High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination modalities.However,it can be diagnosed by pancreatic juice cytology from indirect findings.Most previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic cysts.MRCP revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD dilatation.Thus,course observation was performed.After 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic cyst.We performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology examination.We performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade PanIN.Pancreatic parenchyma invasion was not observed,and curative resection was achieved.CONCLUSION High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

Management of retroperitoneal high-grade serous carcinoma of unknown origin:A case report

BACKGROUND Retroperitoneal high-grade serous carcinoma(HGSC)of unknown origin is a sporadic tumor that can originate from ovarian cancer.Herein,we report the case of a woman with retroperitoneal HGSC of unknown origin and describe how she was diagnosed and treated.CASE SUMMARY A 71-year-old female presented with the tumor marker CA125 elevated to 1041.9 U/mL upon a regular health examination.Computed tomography revealed retroperitoneal lymph node enlargement.Subsequently,positron emission tomography scanning revealed lesions with increased F-18 fluorodeoxyglucose uptake at the nodes.As a result,she underwent laparoscopic lymph node resection,and pathology revealed metastatic adenocarcinoma with CK7(+),PAX8(+),WT1(+),PR(-),and p53 mutational loss of expression,indicating that the origin may be from the adnexa.The patient was admitted to our ward and underwent laparoscopic staging;however,the pathological results were negative.Under the suspicion of retroperitoneal HGSC of unknown origin,chemotherapy and targeted therapy were initiated.Tumor marker levels decreased after treatment.CONCLUSION We present a case of HGSC of unknown origin managed using retroperitoneal lymphadenectomy,staging surgery,chemotherapy,and targeted therapy.

High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality:A case report

BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnormalities and fallopian tube highgrade serous carcinoma(HGSC)in a young woman.CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion.Upon arrival at the emergency room,her abdomen appeared ovoid and distended with palpable shifting dullness.Ascites were identified through abdominal ultrasound,and computed tomography revealed an omentum cake and an enlarged bilateral adnexa.Blood tests showed elevated CA-125 levels.Paracentesis was conducted,and immunohistochemistry indicated that the cancer cells favored an ovarian origin,making us suspect ovarian cancer.The patient underwent debulking surgery,which led to a diagnosis of stage IIIC HGSC of the fallopian tube.Subsequently,the patient received adjuvant chemotherapy with carboplatin and paclitaxel,resulting in stable current condition.CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC.UBE2D3 may affect crucial cancer-related pathways,including P53,BRCA,cyclin D,and tyrosine kinase receptors,thereby possibly contributing to cancer development.In addition,ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.

Transformation of marginal zone lymphoma into high-grade B-cell lymphoma expressing terminal deoxynucleotidyl transferase:A case report

BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 rearrangements.HGBL is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)transformation.HGBL often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate chemotherapy.CASE SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase expression.Gene analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary tumors.The chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and obinutuzumab.The patient tolerated treatment well,and reached partial response.The patient had recurrence of hepatocellular carcinoma and died of multifunctional organ failure.He survived for 12 months after diagnosis.CONCLUSION Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy.

Steel bar penetrating cervical spinal canal without neurological injury:A case report

BACKGROUND We report a rare case of cervical spinal canal penetrating trauma and review the relevant literatures.CASE SUMMARY A 58-year-old male patient was admitted to the emergency department with a steel bar penetrating the neck,without signs of neurological deficit.Computed tomography(CT)demonstrated that the steel bar had penetrated the cervical spinal canal at the C6–7 level,causing C6 and C7 vertebral body fracture,C6 left lamina fracture,left facet joint fracture,and penetration of the cervical spinal cord.The steel bar was successfully removed through an open surgical procedure by a multidisciplinary team.During the surgery,we found that the cervical vertebra,cervical spinal canal and cervical spinal cord were all severely injured.Postoperative CT demonstrated severe penetration of the cervical spinal canal but the patient returned to a fully functional level without any neurological deficits.CONCLUSION Even with a serious cervical spinal canal penetrating trauma,the patient could resume normal work and life after appropriate treatment.

Development of top high-grade non-grain-oriented silicon steels at Baosteel

The development, production and application of top high-grade non-grain-oriented （NGO） silicon steels at Baosteel were introduced in this paper. Top high grades refer to the highest grades in the intemational silicon steel product standard and above. B35A230 and B50A250 were developed at Baosteel in 2009 and have been used in inverter compressors for air-conditioners, small transformers and big hydropower generators in the Three Gorges project. Small- batch production of B35A210 and B50A230, which exceed the highest grades listed in the intemational silicon steel product standard,began in 2010. That was a breakthrough in the silicon steel making history in China. Presently,Baosteel＇ s high- grade NGO products have passed the strict qualifications of the three major electric power equipment manufacturers in China and the leading international power equipment suppliers like ALSTOM, GE, SIEMENS, VESTAS, etc. These products are characterized by low iron loss, low anisotropy, good punchability and a high lamination factor. They have been used in the 770 MW hydropower generator at Xiluodu Power Station in the three gorges area, 1 000 MW thermal power generators and 2.5 MW wind power generators.

Synchronous but separate neuroendocrine tumor and high-grade dysplasia/adenoma of the gall bladder:A case report

BACKGROUND Gall bladder neuroendocrine tumors(GB-NETs)are rare,accounting for less than 0.5%of all NETs.They usually lack specific symptoms and are difficult to diagnose preoperatively.In most cases,GB-NETs are incidentally found after cholecystectomy for large polyps or cholelithiasis,causing acute or chronic cholecystitis.The coexistence of GB-NET and GB adenocarcinoma is very rare.CASE SUMMARY We report a case of synchronous but separate GB-NET and adenoma with high-grade dysplasia in a patient who had undergone surgery for a progressively growing GB polypoid lesion.To the best of our knowledge,simultaneous separation of NETs and cancer in the GB has not been reported.CONCLUSION Coexistent GB carcinoid tumor and adenocarcinoma is rare.A surveillance program is needed for these large GB polyps.

Metabasic Dyke Swarms in a High-Grade Metamorphic Terrane——A Case Study in the Taipingzhai-Jinchangyu Area,Eastern Hebei Province

Geological and petrological studies indicate that three phases of metabasic dykes are present in theTaipingzhai-Jinchangyu area within the high-grade metamorphic terrane of eastern Hebei. Garnet andhornblende in metabasic dykes of the second and third phases occur separately, forming two mineral aggregateareas gl+cpx+pl±hy and hb+cpx+pl-hy. P_(H_2O) in the rocks appears to be the main factor controlling theformation of the two aggregate areas. Both were formed simultaneously at the same metamorphic temperature. The second-phase basic dykes underwent metamorphism of pyroxene-granulite facies at a temperature ofsome 825C: later the dykes, together with the third-phase basic dykes experienced metamorphism ofamphibole-granulite facies at a temperature of about 750C under pressure of 0.9GPa.

Effect of Plastic Deformation and H_2S on Dynamic Fracture Toughness of High Strength Casing Steel

The effects of plastic deformation and H2 S on fracture toughness of high strength casing steel（C110 steel） were investigated. The studied casing specimens are as follows： original casing, plastic deformation（PD） casing and PD casing after being immersed in NACE A solution saturated with H2S（PD＋H2S）. Instrumented impact method was employed to evaluate the impact behaviors of the specimens, meanwhile, dynamic fracture toughness（JId） was calculated by using Rice model and Schindler model. The experimental results show that dynamic fracture toughness of the casing decreases after plastic deformation. Compared with that of the original casing and PD casing, the dynamic fracture toughness decreases further when the PD casing immersed in H2 S, moreover, there are ridge-shaped feature and many secondary cracks present on the fracture surface of the specimens. Impact fracture mechanism of the casing is proposed as follows： the plastic deformation results in the increase of defect density of materials where the atomic hydrogen can accumulate in reversible or irreversible traps and even recombine to form molecular hydrogen, subsequently, the casing material toughness decreases greatly.

Experiment and simulation of launching process of a small-diameter steel cartridge case

In order to explore the rules of the deformation force during the launching of a small-diameter steel cartridge, the semi-closed bomb test method is used to test the greatest strains on chamber outer wall under the different chamber pressures. The pressure curves of cartridge chamber are measured in experiment, and the tensile test data of cartridge are loaded into the numerical calculation to compare with the experimental data. The conclusion was obtained that the calculated results match better with the experimental results by considering strain rate bilinear kinematic hardening material constitutive model. The forces on the various parts of the cartridge during launching and their deformation rules are achieved, in which the equivalent plastic strain decreases and the cylinder ring withstands the maximum equivalent stress when the cartridge case clings to the bore from the mouth to the bottom.

Industrial Experience with Case Hardening of Stainless Steels by Solution Nitriding

SolNit(R) is a novel heat treatment to case harden stainless steels with nitrogen instead of carbon. The calculated equilibrium pressure of N2 corresponds well with the nitrogen content in the steel surface. The process is carried out in vacuum furnaces with pressurized gas quenching. Numerous parts of different stainless steels have been successfully SolNit(R) treated in industry leading to superior properties in respect to hardness/strength and corrosion

Penile and scrotal strangulation by stainless steel rings in an human immunodeficiency virus positive man: A case report

BACKGROUND Penoscrotal constriction devices are either used as autoerotic stimuli or to increase sexual pleasure or performance by maintaining an erection for a longer period,and a variety of metallic and non-metallic objects are used.On the other hand,penile strangulation is a rare urologic emergency that requires prompt evaluation and intervention to prevent long-term complications.The goal of treating penile incarceration is to remove the foreign object as soon as possible.On the other hand,removal can be very challenging,and often requires resourcefulness and a multidisciplinary approach.CASE SUMMARY A 47-year-old man who has sex with men was transferred to our hospital for persistent phallodynia and scrotal pain,accompanying swelling due to strangulation by stainless steel rings.His medical history included acquired immunodeficiency syndrome.One day prior,he had put three stainless steel rings on his penis and scrotum before sexual intercourse.After sexual intercourse,he was unable to remove them,due to swelling of his penis and scrotum.The swelling persisted,and he felt pain in the affected area the next day,then he was transferred to our hospital by ambulance.The emergency department found that his penis and scrotum were markedly engorged and swollen.We established a diagnosis of penile and scrotal strangulation by stainless steel rings.We unsuccessfully attempted to cut the rings using a cutter,then requested a rescue team via emergency medical service.They cut through each ring in two places,using an electric-powered angle grinder,and successfully removed all of the pieces.Finally,he was discharged and went home.CONCLUSION We report the first case of penile and scrotal strangulation by stainless steel rings in an human immunodeficiency virus positive person.

高温许用应力下调对CASE 2180钢使用的影响

介绍了美国机械工程师协会(American Society of Mechanical Engineers,ASME)和日本经济贸易产业省(Ministry of Economy,Trade and Industry,METI)相关标准对CASE2180钢高温许用应力进行下调的情况,并对高温许用应力修正后的CASE2180钢管的最小壁厚进行核算,从而说明高温许用应力下调对CASE2180钢的影响及存在的问题。

基于Dynamo和Advance Steel的水轮机蜗壳快速设计方法

蜗壳是水电站中常用的一种异形结构,其设计质量直接影响水电站的发电效率。为提高蜗壳设计效率及解决蜗壳后续加工的难点,综合利用Dynamo for Revit和Advance Steel软件各自的优点,提出了一种适用于水轮机蜗壳的快速设计方法。利用Dynamo的参数化建模功能,结合蜗壳设计公式,实现了蜗壳结构的快速化建模;再选用合理的数据交换格式将模型导入Advance Steel,经过处理后即可生成蜗壳钢结构加工所需要的各类视图及数据驱动文件,可直接用于蜗壳加工。所提出的方法也可推广应用于水利水电工程中类似异形钢结构部件的设计及加工。

Large pelvic mass arising from the cervical stump: A case report

BACKGROUND A large cervical cyst with a cervical high-grade squamous intraepithelial lesion arising from the cervical stump is rare.After supracervical hysterectomy,there is a risk of various lesions occurring in the cervical stump.We review the types and characteristics of cervical stump lesions and compare total hysterectomy with subtotal hysterectomy.Gynecologists should choose the most suitable surgical method based on both the patient’s condition and wishes.If the cervix is retained,patients require a close follow-up.CASE SUMMARY A 57-year-old woman was admitted to the Gynecology Department for a large pelvic mass.Her chief complaint was abdominal distention for two months.She had undergone subtotal supracervical hysterectomy for leiomyoma 14 years prior.Abdominal ultrasonography detected a 9.1 cm×8.5 cm×8.4 cm anechoic mass with silvery fluid in the pelvic cavity and high-risk human papilloma virus 53(HPV53)was positive.The admission diagnosis we first considered was a pelvic mass mimicking carcinoma of the cervical stump.We performed a laparotomy and a rapid frozen biopsy was suggestive of a fibrous cyst wall coated with a high squamous intraepithelial lesion.The pelvic mass was removed,and a bilateral adnexectomy was implemented.Final pathology confirmed that the pelvic mass was a large inflammatory cyst with a cervical high-grade squamous intraepithelial lesion.After successful intervention,the patient was discharged one week after surgery and there was no recurrence of the vaginal stump at 43 mo.CONCLUSION When addressing benign uterine diseases,gynecologists should pay adequate attention to retaining the cervix.If the cervix is retained,patients require a close follow-up.

The Influence of Method of Carburizing and Nitrocarburizing on the Microstructure and Properties of Tool Steels.

The paper presents the results of wear and metallography tests of tool steel grades: ASTM A681, Chl2M and CH12FS per COST, AMS 6437E i BS X46Crl3, all surface hardened by the Carbo process (carburizing) and by the NiCar process (nitrocarburizing). The thermo-chemical treatment was conducted in powder pack for a duration of 6 h (carburizing) and for 4 h in the case of nitrocarburizing. Factors investigated were: morphology, depth and microhardness of the cases obtained, their microstructure, as well as phase composition. Wear tests were conducted by the three cylinder-cone method. Wear velocity was 0.58 m/s, unit load was 50 MPa and 400Mpa, wear path was 3470 m. Oil SAE30 was applied at the rate of 30 drops per minute.

Mucoepidermoid carcinoma in the infratemporal fossa: A case report

BACKGROUND Mucoepidermoid carcinoma is the most common primary epithelial salivary gland malignancy.It mostly occurs in the major or intraoral minor salivary glands but rarely in the infratemporal fossa.Here,we present a case of aggressive mucoepidermoid carcinoma in the infratemporal fossa with neck lymph node metastasis and also discuss diagnostic and treatment strategies.CASE SUMMARY A 39-year-old woman with a mass located in the right submandibular area presented to our department.Physical examination revealed lymphadenopathy on the right submandibular side measuring 2.5 cm×3 cm that was hard and had poor mobility.Results of nasal endoscopy were unremarkable.Ultrasound examination revealed an enlarged lymph node at level II of the right side.Fine needle aspiration cytology of the metastatic lymph node revealed malignant cells with infection.Contrast-enhanced computed tomography revealed an enhancing ill-defined soft tissue mass in the right infratemporal region.Positron emission tomography/computed tomography revealed hyperintensity in the right infratemporal fossa along with lymphadenopathy at level II of the right-side lymph node.The patient underwent extended resection of the primary tumor,and ipsilateral radical neck dissection was also completed.Hematoxylin-eosin staining and immunohistochemistry revealed a high-grade mucoepidermoid carcinoma.No signs and symptoms of recurrence of the neoplasm were present after 20 mo of follow-up.CONCLUSION Positron emission tomography/computed tomography play a key role in primary tumor localization.Furthermore,histopathology and immunohistochemistry play pivotal roles in disease diagnosis.

Inspection and Assessment of Highway Bridges in Jordan along the Desert Highway: A Case Study

Bridges, especially highway bridges, are a key factor in nations’ development and flourish. Thus, great care should be taken to maintain and inspect their safety and serviceability. An immediate repair will prevent the loss of life and vehicles damage while crossing underpass and overpassing the heavy deteriorated bridges. Reinforced or pre-stressed concrete bridge girders become structurally deficient because of severed reasons including, increasing in the load requirements, corrosion of pre-stressing strands or reinforcement bars and collision of over-height trucks with the bulb of the concrete girders. The purpose of this case study is to evaluate and assess the damages of the highway bridges in Jordan. Since there is no mandatory program in Jordan for inspection of bridges and evaluating their conditions, this paper presents an inspection and assessment of two highway bridges along the desert highway which is the essential nerve connecting Jordan cities, and it also serves as an international road between many middle east countries. These two Bridges have never been investigated or checked since their construction in the late 1980s. The study results showed that the main factor causing the deterioration of these bridges is the collision of the over-height trucks with their elements. Relying on the collected data, solutions and repair methods were introduced to rehabilitate these bridges and assure their structural safety.

ANN Based Model for Estimation of Transformation Hardening of AISI 4340 Steel Plate Heat-Treated by Laser

Quality assessment and prediction becomes one of the most critical requirements for improving reliability, efficiency and safety of laser surface transformation hardening process (LSTHP). Accurate and efficient model to perform non-destructive quality estimation is an essential part of the assessment. This paper presents a structured and comprehensive approach developed to design an effective artificial neural network (ANN) based model for quality estimation and prediction in LSTHP using a commercial 3 kW Nd:Yag laser. The proposed approach examines laser hardening parameters and conditions known to have an influence on performance characteristics of hardened surface such as hardened bead width (HBW) and hardened depth (HD) and builds a quality prediction model step by step. The modeling procedure begins by examining, through a structured experimental investigations and exhaustive 3D finite element method simulation efforts, the relationships between laser hardening parameters and characteristics of hardened surface and their sensitivity to the process conditions. Using these results and various statistical tools, different quality prediction models are developed and evaluated. The results demonstrate that the ANN based assessment and prediction proposed approach can effectively lead to a consistent model able to accurately and reliably provide an appropriate prediction of hardened surface characteristics under variable hardening parameters and conditions.

The current situation and prospect of oil steel pipe in China

The oil steel pipe in the petroleum industry is very important for its high price, large consumption volume and great effect on the development of petroleum industry. The oil steel pipe mainly includes oil well pipe (drill pipe, drill collar, casing and tubing etc.) and oil-gas transportation pipe. This paper is an attempt to make a comprehensive review on the current situation and prospect of the oil steel pipe in China, presenting the past , today and future of the China oil pipe. The first section is a historical review of the China oil pipe. The developing course and progress of the oil steel pipe products are presented. The second section is about the current situation of the China oil pipe. The general situation of the China’s steel pipe corporation and their products types, capability, etc. is introduced. The third section is about the prospect of the China oil pipe. This part mainly describes the new product research and development in China steel pipe corporations, which are facing more and more strict technical requirements of the petroleum industry in oil pipe, and reveals the prosperity of China’s steel pipe corporations.