosis of NPC. The moderate or severe heteroplasia and heterometaplasia of nasopharyngeal mucosa are the precancerous lesions of NPC. Some individual who is in precancerosis or with precancerous lesion should be regarded as the high risk population of NPC. The results are of important scientific basis for screening and second degree prevention of NPC.

Nutritive Equilibrium in Rice Plant Populations for High Yield

The effects of nitrogen, phosphorus and potassium application level, seed rate and transplanting density on the growth and development of rice plants were studied to find out nutrient status in high-yielding rice plants and to increase grain yield by adequate fertilization. There was an equilibrium relationship among nutrient elements for high-yielding rice plant populations. The equilibrium index of nutrient amount, content and distribution in high-yielding rice plants should be generally greater than-2 but less than 2. The optimum nutritive proportion of nitrogen: phosphorus: potassium assimilated by the plants was about 10: 2: 9 at the ripening stage. But the content and the proportion varied with the growth stages. Therefore, the nutrient in rice plant populations should be in a dynamic equilibrium, so as to achieve high yield.

Current molecular methods for the detection of hepatitis C virus in high risk group population:A systematic review

Hepatitis C virus(HCV) is an emerging infection worldwide and the numbers of persons infected are increasing every year. Poor blood transfusion methods along with unsafe injection practices are potential sources for the rapid spread of infection. Early detection of HCV is the need of the hour especially in high riskgroup population as these individuals are severely immunocompromised. Enzyme Immunoassays are the most common detection techniques but they provide no evidence of active viremia or identification of infected individuals in the antibody-negative phase and their efficacy is limited in individuals within high risk group population. Molecular virological techniques have an important role in detecting active infection with utmost specificity and sensitivity. Technologies for assessment of HCV antibody and RNA levels have improved remarkably, as well as our understanding of how to best use these tests in patient management. This review aims to give an overview of the different serological and molecular methods employed in detecting HCV infection used nowadays. Additionally, the review gives an insight in the new molecular techniques that are being developed to improve the detection techniques particularly in High Risk Group population who are severely immunocompromised.

High contrast atomic magnetometer based on coherent population trapping

We present an experimental and theoretical investigation of the coherent population trapping （CPT） resonance excited on the D1 line of 87Rb atoms by bichromatic linearly polarized laser light. The experimental results show that a lin｜｜lin tran- sition scheme is a promising alternative to the conventional circular-circular transition scheme for an atomic magnetometer. Compared with the circular light transition scheme, linear light accounts for high-contrast transmission resonances, which makes this excitation scheme promising for high-sensitivity magnetometers. We also use linear light and circular light to detect changes of a standard magnetic field, separately.

A STUDY OF PRECANCEROUS GASTRIC LESIONS IN A HIGH RISK POPULATION

A study of precancerous gastric lesion was conducted in a randomly selected high risk population in Linqu, Shandong Province of China. 849 subjects aged from 30-64 were examined bioptically. There were 8 cases of gastric cancer, the prevalence rate was 0.9%. 169 subjects were diagnosed to be dysplasia, the prevalence rate of dysplasia was increased significantly with age. The regression equation was Y=0.47X-0.25. The prevalence of CAG was found in 36 per cent of the studied subjects and both dysplasia and CAG were more serious in the antrum than the. fundus. The results showed a natural history of precancerous gastric lesions in a high risk population in a high risk area.

Analysis of Super-high Yield Population in Rice Zhongzao 39

[Objectives] The paper focused on the way how to promote yield of early indica rice Zhongzao 39. [Methods] At different yield levels, the yield components of super-high yield population in Zhongzao 39 were analyzed. Correlation analysis, regression analysis and path analysis were performed to analyze the relationship among traits and their contributions to yield. [Results] The performance of ear, grain and weight in Zhongzao 39 showed significant differences among different yield levels. It showed that the direct contributions of main economic traits to yield were determined to be 1 000-grain weight〉effective ears〉seed setting rate〉filled grains per ear. [Conclusions] The super-high yielding and effective cultivation techniques were suggested as follows： on the basis of the increasing number of effective ears and the remaining of grain weight, a stable seed setting rate should be considered.

Influencing Factors of Long-Term Residence Intention of Highly Educated Inter-Provincial and Intra-Provincial Floating Population From the Perspective of Social Integration:Take Guangdong Province for Example

Floating population plays an important role in the development of cities,regions,and countries.The economic growth path with Guangdong characteristics is inseparable from the support of highly educated groups.Studying the long-term residence intention of the highly educated floating population is helpful for the city to attract and retain talents.From the perspective of social integration,using CMDS 2017 data and taking Guangdong Province for example,this paper studies the influencing factors of long-term residence intention through SPSS logistic regression,taking intra-provincial and inter-provincial floating population with a bachelor’s degree or above as sample.The main conclusions are:(1)Marital and childbearing status is the primitive influencing factor of long-term residence intention among intra-provincial and inter-provincial floating population.Samples with high income,under social insurance system,being female and having non-agricultural hukou,are tend to prefer long-term residence.Samples who connect with the locals and participate in social public welfare are more likely to stay.(2)Personal age and city livability have a significant positive impact on the long-term residence intention of the inter-provincial highly educated floating population,but agricultural hukou and self-employed laborer status will weaken the long-term residence intention of this group.(3)Participation in townsmen/alumni association has a positive effect on the long-term residence intention of the intra-provincial highly educated floating population,and connection with outlanders also promotes the long-term residence intention of this group.(4)The long-term residence intention of inter-provincial highly educated floating population is usually based on reality,therefore they pay more attention to the development,changes,and livability of the destination city.However,the long-term residence intention of intra-provincial highly educated floating population is usually based on perception,so they pay more attention to whether they like the city.Compared with intra-provincial flows,inter-provincial flows have higher economic and emotional migration costs,more institutional barriers,and more life adaptation problems.Therefore,the government should introduce targeted measures to promote social integration and improve long-term residence intention.

MODIFIED CLASSIC RISK FACTORS FOR CORONARY ARTERY DISEASE IN CHINESE HAN POPULATION

Objective To investigate the levels of cardiovascular disease risk factors and their relations to clinical phenotype associated with coronary artery disease(CAD).Methods The subjects were recruited from five independent cardiovascular centers.Coronary angiography was employed to define the CAD with stenosis in each major vessel ≥70% and control with stenosis <10% in every lesion.The classic risk factors including family history,body mass index,smoking habits,hypertension,diabetes mellitus,and serum lipid levels were surveyed according to established criteria.Associations between risk levels and clinical phenotypes were assessed by case control and correlation analysis.Results A total of 762 individuals were collected,including 481 men and 281 women,aged from 17 to 81(mean 60±10) years.The patients with CAD accounted for 55.5% of all participants,and controls 44.5%,respectively.Compared with the pattern in published data,our study showed that mean serum high density lipoprotein cholesterol(HDL-C) level was significantly lower(P<0.001) and triglycerides was significantly higher(P<0.001),while total cholesterol(TC) and low density lipoprotein cholesterol levels were comparative(both P>0.05).The prevalence of low HDL-C(<40 g/L) and hypertriglyceridemia(>150 g/L) were 27.2% and 41.4%,respectively.Mean serum levels of HDL-C and apolipoprotein A1 were significantly higher in female subjects than in male(P<0.001).Lower HDL-C functioned as an independent risk factor for CAD only in men(RR=2.8,95%CI:1.5-4.2,P<0.001),yet increased non-HDL cholesterol combined with diabetes mellitus and obesity seemed to play a key role in the development ofCAD in women.Similarity in risk association with CAD was found for hypertension and TC/HDL ratio in male and female subjects,while family history had no relationship with the presence of CAD.Conclusion It is remarkable that emphasis of intervention in future should be given on the prevalent low serum HDL-C and its strong risk correlation with the presence of CAD in male subjects of Chinese Han population.

Investigation on the Association of Soil Microbial Populations with Ecological and Environmental Factors in the Pearl River Estuary

An investigation on the soil microbe populations from an agricultural inning area at the Pearl River estuary in Guangdong province, China was conducted via high through-put sequencing. The results revealed abundant diversity in the soil bacterial and fungal populations. In total, 197103 sequence tags were obtained from soil samples, most of which represented bacterial genera Actinomycetes, Bacillus and Marinobacter, while a majority of 118378 tags obtained were derived from fungal genera Clostridium, Devosia, Bradyrhizobium, Bdellovibrio, Phenylobacterium, Penicillium, and Emericella. Furthermore, nine physiological indexes (pH, available phosphorous, basic-group nitrogen, available potassium, catalase, sucrose, urease, phosphatase, and organic matters) were measured in three soil samples, and the association between these physiological indexes and microbe population composition was examined. The results revealed obvious inter-sample differences associated with ten dominating microbial groups: genera Clostridium, Devosia, Bradyrhizobium, Bdellovibrio, Phenylobacterium, and Penicillium were mainly impacted by pH (with a positive correlation), genera Sphingomonas and Acinetobacter mainly by available phosphorous (positive correlation), and genera Gemmatimonas and Pseudomonas by both pH and available phosphorous (negative correlation). Our study suggested that regulation of microbial species/populations might help improve soil environment to facilitate the growth of crops’ above-ground parts, and this provides practical information for inning agriculture.

Large Population Screening Identified the Main Risk Factors of Stroke in Shashi District of Jingzhou City

Objective: This paper aims to screen and analyze the current status of high-risk stroke patients in Shashi District of Jingzhou City and the exposure levels of related risk factors, and provides suggestions as the references for prevention and treatment of stroke. Methods: Using cluster sampling, on-site investigations were conducted on 1060 permanent residents aged 40 years and over at 3 townships and 2 communities in Shashi District of Jingzhou City from January 2018 to December 2018. Risk assessment of stroke is based on the stroke risk screening form. Statistical analysis was performed by using SPSS 22.0 software. Results: After making a stroke risk assessment, a total of 313 high-risk stroke patients were screened, and the detection rate was 29.53%. The exposure rate of risk factors from high to low was hypertension (70.93%), dyslipidemia (46.33%), less physical exercise (46.01%), diabetes (36.10%), overweight (33.55%), smoking (33.23%), family history of stroke (24.92%), atrial fibrillation or valvular heart disease (7.35%). There are statistically significant differences among all risk factors between the high-risk group and middle and low-risk groups (P Conclusion: The detection rate of high-risk stroke patients in Shashi District of Jingzhou City is high. Hypertension, dyslipidemia and less physical exercise are the main risk factors of stroke occurrence and recurrence in the region. The prevention and treatment of risk factors for stroke should be strengthened to control the incidence and recurrence rate of stroke.

基于临床基线特征与颈动脉超声参数构建脑卒中高危人群颈动脉易损斑块模型

背景:研究表明,颈动脉斑块的易损性和弹性与斑块内新生血管的存在及形成程度有关。超声作为筛查和评价颈动脉易损斑块的首选检查手段,具有无创、操作便捷、可重复性高和无辐射等的特点。目的:基于临床基线特征与颈动脉超声参数,探讨脑卒中高危人群颈动脉易损斑块的影响因素,基于独立危险因素构建并验证风险列线图(Nomogram)预测模型。方法:回顾性选取2021年11月到2023年11月于抚州市第一人民医院行脑卒中筛查确定为脑卒中高危人群的180例患者作为研究对象,将180例患者按7∶3比例分为建模集(n=126)和验证集(n=54),根据颈动脉超声检查结果将建模集研究对象分为易损斑块组(n=54)和非易损斑块组(n=72)。通过多因素Logistic回归得出独立危险因素,构建Nomogram模型,并使用R语言绘制决策曲线以评估模型的临床效益。采用受试者工作特征曲线和校准曲线检验模型的预测效能,同时分析验证集的病例数据进行外部验证。结果与结论:①多因素Logistic回归结果显示,年龄、脑卒中家族史、颈动脉斑块最大厚度值、颈动脉斑块数量、尿微量白蛋白和尿微量白蛋白/肌酐均与脑卒中高危人群颈动脉易损斑块有关(P<0.05)。②构建的Nomogram模型受试者工作特征曲线下面积为0.917,灵敏度和特异度分别为79.6%和91.7%;决策曲线结果显示,该模型的潜在临床获益可观,可用性较高;校准曲线结果提示,模型具备较好的预测准确性;验证集结果显示,模型的外部预测性能良好。③结果说明,脑卒中高危人群颈动脉易损斑块受年龄、脑卒中家族史、颈动脉斑块最大厚度值等因素影响,基于各独立危险因素构建的风险Nomogram预测模型的预测性能良好,可为临床上治疗此类高危人群提供有力的参考依据。

A genetic adaptive pattern-low hemoglobin concentration in the himalayan highlanders

Mean hemoglobin(Hb) concentration of about 3 500 subjects derived from 17 studies of Himalayan highlanders(Tibetans, Sherpas, and Ladakhis) was compared with lowlanders(Chinese Han, Indian Tamils) lived in the Himalayas, and European climbers during Everest expeditions as well as Andean natives. The results found that Hb concentration in Himalayan highlanders was systemically lower than those reported for Andean natives and lowland immigrants. These comparative data demonstrated that a healthy native population may successfully reside at high altitude without a significant elevation in Hb, and the lower Hb levels of Himalayan highlanders than those of migrated lowlanders and Andean natives are an example of favourable adaptation over the generations. In addition, excessive polycythemia has frequently been used as a marker of chronic mountain sickness(CMS). Altitude populations who have a higher Hb concentration also have a higher incidence of CMS. The low Hb in Himalayans suggested as showing adaptation over many generations in Tibetan stock. Recent work in Tibet, suggested that Tibetans there may have adapted to high altitude as a result of evolutionary pressure selecting for genes which give an advantage at altitude. All of the population genomic and statistical analysis indicated that EPAS1 and EGLN1 are mostly likely responsible for high altitude adaptation and closely related to low Hb concentration in Tibetans. These data supported the hypothesis that Himalayan highlanders have evolved a genetically different erythropoietic response to chronic hypoxia by virtue of their much longer exposure to high altitude.

High-Speed Railways: Present Situation and Future Prospects

Departing from the present situation, this paper attempts to highlight future prospects of high-speed railways. A panorama of high-speed lines worldwide is first given and the limits of a further increase of rail speeds are surveyed. It is explained that rail high speeds are feasible only for large population concentrations. The impact of high speeds on the reduction of travel times is studied. It is established a causal relationship between rail share and reduced travel times. Diversities concerning technical characteristics from one system to another are emphasized together with differences in construction costs from one case to another.

High-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay

Viruses are extremely heterogeneous entities; the size and the nature of their genetic information, as well as the strategies employed to amplify and propagate their genomes, are highly variable. However, as obligatory intracellular parasites, replication of all viruses relies on the host cell. Having co-evolved with their host for several million years, viruses have developed very sophisticated strategies to hijack cellular factors that promote virus uptake, replication, and spread. Identification of host cell factors(HCFs) required for these processes is a major challenge for researchers, but it enables the identification of new, highly selective targets for anti viral therapeutics. To this end, the establishment of platforms enabling genome-wide high-throughput RNA interference(HT-RNAi) screens has led to the identification of several key factors involved in the viral lifecycle. A number of genome-wide HT-RNAi screens have been performed for major human pathogens. These studies enable first inter-viral comparisons related to HCF requirements. Although several cellular functions appear to be uniformly required for the life cycle of most viruses tested(such as the proteasome and the Golgi-mediated secretory pathways), some factors, like the lipid kinase Phosphatidylinositol 4-kinase Ⅲα in the case of hepatitis C virus, are selectively required for individual viruses. However, despite the amount of data available, we are still far away from a comprehensive understanding of the interplay between viruses and host factors. Major limitations towards this goal are the low sensitivity and specificity of such screens, resulting in limited overlap between different screens performed with the same virus. This review focuses on how statistical and bioinformatic analysis methods applied to HTRNAi screens can help overcoming these issues thus increasing the reliability and impact of such studies.

花生高产攻关实收单产12982 kg/hm^(2)技术分析

为进一步挖掘花生高产潜力,示范带动大面积单产提升,自2013年开始山东省农业科学院花生栽培与生理生态创新团队连续组织高产攻关,产量相继突破实收单产11250 kg/hm^(2)、11700 kg/hm^(2)、12000 kg/hm^(2),其中2023年最高产达到12982 kg/hm^(2)。本文从栽培技术、气候条件、产量构成等方面分析了高产纪录产生原因,并对投入、产出进行了比较。栽培技术方面,集成应用了单粒精播、全程可控施肥、生物菌剂耦合、三防三促调控的高产栽培技术体系,通过充分发挥单株生产潜力、构建高质量群体来实现高产,为下一步单产突破13500 kg/hm^(2)提供技术支撑。

人口规模回旋空间与区域产业发展

未来30年是中国式现代化进程的关键时期,实现人口规模巨大的现代化意味着需要雄厚物质基础,这个物质基础需要一个相对完整、自主、庞大而丰裕度较高的产业体系予以支撑。深入认识人口增长时期区域经济发展过程中人口因素在产业发展中起到的作用有助于在人口负增长条件下更好地保持产业体系完整性,进一步提高劳动生产率,提升产业丰裕度。为此,本文基于文献析出方法从理论上阐释区域产业发展过程中存在依据自身人口规模进行专业化与多样性选择的情况,并且存在两者互动关系。在此基础上,选择以地级市和城市群为观察样本,采用两步广义矩模型(GMM)、空间杜宾模型,并通过工具变量解决内生性问题,检验了在一定技术水平和人力资本水平等其他条件下,区域产业专业化和多样性变动发展过程中人口规模的回旋效应和具体作用。研究发现:区域人口规模对区域产业专业化集聚和发展的互动影响呈现倒“U”型;区域人口规模对区域产业多样性集聚和发展的互动影响呈现“U”型;在区域产业专业化、多样性集聚过程中,存在空间溢出效应;中原城市群、珠三角城市群和京津冀城市群产业集聚的专业化效应和多样性效应得到充分释放,长三角城市群产业集聚的多样性效应更加明显。这充分说明在拥有巨大人口规模形成的超大市场和充沛的劳动力供给且国土广袤的前提下,各个空间单元(行政区域)可以根据自身禀赋优势和人口规模,在国内大市场中选择更适宜的产业集聚模式,即专业化和多样性,从而实现区域产业分工协调发展,如此便能够在总体人口负增长和区域人口增减分异明显的状态下,保持全国产业体系完整和基础性产业丰裕度提升。这一结果充分证明巨大的人口规模以及各个区域合理的分布使我国在区域产业专业化、多样性和产业体系完整性方面具有较大的回旋空间。当然,人口规模回旋空间效应的释放不会完全自动形成,需要以国家战略需求为导向,推进国内统一大市场建设,畅通要素流动,破除行政壁垒;人口需要朝着规模稳定、素质提升、结构均衡、分布合理和世代赓续的高质量发展方向和轨道转变。只有人口高质量发展才能够为现代化产业体系建设和经济高质量发展提供更大更多的新动能。

高质量发展视域下的中国人口均衡发展

在人口形势发生重要转折性变化之际,高质量发展要求更加重视人口素质,以“提质”替代“增量”,以“人才”替代“人力”,充分发挥凝结在人口自身的素质要素的作用,使更多民众更好地享受高质量发展的成果,享受高品质生活。长期均衡发展是人口发展的主要目标,也是人口高质量发展的内在要求。人口均衡发展不仅体现在人口系统内部要素间的依存制约以及人口系统与社会经济系统之间的协调适应,还体现在代际间的传承永续。年龄结构失衡是当前人口非均衡发展的突出表现,应聚焦结构失衡,弥补制约人口均衡发展的短板;同时充分发挥作为人口结构中坚力量的劳动年龄人口的作用,通过与经济高质量发展相协调以及推动人口均衡分布,促进人口均衡发展,助力实现人口高质量发展。