Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas

BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients improved after treatment.CONCLUSION Intradermal ColΙinjection improves photoaging,with higher patient satisfaction and fewer adverse reactions,and could be an effective treatment method for populations residing in high-altitude areas.

A comparative study on kinetics and dynamics of two dump truck lifting mechanisms using MATLAB simscape

In this paper,two lifting mechanism models with opposing placements,which use the same hydraulic hoist model and have the same angle of 50°,have been developed.The mechanical and hydraulic simulation models are established using MATLAB Simscape to analyze their kinetics and dynamics in the lifting and holding stages.The simulation findings are compared to the analytical calculation results in the steady state,and both methods show good agreement.In the early lifting stage,Model 1 produces greater force and discharges goods in the container faster than Model 2.Meanwhile,Model 2 reaches a higher force and ejects goods from the container cleaner than its counterpart at the end lifting stage.The established simulation models can consider the effects of dynamic loads due to inertial moments and forces generated during the system operation.It is crucial in studying,designing,and optimizing the structure of hydraulic-mechanical systems.

Atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction

In high-altitude nuclear detonations,the proportion of pulsed X-ray energy can exceed 70%,making it a specific monitoring signal for such events.These pulsed X-rays can be captured using a satellite-borne X-ray detector following atmospheric transmission.To quantitatively analyze the effects of different satellite detection altitudes,burst heights,and transmission angles on the physical processes of X-ray transport and energy fluence,we developed an atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction.The proposed method is an improvement over the traditional analytical method that only computes direct-transmission X-rays.The traditional analytical method exhibits a maximum relative error of 67.79% compared with the Monte Carlo method.Our improved method reduces this error to within 10% under the same conditions,even reaching 1% in certain scenarios.Moreover,its computation time is 48,000 times faster than that of the Monte Carlo method.These results have important theoretical significance and engineering application value for designing satellite-borne nuclear detonation pulsed X-ray detectors,inverting nuclear detonation source terms,and assessing ionospheric effects.

Trajectory compensation for multi-robot coordinated lifting system considering elastic catenary of the rope

The multi-robot coordinated lifting system is an unconstrained system with a rigid and flexible coupling.The deformation of the flexible rope causes errors in the movement trajectory of the lifting system.Based on the kinematic and dynamic analysis of the lifting system,the elastic catenary mod-el considering the elasticity and mass of the flexible rope is established,and the effect of the deform-ation of the flexible rope on the position and posture of the suspended object is analyzed.According to the deformation of flexible rope,a real-time trajectory compensation method is proposed based on the compensation principle of position and posture.Under the lifting task of the low-speed move-ment,this is compared with that of the system which neglects the deformation of the flexible rope.The trajectoy of the lifting system considering the deformation of flexible rope.The results show that the mass and elasticity of the flexible rope can not be neglected.Meanwhile,the proposed trajectory compensation method can improve the movement accuracy of the lifting system,which verifies the ef-fectiveness of this compensation method.The research results provide the basis for trajectory plan-ning and coordinated control of the lifting system。

Research on the Lifting Path of Data Literacy Ability of Applied University Teachers under the Perspective of Organizational Learning

With the arrival of the big data era, the modern higher education model has undergone radical changes, and higher requirements have been put forward for the data literacy of college teachers. The paper first analyzes the connotation of teacher data literacy, and then combs through the status quo and dilemmas of teachers’ data literacy ability in applied universities. The paper proposes to enhance the data literacy ability of teachers from the perspective of organizational learning. Through building a digital culture, building a data-driven teaching environment, and constructing an interdisciplinary learning community to further promote the application of the theory and practice of datafication inside and outside the organization, and ultimately improve the quality of teaching.

Single-Arm Clinical Study of Combination Perindopril-Amlodipine Tablets in the Treatment of High-Altitude Hypertension

Objective:To evaluate the efficacy of combination perindopril/amlodipine tablets in patients with high-altitude hypertension who were previously unable to control their blood pressure with monotherapy.Methods:A total of 151 patients with high-altitude hypertension whose blood pressure remained inadequately controlled with previous monotherapy were enrolled in this study.All patients received an 8-week treatment with a combination of perindopril/amlodipine tablets,consisting of perindopril 10 mg/day and amlodipine 5 mg/day.Blood pressure measurements,including both diastolic and systolic pressures,were taken at baseline,and after 2,4,6,and 8 weeks of treatment.Results:After 8 weeks of treatment,there was a significant reduction in both average systolic and diastolic blood pressure compared to baseline(P<0.0001).Specifically,the average systolic blood pressure decreased by 24.45±13.75 mmHg,and the average diastolic blood pressure decreased by 13.37±8.40 mmHg.The overall heart rate showed no significant changes during the treatment period.Conclusion:A combination of perindopril/amlodipine tablets significantly improved blood pressure control in patients with high-altitude hypertension after 8 weeks of treatment.These results support the efficacy of combination perindopril/amlodipine as a viable treatment option for high-altitude hypertension.

Geostructures, dynamics and risk mitigation of high-altitude and long- runout rockslides

Long-runout rockslides at high altitude could cause disaster chain in river basins and destroy towns and major infrasturctures.This paper firstly explores the initiation mechanism of high-altitude and long-runout rockslides.Two types of sliding-prone geostructure models,i.e.the fault control type in orogenic belt and the fold control type in platform area,are proposed.Then,large-scale experimental apparatus and associated numerical simulations are conducted to understanding the chain-style dynamics of rockslide-debris avalanche-debris flow.The results reveal the fragmentation effects,the rheological behaviors and the boundary layer effect of long-runout avalanche-debris flow.The dynamic character-istics of quasi-static-transition-inertia state and solid-liquid coupling in rapid movement of rockslide-debris avalanche-debris flow are investigated.Finally,the risk mitigation strategy of the non-structure and structure for resilient energy dissipation are illustrated for initiation,transition and deposition zones.The structural prevention and mitigation methods have been successfully applied to the high-altitude and long-runout rockslides in Zhouqu and Maoxian of the Wenchuan earthquake zone,as well as the other major geohazards in Qinghai-Tibet Plateau and its adjacent areas.

Dynamic Analysis of Pipeline Lifting Operations for Different Current Velocities and Wave Heights

Pipelines are widely used for transporting oil resources in the context of offshore oil exploitation.The pipeline stress-strength analysis is an important stage in related design and ensuing construction techniques.In this study,assuming representative work environment parameters,pipeline lifting operations are investigated numerically.More specifically,a time-domain coupled dynamic analysis method is used to conduct a hydrodynamic analysis under different current velocities and wave heights.The results show that proper operation requires the lifting points are reasonably set in combination with the length of the pipeline and the position of the lifting device on the construction ship.The impact of waves on the pipeline is limited,however lifting operations under strong wind and waves should be avoided as far as possible.

Bionic microchannels for step lifting transpiration

Those various cross-sectional vessels in trees transfer water to as high as 100 meters,but the traditional fabrication methods limit the manufacturing of those vessels,resulting in the non-availability of those bionic microchannels.Herein,we fabricate those bionic microchannels with various cross-sections by employing projection micro-stereolithography(PμSL)based 3D printing technique.The circumradius of bionic microchannels(pentagonal,square,triangle,and five-pointed star)can be as small as 100μm with precisely fabricated sharp corners.What's more,those bionic microchannels demonstrate marvelous microfluidic performance with strong precursor effects enabled by their sharp corners.Most significantly,those special properties of our bionic microchannels enable them outstanding step lifting performance to transport water to tens of millimeters,though the water can only be transported to at most 20 mm for a single bionic microchannel.The mimicked transpiration based on the step lifting of water from bionic microchannels is also achieved.Those precisely fabricated,low-cost,various cross-sectional bionic microchannels promise applications as microfluidic chips,long-distance unpowered water transportation,step lifting,mimicked transpiration,and so on.

关联规则分析中兴趣度量Lift与Conviction的关系探讨及教育数据验证

关联规则分析是数据挖掘中最常用的研究方法之一。在关联关系的发现过程中兴趣度量是关联规则发现的理论基础,它可以度量规则的重要程度,其中Lift和Conviction这两个度量在数据分析中被广泛应用于筛选关联规则。本文对这两种兴趣度量进行了研究。首先,提出并证明了当后项集固定时,Conviction取值随Lift取值单调增加,且Conviction (Lift)是一个凸函数。然后,证明了当Confidence固定时,Conviction取值随Lift取值单调增加,且Conviction (Lift)是一个凹函数。最后,综合以上两个方面,得到一个重要结论:当后项集保持不变或当Confidence固定时,根据Conviction和Lift筛选出来的规则都是相同的。最后,利用某高校数学类专业三个年级的成绩数据进行了定理及相应结论的验证。

Study of the Lift Force Induced by An Interceptor on A High-Speed Mono-Hull:The Affecting Factors and Estimation Formula

To find a better way to estimate the lift force induced by an interceptor on a high-speed mono-hull ship,a series of high-speed mono-hull ship models are designed and investigated under different conditions.Different lift forces are obtained by numerical calculations and validated by a model test in a towing tank.The factors that influence the force are the interceptor height,velocity,draft,and deadrise angle.The relationship between each factor and the induced lift force is investigated and obtained.We found that the induced lift mainly depends on the interceptor height and advancing velocity,and is proportional to the square of the interceptor height and velocity.The results also showed that the effects of the draft and deadrise angle are relatively less important,and the relationship between the induced lift and these two factors is generally linear.Based on the results,a formula including the combined effect of all factors used to estimate the lift force induced by the interceptor is developed based on systematic analysis.The proposed formula could be used to estimate the lift force induced by interceptors,especially under high-speed condition.

Construction Technology of Warm Mix Asphalt Pavement in Cold High-Altitude Areas

With the continuous development of domestic highway construction,highway civil engineering and service level quality have attracted much attention.Good pavement quality and high-quality service make people feel comfortable and smooth when traveling.High-quality pavement can significantly reduce the probability of traffic accidents.At present,there is a direct relationship between pavement quality and pavement construction operations.Carrying out pavement construction operations in cold high-altitude areas requires a reasonable selection of construction equipment and methods.The application of warm-mix asphalt pavement construction technology can ensure pavement quality.Therefore,this paper analyzes the advantages of warm-mix technology,the environmental characteristics of cold high-altitude areas,and construction preparations,and discusses the construction technology of warm-mix asphalt pavement in cold high-altitude areas in detail,to improve the overall road quality of cold high-altitude areas.

Settlement Control Technology of High Filled Soil-Rock Embankment in Alpine and High-Altitude Areas

China's infrastructure has gradually achieved large-scale development,and transportation construction has also shifted from east to west,transitioning from plains to mountainous areas.High-fill embankments of different sizes in mountainous areas are unavoidable,and the settlement of high-fill embankments is usually the most concerned issue in high-fill projects.According to the current research of highway projects,most of the high embankments in mountainous areas are soil-rock mixed embankments or rock-filled embankments,and their post-construction settlements are directly related to construction technology and the type of filler used.In this paper,the problems in the settlement control of earth-filled embankment and related factors are analyzed in detail.The settlement control technology of high-fill embankment in high-cold and high-altitude areas is also discussed,so as to ensure the overall quality of high-fill embankment.

改良LIFT手术联合自体富血小板PRP凝胶技术治疗肛瘘的临床研究

目的:探讨改良括约肌间瘘管结扎术(LIFT)手术联合自体富血小板PRP凝胶技术治疗肛瘘的临床疗效。方法:随机将2021年5月至2023年5月在我院接受治疗的62例肛瘘患者分为对照组和观察组,31例一组。对照组采用改良LIFT手术治疗,观察组予以改良LIFT手术联合自体富血小板PRP凝胶技术治疗。随访两个月,比较两组住院时间,创面愈合时间,创面瘢痕面积,临床疗效,术后疼痛评分,肛门功能评分,并发症发生率。结果:观察组的住院时间和创面愈合时间均短于对照组,创面瘢痕面积少于对照组(P<0.05)。观察组治疗有效率为96.77%,高于对照组的80.65%(P<0.05)。观察组术后1天、7天VAS评分及术后1、2个月Wexner评分均低于对照组(P<0.05)。观察组术后并发症发生为6.45%,低于对照组的25.81%(P<0.05)。结论:肛瘘采用改良LIFT手术联合自体富血小板PRP凝胶技术治疗效果突出,可以缓解术后疼痛,改善肛门功能,减少并发症,促进预后恢复,值得临床推广应用。

Analysis of Maximum Liquid Carrying Capacity Based on Conventional Tubing Plunger Gas Lift

China’s unconventional gas fields have a large number of low-productivity and low-efficiency wells, many of whichare located in remote and environmentally harsh mountainous areas. To address the long-term stable productionof these gas wells, plunger-lift technology plays an important role. In order to fully understand and accurately graspthe drainage and gas production mechanisms of plunger-lift, a mechanical model of plunger-liquid column uplift inthe plunger-lift process was established, focusing on conventional plunger-lift systems and representative wellboreconfigurations in the Linxing region. The operating casing pressure of the plunger-lift process and the calculationmethod for the maximum daily fluid production rate based on the work regime with the highest fluid recovery ratewere determined. For the first time, the critical flow rate method was proposed as a constraint for the maximumliquid-carrying capacity of the plunger-lift, and liquid-carrying capacity charts for conventional plunger-lift withdifferent casing sizes were developed. The results showed that for 23/8 casing plunger-lift, with a well depth ofshallower than 808 m, the maximum drainage rate was 33 m3/d;for 27/8 casing plunger-lift, with a well depth ofshallower than 742 m, the maximum drainage rate was 50.15 m3/d;for 31/2 casing plunger-lift, with a well depthof shallower than 560 m, the maximum drainage rate was 75.14 m3/d. This research provides a foundation for thescientific selection of plunger-lift technology and serves as a decision-making reference for developing reasonableplunger-lift work regimes.

消肿生肌汤辅助LIFT对高位单纯性肛瘘术后疼痛与康复进程的影响

目的:研究消肿生肌汤辅助经括约肌间瘘管结扎术(Ligation of intersphincteric fistula tract,LIFT)对高位单纯性肛瘘术后疼痛(Visual analogue scale,VAS)评分、康复进程的影响.方法:选取2020年8月至2022年8月于我院确诊的94例肛瘘患者作为研究对象,依随机对照法分为研究组和对照组,各47例.对照组采用LIFT术治疗,研究组在对照组基础上联合消肿生肌汤治疗.比较两组临床疗效、治疗后恢复情况及住院时间、治疗前后视觉模拟评分(VAS)、大便失禁严重性指数(Fecal incontinence severity index,FISI)、Wexner肛门失禁评分(Wexner)、肛肠动力学、相关血清指标水平.结果:研究组总有效率高于对照组(P<0.05);治疗后,研究组VAS、FISI、Wexner评分均低于对照组(P<0.05);研究组直肠静息压(Rectal resting pressure,RRP)、肛管最大收缩压(Analmaximal contraction pressure,AMCP)、肛管静息压(Anal tube resting pressure,ARP)、肛管最长收缩时间(Anal longest contraction,ALCT)水平高于对照组(P<0.05);研究组血清转化生长因子-β1(Transforming growth factor-β1,TGF-β1)、纤维连接蛋白(Fibronectin,FN)高于对照组,淀粉样蛋白A(Serum amyloid A,SAA)、趋化因子5(Chemokine ligand 5,CCL5)低于对照组(P>0.05);研究组恢复情况及住院时间短于对照组(P<0.05).结论:消肿生肌汤辅助LIFT对高位单纯性肛瘘患者术后效果显著,可有效促进患者创口愈合,减少炎症反应,降低肛肠疼痛度,缩短临床康复进程.

Abdominoplasty, Liposuction and Brazilian Butt Lift (BBL) in Kinshasa in the Democratic Republic of Congo. My Experience in This Aesthetic Plastic Surgery with Black African Women in a Low-Income Country

Background: In low-income African countries, the demand and use of plastic surgery operations including abdominoplasty, liposuction and Brazilian butt lift (BBL) are increasing. The goal of this work is to present my experience and the challenges of this aesthetic plastic surgery among black African women. Material and Methods: A retrospective study was conducted about the abdominoplasties, liposuctions and Brazilian butt lift (BBL) which I operated in public and private hospitals at Kinshasa (Democratic Republic of Congo) in black African women. It covers a period of 13 years, going from December 1, 2010 to December 1, 2023. For this study, I had at least 6 months period (to Juin 1, 2024) to assess the occurrence of early and late postoperative complications. Results: I performed 84 abdominoplasties, 144 liposuctions and 23 Brazilian butt lifts (BBL). The average age at the time of abdominoplasty was 44 years with extremes ranging from 26 to 55 years and a concentration of cases (60.7%) in the age group of 40 to 49 years. The age group of 20 to 29 years old represented the lowest rate of requests for abdominoplasty (4.7%). Patients with a BMI of 30 to 2 were the majority (61.9%), followed by those between 25 to 2 (29.7%). 67.8% of patients were obese (BMI ≥ 30 kg/m2). The average age at the time of liposuction was 41 years with extremes ranging from 21 years to 69 years;and more than half of cases (68%) in the age group between 30 and 49 years. As for Brazilian butt lift (BBL), the average age was 33 years with extremes ranging from 24 to 42 years and a concentration of patients (91.3%) between 20 and 39 years. The immediate postoperative complications of abdominoplasties observed were: seroma in 7% of cases, hematoma and partial infection of the surgical site in 5% of cases. Pathological scars (hypertrophic, keloid) after abdominoplasties were observed in 9% of cases. The most common complication of liposuction was contour deformity. I observed 16 patients (11.1%) with soft-tissue depressions or elevations, skin panniculus or folds. For Brazalian Butt Lift (BBL), complications like asymmetry for 2 patients (8.9%), contour irregularities for 2 patients (8.9%), and excessive fat removal for 6 patients (26%), had observed. I have not recorded any cases of death or pulmonary embolism. Conclusion: I perform aesthetic plastic surgery procedures in black African women with a high socioeconomic standard of living compared to the average of the general population. The renunciation of planned surgery is motivated by the impossibility of paying the cost of the operation as well as by popular and religious perceptions regarding cosmetic surgery. The results of these aesthetic plastic surgery procedures carried out are very satisfactory for them. The challenges to overcome are mainly threefold: the unforeseeable complications of these cosmetic plastic surgery procedures, popular and religious perceptions of cosmetic surgery as well as the poverty of the population.

lift⁃off制程PEB温度对负性光阻显影后截面Profile的影响

本文研究了lift⁃off(揭开-剥离)制程曝光后烘烤温度(post exposure bake,PEB)对负性光阻显影截面Profile(光刻胶结构)的影响。结果表明:在保留原有PEB盘面加热的方式前提下通过增加PEB盘盖加热功能进行烘烤,通过控制PEB盘面温度可调整光阻关键尺寸(critical dimension,CD)及截面Profile形貌,通过控制PEB盘盖加热可调整截面Profile光阻顶端形貌及强度,可显著改善负性光阻显影后截面Profile难以调整的问题。另外,不同的盘面温度、不同盘盖温度以及不同的显影时间相互配合,可以实现一种负性光阻产生不同截面光刻胶结构效果,可以实现同种光阻lift⁃off制程多样化。

一种生成双正交紧支复小波的Lifting方法

提出了一种构造双正交紧支复小波的方法 :以现有任何一种正交或双正交实小波为基础 ,可构造出消失矩阶数可任意选定的无穷多个相频特性 (包括线性相位特性 )不同的双正交紧支复小波。其特点为 :由于是双正交紧支型 ,可采用Mallat算法等快速算法 ,因此使用时实时性好 ;因为是复小波 ,所以能提取电力系统至关重要的相位信息 ;具有多种相频特性 ,便于与相频特性多变的电力系统信号匹配等 ,因此这类小波在电力系统有广泛的应用前景。

Lifting Scheme及其在小波图象编码中的应用

L ifting Schem e是构造第二代小波的关键技术 .相对于第一代小波而言 ,L ifting Scheme是一种比 Mallat算法更快、更简单和更容易操作的算法 ,也是 JPEG2 0 0 0推荐的算法 .为了将其应用到小波图象编码中 ,提出了一种对 L ifting Scheme作适当改进以用于小波图象编码的方法 .该方法就是先用 L ifting Scheme来实现 D9/ 7双正交小波变换 ,然后再用这种技术实现的 D9/ 7双正交小波变换来进行图象压缩编码 .在将 L ifting Schem e算法用于小波图象编码的过程中 ,对该算法做了必要的简化 ,以便保证每个提升 (lifting)环节都是 FIR滤波 .同时 ,根据能量守恒的原则 ,重新调整了尺度因子 .实验结果表明 ,这种经过改进的 L ifting Schem e取得了比