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Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas
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作者 Bin Yang Ao He +6 位作者 Bin-Bin Bu Gong Zhuo Qing-Zhu Zhou Jia-Hang He Liu Liu Wen-Li Huang Xian Zhao 《World Journal of Clinical Cases》 SCIE 2024年第16期2713-2721,共9页
BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injection... BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients improved after treatment.CONCLUSION Intradermal ColΙinjection improves photoaging,with higher patient satisfaction and fewer adverse reactions,and could be an effective treatment method for populations residing in high-altitude areas. 展开更多
关键词 PHOTOAGING TypeΙcollagen Face-Q high-altitude area Skin photodamage Patient satisfaction
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Atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction
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作者 Ding-Han Zhu Xiong Zhang +3 位作者 Xiao-Qiang Li Peng Li Yan-Bin Wang Shuang Zhang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第3期40-52,共13页
In high-altitude nuclear detonations,the proportion of pulsed X-ray energy can exceed 70%,making it a specific monitoring signal for such events.These pulsed X-rays can be captured using a satellite-borne X-ray detect... In high-altitude nuclear detonations,the proportion of pulsed X-ray energy can exceed 70%,making it a specific monitoring signal for such events.These pulsed X-rays can be captured using a satellite-borne X-ray detector following atmospheric transmission.To quantitatively analyze the effects of different satellite detection altitudes,burst heights,and transmission angles on the physical processes of X-ray transport and energy fluence,we developed an atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction.The proposed method is an improvement over the traditional analytical method that only computes direct-transmission X-rays.The traditional analytical method exhibits a maximum relative error of 67.79% compared with the Monte Carlo method.Our improved method reduces this error to within 10% under the same conditions,even reaching 1% in certain scenarios.Moreover,its computation time is 48,000 times faster than that of the Monte Carlo method.These results have important theoretical significance and engineering application value for designing satellite-borne nuclear detonation pulsed X-ray detectors,inverting nuclear detonation source terms,and assessing ionospheric effects. 展开更多
关键词 high-altitude nuclear detonation Atmospheric transmission Pulsed X-rays Scattering correction Analytical method Monte Carlo method
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Single-Arm Clinical Study of Combination Perindopril-Amlodipine Tablets in the Treatment of High-Altitude Hypertension
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作者 Miao Shao Jin Tian Jacinda Huang Wentao Wu 《Journal of Clinical and Nursing Research》 2024年第9期168-173,共6页
Objective:To evaluate the efficacy of combination perindopril/amlodipine tablets in patients with high-altitude hypertension who were previously unable to control their blood pressure with monotherapy.Methods:A total ... Objective:To evaluate the efficacy of combination perindopril/amlodipine tablets in patients with high-altitude hypertension who were previously unable to control their blood pressure with monotherapy.Methods:A total of 151 patients with high-altitude hypertension whose blood pressure remained inadequately controlled with previous monotherapy were enrolled in this study.All patients received an 8-week treatment with a combination of perindopril/amlodipine tablets,consisting of perindopril 10 mg/day and amlodipine 5 mg/day.Blood pressure measurements,including both diastolic and systolic pressures,were taken at baseline,and after 2,4,6,and 8 weeks of treatment.Results:After 8 weeks of treatment,there was a significant reduction in both average systolic and diastolic blood pressure compared to baseline(P<0.0001).Specifically,the average systolic blood pressure decreased by 24.45±13.75 mmHg,and the average diastolic blood pressure decreased by 13.37±8.40 mmHg.The overall heart rate showed no significant changes during the treatment period.Conclusion:A combination of perindopril/amlodipine tablets significantly improved blood pressure control in patients with high-altitude hypertension after 8 weeks of treatment.These results support the efficacy of combination perindopril/amlodipine as a viable treatment option for high-altitude hypertension. 展开更多
关键词 high-altitude hypertension Perindopril/amlodipine Blood pressure control Systolic and diastolic pressure reduction
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Geostructures, dynamics and risk mitigation of high-altitude and long- runout rockslides 被引量:7
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作者 Yueping Yin Bin Li +3 位作者 Yang Gao Wenpei Wang Shilin Zhang Nan Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第1期66-101,共36页
Long-runout rockslides at high altitude could cause disaster chain in river basins and destroy towns and major infrasturctures.This paper firstly explores the initiation mechanism of high-altitude and long-runout rock... Long-runout rockslides at high altitude could cause disaster chain in river basins and destroy towns and major infrasturctures.This paper firstly explores the initiation mechanism of high-altitude and long-runout rockslides.Two types of sliding-prone geostructure models,i.e.the fault control type in orogenic belt and the fold control type in platform area,are proposed.Then,large-scale experimental apparatus and associated numerical simulations are conducted to understanding the chain-style dynamics of rockslide-debris avalanche-debris flow.The results reveal the fragmentation effects,the rheological behaviors and the boundary layer effect of long-runout avalanche-debris flow.The dynamic character-istics of quasi-static-transition-inertia state and solid-liquid coupling in rapid movement of rockslide-debris avalanche-debris flow are investigated.Finally,the risk mitigation strategy of the non-structure and structure for resilient energy dissipation are illustrated for initiation,transition and deposition zones.The structural prevention and mitigation methods have been successfully applied to the high-altitude and long-runout rockslides in Zhouqu and Maoxian of the Wenchuan earthquake zone,as well as the other major geohazards in Qinghai-Tibet Plateau and its adjacent areas. 展开更多
关键词 ROCKSLIDE high-altitude and long-runout Sliding-prone geostructure Large-scale experimental apparatus Risk mitigation strategy Structural prevention technique
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Numerical and experimental study on the falling film flow characteristics with the effect of co-current gas flow in hydrogen liquefaction process 被引量:1
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作者 Chong-Zheng Sun Yu-Xing Li +2 位作者 Hui Han Xiao-Yi Geng Xiao Lu 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1369-1384,共16页
Liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat ... Liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat exchanger structure and hydrogen liquefaction process(LH2). The methods of cryogenic visualization experiment, theoretical analysis and numerical simulation are conducted to study the falling film flow characteristics with the effect of co-current gas flow in LH2spiral wound heat exchanger.The results show that the flow rate of mixed refrigerant has a great influence on liquid film spreading process, falling film flow pattern and heat transfer performance. The liquid film of LH2mixed refrigerant with column flow pattern can not uniformly and completely cover the tube wall surface. As liquid flow rate increases, the falling film flow pattern evolves into sheet-column flow and sheet flow, and liquid film completely covers the surface of tube wall. With the increase of shear effect of gas-phase mixed refrigerant in the same direction, the liquid film gradually becomes unstable, and the flow pattern eventually evolves into a mist flow. 展开更多
关键词 Hydrogen liquefaction Spiral wound heat exchanger Flow pattern transition falling film flow
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Ambulance Records as an Information Source to Document and Prevent Fall Injuries in Sweden
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作者 Stefan Backe 《Health》 2024年第7期615-625,共11页
In Sweden, there has been only limited documentation for injuries requiring ambulance responses. The main objective of this study is, through the use of historic data, to assess the suitability of ambulance records to... In Sweden, there has been only limited documentation for injuries requiring ambulance responses. The main objective of this study is, through the use of historic data, to assess the suitability of ambulance records to describe circumstances with fall injuries. Methods: The injury events data around patients were sourced from the ambulance data register. Descriptive statistics were used to describe injured patients based on age group, type of injury, place of injury, injury mechanism and consequence of an injury event. Two-group comparison was performed with Pearson’s chi-squared. Predictors of transport to hospital were identified using logistic regression analyses. Result: Ambulance provides unique data on all injury events, with direct implications for translational research, public policy and clinical practice (safety promotion). In 2002 ambulance attended 3964 injured people which represents 14% of ambulance attended workload in Värmland county, Sweden. The most common trauma location was the traffic area followed by residential area and nursing home. These three injury sites account for 2320 cases (61.6%). The most common cause of injury was falls (63.9%) followed by contact with another person (26.5%). Contact with another person is the most common site of injury in the traffic area (79.5%), and men aged 25-66 years are overrepresented. Conclusion: Logistic regression found that, age-group and place code were significant predictor for being attended by ambulance. Traffic, home and nursing homes were over-represented injury environments (61.6%) that require special attention. Most injury cases occur in the home and nursing homes among people over 67 years of age. Surprisingly, most of the injury events in the traffic environment are about hitting another person. Paramedics can provide rich and valuable data on injury events. Registration of such data is entirely possible and desirable, and can be used in preventive work. 展开更多
关键词 Injury Surveillance PARAMEDICS fallS Hit with the First Injury
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Construction Technology of Warm Mix Asphalt Pavement in Cold High-Altitude Areas
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作者 Guangxi Wu 《Journal of Architectural Research and Development》 2023年第5期27-33,共7页
With the continuous development of domestic highway construction,highway civil engineering and service level quality have attracted much attention.Good pavement quality and high-quality service make people feel comfor... With the continuous development of domestic highway construction,highway civil engineering and service level quality have attracted much attention.Good pavement quality and high-quality service make people feel comfortable and smooth when traveling.High-quality pavement can significantly reduce the probability of traffic accidents.At present,there is a direct relationship between pavement quality and pavement construction operations.Carrying out pavement construction operations in cold high-altitude areas requires a reasonable selection of construction equipment and methods.The application of warm-mix asphalt pavement construction technology can ensure pavement quality.Therefore,this paper analyzes the advantages of warm-mix technology,the environmental characteristics of cold high-altitude areas,and construction preparations,and discusses the construction technology of warm-mix asphalt pavement in cold high-altitude areas in detail,to improve the overall road quality of cold high-altitude areas. 展开更多
关键词 Cold high-altitude areas Warm mix asphalt Pavement construction technology
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Fuzzy inference system using genetic algorithm and pattern search for predicting roof fall rate in underground coal mines
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作者 Ayush Sahu Satish Sinha Haider Banka 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第1期31-41,共11页
One of the most dangerous safety hazard in underground coal mines is roof falls during retreat mining.Roof falls may cause life-threatening and non-fatal injuries to miners and impede mining and transportation operati... One of the most dangerous safety hazard in underground coal mines is roof falls during retreat mining.Roof falls may cause life-threatening and non-fatal injuries to miners and impede mining and transportation operations.As a result,a reliable roof fall prediction model is essential to tackle such challenges.Different parameters that substantially impact roof falls are ill-defined and intangible,making this an uncertain and challenging research issue.The National Institute for Occupational Safety and Health assembled a national database of roof performance from 37 coal mines to explore the factors contributing to roof falls.Data acquired for 37 mines is limited due to several restrictions,which increased the likelihood of incompleteness.Fuzzy logic is a technique for coping with ambiguity,incompleteness,and uncertainty.Therefore,In this paper,the fuzzy inference method is presented,which employs a genetic algorithm to create fuzzy rules based on 109 records of roof fall data and pattern search to refine the membership functions of parameters.The performance of the deployed model is evaluated using statistical measures such as the Root-Mean-Square Error,Mean-Absolute-Error,and coefficient of determination(R_(2)).Based on these criteria,the suggested model outperforms the existing models to precisely predict roof fall rates using fewer fuzzy rules. 展开更多
关键词 Underground coal mining Roof fall Fuzzy logic Genetic algorithm
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Settlement Control Technology of High Filled Soil-Rock Embankment in Alpine and High-Altitude Areas
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作者 Guangxi Wu 《Journal of World Architecture》 2023年第4期75-81,共7页
China's infrastructure has gradually achieved large-scale development,and transportation construction has also shifted from east to west,transitioning from plains to mountainous areas.High-fill embankments of diff... China's infrastructure has gradually achieved large-scale development,and transportation construction has also shifted from east to west,transitioning from plains to mountainous areas.High-fill embankments of different sizes in mountainous areas are unavoidable,and the settlement of high-fill embankments is usually the most concerned issue in high-fill projects.According to the current research of highway projects,most of the high embankments in mountainous areas are soil-rock mixed embankments or rock-filled embankments,and their post-construction settlements are directly related to construction technology and the type of filler used.In this paper,the problems in the settlement control of earth-filled embankment and related factors are analyzed in detail.The settlement control technology of high-fill embankment in high-cold and high-altitude areas is also discussed,so as to ensure the overall quality of high-fill embankment. 展开更多
关键词 high-altitude and cold areas High soil-rock embankment Settlement control technology
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A Novel Fall Detection Framework Using Skip-DSCGAN Based on Inertial Sensor Data
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作者 Kun Fang Julong Pan +1 位作者 Lingyi Li Ruihan Xiang 《Computers, Materials & Continua》 SCIE EI 2024年第1期493-514,共22页
With the widespread use of Internet of Things(IoT)technology in daily life and the considerable safety risks of falls for elderly individuals,research on IoT-based fall detection systems has gainedmuch attention.This ... With the widespread use of Internet of Things(IoT)technology in daily life and the considerable safety risks of falls for elderly individuals,research on IoT-based fall detection systems has gainedmuch attention.This paper proposes an IoT-based spatiotemporal data processing framework based on a depthwise separable convolution generative adversarial network using skip-connection(Skip-DSCGAN)for fall detection.The method uses spatiotemporal data from accelerometers and gyroscopes in inertial sensors as input data.A semisupervised learning approach is adopted to train the model using only activities of daily living(ADL)data,which can avoid data imbalance problems.Furthermore,a quantile-based approach is employed to determine the fall threshold,which makes the fall detection frameworkmore robust.This proposed fall detection framework is evaluated against four other generative adversarial network(GAN)models with superior anomaly detection performance using two fall public datasets(SisFall&MobiAct).The test results show that the proposed method achieves better results,reaching 96.93% and 92.75% accuracy on the above two test datasets,respectively.At the same time,the proposed method also achieves satisfactory results in terms ofmodel size and inference delay time,making it suitable for deployment on wearable devices with limited resources.In addition,this paper also compares GAN-based semisupervised learning methods with supervised learning methods commonly used in fall detection.It clarifies the advantages of GAN-based semisupervised learning methods in fall detection. 展开更多
关键词 fall detection skip-connection depthwise separable convolution generative adversarial networks inertial sensor
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Factors associated with the incidence of patient falls in hospitals:A scoping review
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作者 Nurul AINANI Andi Masyitha IRWAN 《Journal of Integrative Nursing》 2024年第2期117-126,共10页
When a patient falls within a hospital setting,there is a significant increase in the risk of severe injury or health complications.Recognizing factors associated with such falls is crucial to mitigate their impact on... When a patient falls within a hospital setting,there is a significant increase in the risk of severe injury or health complications.Recognizing factors associated with such falls is crucial to mitigate their impact on patient safety.This review seeks to analyze the factors contributing to patient falls in hospitals.The main goal is to enhance our understanding of the reasons behind these falls,enabling hospitals to devise more effective prevention strategies.This study reviewed literature published from 2013 to 2022,using the Arksey and O’Malley methodology for a scoping review.The research literature was searched from seven databases,namely,PubMed,ScienceDirect,Wiley Library,Garuda,Global Index Medicus,Emerald Insight,and Google Scholar.The inclusion criteria comprised both qualitative and quantitative primary and secondary data studies centered on hospitalized patients.Out of the 893 studies analyzed,23 met the criteria and were included in this review.Although there is not an abundance of relevant literature,this review identified several factors associated with falls in hospitals.These encompass environmental,patient,staff,and medical factors.This study offers valuable insights for hospitals and medical personnel aiming to enhance fall prevention practices.Effective prevention efforts should prioritize early identification of patient risk factors,enhancement of the care environment,thorough training for care staff,and vigilant supervision of high-risk patients.By comprehending the factors that contribute to patient falls,hospitals can bolster patient safety and mitigate the adverse effects of falls within the health-care setting. 展开更多
关键词 Associated factors patient falls patient safety
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A Double-Interactively Recurrent Fuzzy Cerebellar Model Articulation Controller Model Combined with an Improved Particle Swarm Optimization Method for Fall Detection
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作者 Jyun-Guo Wang 《Computer Systems Science & Engineering》 2024年第5期1149-1170,共22页
In many Eastern and Western countries,falling birth rates have led to the gradual aging of society.Older adults are often left alone at home or live in a long-term care center,which results in them being susceptible t... In many Eastern and Western countries,falling birth rates have led to the gradual aging of society.Older adults are often left alone at home or live in a long-term care center,which results in them being susceptible to unsafe events(such as falls)that can have disastrous consequences.However,automatically detecting falls fromvideo data is challenging,and automatic fall detection methods usually require large volumes of training data,which can be difficult to acquire.To address this problem,video kinematic data can be used as training data,thereby avoiding the requirement of creating a large fall data set.This study integrated an improved particle swarm optimization method into a double interactively recurrent fuzzy cerebellar model articulation controller model to develop a costeffective and accurate fall detection system.First,it obtained an optical flow(OF)trajectory diagram from image sequences by using the OF method,and it solved problems related to focal length and object offset by employing the discrete Fourier transform(DFT)algorithm.Second,this study developed the D-IRFCMAC model,which combines spatial and temporal(recurrent)information.Third,it designed an IPSO(Improved Particle Swarm Optimization)algorithm that effectively strengthens the exploratory capabilities of the proposed D-IRFCMAC(Double-Interactively Recurrent Fuzzy Cerebellar Model Articulation Controller)model in the global search space.The proposed approach outperforms existing state-of-the-art methods in terms of action recognition accuracy on the UR-Fall,UP-Fall,and PRECIS HAR data sets.The UCF11 dataset had an average accuracy of 93.13%,whereas the UCF101 dataset had an average accuracy of 92.19%.The UR-Fall dataset had an accuracy of 100%,the UP-Fall dataset had an accuracy of 99.25%,and the PRECIS HAR dataset had an accuracy of 99.07%. 展开更多
关键词 Double interactively recurrent fuzzy cerebellar model articulation controller(D-IRFCMAC) improved particle swarm optimization(IPSO) fall detection
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Analysis of the Clinical Interventions for Falls in Elderly Patients in the Community From 2002 To 2022:A Bibliometric Analysis
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作者 Xiaoxiao Zhu Yue Zhang Fen Gu 《Journal of Clinical and Nursing Research》 2024年第3期32-49,共18页
Objective:To analyze and provide a comprehensive overview of the knowledge structure and research hotspots of clinical interventions for falls in elderly patients in the community.Methods:The search for publications r... Objective:To analyze and provide a comprehensive overview of the knowledge structure and research hotspots of clinical interventions for falls in elderly patients in the community.Methods:The search for publications related to clinical interventions for falls in elderly patients in the community from 2002 to 2022 was conducted on the Web of Science Core Collection(WoSCC)database.VOSviewers,CiteSpace,and the R package“bibliometrix”were used to conduct this bibliometric analysis.Results:2091 articles from 70 countries,primarily the United States and Australia,were included.The number of publications related to clinical interventions for falls in elderly patients is increasing yearly.The main research institutions in this field were the University of Sydney,Harvard University,and the University of California.BioMed Central(BMC)Geriatrics was the most popular journal in this field and Journals of the American Geriatrics Society was the most co-cited journal.These publications came from 8984 authors among which author Lord SR had published the most papers and author Tinetti Me had the most co-citations.The main keywords in this research field were“balance,”“exercise,”and“risk factor.”Conclusion:This was the first bibliometric study that comprehensively summarized the research hot spots and development of clinical interventions for falls in elderly patients in the community.This paper aims to provide a reference for scholars and researchers in this particular field. 展开更多
关键词 BIBLIOMETRICS Vosviewer Clinical intervention fallS COMMUNITY
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Effectiveness of Extended Care in Preventing Falls in Disabled Elderly and Its Impact on Quality of Life
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作者 Chun Tian Na Li Yan Yan 《Journal of Clinical and Nursing Research》 2024年第6期154-159,共6页
Objective:To analyze the value of extended care interventions for disabled elderly in preventing falls and optimizing quality of life.Methods:A sample of 60 cases of disabled elderly in a tertiary hospital from May 20... Objective:To analyze the value of extended care interventions for disabled elderly in preventing falls and optimizing quality of life.Methods:A sample of 60 cases of disabled elderly in a tertiary hospital from May 2022 to May 2023 was selected and grouped by the random number table method.The observation group received extended care,while the control group adopted routine care.The differences in complication rate,fall rate,36-Item Short Form Health Survey(SF-36)score,health knowledge awareness score,and nursing satisfaction were compared.Results:The complication rate and fall rate of the disabled elderly in the observation group were lower than those in the control group,P<0.05;the SF-36 score,health knowledge score,and nursing satisfaction of the observation group were higher than those of the control group,P<0.05.Conclusion:Extended care for the disabled elderly can reduce the risk of falls and complications related to disability,as well as optimize their cognition and improve their quality of life,which is efficient and feasible. 展开更多
关键词 Disabled elderly Extended care fallS Quality of life
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Correlation of vascular endothelial growth factor to permeability of blood-brain barrier and brain edema during high-altitude exposure 被引量:4
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作者 Qiquan Zhou Chang'e Liu +2 位作者 Jing Wang Yunli Wang Bo Zhou 《Neural Regeneration Research》 SCIE CAS CSCD 2009年第10期775-779,共5页
BACKGROUND: Many studies have evaluated the role of vascular endothelial growth factor (VEGF) in traumatic brain edema and hemorrhagic brain edema. OBJECTIVE: To observe the effects of VEGF expression on permeabil... BACKGROUND: Many studies have evaluated the role of vascular endothelial growth factor (VEGF) in traumatic brain edema and hemorrhagic brain edema. OBJECTIVE: To observe the effects of VEGF expression on permeability of the blood-brain barrier (BBB) during high-altitude and hypoxia exposure, and to investigate the correlation between VEGF expression and BBB permeability with regard to Evans blue staining and brain edema during high-altitude exposure. DESIGN, TIME AND SETTING: The randomized, controlled, animal study was performed at the Tanggula Etape, Central Laboratory of Chengdu Medical College, and Central Laboratory of General Hospital of Chengdu Military Area Command of Chinese PLA, China, from July 2003 to November 2004. MATERIALS: Quantitative RT-PCR kit (Sigma, USA), VEGF ELISA kit (Biosource, USA), and Evans blue (Jingchun, China) were acquired for this study. METHODS: A total of 180 Wistar rats were equally and randomly assigned to 15 groups: low-altitude (500 m), middle-altitude (2 880 m), high-altitude (4 200 m), super-high-altitude (5 000 m), 1,3, 5, 7, 9, 11, 13, 15, 17, 19, and 21 days of super high-altitude exposure. Wistar rats were exposed to various altitude gradients to establish a hypoxia model. MAIN OUTCOME MEASURES: Brain water content was calculated according to the wet-to-dry weight ratio. BBB permeability to Evans blue was determined by colorimetric method. VEGF mRNA and protein levels in brain tissues were detected using RT-PCR and double-antibody sandwich ELISA. RESULTS: Brain water content, BBB permeability to Evans blue, and VEGF mRNA and protein levels in brain tissues increased with increasing altitude and prolonged exposure to altitude. The greatest increase was determined on day 9 upon ascending 5 000 m. Simultaneously, VEGF expression positively correlated to BBB permeability of Evans blue and brain water content (r = 0.975, 0.917, P〈 0.01). CONCLUSION: Increased VEGF protein and mRNA expression was responsible for increased BBB permeability, which may be an important mechanism underlying brain edema during high-altitude exposure. 展开更多
关键词 high-altitude blood-brain barrier PERMEABILITY vascular endothelial growth factor
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Comprehensive Marine Observing Experiment Based on High-Altitude Large Unmanned Aerial Vehicle(South China Sea Experiment2020 of the “Petrel Project”) 被引量:4
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作者 Xuefen ZHANG Liangxu LI +11 位作者 Rongkang YANG Ran GUO Xia SUN Jianping LUO Hongbin CHEN Daxin LIU Kebing TANG Wenwu PENG Xiaodong HAN Qiyun GUO Xiaoxia LI Xikun FEI 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2021年第4期531-537,共7页
In collaboration with 12 other institutions, the Meteorological Observation Center of the China Meteorological Administration undertook a comprehensive marine observation experiment in the South China Sea using the Yi... In collaboration with 12 other institutions, the Meteorological Observation Center of the China Meteorological Administration undertook a comprehensive marine observation experiment in the South China Sea using the Yilong-10 high-altitude large unmanned aerial vehicle(UAV). The Yilong-10 UAV carried a self-developed dropsonde system and a millimeter-wave cloud radar system. In addition, a solar-powered unmanned surface vessel and two drifting buoys were used. The experiment was further supported by an intelligent, reciprocating horizontal drifting radiosonde system that was deployed from the Sansha Meteorological Observing Station, with the intent of producing a stereoscopic observation over the South China Sea. Comprehensive three-dimensional observations were collected using the system from 31 July to2 August, 2020. This information was used to investigate the formation and development processes of Typhoon Sinlaku(2020). The data contain measurements of 21 oceanic and meteorological parameters acquired by the five devices, along with video footage from the UAV. The data proved very helpful in determining the actual location and intensity of Typhoon Sinlaku(2020). The experiment demonstrates the feasibility of using a high-altitude, large UAV to fill in the gaps between operational meteorological observations of marine areas and typhoons near China, and marks a milestone for the use of such data for analyzing the structure and impact of a typhoon in the South China Sea. It also demonstrates the potential for establishing operational UAV meteorological observing systems in the future, and the assimilation of such data into numerical weather prediction models. 展开更多
关键词 high-altitude large UAV MARINE typhoon unmanned surface vessel horizontal drifting radiosonde drifting buoy
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Industrial Poverty Alleviation Model in Southwestern High-altitude Mountainous Areas of China——A Case Study of Industrial Poverty Alleviation of Xueshan Township in Luquan County of Yunnan Province through Planting Codonopsis pilosula 被引量:4
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作者 Zisheng YANG Renyi YANG +5 位作者 Yanbo HE Chonghui LU En ZHU Yaohan PI Mingxin WU Ying XIONG 《Asian Agricultural Research》 2019年第3期48-54,共7页
Due to the severe restrictions of natural conditions and ecological environment,high-altitude mountainous areas usually become the " hard bones" in the battle against poverty. Xueshan Township,Luquan Yi and ... Due to the severe restrictions of natural conditions and ecological environment,high-altitude mountainous areas usually become the " hard bones" in the battle against poverty. Xueshan Township,Luquan Yi and Miao Autonomous County of Yunnan Province,located in the alpine valley of Jinsha River,is a major township with wide and deep poverty,and the incidence of poverty is up to 45. 00%. In recent years,Xueshan Township has insisted on the battle against poverty,made effort to develop the Codonopsis pilosula industry,and successfully developed a road to poverty alleviation through C. pilosula industry,and formed a unique industrial poverty alleviation model by the end of 2018,the incidence of poverty dropped to 0. 74%. Based on field survey and interview,this paper analyzes and summarizes the specific practices,main results,practical experience and promotion and application measures of the poverty alleviation model of C. pilosula planting industry in Xueshan Township,in the hope of providing certain reference for the targeted poverty alleviation in similar areas in Yunnan Province and other provinces of China. 展开更多
关键词 high-altitude mountainous areas INDUSTRIAL poverty alleviation Chinese herbal medicine PLANTING CODONOPSIS pilosula Model Xueshan Township of Luquan COUNTY
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Results of an Intentional Introduction of Artemia sinica in the High-Altitude Tibetan Lake Dangxiong Co:On a Base of Surveys in 2011 and 2013 被引量:2
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作者 JIA Qinxian Elena ANUFRIIEVA +4 位作者 LIU Shasha LIU Xifang KONG Fanjing ZHENG Mianping Nickolai SHADRIN 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2014年第S1期74-76,共3页
1 Introduction The human population is projected to reach 9200million by 2050.A fundamental question for science is whether it is possible to increase food production to meet the demands of a human population of that ... 1 Introduction The human population is projected to reach 9200million by 2050.A fundamental question for science is whether it is possible to increase food production to meet the demands of a human population of that magnitude.It’s possible only to increase an aquaculture production.Cultivation of fish/shrimp larvae is a bottleneck in a cultivation of the different organisms.Live food 展开更多
关键词 Results of an Intentional Introduction of Artemia sinica in the high-altitude Tibetan Lake Dangxiong Co LAKE
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Exendin-4 inhibits high-altitude cerebral edema by protecting against neurobiological dysfunction 被引量:1
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作者 Zhong-Lei Sun Xian-Feng Jiang +8 位作者 Yuan-Chi Cheng Ying-Fu Liu Kai Yang Shuang-Long Zhu Xian-Bin Kong Yue Tu Ke-Feng Bian Zhen-Lin Liu Xu-Yi Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第4期653-663,共11页
The anti-inflammatory and antioxidant effects of exendin-4(Ex-4) have been reported previously.However,whether(Ex-4) has anti-inflammatory and antioxidant effects on high-altitude cerebral edema(HACE) remains po... The anti-inflammatory and antioxidant effects of exendin-4(Ex-4) have been reported previously.However,whether(Ex-4) has anti-inflammatory and antioxidant effects on high-altitude cerebral edema(HACE) remains poorly understood.In this study,two rat models of HACE were established by placing rats in a hypoxic environment with a simulated altitude of either 6000-or 7000-m above sea level(MASL) for 72 hours.An altitude of 7000 MASL with 72-hours of hypoxia was found to be the optimized experimental paradigm for establishing HACE models.Then,in rats where a model of HACE was established by introducing them to a 7000 MASL environment with 72-hours of hypoxia treatment,2,10 and,100 μg of Ex-4 was intraperitoneally administrated.The open field test and tail suspension test were used to test animal behavior.Routine methods were used to detect change in inflammatory cells.Hematoxylin-eosin staining was performed to determine pathological changes to brain tissue.Wet/dry weight ratios were used to measure brain water content.Evans blue leakage was used to determine blood-brain barrier integrity.Enzyme-linked immunosorbent assay(ELISA) was performed to measure markers of inflammation and oxidative stress including superoxide dismutase,glutathione,and malonaldehyde values,as well as interleukin-6,tumor necrosis factor-alpha,cyclic adenosine monophosphate levels in the brain tissue.Western blot analysis was performed to determine the levels of occludin,ZO-1,SOCS-3,vascular endothelial growth factor,EPAC1,nuclear factor-kappa B,and aquaporin-4.Our results demonstrate that Ex-4 preconditioning decreased brain water content,inhibited inflammation and oxidative stress,alleviated brain tissue injury,maintain blood-brain barrier integrity,and effectively improved motor function in rat models of HACE.These findings suggest that Ex-4 exhibits therapeutic potential in the treatment of HACE. 展开更多
关键词 high-altitude cerebral edema EXENDIN-4 cyclic adenosine monophosphate EPACI suppressor of cytokine signaling 3 vascular endothelial growth factor HYPOXIA inflammation oxidative stress
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WiSFall:一种非接触式的浴室跌倒监测模型 被引量:1
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作者 段鹏松 李婧馨 +1 位作者 王超 孔金生 《小型微型计算机系统》 CSCD 北大核心 2023年第2期232-238,共7页
封闭浴室场景中的跌倒行为危害性大,救助及时性差,对其高效便捷的监测研究有重要意义.针对现有基于Wi-Fi信号感知的跌倒算法中存在的特征提取不足、识别精度有限问题,本文提出了一种基于深度学习的非接触式浴室跌倒监测模型WiSFall.首先... 封闭浴室场景中的跌倒行为危害性大,救助及时性差,对其高效便捷的监测研究有重要意义.针对现有基于Wi-Fi信号感知的跌倒算法中存在的特征提取不足、识别精度有限问题,本文提出了一种基于深度学习的非接触式浴室跌倒监测模型WiSFall.首先,WiSFall将一维时序CSI数据流重构为二维的频率能量图形式,使得感知数据的特征容纳能力得以增强;其次,对重构后的感知数据进行巴特沃斯滤波,以去除环境噪声;最后,将滤波后的感知数据以频率能量图形式输入到构建好的深度学习模型中,通过对感知特征的有效提取和分类实现Wi-Fi环境下高精度的浴室跌倒监测.实验结果表明,WiSFall在居家浴室环境下对跌倒行为监测的准确率达到99.63%,相比同类模型表现更好,且具有较强泛化能力. 展开更多
关键词 浴室跌倒监测 信道状态信息 数据重构滤波 深度神经网络
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