Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas

BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients improved after treatment.CONCLUSION Intradermal ColΙinjection improves photoaging,with higher patient satisfaction and fewer adverse reactions,and could be an effective treatment method for populations residing in high-altitude areas.

Industrial Poverty Alleviation Model in Southwestern High-altitude Mountainous Areas of China——A Case Study of Industrial Poverty Alleviation of Xueshan Township in Luquan County of Yunnan Province through Planting Codonopsis pilosula

Due to the severe restrictions of natural conditions and ecological environment,high-altitude mountainous areas usually become the " hard bones" in the battle against poverty. Xueshan Township,Luquan Yi and Miao Autonomous County of Yunnan Province,located in the alpine valley of Jinsha River,is a major township with wide and deep poverty,and the incidence of poverty is up to 45. 00%. In recent years,Xueshan Township has insisted on the battle against poverty,made effort to develop the Codonopsis pilosula industry,and successfully developed a road to poverty alleviation through C. pilosula industry,and formed a unique industrial poverty alleviation model by the end of 2018,the incidence of poverty dropped to 0. 74%. Based on field survey and interview,this paper analyzes and summarizes the specific practices,main results,practical experience and promotion and application measures of the poverty alleviation model of C. pilosula planting industry in Xueshan Township,in the hope of providing certain reference for the targeted poverty alleviation in similar areas in Yunnan Province and other provinces of China.

Seismic response of a mid-story isolated structure considering SSI in mountainous areas under long-period earthquakes

At present,there is not much research on mid-story isolated structures in mountainous areas.In this study,a model of a mid-story isolated structure considering soil-structure interaction(SSI)in mountainous areas is established along with a model that does not consider SSI.Eight long-period earthquake waves and two ordinary earthquake waves are selected as inputs for the dynamic time history analysis of the structure.The results show that the seismic response of a mid-story isolated structure considering SSI in mountainous areas can be amplified when compared with a structure that does not consider SSI.The structure response under long-period earthquakes is larger than that of ordinary earthquakes.The structure response under far-field harmonic-like earthquakes is larger than that of near-fault pulse-type earthquakes.The structure response under near-fault pulse-type earthquakes is larger than that of far-field non-harmonic earthquakes.When subjected to long-period earthquakes,the displacement of the isolated bearings exceeded the limit value,which led to instability and overturning of the structure.The structure with dampers in the isolated story could adequately control the nonlinear response of the structure,effectively reduce the displacement of the isolated bearings,and provide a convenient,efficient and economic method not only for new construction but also to retrofit existing structures.

Quantifying the impact of earthquakes and geological factors on spatial heterogeneity of debris-flow prone areas:A case study in the Hengduan Mountains

Understanding the spatial heterogeneity of debris-flow-prone areas holds significant implications for regional risk management, particularly in seismically active regions with geological faults. Despite the significance of this knowledge, a comprehensive quantification of the influence of regional topographical and geological factors on the spatial heterogeneity of debris-flow-prone areas has been lacking. This study selected the Hengduan Mountains, an earthquake-prone region characterized by diverse surface conditions and complex landforms, as a representative study area. An improved units zoning and objective factors identification methodology was employed in earthquake and fault analysis to assess the impact of seismic activity and geological factors on spatial heterogeneity of debrisflow prone areas. Results showed that the application of GIS technology with hydrodynamic intensity and geographical units analysis can effectively analyze debris-flow prone areas. Meanwhile, earthquake and fault zones obviously increase the density of debrisflow prone catchments and make them unevenly distributed. The number of debris-flow prone areas shows a nonlinear variation with the gradual increase of geomorphic factor value. Specifically, the area with 1000 m-2500 m elevation difference, 25°-30° average slope, and 0.13-0.15 land use index is the most favorable conditions for debris-flow occurrence;The average annual rainfall from 600 to 1150 mm and landslides gradient from 16° to 35° are the main causal factors to trigger debris flow. Our study sheds light on the quantification of spatial heterogeneity in debris flow-prone areas in earthquake-prone regions, which can offer crucial support for post-debris flow risk management strategies.

Spatial pattern recognition for near-surface high temperature increases in mountain areas using MODIS and SRTM DEM

Abrupt near-surface temperature changes in mountainous areas are a special component of the mountain climate system.Fast and accurate measurements of the locations,intensity,and width of the near-surface changes are necessary but highly difficult due to the complicated environmental conditions and instrumental issues.This paper develops a spatial pattern recognition method to measure the near-surface high temperature increase(NSHTI),one of the lesser-attended changes.First,raster window measurement was proposed to calculate the temperature lapse rate using MODIS land surface temperature and SRTM DEM data.It fully considers the terrain heights of two neighboring cells on opposite or adjacent slopes with a moving window of 3×3 cell size.Second,a threshold selection was performed to identify the NSHTI cells using a threshold of-0.65℃/100 m.Then,the NSHTI strips were parameterized through raster vectorization and spatial analysis.Taking Yunnan,a mountainous province in southwestern China,as the study area,the results indicate that the NSHTI cells concentrate in a strip-like pattern along the mountains and valleys,and the strips are almost parallel to the altitude contours with a slight northward uplift.Also,they are located mostly at a 3/5 height of high mountains or within 400 m from the valley floors,where the controlling topographic index is the altitude of the terrain trend surface but not the absolute elevation and the topographic uplift height and cutting depth.Additionally,the NSHTI intensity varies with the geographic locations and the proportions increase with an exponential trend,and the horizontal width has a mean of about 1000 m and a maximum of over 5000 m.The result demonstrates that the proposed method can effectively recognize NSHTI boundaries over mountains,providing support for the modeling of weather and climate systems and the development of mountain resources.

Impact of typical environments in China’s western mountainous areas on the durability of railway concrete:a review

Purpose–This study aims to analyze the impact mechanism of typical environments in China’s western mountainous areas on the durability of railway concrete and propose measures to improve durability.Design/methodology/approach–With the continuous promotion of infrastructure construction,the focus of China’s railway construction has gradually shifted to the western region.The four typical environments of large temperature differences,strong winds and dryness,high cold and low air pressure unique to the western mountainous areas of China have adverse effects on the durability of typical railway structure concrete(bridges,ballastless tracks and tunnels).This study identified the characteristics of four typical environments in the western mountainous areas of China through on-site research.The impact mechanism of the four typical environments on the durability of concrete in different structural parts of railways has been explored through theoretical analysis and experimental research;Finally,a strategy for improving the durability of railway concrete suitable for the western mountainous areas of China was proposed.Findings–The daily temperature difference in the western mountainous areas of China is more than twice that of the plain region,which will lead to significant temperature deformation and stress in the multi-layered structure of railway ballastless tracks.It will result in cracking.The wind speed in the western plateau region is about 2.5 to 3 times that of the plain region,and the average annual rainfall is only 1/5 of that in the plain region.The drying effect on the surface of casting concrete will significantly accelerate its cracking process,leading to serious durability problems.The environmental temperature in the western mountainous areas of China is generally low,and there are more freeze-thaw cycles,which will increase the risk of freeze-thaw damage to railway concrete.The environmental air pressure in the western plateau region is only 60%of that in the plain region.The moisture inside the concrete is more likely to diffuse into the surrounding environment under the pressure difference,resulting in greater water loss and shrinkage deformation of the concrete in the plateau region.The above four issues will collectively lead to the rapid deterioration of concrete durability in the western plateau region.The corresponding durability improvement suggestions from theoretical research,new technology development and standard system was proposed in this paper.Originality/value–The research can provide the mechanism of durability degradation of railway concrete in the western mountainous areas of China and corresponding improvement strategies.

A system-integrated approach for the design of tourist areas at the local level under changing conditions:A case study in the Altay Mountains

The existing approaches for the design of tourist areas often lead to limited flexibility in project implementation.To realize a more flexible approach,in this study,we formulated a model for planning and designing tourist areas at the local level.Moreover,specific tools for analyzing tourist areas and ensuring sustainable development under changing conditions were developed.This study was conducted in two tourist regions,Biryuzovaya Katun tourist complex and Belokurikha destination(including Belokurikha City with Belokurikha 2 Gornaya tourist complex and surrounding areas),in the Altay Mountains.We employed the recreation opportunity spectrum and proposed a system-integrated programming approach for the design of tourist areas at the destination and site levels.The key of this approach was the collection and analysis of current spatial data,including the spatial distribution of attractions and visitor flows.We constructed heat maps using video recording and unmanned aerial vehicle(UAV)observation data.Moreover,we analyzed the video stream using an image-analyzing framework You Only Look Once(YOLO)v5 software.The heat map of visitor flows based on video recording data in the Andreevskaya Sloboda museum of Belokurikha 2 Gornaya tourist complex allowed us to highlight the most attractive sites in this area and classify them into one of three types:points of functional concentration,points of transitional concentration,and points of attractions.The heat maps in Biryuzovaya Katun tourist complex,created using UAV observation data,allowed us to determine the spatiotemporal patterns of visitor flows and tourists’preferences throughout the day within four time intervals:09:00-12:00,13:00-14:00,14:00-15:00,and 16:00-18:00(LST).The maximum visitor flow density occurred from 16:00 to 18:00 in the beach area of the artificial lake.A comparison between the visitor-concentrated sites and the current facilities provided insights into the demand for attractions and facilities and the lacking areas.Heat maps are useful in analyzing the land use at the site level,while zoning based on the recreation opportunity spectrum can be used to design tourist areas at the destination level.The proposed methods for analyzing the use of tourist areas contribute to the development of adaptive tourism design.

Dry Breeding and Dry Planting Techniques for Indica Hybrid Rice in Karst Mountain Areas of Gejiu City

Based on the arable land situation in Gejiu City,upland dry planting of indica hybrid rice is being expanded in Karst mountain areas with a rainfall of over 1400 mm and an altitude of 1100-1600 m to develop grain production.This paper gives a specific description of hybrid rice upland dry seedling technology,upland transplanting technology,fertilization technology,field management,weed prevention and control technology,and disease and pest control.

Spatio-temporal Evolution and Optimization of Landscape Ecological Risk in Karst Mountainous Areas

[Objective]The ecological vulnerability and landscape ecological risk of karst mountainous areas have increased as a result of enhanced disturbance of natural resources by human activities.This paper aimed to explore the characteristics of ecological risk evolution under different landscape patterns in the region,with a view to providing reference for land classification protection,sustainable use of resources and regional ecological risk optimization in karst mountainous areas.[Method]Taking Huangping County,a typical karst mountainous area,as an example,eight evaluation factors of natural and landscape patterns were selected to construct a landscape ecological risk evaluation model,to quantitatively explore the spatio-temporal evolution of landscape ecological risk and the trend of risk level transfer in the study area from^(2)010-2018,and to reveal the complex relationship between ecological risk and topography in karst mountainous areas.[Result]①From 2010 to 2018,land use types changed to different degrees,with the most amount of woodland transferred out(1627.37 hm^(2))and the most amount of construction land transferred in(1303.93 hm^(2));a total of 3552.31 hm^(2) of land was transferred,with a change ratio of 2.13%,and there was a significant conversion between construction land,arable land,and woodland.②From 2010 to 2018,the landscape ecological risk in the study area changed significantly,and the landscape ecological risk index decreased from 0.3441 to 0.1733,showing an upward and then downward trend;the landscape ecological risk of the whole region was dominated by low-risk and lower-risk zones,and the ecological risk level generally shifted from a high level to a low level,and the ecological environment was improved.③There was a negative correlation between ecological risk and topographic position,and high-risk zones were mainly distributed among low topographic zones;with the change of time,the advantage of risk level for the selection of topography was gradually weakened,and the influence of anthropogenic factors on the ecological risk of the landscape was becoming more and more prominent.[Conclusion]This paper can provide theoretical basis for land use optimization and ecological protection in karst mountainous areas.

Loading Stress Analysis of Cement Concrete Pavement in Mountainous Areas

The suitable cement concrete pavement for mountainous areas is a form of low-cost cement concrete pavement that uses unconventional graded stones in different proportions in ordinary concrete,allowing the concrete to fully contact the stones and form a stable and well-bonded slab with large particle stones.As large particle stones replace a certain volume of cement concrete,they have good economic performance and are a low-cost form of cement concrete pavement.This study researches the use of ANSYS tools to analyze the influence of geometric dimensions and material properties of rigid pavement structural layers on the mechanical properties of pavement structures.

Minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas

BACKGROUND Colon cancer is associated with a higher incidence among residents in highaltitude areas.Hypoxic environment at high altitudes inhibits the phagocytic and oxygen-dependent killing function of phagocytes,thereby increasing the inflammatory factors,inhibiting the body’s innate immunity and increasing the risk of colon cancer.AIM To examine the effect of minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas.METHODS Ninety-two patients with colon cancer in our hospital from January 2019 to February 2021 were selected and divided into the minimally invasive surgery and laparotomy groups using the random number table method,with 46 patients in each group.Minimally invasive surgery was performed in the minimally invasive group and laparotomy in the laparotomy group.Operative conditions,inflammatory index pre-and post-surgery,immune function index and complication probability were measured.RESULTS Operative duration was significantly longer and intraoperative blood loss and recovery time of gastrointestinal function were significantly less(all P<0.05)in the minimally invasive group than in the laparotomy group.The number of lymph nodes dissected was not significantly different.Before surgery,there were no significant differences in serum C-reactive protein,interleukin-6 and tumor necrosis factor-αlevels between the groups,whereas after surgery,the levels were significantly higher in the minimally invasive group(26.98±6.91 mg/L,146.38±11.23 ng/mL and 83.51±8.69 pg/mL vs 41.15±8.39 mg/L,186.79±15.36 ng/mL and 110.65±12.84 pg/mL,respectively,P<0.05).Furthermore,before surgery,there were no significant differences in CD3+,CD4+and CD4+/CD8+levels between the groups,whereas after surgery,the levels decreased in both groups,being significantly higher in the minimally invasive group(55.61%±4.39%,35.45%±3.67%and 1.30±0.35 vs 49.68%±5.33%,31.21%±3.25%and 1.13±0.30,respectively,P<0.05).Complication probability was significantly lower in the minimally invasive group(4.35%vs 17.39%,P<0.05).CONCLUSION Laparoscopic minimally invasive procedures reduce surgical trauma and alleviate the inflammatory response and immune dysfunction caused by invasive operation.It also shortens recovery time and reduces complication probability.

Construction Technology of Warm Mix Asphalt Pavement in Cold High-Altitude Areas

With the continuous development of domestic highway construction,highway civil engineering and service level quality have attracted much attention.Good pavement quality and high-quality service make people feel comfortable and smooth when traveling.High-quality pavement can significantly reduce the probability of traffic accidents.At present,there is a direct relationship between pavement quality and pavement construction operations.Carrying out pavement construction operations in cold high-altitude areas requires a reasonable selection of construction equipment and methods.The application of warm-mix asphalt pavement construction technology can ensure pavement quality.Therefore,this paper analyzes the advantages of warm-mix technology,the environmental characteristics of cold high-altitude areas,and construction preparations,and discusses the construction technology of warm-mix asphalt pavement in cold high-altitude areas in detail,to improve the overall road quality of cold high-altitude areas.

Settlement Control Technology of High Filled Soil-Rock Embankment in Alpine and High-Altitude Areas

China's infrastructure has gradually achieved large-scale development,and transportation construction has also shifted from east to west,transitioning from plains to mountainous areas.High-fill embankments of different sizes in mountainous areas are unavoidable,and the settlement of high-fill embankments is usually the most concerned issue in high-fill projects.According to the current research of highway projects,most of the high embankments in mountainous areas are soil-rock mixed embankments or rock-filled embankments,and their post-construction settlements are directly related to construction technology and the type of filler used.In this paper,the problems in the settlement control of earth-filled embankment and related factors are analyzed in detail.The settlement control technology of high-fill embankment in high-cold and high-altitude areas is also discussed,so as to ensure the overall quality of high-fill embankment.

Ecological Carrying Capacity in Beijing Mountainous Areas——Taking Fangshan District as an Example

[Objective] The aim was to investigate ecological carrying capacity of Fangshan District in Beijing. [Method] Ecological footprint and carrying capacity of Fangshan District in 2007 and 2008 were analyzed with ecological footprint model and the difference between ecological footprint and carrying capacity there was con- cluded. Furthermore, an assessment was made on relation between Fangshan de- velopment with local ecological carrying capacity to evaluate sustainable development of Fangshan District. [Result] Fangshan District is of lightly ecological deficit; ecologi- cal footprint per capita in 2007-2008 was deficit and tended to expand. Two meth- ods are available to reduce ecological ：deficit, including reduction of ecological foot- print and increase of carrying capacity. In general, supply and demand of carrying capacity in Fangshan are better, though with some problems. It is necessary to fur- ther develop related industries to final eliminate ecological deficit in order to achieve ecological conservation-orientation and sustainable development of Fangshan District. [Conclusion] The research provides theoretical references for overall evaluation on eco- logical carrying capacity of Fangshan District.

Study on Urban Construction Land Suitability Evaluation in Southwestern Mountainous Areas of Yunnan Province Based on the Strategy of "Protecting Farmland in Flatland Areas and Constructing Mountainous Cities" : A Case in Lianghe County

According to the particularity of towns＇ construction in the southwestern mountainous areas of Yunnan Province, this study has built constructive land suit- ability evaluation index system which is different to flat area. Then this study deter- mined single evaluation factors index and comprehensive suitability index using ＂ex- treme conditions method＂ and ＂suitability index method＂, and analyzed and assessed the constructive land suitability on each evaluation unit polygons and its suitability level by using GIS software. Taking Lianghe County of Dehong Dai-Jingpo Au- tonomous Prefecture as an example to evaluate land suitability in Lianghe County＇s main towns around the gentle slope, the results show, in the evaluation area, the area of land suitable for construction and unsuitable for construction respectively ac- count 73.58% and 26.42%. And first-class, second and third-class of land suitable for construction should be composited at the ratio of about 11：49：40. The suitability evaluation index system and method developed in this paper is applicable for evalu- ating the construction land suitability in mountainous areas of southwest Yunnan Province, and will provide theoretical and technical support for land policy measures which strengthen the protection of farmland and promote the scientific development of urbanization in Yunnan Province and even similar mountainous areas of the whole China.

Driving Analysis on Ecological Security in Vulnerable Transition Areas of Mountain and Plain

[Objective] This study aimed to investigate the driving mechanism of eco- logical security in vulnerable areas in mountain and plain. [Method] The ecological security evaluation index system of Lincheng County was established using PSR model. Driving mechanism was analyzed in total system and subsystems respectively by the principal components. The ecological safety driving factor was calculated through the total system and subsystem respectively. And the intersection was adopt- ed as dominant driving factor. [Result] A total of 10 indices including density index of rivers, land degradation index, farmland drought and flood insurance yield, human in- terference index, population density, the natural population growth rate, per capita GDP, the R＆D funds spending accounts for the proportion of GDP, laborer by edu- cation degree and three industry accounted for the proportion of GDP, are the domi- nant driving factors of the regional ecological security. [Conclusion] This study will pro- vide reasonable and feasible advice for the benign development of the area.

Analysis on the Green Space System Planning of Small Cities in Mountainous Areas

With the urban green space system planning of small cities in mountainous areas as the study object,the planning practices are analyzed and studied to summarize the common characteristics of urban green space system planning in those small cities.Being combined with relevant national standards and regulations,the problems that those small cities are faced with in their urban green space system planning are analyzed,then corresponding countermeasures and suggestions are put forward to resolve problems in the practical planning.

Study on the Sustainable Development of Tourism Industry in Gongga Mountainous Areas in Western Sichuan

There are abundant excellent tourism resources in Gongga mountainous areas (Mount Gongga, also known as Minya Konka, the highest mountain in Sichuan, China), yet the development thoughts and management modes in this region are far away from the advanced level in other mountainous areas in China or abroad due to the insufficient knowledge about ecotourism. Generally speaking, tourism development in Gongga mountainous areas are limited by various problems such as lack of overall development plan, system support, brand image, financial support and environmental protection consciousness. In view of the present situation of tourism development in this region, sustainable development measures are proposed on the basis of ecotourism and sustainable development theories, including making ecotourism development plan for Gongga mountainous areas, improving transportation conditions, tourism infrastructures and accommodation facilities, training service and management personnel with professional ecological knowledge; establishing ecotourism product system of Gongga mountainous areas; carrying out ecotourism management, innovating management system, setting up ecological monitoring system, implementing scientific functional division of tourism sites, constructing environment capacity control system and disasters management system of mountainous areas, improving medical and mountainous assistance system. Natural conditions and economic development of Gongga mountainous areas are similar to those in western China, it is expected to provide theoretical basis and practical experience for developing the vast mountainous areas in western China through studying the sustainable tourism development of Gongga mountainous areas.

Study on Sustainable Utilization of Resources of the Damp-heat Karst Mountainous Areas in China

Damp-heat karst mountainous areas are unique areas in terms of socialeconomic development, resource endowment and eco-environment in China, where natural resources are abundant,unique and diverse. However, fragile eco-environment, undeveloped economy and culture, and conflict of human and environment should not be ignored. In the research, a framework of integration of resource-development and environment-protection in damp-heat karst was designed on basis of resource and environment integration, which was applied to Daxin County in Guangxi Province. Furthermore, some integration models were proposed, including integration of development of characteristic agricultural resources and protection of eco-environment, integration of development of manganese ore resources and protection of eco-environment, integration of development of tourism resources and protection of ecoenvironment and integration of development of clean energy and protection of eco-environment.

Human Carrying Capacity of Rangeland Resources in China′s Mountain Areas

Based on analysis of the development potential of rangeland resources in China＇s mountain areas, the paper makes analysis and forecast in human carrying capacity of rangeland resources. It provides some reference for drawing up the development strategy in mountain areas.