BACKGROUND:This meta-analysis aimed to assess the efficacy of high-dose glucose-insulinpotassium(GIK) therapy on clinical outcomes in acute coronary syndrome(ACS) patients receiving reperfusion therapy.METHODS:We sear...BACKGROUND:This meta-analysis aimed to assess the efficacy of high-dose glucose-insulinpotassium(GIK) therapy on clinical outcomes in acute coronary syndrome(ACS) patients receiving reperfusion therapy.METHODS:We searched the PubMed,Web of Science,MEDLINE,Embase,and Cochrane Library databases from inception to April 26,2022,for randomized controlled trials(RCTs) that compared high-dose GIK and placebos in ACS patients receiving reperfusion therapy.The primary endpoint was major adverse cardiovascular events(MACEs).RESULTS:Eleven RCTs with 884 patients were ultimately included.Compared with placebos,high-dose GIK markedly reduced MACEs(risk ratio [RR] 0.57,95% confidence interval [95% CI]:0.35 to 0.94,P=0.03) and the risk of heart failure(RR 0.48,95% CI:0.25 to 0.95,P=0.04) and improved the left ventricular ejection fraction(LVEF)(mean difference [MD] 2.12,95% CI:0.40 to 3.92,P=0.02) at 6 months.However,no difference was observed in all-cause mortality at 30 d or 1 year.Additionally,high-dose GIK was significantly associated with increased incidences of phlebitis(RR 4.78,95% CI:1.36 to 16.76,P=0.01),hyperglycemia(RR 9.06,95% CI:1.74 to 47.29,P=0.009) and hypoglycemia(RR 6.50,95% CI:1.28 to 33.01,P=0.02) but not reinfarction,hyperkalemia or secondary reperfusion.In terms of oxidative stress-lowering function,high-dose GIK markedly reduced superoxide dismutase(SOD) activity but not glutathione peroxidase(GSH-Px) or catalase(CAT) activity.CONCLUSION:Patients with ACS receiving reperfusion therapy exhibited a reduction in MACEs and good oxidative stress-lowering eflcacy in response to high-dose GIK.Moreover,with a higher incidence of complications such as phlebitis,hyperglycemia,and hypoglycemia.Furthermore,there were no observed survival benefits associated with high-dose GIK.More trials with long-term follow-up are still needed.展开更多
针对等矩柱状投影(equirectangular projection,ERP)全景视频多功能视频编码(versatile video coding,VVC)帧内编码复杂度过高的问题,提出一种编码单元(coding unit,CU)快速划分算法。根据ERP采样特性,将编码帧分为不同纬度区域。基于...针对等矩柱状投影(equirectangular projection,ERP)全景视频多功能视频编码(versatile video coding,VVC)帧内编码复杂度过高的问题,提出一种编码单元(coding unit,CU)快速划分算法。根据ERP采样特性,将编码帧分为不同纬度区域。基于不同纬度区域CU四叉树深度的分布特性和相邻CU的相关性,对当前CU的划分模式进行提前终止决策;利用梯度差异评估当前CU纹理特性,跳过冗余的水平或垂直划分模式。针对纹理模糊CU,通过纬度采样权重加权的二次比较,判断是否跳过垂直划分模式;利用二维哈尔小波变换系数评估当前CU子块间的差异,判断是否跳过三叉树划分模式。实验结果表明,在全帧内模式下,与VVC官方测试平台相比,所提算法能节省43.85%的编码时间,码率仅增加0.85%,视频质量没有明显下降。展开更多
基金supported by grants from the National Natural Science Foundation of China (82370378 and 82070388)Taishan Scholar Program of Shandong Province (tsqn202211310)National Natural Science Foundation of Shandong Province (ZR2020MH035)。
文摘BACKGROUND:This meta-analysis aimed to assess the efficacy of high-dose glucose-insulinpotassium(GIK) therapy on clinical outcomes in acute coronary syndrome(ACS) patients receiving reperfusion therapy.METHODS:We searched the PubMed,Web of Science,MEDLINE,Embase,and Cochrane Library databases from inception to April 26,2022,for randomized controlled trials(RCTs) that compared high-dose GIK and placebos in ACS patients receiving reperfusion therapy.The primary endpoint was major adverse cardiovascular events(MACEs).RESULTS:Eleven RCTs with 884 patients were ultimately included.Compared with placebos,high-dose GIK markedly reduced MACEs(risk ratio [RR] 0.57,95% confidence interval [95% CI]:0.35 to 0.94,P=0.03) and the risk of heart failure(RR 0.48,95% CI:0.25 to 0.95,P=0.04) and improved the left ventricular ejection fraction(LVEF)(mean difference [MD] 2.12,95% CI:0.40 to 3.92,P=0.02) at 6 months.However,no difference was observed in all-cause mortality at 30 d or 1 year.Additionally,high-dose GIK was significantly associated with increased incidences of phlebitis(RR 4.78,95% CI:1.36 to 16.76,P=0.01),hyperglycemia(RR 9.06,95% CI:1.74 to 47.29,P=0.009) and hypoglycemia(RR 6.50,95% CI:1.28 to 33.01,P=0.02) but not reinfarction,hyperkalemia or secondary reperfusion.In terms of oxidative stress-lowering function,high-dose GIK markedly reduced superoxide dismutase(SOD) activity but not glutathione peroxidase(GSH-Px) or catalase(CAT) activity.CONCLUSION:Patients with ACS receiving reperfusion therapy exhibited a reduction in MACEs and good oxidative stress-lowering eflcacy in response to high-dose GIK.Moreover,with a higher incidence of complications such as phlebitis,hyperglycemia,and hypoglycemia.Furthermore,there were no observed survival benefits associated with high-dose GIK.More trials with long-term follow-up are still needed.
文摘针对等矩柱状投影(equirectangular projection,ERP)全景视频多功能视频编码(versatile video coding,VVC)帧内编码复杂度过高的问题,提出一种编码单元(coding unit,CU)快速划分算法。根据ERP采样特性,将编码帧分为不同纬度区域。基于不同纬度区域CU四叉树深度的分布特性和相邻CU的相关性,对当前CU的划分模式进行提前终止决策;利用梯度差异评估当前CU纹理特性,跳过冗余的水平或垂直划分模式。针对纹理模糊CU,通过纬度采样权重加权的二次比较,判断是否跳过垂直划分模式;利用二维哈尔小波变换系数评估当前CU子块间的差异,判断是否跳过三叉树划分模式。实验结果表明,在全帧内模式下,与VVC官方测试平台相比,所提算法能节省43.85%的编码时间,码率仅增加0.85%,视频质量没有明显下降。
