Serum cystatin C,monocyte/high-density lipoprotein-C ratio,and uric acid for the diagnosis of coronary heart disease and heart failure

BACKGROUND Coronary heart disease(CHD)and heart failure(HF)are the major causes of morbidity and mortality worldwide.Early and accurate diagnoses of CHD and HF are essential for optimal management and prognosis.However,conventional diagnostic methods such as electrocardiography,echocardiography,and cardiac biomarkers have certain limitations,such as low sensitivity,specificity,availability,and cost-effectiveness.Therefore,there is a need for simple,noninvasive,and reliable biomarkers to diagnose CHD and HF.AIM To investigate serum cystatin C(Cys-C),monocyte/high-density lipoprotein cholesterol ratio(MHR),and uric acid(UA)diagnostic values for CHD and HF.METHODS We enrolled 80 patients with suspected CHD or HF who were admitted to our hospital between July 2022 and July 2023.The patients were divided into CHD(n=20),HF(n=20),CHD+HF(n=20),and control groups(n=20).The serum levels of Cys-C,MHR,and UA were measured using immunonephelometry and an enzymatic method,respectively,and the diagnostic values for CHD and HF were evaluated using receiver operating characteristic(ROC)curve analysis.RESULTS Serum levels of Cys-C,MHR,and UA were significantly higher in the CHD,HF,and CHD+HF groups than those in the control group.The serum levels of Cys-C,MHR,and UA were significantly higher in the CHD+HF group than those in the CHD or HF group.The ROC curve analysis showed that serum Cys-C,MHR,and UA had good diagnostic performance for CHD and HF,with areas under the curve ranging from 0.78 to 0.93.The optimal cutoff values of serum Cys-C,MHR,and UA for diagnosing CHD,HF,and CHD+HF were 1.2 mg/L,0.9×10^(9),and 389μmol/L;1.4 mg/L,1.0×10^(9),and 449μmol/L;and 1.6 mg/L,1.1×10^(9),and 508μmol/L,respectively.CONCLUSION Serum Cys-C,MHR,and UA are useful biomarkers for diagnosing CHD and HF,and CHD+HF.These can provide information for decision-making and risk stratification in patients with CHD and HF.

Tandem hydroalkylation and deoxygenation of lignin-derived phenolics to synthesize high-density fuels

Lignin is the most abundant naturally phenolic biomass,and the synthesis of high-performance renewable fuel from lignin has attracted significant attention.We propose the efficient synthesis of high-density fuels using simulated lignin cracked oil in tandem with hydroalkylation and deoxygenation reactions.First,we investigated the reaction pathway for the hydroalkylation of phenol,which competes with the hydrodeoxygenation form cyclohexane.And then,we investigated the effects of metal catalyst types,the loading amount of metallic,acid dosage,and reactant ratio on the reaction results.The phenol hydroalkylation and hydrodeoxygenation were balanced when 180℃ and 5 MPa H_(2)with the alkanes yield of 95%.By extending the substrate to other lignin-derived phenolics and simulated lignin cracked oil,we obtained the polycyclic alkane fuel with high density of 0.918 g·ml^(-1)and calorific value of41.2 MJ·L^(-1).Besides,the fuel has good low-temperature properties(viscosity of 9.3 mm^(2)·s^(-1)at 20℃ and freezing point below-55℃),which is expected to be used as jet fuel.This work provides a promising way for the easy and green production of high-density fuel directly from real lignin oil.

Kinetic-Thermodynamic Promotion Engineering toward High-Density Hierarchical and Zn-Doping Activity-Enhancing ZnNiO@CF for High-Capacity Desalination

Despite the promising potential of transition metal oxides(TMOs)as capacitive deionization(CDI)electrodes,the actual capacity of TMOs electrodes for sodium storage is significantly lower than the theoretical capacity,posing a major obstacle.Herein,we prepared the kinetically favorable Zn_(x)Ni_(1−x)O electrode in situ growth on carbon felt(Zn_(x)Ni_(1−x)O@CF)through constraining the rate of OH^(−)generation in the hydrothermal method.Zn_(x)Ni_(1−x)O@CF exhibited a high-density hierarchical nanosheet structure with three-dimensional open pores,benefitting the ion transport/electron transfer.And tuning the moderate amount of redox-inert Zn-doping can enhance surface electroactive sites,actual activity of redox-active Ni species,and lower adsorption energy,promoting the adsorption kinetic and thermodynamic of the Zn_(0.2)Ni_(0.8)O@CF.Benefitting from the kinetic-thermodynamic facilitation mechanism,Zn_(0.2)Ni_(0.8)O@CF achieved ultrahigh desalination capacity(128.9 mgNaCl g^(-1)),ultra-low energy consumption(0.164 kW h kgNaCl^(-1)),high salt removal rate(1.21 mgNaCl g^(-1) min^(-1)),and good cyclability.The thermodynamic facilitation and Na^(+)intercalation mechanism of Zn_(0.2)Ni_(0.8)O@CF are identified by the density functional theory calculations and electrochemical quartz crystal microbalance with dissipation monitoring,respectively.This research provides new insights into controlling electrochemically favorable morphology and demonstrates that Zn-doping,which is redox-inert,is essential for enhancing the electrochemical performance of CDI electrodes.

Low Stress TSV Arrays for High-Density Interconnection

In three-dimensional(3D)stacking,the thermal stress of through-silicon via(TSV)has a significant influence on chip performance and reliability,and this problem is exacerbated in high-density TSV arrays.In this study,a novel hollow tungsten TSV(W-TSV)is presented and developed.The hollow structure provides space for the release of thermal stress.Simulation results showed that the hollow W-TSV structure can release 60.3%of thermal stress within the top 2 lm from the surface,and thermal stress can be decreased to less than 20 MPa in the radial area of 3 lm.The ultra-high-density(1600 TSV∙mm2)TSV array with a size of 640×512,a pitch of 25 lm,and an aspect ratio of 20.3 was fabricated,and the test results demonstrated that the proposed TSV has excellent electrical and reliability performances.The average resistance of the TSV was 1.21 X.The leakage current was 643 pA and the breakdown voltage was greater than 100 V.The resistance change is less than 2%after 100 temperature cycles from40 to 125℃.Raman spectroscopy showed that the maximum stress on the wafer surface caused by the hollow W-TSV was 31.02 MPa,which means that there was no keep-out zone(KOZ)caused by the TSV array.These results indicate that this structure has great potential for applications in large-array photodetectors and 3D integrated circuits.

Predictive value of intracranial high-density areas in neurological function

BACKGROUND Intracranial high-density areas(HDAs)have attracted considerable attention for predicting clinical outcomes;however,whether HDAs predict worse neurological function and mental health remains controversial and unclear,which requires further investigation.In this prospective study,96 patients with acute ischemic stroke(AIS)who accepted endovascular mechanical thrombectomy(EMT)were included.The enrolled patients underwent cranial computed tomography(CT)examination within 24 hours after EMT.Clinical data in terms of National Institutes of Health Stroke Scale(NIHSS),the 3-month modified Rankin Scale(mRS),self-rating depression scale(SDS),and self-rating anxiety scale(SAS)scores were collected and compared between patients with HDAs and non-HDAs and between patients with good and poor clinical prognosis.Compared to patients without HDAs,patients with HDAs presented severe neurological deficits(admission NIHSS score:18±3 vs 19±4),were more likely to have post-stroke disabilities(mRS<3:35%vs 62%),and suffered more severe depression(SDS score:58±16 vs 64±13)and anxiety disorder(SAS score:52±8 vs 59±10).Compared to patients with a good prognosis,patients with a poor prognosis presented severe neurological deficits(admission NIHSS score:17±4 vs 20±3),were more likely to have HDAs on CT images(64%vs 33%),and suffered more severe depression(SDS score:55±19 vs 65±11)and anxiety(SAS score:50±8 vs 58±12).Multivariate analysis revealed that HDAs were independent nega-tive prognostic factors.CONCLUSION In conclusion,HDAs on CT images predicted poor prognosis and severe depressive and anxiety symptoms in patients with AIS who underwent EMT.

Flash阵列无效块管理

Flash阵列在当今数据存储领域占据着重要地位,提高Flash阵列可靠性的关键在于提出合理的坏块管理方法。针对固有坏块,提出基于整合块的坏块管理方法和基于EEPROM查找表的坏块管理方法。对于在使用过程中出现的突发坏块,提出基于页跳过和页替换的突发坏块管理方法。经过实验分析表明坏块管理方法提高了NAND Flash数据存储的可靠性,在保证存储速度的情况下对NAND Flash存储空间得到最大化利用。

闪光放射治疗(Flash-RT)技术的研究进展

经过多年发展,精准放射治疗技术已广泛应用,但现有技术仍受限于正常组织耐受剂量的限制,无法实现肿瘤治疗的最佳目标。闪光放射治疗(Flash-RT)是一种以超高剂量率射束(UHDR)进行照射的放射治疗技术,能够在显著降低正常组织辐射损伤的同时,最大限度地治疗肿瘤。但直到目前,Flash-RT的生物学机制、关键物理参数及触发机制等尚不明确,其原理及临床转化应用仍处于研究阶段。本综述通过归纳Flash-RT相关研究,阐明Flash-RT研究的技术进展及临床转化应用。

基于有限状态机的电口模块Flash初始化系统设计与实现

在10GBASE-T RJ45 SFP+模块生产过程中,常用的生产方式是在贴片前对Flash进行烧录,当出现固件更新、烧录出错的情况时,模块无法方便地实现反复烧录。分析并提出了一种基于有限状态机的初始化系统,并在自主设计的模块中进行了实验验证。在上位机之中存储固件数据,并对初始化流程进行整体控制;在MCU之中完成一个有限状态机,并通过MDIO控制PHY芯片,将数据写入到Flash之中,同时通过CRC完成固件数据的校验。测试结果表明,该系统能够实现模块在贴片后的重复烧录工作,减少88.55%的返工时间。

Conversion of lignin oil and hemicellulose derivative into high-density jet fuel

Synthesizing high-density fuel from lignocellulose can not only achieve green and low-carbon development,but also expand the feedstock source of hydrocarbon fuel.Here,we reported a route of producing high-density fuel from lignin oil and hemicellulose derivative cyclopentanol through alkylation and hydrodeoxygenation,HY with SiO_(2)/Al_(2)O_(3) molar ratio of 5.3 was screened as the alkylation catalyst in the reaction of model phenolic compounds and mixtures,and the reaction conditions were optimized to achieve conversion of phenolic compounds higher than 87%and selectivity of bicyclic and tricyclic products higher than 99%.Then two phenolic pools simulating the composition of two typic lignin oils were studied to validate the alkylation and analyze the competition mechanism of phenolic compounds in mixture system.Finally,real lignin oil from depolymerized of beech powder was tested,and notably80%of phenolic monomers in the oil were converted into fuel precursor.After hydrodeoxygenation,the alkylated product was converted to fuel blend with a density of 0.91 g/mL at 20℃and a freezing point lower than-60℃,very promising as high density fuel.This work provides a facile and energyefficient way of synthesizing high-performance jet fuel directly from lignocellulosic derivatives,which decreases processing energy consumption and improve the utilization rate of feedstock.

QTL mapping for berry shape based on a high-density genetic map constructed by whole-genome resequencing in grape

Grape berry shape is an important agricultural trait.Clarifying its genetic basis is significant for cultivating grape varieties that meet market demands.However,the current study by forward genetics has not achieved in-depth results.Here,a high-density map was constructed to identify quantitative trait loci(QTLs)for berry shape.A total of 358709 polymorphic SNPs were obtained using whole-genome resequencing(WGS)based on 208 F2 individuals derived from round grape‘E42-6’and oblong grape‘Rizamat’.The 1635.65 cM high-density map was divided into 19 linkage groups with an average distance of 0.37 cM.Using this map,three significant QTLs for fruit shape index(ShI:ratio of berry length to berry width)identified over three years were mapped onto LG4 and LG5,including one stable QTL on Chr5 with the genomic region of 0.47–1.94 Mb.Combining with gene annotation and expression patterns based on RNA-seq data from two contrasting F2 individuals with round and oblong berry(their average ShI was 1.89 and 1.10,respectively)at four developmental stages,four candidate genes were selected from the above QTLs.They were mainly involved in DNA replication,cell wall modification,and phytohormone biosynthesis.Further analysis of RNA-seq data revealed that several important phytohormone synthesis and metabolic pathways were enriched based on differentially expressed genes(DEGs),which was consistent with the results of QTL mapping for genes related to plant hormone biosynthesis in the F2 population.Furthermore,a comparison of plant hormone content showed that there were significant differences in IAA and tZ content between the two contrasting F2 individuals at different developmental stages.Our findings provide molecular insights into the genetic variation in grape berry shape.Stable QTLs and their tightly linked markers offer the possibility of marker-assisted selection to accelerate berry shape breeding.

闪光放射治疗(Flash-RT)在肿瘤治疗中的研究进展

闪光放射治疗(Flash-RT)作为放射治疗技术基础领域的关键性突破,可能引起放疗领域新的大变革。本文综述了Flash-RT在肿瘤治疗中应用和机制探索的最新研究进展。目前研究发现无论是电子束和光子Flash-RT还是质子FlashRT相较于常规剂量率放疗均可以降低对正常组织的损伤,但相关机制还未明确,包括但不限于氧耗竭、DNA损伤、细胞衰老、凋亡和免疫反应等。Flash-RT在肿瘤组织与正常组织损伤间的差异进一步减少了放疗的局限性,相较于常规放疗减少了不良反应和并发症,具有广阔应用前景。

Flash片内数据的高速回读系统设计

针对导弹飞行后数据记录装置的部分接口受损而无法顺利回读飞行数据的问题,研发了可以高速回读存储芯片片内数据的Flash读写设备,在FPGA内置的LVDS收发器基础上利用Aurora协议设计了每通道速率可达1.5625 Gb/s的高速并行收发链路,以及在串/并转换的基础上设计了传输速度较慢的备用串行读数链路。系统实现了高速读数接口和备用读数接口皆可顺利将Flash芯片片内的数据无丢帧地回读传输至测试台进行评估、分析、利用,具有硬件设计简单、回读数据方便快捷的特点。

通过PO-KELM的3D NAND FLASH寿命预测方法研究

随着半导体行业的快速发展,以及各种芯片国产化的趋势越来越明显,3D NAND FLASH作为当前存储器件的重要代表,其寿命预测对于保障系统可靠性至关重要。因此,通过硬件搭建现场可编程门阵列采集平台,对3D NAND FLASH进行特性分析,在不同擦除/写入次数下模拟FLASH可能发生的不同误码情况,分析耐久性、数据保持特性以及读、写干扰特性的变化趋势。同时提出鹦鹉优化器改进的核极限机器学习机,由于核极限学习机参数寻优困难,鹦鹉优化器通过搜索位置提高参数寻优速度和准确度。采用将已使用的循环次数作为输出结果对FLASH进行寿命预测。实验结果表明,相比其他机器学习,采用鹦鹉优化的核极限学习机预测模型精度可以达到98.5%,在提升训练速度和准确度中具有重要的现实意义。

Monitoring Study of Long-Term Land Subsidence during Subway Operation in High-Density Urban Areas Based on DInSAR-GPS-GIS Technology and Numerical Simulation

During subway operation,various factors will cause long-term land subsidence,such as the vibration subsidence of foundation soil caused by train vibration load,incomplete consolidation deformation of foundation soil during tunnel construction,dense buildings and structures in the vicinity of the tunnel,and changes in water level in the stratum where the tunnel is located.The monitoring of long-term land subsidence during subway operation in high-density urban areas differs from that in low-density urban construction areas.The former is the gathering point of the entire urban population.There are many complex buildings around the project,busy road traffic,high pedestrian flow,and less vegetation cover.Several existing items requiremonitoring.However,monitoring distance is long,and providing early warning is difficult.This study uses the 2.8 km operation line between Wulin Square station and Ding’an Road station of Hangzhou Subway Line 1 as an example to propose the integrated method of DInSAR-GPS-GIS technology and the key algorithm for long-term land subsidence deformation.Then,it selects multiscene image data to analyze long-termland subsidence of high-density urban areas during subway operation.Results show that long-term land subsidence caused by the operation of Wulin Square station to Ding’an Road station of Hangzhou Subway Line 1 is small,with maximumsubsidence of 30.64 mm,and minimumsubsidence of 11.45 mm,and average subsidence ranging from 19.27 to 21.33 mm.And FLAC3D software was used to verify the monitoring situation,using the geological conditions of the soil in the study area and the tunnel profile to simulate the settlement under vehicle load,and the simulation results tended to be consistent with the monitoring situation.

Identification of the dominant loop of a dual-loop macro-reentry left atrial flutter without prior intervention using high-density mapping technology:A case report

BACKGROUND Left atrial flutter without prior cardiac interventions is uncommon,especially dual-loop macro-reentry atrial flutter.The critical step to ablate dual-loop macroreentry atrial flutter is to identify the dominant loop and key isthmus.Although entrainment mapping could help identify the dominant loop and key isthmus,it may alter or terminate tachycardia.High-density mapping allows the generation of electroanatomic maps without altering or terminating tachycardia.CASE SUMMARY Here,we report a case of symptomatic left atrial flutter without prior intervention.In this case,high-density mapping revealed a dual-loop macro-reentry around the mitral annulus and central scar of the anterior wall.The propagation result showed that the dominant loop was around the mitral annulus,and the key isthmus was between the central scar and mitral annulus.The atrial flutter terminated successfully after ablation was performed.CONCLUSION In this case,we demonstrate that high-density mapping technology may help identify the dominant loop of dual-loop atrial flutter without entrainment,which makes ablation easier.

适用于Flash型FPGA的宽范围输出负压电荷泵设计

在Flash型FPGA的编程、擦除和回读检验等操作中,需要对Flash单元提供不同的正负高压偏置。提出一种适用于Flash型FPGA的负压电荷泵,该电荷泵采用三阱Flash工艺,消除了衬偏效应和衬底漏电的影响。电荷泵主体采用双支路并联结构,级数为6级。通过参考电压产生电路提供不同的输入参考电压,并结合电荷泵控制系统,可以实现电荷泵输出电压的自由调节,满足Flash型FPGA编程、擦除的负压要求。基于0.13μm Flash工艺对电荷泵进行设计及流片,在200 pF负载电容下,实测得到-5.5 V输出的建立时间仅为8μs,输出纹波为72 mV,-17.5 V输出的建立时间为30μs,输出纹波仅为56 mV,满足Flash型FPGA操作要求。

Global Change in Agricultural Flash Drought over the 21st Century

Agricultural flash droughts are high-impact phenomena, characterized by rapid soil moisture dry down. The ensuing dry conditions can persist for weeks to months, with detrimental effects on natural ecosystems and crop cultivation. Increases in the frequency of these rare events in a future warmer climate would have significant societal impact. This study uses an ensemble of 10 Coupled Model Intercomparison Project(CMIP) models to investigate the projected change in agricultural flash drought during the 21st century. Comparison across geographical regions and climatic zones indicates that individual events are preceded by anomalously low relative humidity and precipitation, with long-term trends governed by changes in temperature, relative humidity, and soil moisture. As a result of these processes, the frequency of both upperlevel and root-zone flash drought is projected to more than double in the mid-and high latitudes over the 21st century, with hot spots developing in the temperate regions of Europe, and humid regions of South America, Europe, and southern Africa.

Research and Application of High-Density Resistivity Method in Seawater Intrusion Investigation in Laizhou Bay

The disaster of seawater intrusion seriously affects people's lives and restricts economic development,so the detection and treatment of seawater intrusion is a long-term task.On the basis of field investigation and water quality analysis,according to the change characteristics of apparent resistivity of groundwater after Cl-reaches 250 mg/L,the theoretical basis for the application of high-density resistivity method was determined,and the characteristic values of apparent resistivity for seawater intrusion interfaces in different geological characteristic regions in Laizhou Bay area were determined by typical profile tests.Combined with water quality investigation and other means,profiles for the high-density resistivity method were arranged,and the interfaces between saline and fresh water were accurately divided.

结合Roberta和Bi-FLASH-SRU的中文事件因果关系抽取

针对现有基于填表的事件关系抽取方法填表数目过多、表格特征获取不充分的问题,本文提出了结合Roberta和Bi-FLASH-SRU的中文事件因果关系抽取方法 TF-ChineseERE.该方法通过制定填表策略,利用文本中已标记关系,将其转化为带有标签的表格;借助Roberta预训练模型和本文提出的双向内置闪电注意力简单循环单元(bidirectional built-in flash attention simple recurrent unit,Bi-FLASH-SRU)获取主客体事件特征,再利用表格特征循环学习模块挖掘全局特征,最后进行表格解码获得事件因果关系三元组.实验采用金融领域两个公开数据集进行验证,结果表明,本文提出的方法 F_(1)值分别达到59.2%和62.5%,且Bi-FLASH-SRU模型训练速度更快,填表数目更少,证明了该方法的有效性.

基于FPGA的FLASH存储器三温功能测试系统设计

由于大容量FLASH存储器全地址功能测试时间较长,在自动化测试设备(ATE)上进行高低温测试时,长时间使用热流罩会导致测试设备运行异常。为把存储器测试过程中耗时最长的全地址功能测试部分从ATE机台上分离出来,设计一个基于FPGA的驱动板卡,结合MSCAN和Checkerboard算法实现了对被测芯片激励信号的施加;然后,设计一个12工位的驱动板卡,实现了在三温条件下的多芯片同步测试;接着,设计一个基于Qt的上位机软件,实现了对测试结果的实时显示与存储;最后,对2 GB大容量FLASH存储器进行测试验证。测试结果表明,与传统的ATE测试相比,基于驱动板和工位板的测试系统可实现对大容量FLASH的全地址功能的高低温测试,且工位板具有的高可扩展性可实现多芯片的同步测试,大幅提高了测试效率。