Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas

BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients improved after treatment.CONCLUSION Intradermal ColΙinjection improves photoaging,with higher patient satisfaction and fewer adverse reactions,and could be an effective treatment method for populations residing in high-altitude areas.

Atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction

In high-altitude nuclear detonations,the proportion of pulsed X-ray energy can exceed 70%,making it a specific monitoring signal for such events.These pulsed X-rays can be captured using a satellite-borne X-ray detector following atmospheric transmission.To quantitatively analyze the effects of different satellite detection altitudes,burst heights,and transmission angles on the physical processes of X-ray transport and energy fluence,we developed an atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction.The proposed method is an improvement over the traditional analytical method that only computes direct-transmission X-rays.The traditional analytical method exhibits a maximum relative error of 67.79% compared with the Monte Carlo method.Our improved method reduces this error to within 10% under the same conditions,even reaching 1% in certain scenarios.Moreover,its computation time is 48,000 times faster than that of the Monte Carlo method.These results have important theoretical significance and engineering application value for designing satellite-borne nuclear detonation pulsed X-ray detectors,inverting nuclear detonation source terms,and assessing ionospheric effects.

Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests

The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong earthquakes.While extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains unclear.This research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active fault.The prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation corridor.The results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)increased.The PGAs of different engineering structures were weakened by the fault rupture zone.Nevertheless,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic vibration.Additionally,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active faults.The findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor.

Influence of Transportation Accessibility on Urban-rural Income Disparity and Its Spatial Heterogeneity

Transportation accessibility has been treated as an important means of reducing the urban-rural income disparity.However,only a few studies have examined the effects of different types of transportation accessibility on urban-rural income disparity and their spatial heterogeneity.Based on data from 285 prefecture-level(and above)Chinese cities in 2000,2005,2010,2015,and 2020,this study uses spatial econometric models to examine how highway accessibility and railway accessibility influence the urban-rural income disparity and to identify their spatial heterogeneity.The result reveals that highway accessibility and railway accessibility have‘coreperiphery’ring-like circle structures.The urban-rural income disparity exhibits strong spatial clustering effects.Both highway accessibility and railway accessibility are negatively associated with urban-rural income disparity,and the former having a greater effect size.Moreover,there is a substitution effect between highway accessibility and railway accessibility in the whole sample.Furthermore,these associations differ in geographic regions.In the central region,highway accessibility is more important in reducing the urban-rural income disparity,but its effect is weakened with the increase of railway accessibility.In the western region,railway accessibility has a larger effect on narrowing the urban-rural income disparity,and this effect is strengthened by the increase of highway accessibility.We conclude that improving transportation accessibility is conducive to reducing the urban-rural income disparity but its effect is spatial heterogenetic.Highways and railways should be developed in a coordinated manner to promote an integrated transport network system.

Analyzing the transportation infrastructure-rural industry integration relationship in China

Transportation infrastructure is crucial to China’s economic growth because it substantially contributes to the holistic development of rural primary,secondary,and tertiary industries.This study innovatively examines transportation infrastructure and urbanization levels to explore,both theoretically and empirically,their relationship with the holistic development of primary,secondary,and tertiary industries in rural China,and the mediating role of urbanization on this relationship.We employed fixed-effects models,the entropy weight approach,mixed regression,and generalized method of moments to analyze the data of 30 provinces across China from 2013 to 2020.The results indicate that the construction of transportation infrastructure directly fosters the collective advancement of such industries in rural areas and that urbanization partially mediates the transportation infrastructure-rural industry integration relationship.However,the western region shows disparities in the integrated development of these sectors.Further analysis reveals that foreign investments amplify the positive influence of transportation infrastructure on rural industry integration.Essentially,the enhancement of rural transportation infrastructure,promotion of urbanization,implementation of strategic planning,and strengthening of support mechanisms are crucial aspects in the comprehensive development of rural industries and the achievement of rural revitalization in China.

A Study on Integrated Construction of Luzhou Comprehensive Transportation Hub

The target of integrated construction of comprehensive transportation hub is to integrate the traffic resources,achieve butt joint of pan-regional transportation mode,and finally realize the"seamless connection"of the goods and"zero transfer"of the passenger traffic.Relying on the particularity of the geographical location and the convenience of the Yangtze River channel,Luzhou puts forth effort to build a comprehensive transport hub in Southern Sichuan and has made great efforts in traffic infrastructure construction.However,there are still some problems.Combining practice of Luzhou,using the advanced experience of foreign and domestic cities for reference,the paper pointed out that for the sake of constructing a comprehensive transportation hub,we need to build the traffic integration on the basis of the efficiency.Besides,the paper proposed the strategies for construction.

Optimizing a Transportation System Using Metaheuristics Approaches (EGD/GA/ACO): A Forest Vehicle Routing Case Study

The large-scale optimization problem requires some optimization techniques, and the Metaheuristics approach is highly useful for solving difficult optimization problems in practice. The purpose of the research is to optimize the transportation system with the help of this approach. We selected forest vehicle routing data as the case study to minimize the total cost and the distance of the forest transportation system. Matlab software helps us find the best solution for this case by applying three algorithms of Metaheuristics: Genetic Algorithm (GA), Ant Colony Optimization (ACO), and Extended Great Deluge (EGD). The results show that GA, compared to ACO and EGD, provides the best solution for the cost and the length of our case study. EGD is the second preferred approach, and ACO offers the last solution.

Research on a TOPSIS energy efficiency evaluation system for crude oil gathering and transportation systems based on a GA-BP neural network

As the main link of ground engineering,crude oil gathering and transportation systems require huge energy consumption and complex structures.It is necessary to establish an energy efficiency evaluation system for crude oil gathering and transportation systems and identify the energy efficiency gaps.In this paper,the energy efficiency evaluation system of the crude oil gathering and transportation system in an oilfield in western China is established.Combined with the big data analysis method,the GA-BP neural network is used to establish the energy efficiency index prediction model for crude oil gathering and transportation systems.The comprehensive energy consumption,gas consumption,power consumption,energy utilization rate,heat utilization rate,and power utilization rate of crude oil gathering and transportation systems are predicted.Considering the efficiency and unit consumption index of the crude oil gathering and transportation system,the energy efficiency evaluation system of the crude oil gathering and transportation system is established based on a game theory combined weighting method and TOPSIS evaluation method,and the subjective weight is determined by the triangular fuzzy analytic hierarchy process.The entropy weight method determines the objective weight,and the combined weight of game theory combines subjectivity with objectivity to comprehensively evaluate the comprehensive energy efficiency of crude oil gathering and transportation systems and their subsystems.Finally,the weak links in energy utilization are identified,and energy conservation and consumption reduction are improved.The above research provides technical support for the green,efficient and intelligent development of crude oil gathering and transportation systems.

An Efficient Approach for Transforming Unbalanced Transportation Problems into Balanced Problems in Order to Find Optimal Solutions

In operations research, the transportation problem (TP) is among the earliest and most effective applications of the linear programming problem. Unbalanced transportation problems reflect the reality of supply chain and logistics situations where the available supply of goods may not precisely match the demand at different locations. To deal with an unbalanced transportation problem (UTP), it is essential first to convert it into a balanced transportation problem (BTP) to find an initial basic feasible solution (IBFS) and hence the optimal solution. The present paper is concerned with introducing a new approach to convert an unbalanced transportation problem into a balanced one and as a consequence to obtain optimum total transportation cost. Numerical examples are provided to demonstrate the suggested method.

Existing Case of Transportation System in Turkey and Transportation Trends in Istanbul

Transportation sector is one of the most important elements of a country’s economy with its highway,railway,airway and seaway modes,besides the information and communication infrastructure.Transportation sector has a pattern that affects the society continuously with its economic and social inputs that has a significant role in economies of countries in terms of being an important part of manufacturing process and effects of sizable investments on economy.Demands of more comfortable,more reliable,more safe and more punctual transport in developing economy is an arising trend worldwide and this shows an increase the importance of the transportation sector.Establishment of an efficient and functional transportation system is closely related with traffic safety,intermodal integration and balanced modal distribution.In Turkey,an important improvement has been achieved in these issues,but also some basic constitutive problems are still continuing.These constitutional problems can be summarized as providing traffic safety,integration of innovative implementations to transportation system,enhancing of infrastructure and an effective usage of existing infrastructure.

Single-Arm Clinical Study of Combination Perindopril-Amlodipine Tablets in the Treatment of High-Altitude Hypertension

Objective:To evaluate the efficacy of combination perindopril/amlodipine tablets in patients with high-altitude hypertension who were previously unable to control their blood pressure with monotherapy.Methods:A total of 151 patients with high-altitude hypertension whose blood pressure remained inadequately controlled with previous monotherapy were enrolled in this study.All patients received an 8-week treatment with a combination of perindopril/amlodipine tablets,consisting of perindopril 10 mg/day and amlodipine 5 mg/day.Blood pressure measurements,including both diastolic and systolic pressures,were taken at baseline,and after 2,4,6,and 8 weeks of treatment.Results:After 8 weeks of treatment,there was a significant reduction in both average systolic and diastolic blood pressure compared to baseline(P<0.0001).Specifically,the average systolic blood pressure decreased by 24.45±13.75 mmHg,and the average diastolic blood pressure decreased by 13.37±8.40 mmHg.The overall heart rate showed no significant changes during the treatment period.Conclusion:A combination of perindopril/amlodipine tablets significantly improved blood pressure control in patients with high-altitude hypertension after 8 weeks of treatment.These results support the efficacy of combination perindopril/amlodipine as a viable treatment option for high-altitude hypertension.

Analysis of Historic Pavement and Bridge Conditions and Alternative Funding Levels for the Michigan Department of Transportation

In 1997 the Michigan Department of Transportation (MDOT) established an ambitious set of condition targets for its pavements and bridges, and the Department received increased revenue from a 4-cent-per-gallon increase in the state motor fuels tax to help meet its targets. However, over time, actual revenue was less than both what was initially estimated as needed to meet the targets and what was projected from the tax increase. Consequently, actual conditions were projected to fall short of the target levels, so the department issued bonds to address the shortfall through 2012. To support deliberations on future funding, in 2013 MDOT performed an analysis of historic conditions to determine what additional fuel tax revenues would have been required beginning in 1997 to: replace bond revenues used to fund pavement and bridge projects from 1997 to 2012;and enable MDOT to meet its condition targets. The analysis was performed using data on actual pavement and bridge funding and conditions;as well as predicted funding and conditions for different hypothetical increases in fuel taxes. The analysis concluded that, in addition to the actual increase of 4 cents per gallon, a fuel tax increase of another 10 cents per gallon would have been required in 1997 to replace bond revenue used for pavement and bridges and allow MDOT to meet its condition targets. The analysis results were used to help inform the discussion of Michigan’s target asset conditions and funding, and demonstrate application of MDOT’s pavement and bridge management systems for performing historic analyses.

A Study on Optimizing the Double-Spine Type Flow Path Design for the Overhead Transportation System Using Tabu Search Algorithm

Optimizing Flow Path Design(FPD)is a popular research area in transportation system design,but its application to Overhead Transportation Systems(OTSs)has been limited.This study focuses on optimizing a double-spine flow path design for OTSs with 10 stations by minimizing the total travel distance for both loaded and empty flows.We employ transportation methods,specifically the North-West Corner and Stepping-Stone methods,to determine empty vehicle travel flows.Additionally,the Tabu Search(TS)algorithm is applied to branch the 10 stations into two main layout branches.The results obtained from our proposed method demonstrate a reduction in the objective function value compared to the initial feasible solution.Furthermore,we explore howchanges in the parameters of the TS algorithm affect the optimal result.We validate the feasibility of our approach by comparing it with relevant literature and conducting additional tests on layouts with 20 and 30 stations.

Research on the Interactive Impact of Transportation Systems on Socio-Economic Development

This paper aims to explore the interactive impact between transportation systems and socio-economic development,employing Structural Equation Modeling(SEM)to analyze data from 31 provincial-level administrative regions in China from 2013 to 2022.It comprehensively considers key indicators from the economic,social,and transportation sectors.The paper constructs a model encompassing 5 latent variables and 15 observed variables.Through in-depth analysis,it reveals the promoting role of transportation systems on economic growth and social development,as well as the demand for transportation system construction and optimization driven by socio-economic development levels.The results indicate that an efficient transportation system can not only directly drive economic growth but also indirectly promote social development by improving social welfare and enhancing quality of life.This paper provides new insights into understanding the complex relationship between transportation systems and socio-economic development and holds significant implications for policymakers in optimizing transportation infrastructure to foster economic and social development.

Analysis of the Application of Artificial Intelligence in Transportation

With the advancement of the information age,the transportation industry has experienced rapid growth,leading to an expansion in the scale and number of highway constructions.However,this development has also given rise to numerous traffic issues,including frequent vehicle congestion and traffic accidents.To address these problems,it is essential to leverage modern technology for real-time information collection and analysis,providing robust technical support for intelligent transportation systems.This paper focuses on artificial intelligence(AI)technology,explaining its concept and its role in intelligent transportation.It reviews the various application areas and analyzes the use of AI in intelligent transportation.Finally,it proposes strategies for applying AI to promote the healthy development of intelligent transportation systems.

Automobile Transportation Logistics Supply Chain Management Strategy

To enhance the management level and quality of the automobile transportation logistics supply chain and promote innovation and development in automobile transportation logistics enterprises,it is essential to strengthen the construction of the automobile transportation logistics supply chain management model.This can be achieved through the gradual improvement of the automobile transportation logistics management process,ensuring that the management of the automobile transportation logistics supply chain proceeds in an orderly manner.The aim is to improve automobile transportation and logistics service levels while meeting the changing market supply needs.This will enable automobile transportation and logistics enterprises to maintain steady economic benefits and enhance their core competitiveness in the market.Therefore,this paper has conducted a comprehensive exploration and research on managing the automobile transportation logistics supply chain.Corresponding management strategies are proposed as a starting point to achieve the aforementioned goals.

Design and Application of Intelligent Control System for Molten Iron Transportation Based on 5G Technology

Molten transport is an important link in the iron and steel enterprise production,involves many complex factors,artificial management is difficult.Therefore,puts forward a kind of molten iron transport wisdom control system based on 5G technology,which mainly contains the intelligent identification tracking system,equipment status collection information acquisition system,locomotive vehicle terminal system,etc.Combined with the analysis of the actual application situation,the system could integrate all the processes and elements of molten iron produc-tion and transportation,realize the integration of operation and management,and also promote the improvement of the turnover efficiency of molten iron tank,reduce the demand for personnel,and reduce the labor cost.

Combinations of Transportation Policies to Promote BRT Usage Using Artificial Society Model

Various transportation systems have been developed in recent years.In this study,an artificial society model is developed to examine the combination of transportation policies in urban areas.In this model,each trip maker selects the primary and terminal transportation modes.An artificial society model is applied to the southeastern region of Osaka City,Japan.The effects of introducing BRT(bus rapid transit,primary transportation)and on-demand buses(terminal transportation)are investigated.The results confirm that BRT is used by a certain number of users.An increase in the use of BRT will increase the amount of walking,thus resulting in a healthy city.However,on-demand buses are rarely used as terminal transportation.Additionally,the development of bicycle parking stations near BRT stops is shown to be effective in the northern section of the BRT route.

Geostructures, dynamics and risk mitigation of high-altitude and long- runout rockslides

Long-runout rockslides at high altitude could cause disaster chain in river basins and destroy towns and major infrasturctures.This paper firstly explores the initiation mechanism of high-altitude and long-runout rockslides.Two types of sliding-prone geostructure models,i.e.the fault control type in orogenic belt and the fold control type in platform area,are proposed.Then,large-scale experimental apparatus and associated numerical simulations are conducted to understanding the chain-style dynamics of rockslide-debris avalanche-debris flow.The results reveal the fragmentation effects,the rheological behaviors and the boundary layer effect of long-runout avalanche-debris flow.The dynamic character-istics of quasi-static-transition-inertia state and solid-liquid coupling in rapid movement of rockslide-debris avalanche-debris flow are investigated.Finally,the risk mitigation strategy of the non-structure and structure for resilient energy dissipation are illustrated for initiation,transition and deposition zones.The structural prevention and mitigation methods have been successfully applied to the high-altitude and long-runout rockslides in Zhouqu and Maoxian of the Wenchuan earthquake zone,as well as the other major geohazards in Qinghai-Tibet Plateau and its adjacent areas.

How Generative Adversarial Networks Promote the Development of Intelligent Transportation Systems:A Survey

In current years,the improvement of deep learning has brought about tremendous changes:As a type of unsupervised deep learning algorithm,generative adversarial networks(GANs)have been widely employed in various fields including transportation.This paper reviews the development of GANs and their applications in the transportation domain.Specifically,many adopted GAN variants for autonomous driving are classified and demonstrated according to data generation,video trajectory prediction,and security of detection.To introduce GANs to traffic research,this review summarizes the related techniques for spatio-temporal,sparse data completion,and time-series data evaluation.GAN-based traffic anomaly inspections such as infrastructure detection and status monitoring are also assessed.Moreover,to promote further development of GANs in intelligent transportation systems(ITSs),challenges and noteworthy research directions on this topic are provided.In general,this survey summarizes 130 GAN-related references and provides comprehensive knowledge for scholars who desire to adopt GANs in their scientific works,especially transportation-related tasks.