Tetramethylpyrazine and paeoniflorin combination(TMP-PF)alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway

Atherosclerosis remains a great threat to human health worldwide.Previous studies found that tetramethylpyrazine(TMP)and paeonifl orin(PF)combination(TMP-PF)exerts anti-atherosclerotic effects in vitro.However,whether TMP-PF improves atherosclerosis in vivo needs further exploration.The present study aims to assess the anti-atherosclerotic properties of TMP-PF in ApoE^(-/-)mice and explore the related molecule mechanisms.Results showed that TMP and high-dose TMP-PF decreased serum triglyceride and low-density lipoprotein cholesterol levels,suppressed vascular endothelial growth factor receptor 2(VEGFR2)and nuclear receptor subfamily 4 group A member 1(NR4A1)expression in aortic tissues,inhibited plaque angiogenesis,reduced plaque areas,and alleviated atherosclerosis in ApoE^(-/-)mice.Also,TMP-PF exhibited a better modulation effect than TMP or PF alone.However,NR4A1 agonist abolished the anti-atherosclerotic effects of TMP-PF.In conclusion,TMP-PF was first found to alleviate atherosclerosis progression by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway,indicating that TMP-PF had a positive effect on reducing hyperlipemia and attenuating atherosclerosis development.

Modeling of Gate Tunneling Current for Nanoscale MOSFETs with High-k Gate Stacks

A quantum model based on solutions to the Schrodinger-Poisson equations is developed to investigate the device behavior related togate tunneling current for nanoscale MOSFETs with high-k gate stacks. This model can model various MOS device structures with combinations of high-k dielectric materials and multilayer gate stacks,revealing quantum effects on the device performance. Comparisons are made for gate current behavior between nMOSFET and pMOSFET high- k gate stack structures. The results presented are consistent with experimental data, whereas a new finding for an optimum nitrogen content in HfSiON gate dielectric requires further experimental verifications.

CLINICAL ANALYSIS ON TREATMENT OF 40 CASES OF HYPERLIPEMIA WITH POINT-INJECTION OF RADIX SALVIAE MILTIORRZHIZAE INJECTION

In the present paper, the effect of point-injection of Radix Salviae Miltiorrhizae injectio on blood-lipid was observed in 65 cases of hyperlipemia. The 65 patients were divided into point-injection group (40 cases who were treated with point-injection of Radix Salviae Miltiorrhizae injectio and oral administration of Shujiangzhi) and control group (25 cases who were treated with oral administration of Shujiangzhi only). Results showed that the total effective rate of the point-injection group was significantly higher than that of the control group (P<0. 05); point-injection of Radix Salviae Miltiorrhizae injectio could effectively raise the level of HDL-C, decrease lower LDL-C and regulate estrogen level of women. The slow releasing action of red sage root solution in the topical acupoint region prolonged and enhanced its effect in lowering blood-lipid. There was a significant difference between the two groups in the effect of lowering blood-fat (P< 0. 01).

High- and Ultrahigh-pressure Metamorphism and Retrogressive Textures of Gneiss in the Donghai Area——Evidence from gneisses in drillhole ZK2304

In the gneisses from the drillhole ZK2304 of the Donghai area, there have been preserved high- and ultrahigh-pressure metamorphic mineral assemblages, a series of complicated retrogressive textures and relevant metamorphic reactions. In addition to garnet, jadeititic-clinopyroxene and rutile, other peak stage (M2) minerals in some gneisses include phengite, aragonite and coesite or quartz pseudomorphs after coesite. The typical peak-stage mineral assemblages in gneisses are characterized by garnet + jadeitic-clinopyroxene + rutile + coesite, garnet + jadeitic-clinopyroxene + phengite + rutile ± coesite and garnet + jadeitic-clinopyroxene + aragonite + rutile ± coesite. The grossular content (Gro) in garnet is high and may reach 50. 1 mol%. The SiO2 content of phengite ranges from 54.37% to 54.84% with 3.54-3.57 p.f.u. Quartz pseudomorphs after coesite occur as inclusions in garnet.The gneisses of the Donghai area have been subjected to multistage recrystallization and exhibit a closewise P-T evolutional path characterized by the near-isothermal decompression. The inclusion assemblage (Hb+Ep+Bi+Pl+Qz) within garnet and other minerals has recorded a pre-peak stage (Mi) epidote amphibole fades metamorphic event. High- and ultrahigh-pressure peak metamorphism (M2) took place at T=750-860℃ and P>2.7 GPa. The symplectitic assemblages after garnet, jadeitic-clinopyroxene and rutile imply a near-isothermal decompression metamorphism (M3, M4) during the rapid exhumation. Several lines of evidence of petrography and metamorphic reactions indicate that both gneisses and eclogites have experienced ultrahigh-pressure metamorphism in the Donghai area. This research may be of great significance for an in-depth study of the metamorphism and tectonic evolution in the Su-Lu ultrahigh-pressure metamorphic belt.

EXPERIMENTAL STUDY ON THE PREVENTION AND TREATMENT EFFECT OF WARMING-REINFORCING METHOD ON RABBIT'S HYPERLIPEMIA

In this experiment, the contents of serum total cholesterol (TC), triglyceride(TG),low-density lipoprotein(LDL), high-density lipoprotein(HDL) were used as indexes to observe the effects of warming-reinforcing method on rabbit’s lipide, liopoprotein. The results indicated that in the warming-reinforcing group, TC decreased markedly and HDL increased obviously with significant difference as compared with the twirling-reinforcing group:TC and LDL also decreased, but no significant differencte as compared with the twirling-reinforcing group. Warming-reinforcing method can decrease lipids more effectively than twirling-reinforcing method.

Severe hyperlipemia-induced pseudoerythrocytosis - Implication for misdiagnosis and blood transfusion: A case report and literature review

BACKGROUND Severe hyperlipemia(SHLE)has an impact on the results of many kinds of laboratory tests.Complete blood count(CBC)examination by automated blood cell counter(ABCC)is a quick and convenient measurement for screening abnormalities of blood cells that are triggered by various pathogenic insults in disease diagnosis and for monitoring changes in the treatment of existing hematological conditions.However,CBC results are frequently affected by many intrinsic and extrinsic factors from blood samples,such as in the setting of hypergammaglobulinemia and certain anticoagulants.SHLE could also affect CBC results.CASE SUMMARY A 33-year-old Chinese male presented with painful foot numbness and abdominal pain.He was initially misdiagnosed as having a myeloproliferative neoplasm(MPN)because of the marked abnormalities in CBC examination by the ABCC.Morphological evaluation of the bone marrow smears and biopsy showed no evidence of MPN.Gene mutations in Breakpoint cluster regions-Abelson murine leukemia viral oncogene homologue 1(BCR-ABL1),Janus kinase 2(JAK2),calreticulin(CALR),myeloproliferative leukemia virus(MPL),and colony-stimulating factor 3 receptor(CSF3R)were negative.Having noticed the thick chylomicron layer on blood samples and the dramatically fluctuating CBC results,we speculated that the fat droplets formed by shaking the blood samples in the setting of SHLE were mistakenly identified as blood cells due to the limited parameters of ABCC.Therefore,we removed a large part of the chylomicron layer and then reexamined the CBC,and the CBC results,as we expected,differed significantly from that of the sample before the chylomicron layer was removed.These significant differences had been validated by the subsequently repeated laboratory tests by measuring dual blood samples that the chylomicron layer was removed in one sample and was not in another,and comparing the CBC results.Computerized tomography reexamination of the upper abdomen revealed an exudative lesion surrounding his pancreas.After intensive consultation,definitive diagnosis was made as recurrent pancreatitis,hyperlipemia and pseudoerythrocytosis.CONCLUSION SHLE may become a potential cause of misdiagnosis of hyperlipemia-related diseases as MPNs and the resultant mistreatment.It may also lead to the misinterpretation of transfusion indications in patients with hematological disorders who critically need blood transfusion for supportive treatment.

Comparison of Diurnal,Seasonal and Solar Cycle Variations of High-latitude,Mid-latitude and Low-latitude Ionosphere

Comparison of regular(diurnal,seasonal and solar cycle)variations of high-latitude,mid-latitude and low-latitude ionospheric characteristics has been provided on basis of local empirical models of the peak electron density and the peak height.The local empirical models were derived from the hand-scaled ionogram data recorded by DPS-4 digisondes located at Norilsk(69°N,88°E),Irkutsk(52°N,104°E)and Hainan(19°N,109°E)for a 6-year period from December,2002 to December,2008.The technique used to build the local empirical model is described.The primary focus is diurnal-seasonal behavior under low solar activity and its change with increasing solar activity.Both common and specific features of the high-latitude(Norilsk),mid-latitude(Irkutsk)and low-latitude(Hainan)regular variations were revealed using their local empirical models.

The Alimentary Therapy for Hyperlipemia Complicated with NIDDM

Hyperlipemia is a complication commonly seen in non-insulin-dependent diabetes(NIDDM).This complication can causeischemic heart disease,cerebro-vascular disease and even lifethreatening.In order to prevent this complication and to reduce mortality of NIDDM,60patients with NIDDMand hyperlipemia were investigated.Alimentary therapy consisting of the following items was given:(1)routine control of total calorie consumption:(2)carbohydrates,lipids,proteins,vitamins and minerals taken in proportional amounts;(3)fish proteins were the main proteins in the diet;(4)dried mushroom(3g/day);(5)little tea after meal;(6)corn meal or millet gruel(5-10g./day).With this dietary regime,majority of the NIDDMpatiens with serum total lipid returned to normal or near normal.

Phase control of magnetron sputtering deposited Gd_2O_3 thin films as high-κ gate dielectrics

Gd2O3 thin films as high-κ gate dielectrics were deposited directly on Si（001） substrates by magnetron sputtering at a pressure of 1.3 Pa and different temperatures. X-ray diffraction results revealed that all the films grown from 450 to 570 ℃ were crystalline, and the Gd2O3 thin films consisted of a mixture of cubic and monoclinic phases. The growth temperature was a critical parameter for the phase constituents and their relative amount. Low temperature was favorable for the formation of cubic phase while higher temperature gave rise to more monoclinic phase. All the Gd2O3 thin films grown from different temperatures exhibited acceptable electrical properties, such as low leakage current density （JL） of 10-5 A/cm^2 at zero bias with capacitance equivalent SiO2 thickness in the range of 6-13 nm. Through the comparison between films grown at 450 and 570 ℃, the existence of monoclinic phase caused an increase in JL by nearly one order of magnitude and a reduction of effective dielectric constant from 17 to 9.

The effectiveness of a high-fidelity teaching simulation based on an NLN/Jeffries simulation in the nursing education theoretical framework and its influencing factors

Objective： To investigate the effectiveness of a high-fidelity teaching simulation based on an NLN/Jeffries simulation in the nursing education theoretical framework and its influencing factors. Methods： A high-fidelity teaching simulation on clinical nursing practices using intelligent human analogues was conducted with 200 students, and The Simulation Design Scale, and the Student Satisfaction and Self-Confidence in Learning Scale developed by the National League for Nursing were used to evaluate the training effectiveness and its influencing factors. Results： For the high-fidelity teaching simulation, students gave scores of 4.36± 0.54 points for satisfaction and 4.33 ± 0.46 points for Self-Confidence. The students highly rated the five dimensions of teaching design, i.e., teaching objectives/information, assistance/support for students, problem solving, guided feedback, and fidelity. The teaching design was closely correlated with the satisfaction of the high-fidelity teaching simulation and self-efficacy, and the dimensions of teaching objectives/informa- tion and assistance/support for students were particularly strong predictors of teaching effectiveness. Conclusions： A high-fidelity teaching simulation based on Jeffries＇ theoretical framework improved student satisfaction with the simulation and their Self-Confidence. In planning simulations, teachers should take into account five characteristics, i.e., teaching objectives/information on simulation education, assistance/support for students, problem solving, guided reflection, and fidelity, to achieve better teaching effectiveness.

A Clinical Study on Diabetes, Cholesteremia and Hyperlipemia

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Materials Design on the Origin of Gap States in a High-κ/GaAs Interface

Given the demand for constantly scaling micro- electronic devices to ever smaller dimensions, a SiO2 gate dielectric was substituted with a higher dielectric-constant material, Hf（Zr）O2, in order to minimize current leakage through dielectric thin film. However, upon interfacing with high dielectric constant （high-κ） dielectrics, the electron mobility in the conventional Si channel degrades due to Coulomb scattering, surface-roughness scattering, remotephonon scattering, and dielectric-charge trapping.Ⅲ-Ⅴ and Ge are two promising candidates with superior mobility over Si. Nevertheless, Hf（Zr）O2/Ⅲ-Ⅴ（Ge） has much more complicated interface bonding than Si-based interfaces. Successful fabrication of a high-quality device critically depends on understanding and engineering the bonding configurations at Hf（Zr）O2/Ⅲ-Ⅴ（Ge） interfaces for the optimal design of device interfaces. Thus, an accurate atomic insight into the interface bonding and mechanism of interface gap states formation becomes essential. Here, we utilize first- principle calculations to investigate the interface between HfO2 and GaAs. Our study shows that As--As dimer bonding, Ga partial oxidation （between 3＋ and 1＋） and Ga- dangling bonds constitute the major contributions to gap states. These findings provide insightful guidance for optimum interface passivation.

EFFECT OF HERB-MEDICINE-CAKE-SEPARATED MOXIBUSTION ON SERUM LIPOPROTEIN CONTENTS AND RATIO OF HDL-Ch AND LDL-Ch IN HYPERLIPEMIA RABBITS

Objective: To observe the effect of herb-medicine-cake-separated moxibustion on serum lipoprotein in hyperlipemia rabbits. Methods: 55 New-Zealand rabbits were randomly divided into control group (n=13), model group (n=14), direct moxibustion group (n=14) and herb-medicine-cake-separated moxibustion (indirect moxibustion) group (n=14). Hyperlipemia model was established by feeding the animals with specialized forage (15% vitellus powder, 5% lard, 0.5% cholesterol and common forage) for 6 weeks. Moxibustion was applied to “Juque”(CV 14), “Tianshu”(ST 25), “Fenglong”(ST 40), etc., 4 moxa-cones for every acupoint, once daily and continuously for 40 days. Serum high density lipoprotein-cholesterol (HDL-Ch), low density lipoprotein-cholesterol (LDL-Ch) and total cholesterol (TCh) contents were assayed with colorimetric method. Results: Compared with control group, serum LDL-Ch content, HDL-Ch/LDL-Ch and HDL-Ch/TCh of model group were significantly higher (P<0.05～0.01), while compared with model group, LDL-Ch contents of two moxibustion groups were strikingly lower (P<0.01). No significant differences were found between two moxibustion groups in all the 4 indexes. Conclusion: Both direct and indirect moxibustion can effectively lower serum LDL-Ch, raise HDL-Ch, HDL-Ch/LDL-Ch and HDL-Ch/TCh, and regulate lipoprotein metabolism in hyperlipemia rabbits.

EFFECT OF HERB-MEDICINE-CAKE-SEPARATED MOXIBUSTION ON SERUM LIPOPROTEIN CONTENTS IN HYPERLIPEMIA RABBITS

Objective: To study the effect of medicinal herb-cake-separated moxibustion on serum lipoprotein levels in hyperlipemia rabbits. Methods: A total of 55 New-Zealand rabbits were randomly divided into control group (n=13), model group (n=14), direct moxibustion group (n=14) and medicinal herb-cake-separated moxibustion (indirect moxibustion) group (n=14). Hyperlipemia model was established by feeding the animals with specialized forage (15% vitellus powder, 5% lard, 0.5% cholesterol and common forage) for 6 weeks. Moxibustion was applied to “Juque”(CV 14), “Tianshu”(ST 25), “Fenglong”(ST 40), etc., 4 moxa-cones for every acupoint, once daily and continuously for 40 days. Serum triglyceride (TG) and total cholesterol (TCh) contents were assayed with colorimentric method. Results: Compared with control group, TCh and TG levels of model group increased significantly (P< 0.01). TCh and TG contents of direct moxibustion and indirect moxibustion groups were significantly lower than those of model group (P<0.01). Comparison between two moxibustion groups showed that serum TCh level of indirect moxibustion group was strikingly lower than that of direct moxibustion group (P<0.01). It indicated that both direct and indirect moxibustion could effectively lower hyperlipemia and the therapeutic effect of indirect moxibustion was significantly superior to that of direct moxibustion in lowering serum TCh level. Conclusion: Both direct and indirect moxibustion can regulate lipid metabolism and the therapeutic effect of medicinal herb-cake-separated moxibustion is superior to that of direction moxibustion in hyperlipemia rabbits.

Differential Effects of Voluntary Ethanol Consumption on Dopamine Output in the Nucleus Accumbens Shell of Roman High- and Low-Avoidance Rats: A Behavioral and Brain Microdialysis Study

The Roman high(RHA) and low-Avoidance (RLA) rats were selectively bred for rapid vs poor acquisition of two-way active avoidance behavior. These lines differ in numerous behavioral traits, with RLA rats being more fearful/anxious than RHA rats, and the latter being novelty-seekers and showing larger intake of, and preference for, addictive substances including ethanol (ETH). Moreover, several differences in central dopaminergic, serotonergic, and GABAergic functions have been reported in these two lines. Since those neural systems are involved in the regulation of ETH consumption, it was considered of interest to investigate: 1) the differences in ETH intake and preference between RHA and RLA rats, 2) the effects of ETH on DA release in the shell of the nucleus accumbens (AcbSh) using brain microdialysis. ETH solutions of increasing concentrations (2% - 10%) were presented on alternate days in a free choice with water. To examine ETH intake and preference stability, animals were subsequently switched to daily presentations of 10% ETH for 10 consecutive days. RHA rats consumed significantly larger amounts of ETH and displayed higher ETH preference than did RLA rats throughout the acquisition and maintenance phases. Following chronic exposure to ETH the animals were habituated to a restricted access to ETH schedule (2% ETH, 2 h per day × 4 days) before surgical implantation of a dialysis probe in the AcbSh. Under these experimental conditions, voluntary ETH intake (2%, 1 h, p.o.) produced a significant increase in accumbal DA output in RHA rats but not in their RLA counterparts. Finally, the i.p. administration of ETH (0.25 g/kg) to na?ve Roman rats produced a significant increment in accumbal DA output only in RHA rats. These results indicate that the mesolimbic dopaminergic system of RHA rats is more responsive to the effects of ETH than that of RLA rats.

Curative effect analysis of therapeutic ultrasonic in vitro on hyperlipemia

Objective To observe the effects of therapeuti c ultrasound in vitro on hyperlipemi a.Methods Comparing clinical effects of only ultrasound treatment,only adminis tration of Geminifbrozip and combin ation of these two therapies.These p atientswere divided into three grou ps and the follow-up observation was 3months.Result Curative effect of the ultrasound gr oup was better than that of drug group(P <0.05).Curative effect of the combined therapy group was the best(P <0.01).Result of follow-up suggested that serum glyceryl trioleate and cholesterol relapse rate of ultrasonic group was lower than that of drug group .Serum g lyceryl trioleate and cholesterol r elapse rate of combined therapy grou p was the lowest.Conclusion Combination of ultrasound treatmen t in vitro and administration of Gemi nifbrozip is the best way to treat hyper-lipemia,and it is not easy to relapse.

EFFECTS OF HERBAL CAKE-SEPARATED MOXIBUSTION ON BLOOD LIPIDS, PLASMA THROMOXANE B2 AND 6-KETO-PROSTAGLANDIN F_(1α) CONTENTS IN THE RABBIT WITH HYPERLIPEMIA

Objective: To observe effects of herbal cake-separated moxibustion on blood lipids, including total cholesterol (TCh), triglyceride (TG), high density lipoprotein-Ch (HDL-Ch), low density lipoprotein-Ch (LDL-Ch), apolipoprotein A (Apo A), apolipoprotein B (Apo B), and plasma thromboxane B2 (TXB2) and 6-keto-prostaglandin F 1α (6-keto-PGF 1α) contents and analyse its mechanism. Methods: The hyperlipemia rabbit model was established by breeding of high fat forage and injection of bovine serum albumin. They were treated respectively by direct moxibustion and herbal cake-separated moxibustion at Juque (巨阙 CV 14), Tianshu (天枢 ST 25), Fenglong (丰隆 ST 40), etc., once daily, continuously for 40 days. Blood TCh and TG contents were detected with enzymatic method, LDL-Ch and HDL-Ch with colorimetric method, Apo A and Apo B with electrophoretic method, and TXB2 and 6-keto-PGF 1α with radioimmunoassay. Results: Both the herbal cake-separated moxibustion and direct moxibustion could effectively decrease TCh, TG, LDL-Ch, Apo B and TXB2 contents and TXB2/6-keto-PGF 1α, and increase HDL-CH and 6-keto-PGF 1α contents in the rabbit of hyperlipemia. Conclusion: 6-keto-PGF 1α and TXB2 are possibly involved in the mechanism of herbal cake-separated moxibustion decreasing blood lipids.

孕妇脂血对生化检验的影响及其与不良妊娠结局关系

目的:探究高脂血症孕妇脂血标本生化检验时的影响及处理效果,分析高脂血症与不良妊娠结局关系。方法:回顾性收集2018年12月-2023年12月本院接受产前检查并分娩的高脂血症孕妇102例纳入高脂血症组,同期产前检查并分娩的正常孕妇102例纳入健康组。将观察组血液标本采取低温高速离心法处理,对比标本处理前后生化检验指标血肌酐(Cr)、血清碱性磷酸酶(ALP)、肌酸激酶同工酶(CK-MB)、空腹血糖(FBG)、天门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)变化;对比两组不良母婴结局;采用受试者工作特征(ROC)曲线分析高脂血对不良妊娠结局的评估价值;采用Spearman相关性分析脂血与不良妊娠结局相关性。结果:高脂血症组血标本处理后Cr、ALP、CK-MB、FBG、AST和ALT水平均较处理前降低,且血TC、TG、HDL-C和LDL-C水平均高于健康组(均P<0.05)。不良妊娠结局高脂血症组(23.5%)高于健康组(6.9%)(P<0.05),但不同孕期诊断高血脂症孕妇其不良妊娠结局发生率未见差异(P>0.05);脂血检测评估不良妊娠结局的ROC曲线下面积为0.720、特异性57.2%、敏感度90.3%,孕妇血脂水平与母体、胎儿不良结局均存在正相关性(均P<0.001)。结论:孕妇脂血对其他生化检验项目均有影响,采用低温离心再处理有一定效果。存在脂血孕妇不良妊娠结局发生率更高。

益生菌对糖脂代谢紊乱相关疾病的缓解作用及机制

糖脂代谢紊乱是常见内源性疾病发病的重要因素,其相关疾病的发病率逐年上升,严重影响患者的生活质量。益生菌是对人体健康有益的微生物,可通过调节肠道微生物起到降低血糖、调节血脂、改善氧化应激及炎症的作用。作者综述了益生菌在高脂血症、糖尿病、高血压这3种糖脂代谢紊乱相关疾病中的具体作用效果及其相关机制。作为一种非药物性降糖、降脂方法,益生菌为糖脂代谢紊乱相关疾病的干预治疗提供了新思路。