Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study

BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory condition requiring continuous treatment and monitoring.There is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thiopurines on vedolizumab trough concentrations is unknown.AIM To investigate the exposure-response relationship of vedolizumab and the impact of thiopurine withdrawal in UC patients who have achieved sustained clinical and endoscopic remission during maintenance therapy.METHODS This is a post-hoc analysis of prospective randomized clinical trial(VIEWS)involving UC patients across 8 centers in Australia from 2018 to 2022.Patients in clinical and endoscopic remission were randomized to continue or withdraw thiopurine while receiving vedolizumab.We evaluated vedolizumab serum trough concentrations,presence of anti-vedolizumab antibodies,and clinical outcomes over 48 weeks to assess exposure-response asso-ciation and impact of thiopurine withdrawal.RESULTS There were 62 UC participants with mean age of 43.4 years and 42%were females.All participants received vedolizumab as maintenance therapy with 67.7%withdrew thiopurine.Vedolizumab serum trough concentrations remained stable over 48 weeks regardless of thiopurine use,with no anti-vedolizumab antibodies detected.Pa-tients with clinical remission had higher trough concentrations at week 48.In quartile analysis,a threshold of>11.3μg/mL was associated with sustained clinical remission,showing a sensitivity of 82.4%,specificity of 60.0%,and an area of receiver operating characteristic of 0.71(95%CI:0.49-0.93).Patients discontinuing thiopurine required higher vedolizumab concentrations for achieving remission.CONCLUSION A positive exposure-response relationship between vedolizumab trough concentrations and UC outcomes suggests that monitoring drug levels may be beneficial.While thiopurine did not influence vedolizumab levels,its with-drawal may necessitate higher vedolizumab trough concentrations to maintain remission.

Impact of Pollutant Concentration and Particle Deposition on the Radiative Flow of Casson-Micropolar Fluid between Parallel Plates

Assessing the behaviour and concentration of waste pollutants deposited between two parallel plates is essential for effective environmental management.Determining the effectiveness of treatment methods in reducing pollution scales is made easier by analysing waste discharge concentrations.The waste discharge concentration analysis is useful for assessing how effectively wastewater treatment techniques reduce pollution levels.This study aims to explore the Casson micropolar fluid flow through two parallel plates with the influence of pollutant concentration and thermophoretic particle deposition.To explore the mass and heat transport features,thermophoretic particle deposition and thermal radiation are considered.The governing equations are transformed into ordinary differential equations with the help of suitable similarity transformations.The Runge-Kutta-Fehlberg’s fourthfifth order technique and shooting procedure are used to solve the reduced set of equations and boundary conditions.The integration of a neural network model based on the Levenberg-Marquardt algorithm serves to improve the accuracy of predictions and optimize the analysis of parameters.Graphical outcomes are displayed to analyze the characteristics of the relevant dimensionless parameters in the current problem.Results reveal that concentration upsurges as the micropolar parameter increases.The concentration reduces with an upsurge in the thermophoretic parameter.An upsurge in the external pollutant source variation and the local pollutant external source parameters enhances mass transport.The surface drag force declines for improved values of porosity and micropolar parameters.

Design of Reflective Concentrator Model with Application for Concentrator Photovoltaic System

The nonuniform irradiation in the standard photovoltaic（PV） cells causes their relatively high series resistance,which results in a considerably lowered efficiency of PV cells.Currently the concentrator of uniform irradiation designed for concentrator photovoltaic is rare in China and lack sufficient theoretical research.In this paper,a systematic research on the solar reflective concentrator is conducted.A novel structure for a solar reflective concentrator is designed with the application of a flat mirror matrix to concentrate the sunlight for concentrator photovoltaic（CPV） systems.Sunlight beams are focused through the reflection of the mirror array on the solar cell to generate electricity.The concentrator is capable of producing much more uniform sunlight with a certain concentration ratio.The design scheme includes laying out the flat mirrors,optimizing the optical pathway and the parameters of each mirror.The prototype of the CPV system was installed at Nanjing,China.In the configuration of the prototype,it is composed of 24 pieces parallelogram flat mirrors,which are arranged into a total reflective array of 5 rows and 5 columns.In comparison with the parabolic trough concentrator,the experimental measurements verify such design has high efficiency.The concentrator model of a flat mirror matrix and the proposed new design method will lay a solid foundation for designing the concentrator of uniform irradiation.

Three-dimensional photoelasticity analysis of Nitinol Patellar Concentrator for treating patellar fractures

Objective: To analyze the biomechanical elements of Nitinol Patellar Concentrator (NT-PC) in heating commi nuted patellar fractures. Methods: The epoxy resin three dimensional photoelasticity pobal model was loaded with Nitinol Patellar Connector and frozen. After dividing layer, photographing and tracing, iterative method was used to calculate the stress value of every tuteed node. Rasults: Stress values of 1 262 nodes scattered in 12 layers were obtained The stress distribution indicated that an overall stress field was yield when the NT-PC fixated the patellar model, and there existed fixative stress in the facies articularis and distal pole of the patellar model. Conclusion: The NT-PC has evident therapeutic effect for the comminuted patellar fractures. The existing stress is helpful in maintaining anatomical reduction and enhancing fracture healing.

Application of millimeter-sized polymer cylindrical lens array concentrators in solar cells

A unique method is proposed to encapsulate solar cells and improve their power conversion efficiency by using a millimeter-sized cylindrical lens array concentrator. Millimeter-sized epoxy resin polymer（ERP） cylindrical lens array concentrators are fabricated by the soft imprint technique based on polydimethylsiloxane stamps. The photovoltaic measurements show that millimeter-sized ERP cylindrical lens array concentrators can considerably improve the power conversion efficiency of silicon solar cells. The validity of the proposed method is proved by the coupled optical and electrical simulations. The designed solar cell devices with the advantages of high-efficiency and convenient cleaning are very useful in practical applications.

Effects of different poses and wind speeds on flow field of dish solar concentrator based on virtual wind tunnel experiment with constant wind

In order to improve structure performance of the dish solar concentrator,a three-dimensional model of dish solar concentrator was established based on the high-precision numerical algorithms.And a virtual wind tunnel experiment with constant wind is adopted to investigate the pressure distribution of the reflective surface,velocity distribution of the fluid domain for the dish solar concentrator in different poses and wind speeds distribution.Some results about wind pressure distribution before and after dish solar concentrator surface and wind load velocity distribution in the entire fluid domain had been obtained.In particular,it is necessary to point out that the stiffness at the center of the dish solar concentrator should be relatively raised.The results can provide a theoretical basis for the improvement of solar concentrator dish structure as well as the failure analysis of dish solar concentrator in engineering practice.

Spectral Transmittance of Di-methyl Silicon Oil as a Heat Transfer Material for Concentrator Solar Cells

The accelerated life test was carded out to investigate the change of spectral transmittance of di-methyl silicon oil and the effects on the electrical performance of silicon solar cell. The di-methyl silicon oil samples be- fore and after accelerated life test were analyzed by FT-IR, GC-MS and LC-MS. The ring compounds and linear compounds with larger molecular weight were detected. The spectral transmittance of di-methyl silicon oil de- creased because the chromophore and auxochrome of the products made a sunlight receive decrease on the surface of the solar celt, and resulted in the reduction of cell performance. According to the decrease of spectral transmit- tance of di-methyl silicon oil, two recovery methods were proposed. The results showed that extraction was supe- rior to vacuum distillation in recovering the aged di-methyl silicon oil.

Metals Recovery from Fine Printed Circuit Boards Using Falcon SB Concentrator

Physical methods show great potential and advantages on comprehensive reutilization of waste printed circuit boards (PCBs) because of lower investment and operation cost, higher efficiency and environment friendliness. However, metals contained in fine fraction of PCBs cannot be recovered effectively by conventional equipments such as high tension electrostatic separator or shaking table. In the paper, this conundrum was resolved successfully with the enhanced Falcon SB concentrator. The separation mechanism of Falcon SB concentrator was analyzed and main factors affecting separation efficiency such as magnitude of rotation frequency of bowl, water counter pressure and slurry concentration of feed were studied and interaction of factors above also were investigated using Design-Expert software. Experiment results show that complete liberation degree and great difference of density between metals and nonmetals are suitable to recover metals from -74 μm PCBs using enhanced Falcon SB concentrator and 80.77 % integration efficiency can be achieved when slurry concentration of feed is 40 g/L with the water counter pressure of 0.01 MPa and rotation frequency of 50 Hz.

System design and measurements of flux concentrator and its solid-state modulator for CEPC positron source

Positron sources are one of the most important components of the injector of a circular electron positron collector(CEPC).The CEPC is designed as an e^(+)e^(−)collider for a Higgs factory.Its accelerator system is composed of 100-km-long storage rings and an injector.The design goal of the positron source is to obtain positron beams with a bunch charge of 3 nC.The flux concentrator(FC)is one of the cores of the positron source.This paper reports the design,development,and measurements of an FC prototype system.The prototype includes an FC and an all-solid-state high-current pulse modulator.Preliminary tests show that the peak current on the FC can reach 15.5 kA,and the peak magnetic field can reach 6.2 T.The test results are consistent with the theoretical simulation.The FC system fulfills the requirements of the CEPC positron source as well as provides a reference for the development of similar devices both domestically and abroad.

Thermal modeling and the optimized design of metal plate cooling systems for single concentrator solar cells

A metal plate cooling model for 400~ single concentrator solar cells was established. The effects of the thickness and the radius of the metal plate, and the air environment on the temperature of the solar cells were analyzed in detail. It is shown that the temperature of the solar cells decreased sharply at the beginning, with the increase in the thickness of the metal plate, and then changed more smoothly. When the radius of the metal plate was 4 cm and the thickness increased to 2 mm or thicker, the temperature of the solar cell basically stabilized at about 53℃. Increasing the radius of the metal plate and the convective transfer coefficient made the temperature of the solar cell decrease remarkably. The effects of A1 and Cu as the metal plate material on cooling were analyzed contrastively, and demonstrated the superiority of A1 material for the cooling system. Furthermore, considering cost reduction, space holding and the stress of the system, we optimized the structural design of the metal plate. The simulated results can be referred to the design of the structure for the metal plate. Finally, a method to devise the structure of the metal plate for single concentrator solar cells was given.

New design of ferroelectric solar cell combined with luminescent solar concentrator

A new transparent photovoltaic panel composed of a luminescent solar concentrator and Al/BaTiO3/ZnO/Pt ferroelectric solar cells is presented,in which a portion of the incoming solar illumination is converted by the fluorophores to ultraviolet(UV)light which is then absorbed by ZnO.Firstly,the solar cells are simulated using Atlas-Silvaco.Then,the panel is modelled based on the obtained solar cell characteristics.This panel would be of great importance for building integrated photovoltaics domain because of its high transparency.

Thermal modeling optimization and experimental validation for a single concentrator solar cell system with a heat sink

A single concentrator solar cell model with a heat sink is established to simulate the thermal performance of the system by varying the number, height, and thickness of fins, the base thickness and thermal resistance of the thermal conductive adhesive. Influence disciplines of those parameters on temperatures of the solar cell and heat sink are obtained. With optimized number, height and thickness of fins, and the thickness values of base of 8, 1.4 cm, 1.5 mm, and 2 mm, the lowest temperatures of the solar cell and heat sink are 41.7 ~C and 36.3 ~C respectively. A concentrator solar cell prototype with a heat sink fabricated based on the simulation optimized structure is built. Outdoor temperatures of the prototype are tested. Temperatures of the solar cell and heat sink are stabilized with time continuing at about 37 ℃-38 ℃ and 35 ℃-36 ℃respectively, slightly lower than the simulation results because of effects of the wind and cloud. Thus the simulation model enables to predict the thermal performance of the system, and the simulation results can be a reference for designing heat sinks in the field of single concentrator solar cells.

A compact and high-power silicon-wafer solar strip-cells-array module integrated with an array concentrator

A compact, low-cost and high-output-power silicon-wafer solar strip-cells-array module （SCAM） wus experimentally demonstrated. The proposed SCAM consisted mainly of a silicon-wafer strip-cell sparse array and low-concentration- ratio array concentrator based on an epoxy resin polymer （ERP） cylindrical piano-convex lens. A polymer replication process based on a polydimethylsiloxane mold was used to fabricate the ERP lens array concentrator. The results show that 46.94% of the silicon-wafer cell was saved in the designed SCAM. Moreover, the output power of the SCAM with a low concentration ratio of 8 suns was improved by 8.6%, compared with a whole piece of a conventional silicon-wafer solar cell with the same area as the module. The proposed method encapsulating solar cells provides a means to reduce the usage of silicon cells in modules as well as improving the output power of modules.

Characteristics and Energy Efficiency of the Industrial Concentrators with Thermocompression

An analysis of the thermal characteristics of the industrial thermocompression heat pump systems is presented in this paper By using thermocompression, waste heat is thermotransformed to a higher temperature level to be convenient for its usage in thermal processes. The thermocompression heat pumps can be optimally applied in various industrial plants （production of fruit, grape and tomato concentrates, in beer, sugar and dairy industries, in chemical and pharmaceutical industries etc.）. The range of optimal application of the turbo compressor, screw compressor and ejector thermocompression is estimated. The complex thermal and flow phenomena in the processes of thermocompression, evaporation and condensation are discussed. The theoretical and experimental results of the investigations on the experimental grape vacuum concentrator and on the industrial NaOH concentrator are presented. A significant increment of the energy efficiency can be achieved by optimal application of the thermocompression in the thermal concentrating processes. A significant feature and great advantage of the concentrating technology with thermocompression are a possibility for realization of the low temperature concentrating processes, which is very important for the quality of many concentrating products with high energy efficiency technology.

Power Output Improvement of PV Module for Agricultural Use by Using Inexpensive Sunlight Concentrator

PV modules are used as stand alone power sources for agricultural equipments such as lifting pumps in farms, where the power infrastructure is not yet improved. In order to expand the agricultural use of PV module, the cost of PV generation should be reduced. In this paper, the power output performance of a commercial PV module was improved by using a sunlight concentrator that could be assembled inexpensively and a simple sun-tracking method.

A Facile Li_(2)TiO_(3) Surface Modification to Improve the Structure Stability and Electrochemical Performance of Full Concentration Gradient Li-Rich Oxides

Full concentration gradient lithium-rich layered oxides are catching lots of interest as the next generation cathode for lithium-ion batteries due to their high discharge voltage,reduced voltage decay and enhanced rate performance,whereas the high lithium residues on its surface impairs the structure stability and long-term cycle performance.Herein,a facile multifunctional surface modification method is implemented to eliminate surface lithium residues of full concentration gradient lithium-rich layered oxides by a wet chemistry reaction with tetrabutyl titanate and the post-annealing process.It realizes not only a stable Li_(2)TiO_(3)coating layer with 3D diffusion channels for fast Li^(+)ions transfer,but also dopes partial Ti^(4+)ions into the sub-surface region of full concentration gradient lithium-rich layered oxides to further strengthen its crystal structure.Consequently,the modified full concentration gradient lithium-rich layered oxides exhibit improved structure stability,elevated thermal stability with decomposition temperature from 289.57℃to 321.72℃,and enhanced cycle performance(205.1 mAh g^(-1)after 150 cycles)with slowed voltage drop(1.67 mV per cycle).This work proposes a facile and integrated modification method to enhance the comprehensive performance of full concentration gradient lithium-rich layered oxides,which can facilitate its practical application for developing higher energy density lithium-ion batteries.

Test Standards for Direct Steam Generating Solar Concentrators

There are a few standards reported in the literature for testing and evaluation of thermal performance of solar concentrators based on sensible heating of working fluid. The preceding standard measures only the cooking efficiency and cooking capacity. Apart from thermal efficiency, there is an imperative need for other important parameters of the solar concentrators such as its stagnation temperature, cooking capacity, cost per watts delivered, weight of the cooker, ease of handling and aesthetics. The characterization of a concentrator at its operating temperature settles appropriate size and type of concentrator for any thermal application. The performance test is conducted at Chandwad (20.3292°N, 74.2444°E), Maharashtra and the proposed protocol aims for evaluation of thermal performance of solar cooking system and standardization of reporting the test results so that anyone can easily recognize and use it.

Comparison of Collocation of Solar Concentrators with Bean Fields in Mexico and Potato Fields in Canada and Micromechanical Equipment for Their Production

There is an increased interest in renewable forms of energy across the world,with solar energy being one of the most promising forms.Over the last couple of years,we have developed the MET(MicroEquipment Technology).As an application of the MET,we selected the task of production of solar concentrators.Different types of solar concentrators with flat mirrors were developed and prototypes of these solar concentrators(approximately 1 m in diameter)were made.The proposed solar concentrators were developed on the basis of concentrators patented in Mexico,Spain,and USA.It may be possible to install these concentrators on horizontal roofs of buildings.However,installing them on agricultural fields has become the new trend.As an example,we propose to use them in the potato fields in Canada to obtain dual advantages such as for electrical energy generation and for the minimal loss of agricultural harvest.The second example was analyzed for bean fields,in Mexico.In this paper,we describe the main results in regard to microequipment development for solar concentrator production,several prototypes of solar concentrators with flat mirrors and their co-location and agricultural fields.

Trends of surface ozone based on hourly concentrations in the Beijing–Tianjin–Hebei region during 2017–2021

As a typical secondary air pollutant,surface ozone has been monitored routinely since 2013 in China.Most studies on the spatiotemporal variation of ozone have been centered around the daily maximum 8-h average,with little attention paid to the trends of hourly ozone,especially hourly ozone exceedances.Focusing on hourly ozone exceedances and peak values,the spatiotemporal trends of hourly ozone at 77 sites in 13 cities of the Beijing-Tianjin-Hebei(BTH)region during 2017-2021 were analyzed in this study.The number of hours with exceedances(N_(H200))in 2019 was nearly three times that of 2021.On a five-year average,the percentage of cumulative NH200 in June accounted for up to 40.5%of all hourly exceedances.Cities in central Hebei Province had the highest cumulative annual N_(H200).June had the highest average hourly ozone exceeded multiples of 0.158.The top two cities with the highest average exceeded multiple were Tangshan(0.166)and Beijing(0.158).Tangshan and Xingtai ranked as the top two in terms of the mean of the 10 highest daily maximum ozone concentrations(MTDM),with 286.74 and 285.37μg m^(−3),respectively.The gap between the MTDM and the daily maximum of hourly ozone averaged over all sites had narrowed to 97.88μg m^(−3) in 2021,much lower than that in other years,which indicated that the stability and convergence of ozone pollution in BTH region had been enhanced in 2021 to some extent.

Dynamics and genetic regulation of macronutrient concentrations during grain development in maize

Nitrogen(N), phosphorus(P), and potassium(K) are essential macronutrients that are crucial not only for maize growth and development, but also for crop yield and quality. The genetic basis of macronutrient dynamics and accumulation during grain filling in maize remains largely unknown. In this study, we evaluated grain N, P, and K concentrations in 206 recombinant inbred lines generated from a cross of DH1M and T877 at six time points after pollination. We then calculated conditional phenotypic values at different time intervals to explore the dynamic characteristics of the N, P, and K concentrations. Abundant phenotypic variations were observed in the concentrations and net changes of these nutrients. Unconditional quantitative trait locus(QTL) mapping revealed 41 non-redundant QTLs, including 17, 16, and 14 for the N, P, and K concentrations, respectively. Conditional QTL mapping uncovered 39 non-redundant QTLs related to net changes in the N, P, and K concentrations. By combining QTL, gene expression, co-expression analysis, and comparative genomic data, we identified 44, 36, and 44 candidate genes for the N, P, and K concentrations, respectively, including GRMZM2G371058 encoding a Doftype zinc finger DNA-binding family protein, which was associated with the N concentration, and GRMZM2G113967encoding a CBL-interacting protein kinase, which was related to the K concentration. The results deepen our understanding of the genetic factors controlling N, P, and K accumulation during maize grain development and provide valuable genes for the genetic improvement of nutrient concentrations in maize.