Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas

BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients improved after treatment.CONCLUSION Intradermal ColΙinjection improves photoaging,with higher patient satisfaction and fewer adverse reactions,and could be an effective treatment method for populations residing in high-altitude areas.

Atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction

In high-altitude nuclear detonations,the proportion of pulsed X-ray energy can exceed 70%,making it a specific monitoring signal for such events.These pulsed X-rays can be captured using a satellite-borne X-ray detector following atmospheric transmission.To quantitatively analyze the effects of different satellite detection altitudes,burst heights,and transmission angles on the physical processes of X-ray transport and energy fluence,we developed an atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction.The proposed method is an improvement over the traditional analytical method that only computes direct-transmission X-rays.The traditional analytical method exhibits a maximum relative error of 67.79% compared with the Monte Carlo method.Our improved method reduces this error to within 10% under the same conditions,even reaching 1% in certain scenarios.Moreover,its computation time is 48,000 times faster than that of the Monte Carlo method.These results have important theoretical significance and engineering application value for designing satellite-borne nuclear detonation pulsed X-ray detectors,inverting nuclear detonation source terms,and assessing ionospheric effects.

Single-Arm Clinical Study of Combination Perindopril-Amlodipine Tablets in the Treatment of High-Altitude Hypertension

Objective:To evaluate the efficacy of combination perindopril/amlodipine tablets in patients with high-altitude hypertension who were previously unable to control their blood pressure with monotherapy.Methods:A total of 151 patients with high-altitude hypertension whose blood pressure remained inadequately controlled with previous monotherapy were enrolled in this study.All patients received an 8-week treatment with a combination of perindopril/amlodipine tablets,consisting of perindopril 10 mg/day and amlodipine 5 mg/day.Blood pressure measurements,including both diastolic and systolic pressures,were taken at baseline,and after 2,4,6,and 8 weeks of treatment.Results:After 8 weeks of treatment,there was a significant reduction in both average systolic and diastolic blood pressure compared to baseline(P<0.0001).Specifically,the average systolic blood pressure decreased by 24.45±13.75 mmHg,and the average diastolic blood pressure decreased by 13.37±8.40 mmHg.The overall heart rate showed no significant changes during the treatment period.Conclusion:A combination of perindopril/amlodipine tablets significantly improved blood pressure control in patients with high-altitude hypertension after 8 weeks of treatment.These results support the efficacy of combination perindopril/amlodipine as a viable treatment option for high-altitude hypertension.

北京地区育龄男性与女性TORCH感染情况回顾分析

目的 回顾分析近2016年7月至2022年12月来我院就诊人群的TORCH感染情况,为本地区优生优育工作提供数据参考。方法 利用酶联免疫吸附实验检测男性和非妊娠期女性血清中TORCH各病原体IgG抗体和IgM抗体的阳性情况,对数据进行处理分析。结果 进行TORCH检测的人群,女性人数远高于男性人数;男性和女性之间TOX、RV、CMV和HSV的IgM抗体阳性率均存在差异,男性和女性之间TOX和HSV的所有感染模式存在差异,且所有差异均表现为女性的抗体阳性率高于男性的抗体阳性率;男性RV和CMV的IgM抗体阳性率在不同的季节存在差异,女性的TOX、RV、CMV和HSV-1的IgM抗体阳性率在不同的季节存在差异;男、女性HSV-1和HSV-2抗体IgM阳性率在各季节均存在差异,且男、女性HSV-2的所有感染模式在各个季节中也完全不同;在合并感染中,男、女性的IgG抗体阳性率均以RV+CMV、RV+HSV-1、CMV+HSV-1和RV+CMV+HSV-1为主,且女性的抗体阳性率高于男性,在IgM抗体的阳性率分析中,女性主要以HSV-1+HSV-2为主,男性主要以RV+HSV-1为主,其女性的抗体阳性率也远高于男性。结论 本地区TORCH感染人群主要为女性,TORCH感染的病原体有季节性差异,可针对此特点进行预防;建议增加育龄男性检测TORCH相关项目,可有助于夫妇备孕期感染的预防。

IVF/ICSI-ET患者TORCH血清学检测与出生缺陷分析:基于倾向性评分匹配法

目的:探讨实施体外受精-胚胎移植(In vitro fertilization and embryo transfer,IVF-ET)和卵泡内单精子注射(In vitro fertilization and embryo transfer,IVF-ET)技术患者TORCH血清学检测与出生缺陷的相关性。方法:,基于倾向性评分匹配(Propensityscorematching,PSM)的方法分析2017年1月-2020年12月期间在山东大学附属生殖医院实施IVF/ICSI-ET治疗患者的临床资料,根据既往妊娠结局分为出生缺陷组与正常组。比较倾向性评分匹配前后的TORCH血清学检测结果。结果:PSM前,不同组别的基线资料分布不均衡。出生缺陷组CMV-IgM、HSV-IgM阳性率高于正常组(P<005)。经倾向性评分匹配后,基线资料分布均衡。出生缺陷组TORCH-IgM阳性率与正常组无显著差异(P>0.05)。出生缺陷组TORCH-IgG阳性率与正常组无显著差异(P>0.05)。结论:行IVF/ICSI-ET治疗的患者TORCH感染与出生缺陷不存在相关性,出生缺陷患儿人数构成以先天性心脏病最多。

Geostructures, dynamics and risk mitigation of high-altitude and long- runout rockslides

Long-runout rockslides at high altitude could cause disaster chain in river basins and destroy towns and major infrasturctures.This paper firstly explores the initiation mechanism of high-altitude and long-runout rockslides.Two types of sliding-prone geostructure models,i.e.the fault control type in orogenic belt and the fold control type in platform area,are proposed.Then,large-scale experimental apparatus and associated numerical simulations are conducted to understanding the chain-style dynamics of rockslide-debris avalanche-debris flow.The results reveal the fragmentation effects,the rheological behaviors and the boundary layer effect of long-runout avalanche-debris flow.The dynamic character-istics of quasi-static-transition-inertia state and solid-liquid coupling in rapid movement of rockslide-debris avalanche-debris flow are investigated.Finally,the risk mitigation strategy of the non-structure and structure for resilient energy dissipation are illustrated for initiation,transition and deposition zones.The structural prevention and mitigation methods have been successfully applied to the high-altitude and long-runout rockslides in Zhouqu and Maoxian of the Wenchuan earthquake zone,as well as the other major geohazards in Qinghai-Tibet Plateau and its adjacent areas.

北京地区孕产妇TORCH血清流行病学调查研究

目的分析2018-2022年在该院就诊的孕产妇血清TORCH感染情况及流行特点。方法对2018-2022年在该院进行孕期筛查的女性共计27357例结果进行分析,按年龄段、年度进行分组,结果用SPSS软件进行统计分析。结果孕产妇TOX、RV、CMV、HSV-ⅡIgM的阳性率分别为0.03%、1.27%、1.86%和0.08%,IgG的阳性率分别为4.46%、90.31%、92.87%和4.49%。≥35岁高龄孕妇组CMV IgM、RV IgG抗体阳性率显著低于<35岁组,差异有统计学意义(均P<0.05),TOX IgG、HSV-ⅡIgG抗体阳性率显著高于<35岁组,差异有统计学意义(均P<0.05)。CMV IgG阳性率近几年呈递减趋势。结论高龄组CMV IgM、RV IgG抗体阳性率更低,TOX IgG、HSV-ⅡIgG抗体阳性率更高。CMV IgG阳性率有呈逐年下降趋势,RV IgG和HSV-ⅡIgG阳性率逐年上升。

拉萨市育龄妇女及孕妇TORCH感染情况分析

目的分析拉萨市育龄妇女及孕妇的TORCH病原体感染情况,为优生优育提供数据支持及指导建议。方法收集从2018年~2021年在本院进行优生优育检查的2020名育龄妇女及孕妇TORCH检测结果。分别从民族、年龄、季节方面进行流行病学分析。结果TORCH四种病原体即弓形虫(Toxoplasma gondii,Tox)、风疹病毒(rubella virus,RV)、巨细胞病毒(cytomegalovirus,CMV)、单纯疱疹病毒(herpes simplex virus,HSV)的IgM阳性率分别为0.94%、0.94%、0.25%和20.74%,而IgG阳性率分别为8.54%、86.92%、97.94%和95.92%。不同民族之间RV-IgM(P=0.01)、HSV-I/II-IgM(P=0.00)和TOX-IgG(P=0.00)、CMV-IgG(P=0.00)差异有统计学意义。只有HSV-I/II-IgG在不同年龄组间差异有统计学意义(P=0.04)。而不同季节间只有RV-IgG差异有统计学意义(P=0.03)。结论TORCH四种病原体中,RV和CMV对拉萨地区育龄妇女及孕妇威胁性较国内其它地区小,而TOX和HSV威胁性较大。

Analysis of TORCH results of retinal exudative changes in neonates

AIM:To explore the relationship between retinal exudative changes in neonates and perinatal toxoplasmosis,others,rubella,cytomegalovirus,and herpes simplex virus(TORCH)infections,as well as the characteristics of TORCH infection in neonates with retinal exudative changes.METHODS:Retrospective study.A total of 612 neonates with retinal exudative changes detected during ophthalmic screening in our hospital from May 2019 to March 2023 were selected.TORCH tests were performed on these neonates,and the results were subjected to statistical analysis to determine the infection characteristics.The neonates with retinal exudative changes were grouped by sex and age,the characteristics of TORCH infection were analyzed,and the positive rates were compared.RESULTS:Among the 612 neonates with retinal exudative changes,the highest positive rate was observed for cytomegalovirus(CMV-IgG)(96.7%),followed by rubella virus(RV-IgG)(73.9%).Mixed infections with two or three viruses were also observed,with the highest positive rate for mixed infection of RV-IgG and CMV-IgG reaching 71.2%.There was no statistically significant difference in TORCH infection among neonates of different sex(P>0.05).However,there were statistically significant differences in RV-IgG and CMV-IgM infections with retinal exudative changes among neonates of different age groups(P<0.05).CONCLUSION:Perinatal TORCH infection may be an important factor causing retinal exudative changes in neonates.The differences in various infections are not related to sex but are related to different age groups.

皖南地区8199例婴幼儿TORCH感染血清学检测结果分析

目的探讨皖南地区近年来TORCH病原体,即弓形虫(Toxoplasma gondii,TOX)、风疹病毒(rubella virus,RV)、巨细胞病毒(cytomegalovirus,CMV)和单纯疱疹病毒(herpes simplex virus,HSV)在婴幼儿人群的感染状况及流行特点,为儿童相关疾病的预防、诊断和治疗提供参考。方法回顾性分析2016年4月—2023年3月皖南医学院第一附属医院接诊的0~3岁婴幼儿TORCH感染血清IgM和IgG抗体检测结果,并对不同年龄、年份的TORCH阳性率进行比较分析。结果共有8199例0~3岁婴幼儿进行TORCH感染血清学筛查检测,其中男性4631例,女性3568例。婴幼儿TOX、RV、CMV、HSVⅠ和HSVⅡ的IgM抗体阳性率分别为0.11%、0.20%、0.89%、0和0,差异有统计学意义(χ^(2)=100.000,P<0.05);相对应的IgG抗体阳性率分别为10.81%、78.36%、98.32%、82.38%和13.45%,差异有统计学意义(χ^(2)=22828.211,P<0.05)。不同年龄组比较,婴儿组CMV-IgM阳性率(11.90%)高于新生儿组(0.20%)和幼儿组(1.40%),差异均有统计学意义(χ^(2)=672.920、20.569,P均<0.017);新生儿组TOX-IgG、RV-IgG、CMV-IgG、HSVⅠ-IgG和HSVⅡ-IgG阳性率(11.01%、79.88%、98.76%、85.35%、13.72%)高于婴儿组(6.71%、49.35%、96.54%、50.87%、9.74%),差异均有统计学意义(χ^(2)=8.369、237.184、16.033、373.121、5.902,P均<0.017)。不同年份比较,CMV-IgM阳性率2016年最高,各年差异有统计学意义(χ^(2)=15.816,P<0.05);不同年份TOX-IgG、RV-Ig G、CMV-IgG、HSVⅠ-IgG、HSVⅡ-IgG阳性率差异均有统计学意义(χ^(2)=216.002、90.545、37.047、59.527、57.623,P均<0.05)。结论皖南地区0~3岁婴幼儿中TORCH既往感染以CMV、HSVⅠ和RV为主,现症感染主要为CMV,对婴幼儿进行TORCH感染筛查检测对于保护儿童的健康至关重要。此外,应做好妊娠规划、产前保健和筛查,预防TORCH感染。

Construction Technology of Warm Mix Asphalt Pavement in Cold High-Altitude Areas

With the continuous development of domestic highway construction,highway civil engineering and service level quality have attracted much attention.Good pavement quality and high-quality service make people feel comfortable and smooth when traveling.High-quality pavement can significantly reduce the probability of traffic accidents.At present,there is a direct relationship between pavement quality and pavement construction operations.Carrying out pavement construction operations in cold high-altitude areas requires a reasonable selection of construction equipment and methods.The application of warm-mix asphalt pavement construction technology can ensure pavement quality.Therefore,this paper analyzes the advantages of warm-mix technology,the environmental characteristics of cold high-altitude areas,and construction preparations,and discusses the construction technology of warm-mix asphalt pavement in cold high-altitude areas in detail,to improve the overall road quality of cold high-altitude areas.

TORCH联合血清β-hCG、AFP、uE3检测诊断超声软指标异常胎儿价值

目的:探究TORCH联合血清人绒膜促性腺激素(β-hCG)、甲胎蛋白(AFP)和游离雌三醇(uE3)检测对超声软指标异常胎儿产前诊断价值。方法:选取2021年7月-2023年12月于本院产前检查胎儿超声软指标异常的孕妇324例(300例单项软指标异常、24例≥2项软指标异常)纳入异常组,产前检查健康产妇300例纳入对照组。均行TORCH血清学检测,测定血清AFP、freeβ-hCG及uE3水平。对比两组血清TORCH、β-hCG、AFP和uE3检测结果;对比不同软指标异常组血清TORCH、β-hCG、AFP和uE3检测结果;ROC分析TORCH联合血清β-hCG、AFP和uE3对超声软指标异常胎儿产前诊断价值。结果:与对照组相比,异常组血清TORCH阳性率、β-hCG、AFP水平更高,血清uE3水平更低(均P<0.05);与单项软指标异常组相比,多项软指标异常组血清TORCH阳性率、β-hCG、AFP更高,血清uE3水平更低(均P<0.05);ROC工作曲线结果显示,血清TORCH、β-hCG、AFP和uE3联合检测诊断超声软指标异常孕妇的AUC分别为0.927,显著高于指标单独检测,且敏感度和特异度均较高,分别为90.00%和92.59%。结论:对产前检查孕妇行血清TORCH联合β-hCG、AFP和uE3检测,有助于提升超声软指标异常胎儿的产前诊断率,可为临床提供一种准确有效的诊断方法。

Settlement Control Technology of High Filled Soil-Rock Embankment in Alpine and High-Altitude Areas

China's infrastructure has gradually achieved large-scale development,and transportation construction has also shifted from east to west,transitioning from plains to mountainous areas.High-fill embankments of different sizes in mountainous areas are unavoidable,and the settlement of high-fill embankments is usually the most concerned issue in high-fill projects.According to the current research of highway projects,most of the high embankments in mountainous areas are soil-rock mixed embankments or rock-filled embankments,and their post-construction settlements are directly related to construction technology and the type of filler used.In this paper,the problems in the settlement control of earth-filled embankment and related factors are analyzed in detail.The settlement control technology of high-fill embankment in high-cold and high-altitude areas is also discussed,so as to ensure the overall quality of high-fill embankment.

2015-2021年新疆阿克苏地区孕妇和新生儿TORCH感染情况分析

目的调查2015-2021年新疆阿克苏地区孕妇和新生儿TORCH感染趋势,分析孕妇和新生儿TORCH感染特征。方法回顾性分析,收集于2015-2021年在新疆阿克苏地区接受TORCH感染筛查的4349名孕妇和配对的4058名新生儿临床资料,采用酶联免疫吸附法检测孕妇和新生儿外周血、孕妇产前脐血的TORCH-IgM抗体、IgG抗体并分析结果;比较不同年龄孕妇的TORCH-IgM抗体、IgG抗体阳性率;并比较正常妊娠、不良妊娠孕妇TORCH-IgM抗体阳性率。结果2015年-2021年4349名孕妇TORCH感染呈下降趋势;TORCH感染孕妇中,TORCH-IgM总阳性率为2.23%(97/4349),TORCH-IgG总阳性率为3.66%(159/4349)。风疹病毒(RV)、巨细胞病毒(CMV)病毒IgG抗体的阳性率高于弓形虫(TOX)、单纯疱疹病毒(HSV)(P<0.05)。2015年-2021年4058名新生儿TORCH感染呈下降趋势;TORCH感染新生儿中,TORCH-IgM总阳性率为1.75%(71/4058),TORCH-IgG总阳性率为1.82%(74/4058)。各病毒IgM、IgG抗体阳性率比较,差异无统计学意义(P>0.05)。4349名孕妇经产前脐血检查,TORCH-IgM抗体总阳性率为0.78%(34/4349),其中CMV阳性率最高,占总阳性例数的76.47%。不良妊娠组产前脐血TORCH-IgM抗体阳性率高于正常妊娠组,差异有统计学意义(P<0.05)。≤35岁的孕妇HSV-IgM抗体阳性率、RV-IgG抗体阳性率均高于>35岁孕妇,但CMV-IgG、HSV-IgG抗体阳性率均低于>35岁孕妇,均差异有统计学意义(P<0.05);不同年龄组孕妇TOX-IgM、RV-IgM、CMV-IgM、TOX-IgG抗体阳性率比较,差异无统计学意义(P>0.05)。结论2015-2021年新疆阿克苏地区孕妇和新生儿TORCH感染率逐渐降低,CMV是孕妇及新生儿感染的主要病原体,HSV-IgM阳性率以低龄孕妇为主,应强化孕前TORCH检测,降低感染率。

孕妇早孕期血清ALT升高与TORCH感染的相关性研究

目的 分析孕妇早孕期血清谷丙转氨酶(ALT)升高与TORCH感染的相关性。方法 选取本院282例免费孕前优生及早孕TORCH感染患者和同期未感染的282例免费孕前优生及早孕建卡者为研究对象,所有入选对象均接受ALT检测,对比分析两组ALT水平,并应用Logistic多因素回归分析方法对血清ALT升高与TORCH感染的相关性进行分析。结果 不同类型TORCH感染者ALT水平相比差异无统计学意义(P>0.05)。感染组血清ALT水平显著高于健康组,差异有统计学意义(P<0.05)。Logistic多因素回归分析结果显示,孕期血清ALT升高是TORCH感染的影响因素(P<0.05)。结论 孕妇早孕期血清ALT升高与TORCH感染密切相关,孕妇在孕前及孕期需积极加强ALT、TORCH监测。

优生优育检查中TORCH检测的临床价值

目的:分析优生优育检查中TORCH检测的临床价值。方法:回顾性选取厦门大学附属妇女儿童医院2022年6月至2023年4月期间发生不良妊娠结局产妇86例作为观察组,另选取同期正常妊娠结局产妇134例作对照组,均行TORCH检测,观察两组产妇的特异性免疫球蛋白(Ig)M、IgG检出结果,分析不同IgM、IgG结果发生不良妊娠结局的危险度。结果:观察组单纯性疱疹病毒(HSV)-IgM、巨细胞病毒(CMV)-IgM阳性率高于对照组,差异均具有统计学意义(P<0.05);经危险度分析,CMV-IgM、HSV-IgM阳性者发生不良妊娠结局的危险度为阴性者的5.302倍、9.279倍,差异均具有统计学意义(P<0.05);TOX-IgG、RUV-IgG、CMV-IgG、HSV-IgG阳性者发生不良妊娠结局的危险度为阴性者的1.329倍、0.932倍、0.962倍、0.780倍,但差异均无统计学意义(P>0.05)。结论:TORCH感染和不良妊娠结局存在关联性,当HSV、CMV的IgG为阳性时,发生不良妊娠结局的危险度较高,需增强产前筛查,以实现优生优育。

广元地区1311例育龄妇女及婴幼儿TORCH感染情况的调查分析

目的了解广元地区育龄妇女及婴幼儿TORCH感染情况,为优生优育提供相关信息。方法采用化学发光检测系统测定2020年12月~2022年1月广元地区育龄妇女(1147例)及婴幼儿(164例)血清中弓形虫(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)及单纯疱疹病毒I型(HSVⅠ)和Ⅱ型(HSVⅡ)特异性抗体IgG和IgM。结果1147例育龄妇女TORCH-IgG抗体阳性率分别为:CMVIgG95.90%,RVIgG85.00%,HSVⅠ-IgG23.89%,HSVⅡ-IgG12.29%,Tox-IgG6.45%。TORCH-IgM抗体阳性率分别为:CMV-IgM1.74%,HSVⅡ-IgM1.13%,RV-IgM0.52%,Tox-IgM0.44%,HSVⅠ-IgM0.08%。婴幼儿TORCH-IgG抗体阳性率分别为:CMVIgG83.53%,RVIgG70.12%,HSVⅠ-IgG82.93%,HSVⅡ-IgG15.24%,Tox-IgG7.32%。TORCH-IgM抗体阳性率分别为:CMV-IgM26.83%,HSVⅡ-IgM1.22%,RV-IgM1.22%,Tox-IgM0%,HSV I-IgMO%。结论广元地区育龄妇女及婴幼儿存在一定的TORCH感染率,育龄妇女及婴幼儿TORCH监测非常有意义。

广元市育龄妇女及婴幼儿TORCH感染情况调查

目的:了解四川省广元市部分育龄妇女及婴幼儿TORCH感染情况,为优生优育提供相关信息。方法:选取2020年12月—2022年1月在广元市中心医院进行体检或产前筛查的育龄妇女(20~42岁)及婴幼儿为研究对象,排除其中患基础疾病者,共纳入育龄妇女1147名、婴幼儿164名,采用化学发光检测系统测定其血清中弓形虫(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)、单纯疱疹病毒I型(HSV I)和单纯疱疹病毒II型(HSV II)特异性抗体IgG和IgM。结果:1147名育龄妇女TORCH-IgG抗体阳性率分别为:CMV-IgG 95.90%,RV-IgG 85.00%,HSV I-IgG 23.89%,HSV II-IgG12.29%,Tox-IgG 6.45%。TORCH-IgM抗体阳性率分别为:CMV-IgM 1.74%,HSV II-IgM 1.13%,RV-IgM 0.52%,Tox-IgM0.44%,HSV I-IgM 0.08%。婴幼儿TORCH-IgG抗体阳性率分别为:CMV-IgG 83.53%,RV-IgG 70.12%,HSV I-IgG82.93%,HSV II-IgG 15.24%,Tox-IgG 7.32%。TORCH-IgM抗体阳性率分别为:CMV-IgM 26.83%,HSV II-IgM 1.22%,RV-IgM 1.22%,Tox-IgM 0,HSV I-IgM 0。结论:四川省广元市部分育龄妇女及婴幼儿存在一定的TORCH感染,针对育龄妇女及婴幼儿的TORCH监测非常有意义。

基于IVF-ET技术的自然流产患者TORCH感染情况调查

目的 分析山东地区实施体外受精-胚胎移植技术的自然流产患者TORCH感染情况及流行特点。方法 选择2017年1月至2020年12月于山东大学生殖医学研究中心实施体外受精-胚胎移植技术的2 819例自然流产患者为研究对象,比较不同年龄、季节、城乡居住地、文化程度、年度患者TORCH-IgM、TORCH-IgG阳性率。结果 不同年龄患者巨细胞病毒(CMV)-IgG、风疹病毒(RV)-IgG阳性率比较,差异均有统计学意义(P<0.05)。不同季节患者TORCH-IgM阳性率比较,差异无统计学意义(P>0.05)。农村患者单纯疱疹病毒(HSV)-IgM、CMV-IgG、HSV-IgG、RV-IgG阳性率均高于城市,差异均有统计学意义(P<0.05)。大专以下文化程度患者CMV-IgG、HSV-IgG阳性率高于大专及以上文化程度,差异均有统计学意义(P<0.05)。2019年起HSV-IgM阳性率有升高趋势。结论 山东地区实施体外受精-胚胎移植技术的自然流产患者TORCH某些病原体存在年龄、城乡、文化程度差异。

北京地区妊娠期女性TORCH感染情况回顾和分析

目的分析近年来我院就诊的妊娠期女性TORCH感染情况,为本地区优生优育工作提供参考。方法选取2016年至2020年来我院就诊的4014例妊娠期女性为研究对象。采集患者血清,利用酶联免疫反应实验检测血清中TORCH各病原体抗体IgG和IgM的阳性情况,并对数据进行处理和分析。结果妊娠期女性的TORCH检测率随孕周增加而增加。TOX、RV和HSV-1的感染在不同年龄的妊娠女性中存在差异。各孕期IgG的阳性率由高到低均为CMV、RV、HSV-1、HSV-2、TOX,孕早期和孕中期IgM的阳性率由高到低为HSV-1、HSV-2、CMV、RV、TOX,孕晚期RV IgM阳性率高于CMV。TORCH的合并感染以双重感染居多,其中IgG阳性的合并感染以RV、CMV、HSV-1为主,IgM阳性的合并感染以HSV-1和HSV-2为主。相较于RV、CMV和HSV-1,妊娠期女性对TOX和HSV-2的整体免疫基础较弱,且4种感染模式在不同孕期存在较显著的差异(P<0.001)。妊娠女性的整体和各孕期的感染模式分析中,IgG+/IgM+感染模式HSV-1阳性率最高,IgG-/IgM+感染模式HSV-2阳性率最高。本地区季节变换对妊娠期女性TORCH的感染无影响。结论本地区妊娠期女性应着重注意对HSV感染的预防,避免复发和再次感染。