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Instability mechanism of mining roadway passing through fault at different angles in kilometre-deep mine and control measures of roof cutting and NPR cables 被引量:2
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作者 SUN Xiaoming WANG Jian +6 位作者 ZHAO Wenchao MING Jiang ZHANG Yong LI Zhihu MIAO Chengyu GUO Zhibiao HE Manchao 《Journal of Mountain Science》 SCIE CSCD 2024年第1期236-251,共16页
The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and ... The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and field experiments in the context of the Daqiang coal mine located in Shenyang, China. The stability control countermeasure of "pre-splitting cutting roof + NPR anchor cable"(PSCR-NPR) is simultaneously proposed. According to the different deformation characteristics of the roadway, the faults are innovatively classified into three types, with α of type I being 0°-30°, α of type II being 30°-60°, and α of type III being 60°-90°. The full-cycle stress evolution paths during mining roadway traverses across different types of faults are investigated by numerical simulation. Different pinch angles α lead to high stress concentration areas at different locations in the surrounding rock. The non-uniform stress field formed in the shallow surrounding rock is an important reason for the instability of the roadway. The pre-cracked cut top shifted the high stress region to the deep rock mass and formed a low stress region in the shallow rock mass. The high prestressing NPR anchor cable transforms the non-uniform stress field of the shallow surrounding rock into a uniform stress field. PSCR-NPR is applied in the fault-through roadway of Daqiang mine. The low stress area of the surrounding rock was enlarged by 3-7 times, and the cumulative convergence was reduced by 45%-50%. It provides a reference for the stability control of the deep fault-through mining roadway. 展开更多
关键词 Kilometre-deep mine Fault Mining roadway Failure mechanism Pre-splitting cutting roof High pre-stress NPR anchor cable
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High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report 被引量:2
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作者 Nao Furuya Atsushi Yamaguchi +13 位作者 Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka 《World Journal of Clinical Cases》 SCIE 2024年第8期1487-1496,共10页
BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination modalities.However,it can be diagnosed by pancreatic juice cytology from indirect findings.Most ... BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination modalities.However,it can be diagnosed by pancreatic juice cytology from indirect findings.Most previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic cysts.MRCP revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD dilatation.Thus,course observation was performed.After 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic cyst.We performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology examination.We performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade PanIN.Pancreatic parenchyma invasion was not observed,and curative resection was achieved.CONCLUSION High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation. 展开更多
关键词 Pancreatic cancer Pancreatic intraepithelial neoplasm high-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report
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Bulk geochemistry,Rb-Sr,Sm-Nd,and stable O-H isotope systematics of the Metzimevin high-grade iron ore deposit,Mbalam iron ore district,southern Cameroon
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作者 Samndong Cyril Tufoin Cheo Emmanuel Suh +1 位作者 Tabod Charles Tabod George Lemewihbwen Ngiamte 《Acta Geochimica》 EI CAS CSCD 2024年第4期677-706,共30页
Bulk geochemistry,Sr,Nd,and O-H isotope systematics are reported for the first time on banded iron formation(BIF)-hosted high-grade iron ore at the northwestern segment of Congo Craton(CC).Located in Mbalam iron ore d... Bulk geochemistry,Sr,Nd,and O-H isotope systematics are reported for the first time on banded iron formation(BIF)-hosted high-grade iron ore at the northwestern segment of Congo Craton(CC).Located in Mbalam iron ore district,Southern Cameroon,Metzimevin iron ore deposit is a hematite-magnetite BIF system,dominated by SiO_(2)+Fe_(2)O_(3)(97.1 to 99.84 wt%),with low concentrations of clastic elements e.g.,Al_(2)O_(3),TiO_(2),and HFSE,depicting a nearly pure chemical precipitate.The REE+Y signature of the iron deposit displays strong positive Eu anomaly,strong negative Ce anomaly,and chondritic to superchondritic Y/Ho ratios,suggestive of formation by mixed seawater-high temperature hydrothermal fluids in oxidising environment.The^(87)Sr/^(86)Sr ratios of the BIF are higher than the maximum^(87)Sr/^(86)Sr evolution curves for all Archean reservoirs(bulk silicate earth,Archean crust and Archean seawater),indicating involvement of continentally-derived components during BIF formation and alteration.TheƐ_(Nd)(t)(+2.26 to+3.77)and Nd model age indicate that chemical constituents for the BIF were derived from undifferentiated crustal source,between 3.002 and 2.88 Ga.The variable and diverse O and H isotope data(−1.9‰to 17.3‰and−57‰to 136‰respectively)indicate that the Metzimevin iron ore formed initially from magmatic plumes and later enriched by magmatic-metamorphic-modified meteoric fluids.Mass balance calculations indicate mineralisation by combined leaching and precipitation,with an average iron enrichment factor of>2.67 and SiO_(2)depletion factor of>0.99.This is associated with an overall volume reduction of 28.27%,reflecting net leaching and volume collapse of the BIF protholith. 展开更多
关键词 Bulk geochemistry RB-SR SM-ND Mitzimevin high-grade iron ore
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Sub-Homogeneous Peridynamic Model for Fracture and Failure Analysis of Roadway Surrounding Rock
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作者 Shijun Zhao Qing Zhang +3 位作者 Yusong Miao Weizhao Zhang Xinbo Zhao Wei Xu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期3167-3187,共21页
The surrounding rock of roadways exhibits intricate characteristics of discontinuity and heterogeneity.To address these complexities,this study employs non-local Peridynamics(PD)theory and reconstructs the kernel func... The surrounding rock of roadways exhibits intricate characteristics of discontinuity and heterogeneity.To address these complexities,this study employs non-local Peridynamics(PD)theory and reconstructs the kernel function to represent accurately the spatial decline of long-range force.Additionally,modifications to the traditional bondbased PD model are made.By considering the micro-structure of coal-rock materials within a uniform discrete model,heterogeneity characterized by bond random pre-breaking is introduced.This approach facilitates the proposal of a novel model capable of handling the random distribution characteristics of material heterogeneity,rendering the PD model suitable for analyzing the deformation and failure of heterogeneous layered coal-rock mass structures.The established numerical model and simulation method,termed the sub-homogeneous PD model,not only incorporates the support effect but also captures accurately the random heterogeneous micro-structure of roadway surrounding rock.The simulation results obtained using this model show good agreement with field measurements from the Fucun coal mine,effectively validating the model’s capability in accurately reproducing the deformation and failure mode of surrounding rock under bolt-supported(anchor cable).The proposed subhomogeneous PD model presents a valuable and effective simulation tool for studying the deformation and failure of roadway surrounding rock in coal mines,offering new insights and potential advancements. 展开更多
关键词 roadway surrounding rock PERIDYNAMICS heterogeneous material fracture analysis numerical simulation
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Management of retroperitoneal high-grade serous carcinoma of unknown origin:A case report
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作者 Wen-Lin Hsieh Dah-Ching Ding 《World Journal of Clinical Cases》 SCIE 2024年第6期1190-1195,共6页
BACKGROUND Retroperitoneal high-grade serous carcinoma(HGSC)of unknown origin is a sporadic tumor that can originate from ovarian cancer.Herein,we report the case of a woman with retroperitoneal HGSC of unknown origin... BACKGROUND Retroperitoneal high-grade serous carcinoma(HGSC)of unknown origin is a sporadic tumor that can originate from ovarian cancer.Herein,we report the case of a woman with retroperitoneal HGSC of unknown origin and describe how she was diagnosed and treated.CASE SUMMARY A 71-year-old female presented with the tumor marker CA125 elevated to 1041.9 U/mL upon a regular health examination.Computed tomography revealed retroperitoneal lymph node enlargement.Subsequently,positron emission tomography scanning revealed lesions with increased F-18 fluorodeoxyglucose uptake at the nodes.As a result,she underwent laparoscopic lymph node resection,and pathology revealed metastatic adenocarcinoma with CK7(+),PAX8(+),WT1(+),PR(-),and p53 mutational loss of expression,indicating that the origin may be from the adnexa.The patient was admitted to our ward and underwent laparoscopic staging;however,the pathological results were negative.Under the suspicion of retroperitoneal HGSC of unknown origin,chemotherapy and targeted therapy were initiated.Tumor marker levels decreased after treatment.CONCLUSION We present a case of HGSC of unknown origin managed using retroperitoneal lymphadenectomy,staging surgery,chemotherapy,and targeted therapy. 展开更多
关键词 high-grade serous carcinoma RETROPERITONEUM ORIGIN Chemotherapy Lymph node Case report
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Failure mechanism and safety control technology of a composite strata roadway in deep and soft rock masses:a case study
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作者 ZHAO Chengwei ZHOU Hui +3 位作者 SUN Xiaoming ZHANG Yong MIAO Chengyu WANG Jian 《Journal of Mountain Science》 SCIE CSCD 2024年第7期2427-2444,共18页
The construction of coal mines often encounters deep composite soft rock roadways,which is characterized by significant deformation and poor stability.To deeply study the failure mechanism and large deformation challe... The construction of coal mines often encounters deep composite soft rock roadways,which is characterized by significant deformation and poor stability.To deeply study the failure mechanism and large deformation challenges of a composite strata roadway in deep and soft rock masses,a numerical model of 3DEC tetrahedral blocks was established based on the method of rock quality designation(RQD).The results showed that original support cannot prevent asymmetric failure and large deformation due to the adverse geological environment and unsuitable support design.According to the failure characteristics,a coupling support of“NPR bolt/cable+mesh+shotcrete+steel pipe”was proposed to control the stability of the surrounding rock.The excellent mechanical properties of large deformation(approximately 400 mm)and high constant resistance force(bolt with 180 k N;cable with 350 k N)were evaluated by the tensile tests.The numerical results showed that the maximum deformation was minimized to 243 mm,and the bearing capacity of the surrounding rock of the roadway was enhanced.The field test results showed that the maximum deformation of the surrounding rock was 210 mm,and the forces of the NPR bolt and cable were stable at approximately 180 k N and 350 k N,respectively.This demonstrated the effectiveness of the coupling support with the NPR bolt and cable,which could be a guiding significance for the safety control of large deformation and failure in deep composite soft rock roadways. 展开更多
关键词 3DEC Composite strata roadway Soft rock NPR bolt and cable Asymmetric large deformation
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The Impact of Sea Level Rise on Roadway Design and Evacuation Routes in Delaware
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作者 Jack Palevich Ardeshir Faghri Ahmet Karakurt 《American Journal of Climate Change》 2024年第1期69-82,共14页
As the global temperature continues to increase, the sea level continues to rise at a rapid rate that has never been seen before. This becomes an issue for many facets of life but one of the most impacted is the trans... As the global temperature continues to increase, the sea level continues to rise at a rapid rate that has never been seen before. This becomes an issue for many facets of life but one of the most impacted is the transportation infrastructure. Many people living in low elevation coastal areas can become trapped by flooding with no way in or out. With Delaware being a coastal state, this would affect a large portion of the population and will have detrimental effects over time if nothing is done to combat sea level rise. The issue with sea level rise in transportation is that once the roads become flooded, they become virtually unusable and detour routes would be needed. If all the roads in a coastal area were to be affected by sea level rise, the options for detours would become limited. This article looks at direct solutions to combat sea level rise and indirect solutions that would specifically help transportation infrastructure and evacuation routes in Delaware. There is not one solution that can fix every problem, so many solutions are laid out to see what is applicable to each affected area. Some solutions include defense structures that would be put close to the coast, raising the elevation of vulnerable roads throughout the state and including pumping stations to drain the water on the surface of the road. With an understanding of all these solutions around the world, the ultimate conclusion came in the form of a six-step plan that Delaware should take in order to best design against sea level rise in these coastal areas. 展开更多
关键词 Sea Level Rise roadway Design Evacuation Routes
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Bearing mechanism of roof and rib support structure in automatically formed roadway and its support design method
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作者 JIANG Bei WANG Ming-zi +4 位作者 WANG Qi XIN Zhong-xin XING Xue-yang DENG Yu-song YAO Liang-di 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第7期2467-2487,共21页
Non-pillar mining technology with automatically formed roadway is a new mining method without coal pillar reservation and roadway excavation.The stability control of automatically formed roadway is the key to the succ... Non-pillar mining technology with automatically formed roadway is a new mining method without coal pillar reservation and roadway excavation.The stability control of automatically formed roadway is the key to the successful application of the new method.In order to realize the stability control of the roadway surrounding rock,the mechanical model of the roof and rib support structure is established,and the influence mechanism of the automatically formed roadway parameters on the compound force is revealed.On this basis,the roof and rib support structure technology of confined lightweight concrete is proposed,and its mechanical tests under different eccentricity are carried out.The results show that the bearing capacity of confined lightweight concrete specimens is basically the same as that of ordinary confined concrete specimens.The bearing capacity of confined lightweight concrete specimens under different eccentricities is 1.95 times higher than those of U-shaped steel specimens.By comparing the test results with the theoretical calculated results of the confined concrete,the calculation method of the bearing capacity for the confined lightweight concrete structure is selected.The design method of confined lightweight concrete support structure is established,and is successfully applied in the extra-large mine,Ningtiaota Coal Mine,China. 展开更多
关键词 automatically roadway with non-pillar confined lightweight concrete roof and rib support mechanical model bearing behaviour
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High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality:A case report
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作者 Kai-Cheng Zhang Shao-Yin Chu Dah-Ching Ding 《World Journal of Clinical Cases》 SCIE 2024年第18期3539-3547,共9页
BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnorm... BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnormalities and fallopian tube highgrade serous carcinoma(HGSC)in a young woman.CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion.Upon arrival at the emergency room,her abdomen appeared ovoid and distended with palpable shifting dullness.Ascites were identified through abdominal ultrasound,and computed tomography revealed an omentum cake and an enlarged bilateral adnexa.Blood tests showed elevated CA-125 levels.Paracentesis was conducted,and immunohistochemistry indicated that the cancer cells favored an ovarian origin,making us suspect ovarian cancer.The patient underwent debulking surgery,which led to a diagnosis of stage IIIC HGSC of the fallopian tube.Subsequently,the patient received adjuvant chemotherapy with carboplatin and paclitaxel,resulting in stable current condition.CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC.UBE2D3 may affect crucial cancer-related pathways,including P53,BRCA,cyclin D,and tyrosine kinase receptors,thereby possibly contributing to cancer development.In addition,ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses. 展开更多
关键词 high-grade serous carcinoma Fallopian tube Young age Chromosomal abnormality Mental retardation AGING Case report
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Theory,technology and application of grouted bolting in soft rock roadways of deep coal mines
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作者 Hongpu Kang Jianwei Yang +4 位作者 Pengfei Jiang Fuqiang Gao Wenzhou Li Jiafeng Li Huiyuan Chen 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第7期1463-1479,共17页
The grouted bolt,combining rock bolting with grouting techniques,provides an effective solution for controlling the surrounding rock in deep soft rock and fractured roadways.It has been extensively applied in numerous... The grouted bolt,combining rock bolting with grouting techniques,provides an effective solution for controlling the surrounding rock in deep soft rock and fractured roadways.It has been extensively applied in numerous deep mining areas characterized by soft rock roadways,where it has demonstrated remarkable control results.This article systematically explores the evolution of grouted bolting,covering its theoretical foundations,design methods,materials,construction processes,monitoring measures,and methods for assessing its effectiveness.The overview encompassed several key elements,delving into anchoring theory and grouting reinforcement theory.The new principle of high pretensioned high-pressure splitting grouted bolting collaborative active control is introduced.A fresh method for dynamic information design is also highlighted.The discussion touches on both conventional grouting rock bolts and cable bolts,as well as innovative grouted rock bolts and cables characterized by their high pretension,strength,and sealing hole pressure.An examination of the merits and demerits of standard inorganic and organic grouting materials versus the new inorganic–organic composite materials,including their specific application conditions,was conducted.Additionally,the article presents various methods and instruments to assess the support effect of grouting rock bolts,cable bolts,and grouting reinforcement.Furthermore,it provides a foundation for understanding the factors influencing decisions on grouted bolting timing,the sequence of grouting,the pressure applied,the volume of grout used,and the strategic arrangement of grouted rock bolts and cable bolts.The application of the high pretensioned high-pressure splitting grouted bolting collaborative control technology in a typical kilometer-deep soft rock mine in China—the soft coal seam and soft rock roadway in the Kouzidong coal mine,Huainan coal mining area,was introduced.Finally,the existing problems in grouted bolting control technology for deep soft rock roadways are analyzed,and the future development trend of grouted bolting control technology is anticipated. 展开更多
关键词 deep coal mine soft rock roadway grouted bolting rock bolt and cable grouting material high-pressure splitting grouting collaborative control technology
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Transformation of marginal zone lymphoma into high-grade B-cell lymphoma expressing terminal deoxynucleotidyl transferase:A case report
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作者 Zhi-Min Fan Dao-Lei Wu +4 位作者 Neng-Wen Xu Li Ye Li-Ping Yan Lin-Jie Li Jun-Yu Zhang 《World Journal of Clinical Cases》 SCIE 2024年第15期2655-2663,共9页
BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and... BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 rearrangements.HGBL is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)transformation.HGBL often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate chemotherapy.CASE SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase expression.Gene analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary tumors.The chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and obinutuzumab.The patient tolerated treatment well,and reached partial response.The patient had recurrence of hepatocellular carcinoma and died of multifunctional organ failure.He survived for 12 months after diagnosis.CONCLUSION Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy. 展开更多
关键词 Marginal zone lymphoma high-grade B-cell lymphoma Terminal deoxynucleotidyl transferase Venetoclax TP53 mutation Case report
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Surrounding Rock Control Technology of Strong Dynamic Pressure Roadway in Hudi Coal Industry
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作者 Yixue Jia 《World Journal of Engineering and Technology》 2024年第2期362-372,共11页
Aiming at the problems of large deformation and difficult maintenance of deep soft rock roadway under the influence of high ground stress and strong dynamic pressure, taking the surrounding rock control of 1105 lane i... Aiming at the problems of large deformation and difficult maintenance of deep soft rock roadway under the influence of high ground stress and strong dynamic pressure, taking the surrounding rock control of 1105 lane in Hudi Coal Industry as an example, the deformation characteristics and surrounding rock control measures of deep soft rock roadway are analyzed and discussed by means of geological data analysis, roadway deformation monitoring, rock crack drilling and field test. The results show that the main causes of roadway deformation are high ground stress, synclinal tectonic stress, advance mining stress, roadway penetration and surrounding rock fissure development. Based on the deformation characteristics and mechanism of lane 1105, the supporting countermeasures of “roof synergic support, layered grouting, anchor cable beam support, closed hardening of roadway surface” are proposed, which can provide reference for the control of deep roadway surrounding rock under similar conditions. 展开更多
关键词 Deep roadway Combined Support Surrounding Rock Control Soft Rock roadway
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Laboratory test on the combined cooling effect of L-shaped thermosyphons and thermal insulation on high-grade roadway construction in permafrost regions 被引量:3
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作者 YuanHong Dong,YuanMing Lai,MingYi Zhang,ShuangYang Li State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou,Gansu 730000,China. 《Research in Cold and Arid Regions》 2009年第4期307-315,共9页
With the completion of the Qinghai-Tibetan Railway,economic development of related areas has been greatly accelerated.This,in return,calls for building or upgrading more roadways,especially high-grade roadways.In cold... With the completion of the Qinghai-Tibetan Railway,economic development of related areas has been greatly accelerated.This,in return,calls for building or upgrading more roadways,especially high-grade roadways.In cold regions,the thawing of permafrost can induce settlement damage of and even failure to railway (or roadway) embankments.Thermosyphons (self-powered refrigera-tion devices that are used to help keep the permafrost cool) have proved effective in mitigating thaw settlement by maintaining the thermal stability of the embankments.However,for high-grade roadway embankments of great width,stabilizing or cooling ef-fects of traditional geotechnological measures may be limited.To enhance the cooling effect of thermosyphons,an L-shaped thermosyphon was designed.A laboratory test was carried out to study the combined cooling effect of the L-shaped thermosyphon and thermal insulation applying to roadbed construction.The angle between the evaporator and condenser sections of the L-shaped thermosyphon is 134 degrees,and the L-shaped thermosyphon was inserted into the soil at an angle of 5 degrees with the road surface.The tested results show that the L-shaped thermosyphon is effective in removing heat from a roadway in winter.When the ambient air temperature is lower than the soil temperature,the thermosyphon is active and extracts the heat in the soil around it.When the ambient air temperature is higher than the soil temperature,the thermosyphon is inactive,and no heat is in-jected into the soil through the L-shaped thermosyphon.Compared to embankments with straight thermosyphons,the inner parts of the embankments with L-shaped thermosyphons were significantly cooled.It is hoped that the present study would be useful to the application of L-shaped thermosyphons in the construction of high-grade roadways in cold regions. 展开更多
关键词 L-shaped thermosyphon thermal insulation cooling effect foundation soils high-grade roadway
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Comparison of biological behavior of lacrimal gland adenoid cystic carcinoma with high-grade transformation cells 被引量:2
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作者 Chuan-Li Zhang Li-Min Zhu +3 位作者 Xun Liu Mei-Xia Jiang Ting-Ting Lin Yan-Jin He 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第2期163-171,共9页
AIM:To evaluate the differences between human lacrimal gland adenoid cystic carcinoma with high-grade transformation(LACC-HGT)primar y cells cultured by high-grade transformation tissue and non-high-grade transformati... AIM:To evaluate the differences between human lacrimal gland adenoid cystic carcinoma with high-grade transformation(LACC-HGT)primar y cells cultured by high-grade transformation tissue and non-high-grade transformation(non-HGT)primary cells cultured by non-highgrade transformation tissue in proliferation,metastasis,drug susceptibility,and genes.METHODS:LACC-HGT primary cells were established by tissue block culture,and the 4^(th)to 10^(th)generation primary cells were selected as research objects.The cells were preliminarily identified by immunofluorescent staining.The differences between non-HGT and LACC-HGT primary cells in terms of proliferation,metastasis,and drug susceptibility were compared by cell counting kit-8(CCK-8)assay,wound healing,and drug sensitivity experiments.Differentially expressed genes were screened using mRNA array.Gene expression was analyzed using real-time quantitative polymerase chain reaction(RT-qPCR).RESULTS:LACC-HGT primary cells were successfully cultured by tissue block culture.Immunofluorescence staining results showed that cytokeratin(CK)and CK7 expression levels were positive in LACC-HGT primary cells.CCK-8 results showed that the proliferation ability of LACCHGT cells was significantly higher than that of non-HGT cells.Wound healing experiment showed that the migration ability of LACC-HGT cells was significantly higher than that of non-HGT cells.LACC-HGT cells were also less sensitive to cisplatin and paclitaxel than non-HGT cells.Compared with non-HGT cells,9566 differentially expressed genes were found in LACC-HGT primary cells,of which 5162 were upregulated and 4404 were down-regulated.The expression of N-acetylneuraminate pyruvate lyase(NPL),MARVEL domain containing 3(MARVELD3),syntabulin(SYBU),and allograft inflammatory factor 1(AIF1)was higher in LACCHGT cells than in non-HGT cells,whereas that of periostin(POSTN)was lower.CONCLUSION:LACC-HGT primary cells have faster proliferation,stronger migration ability,and poorer sensitivity to chemotherapy drugs than non-HGT primary cells.The expression of mRNAs in non-HGT and LACC-HGT primary cells are significantly different.These features are speculated to be the reasons why high-grade transformation tissues exhibit higher malignant degree and poorer prognosis than their counterparts. 展开更多
关键词 lacrimal gland lacrimal gland adenoid cystic carcinoma high-grade transformation primary cell culture biological behavior mRNA array
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Stability control measures for roof cutting and NPR supporting of mining roadways in fault areas of kilometre-deep coal mine 被引量:1
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作者 SUN Xiao-ming WANG Jian +5 位作者 ZHANG Yong ZHAO Wen-chao GUO Zhi-biao HE Man-chao CHEN Feng MIAO Cheng-yu 《Journal of Mountain Science》 SCIE CSCD 2023年第10期3051-3065,共15页
The study focuses on the stability control measures for mining roadways in fault zones of deep mines,using Daqiang Coal Mine as a case study.The control system under consideration,referred to as"pre-splitting cut... The study focuses on the stability control measures for mining roadways in fault zones of deep mines,using Daqiang Coal Mine as a case study.The control system under consideration,referred to as"pre-splitting cutting roof+NPR anchor cable"(PSCR-NPR),is subjected to scrutiny through theoretical analysis,numerical modelling,and field trials.Furthermore,a comprehensive analysis is undertaken to evaluate the stability control mechanism of this particular technology.The study provides evidence that the utilization of deep-hole directional energy-concentrated blasting facilitates the attainment of directional roof cutting in roadways.The aforementioned procedure leads to the formation of a uniform structural surface on the roof of the roadway and causes modifications in the surrounding geological formation.The examination of the lateral abutment pressure and shear stress distribution,both prior to and subsequent to roof cutting,indicates that the implementation of pre-splitting techniques leads to a noteworthy reduction in pressure.The proposition of incorporating the safety factor Q for roof cutting height is suggested as a method to augment comprehension of the pressure relief phenomenon in the field of engineering.The analysis of numerical simulation has indicated that the optimal pressure relief effect of a mining roadway in a fault area is attained when the value of Q is 1.8.The NPR anchor cable exhibits noteworthy characteristics,including a high level of prestress,continuous resistance,and substantial deformation.After the excavation of the roadway,a notable reduction in radial stress occurs,leading to the reinstatement of the three-phase stress state in the surrounding rock.This restoration is attributed to the substantial prestress exerted on the radial stress.The termination point of the NPR anchor cable is strategically positioned within a stable rock formation,allowing for the utilization of the mechanical characteristics of the deep stable rock mass.This positioning serves to improve the load-bearing capacity of the surrounding rock.The mining roadway within the fault region of Daqiang Coal Mine is outfitted with the PSCR-NPR technology.The drop in shear stress experienced by the rock surrounding the roadway is estimated to be around 30%,whilst the low-stress region of the mining roadway extends by a factor of approximately 5.5.The magnitude of surface displacement convergence experiences a decrease of approximately 45%-50%.The study’s findings provide useful insights regarding the stable of mining roadway in characterized by fault zones. 展开更多
关键词 Kilometre-deep mine FAULT Mining roadway Pre-splitting cutting roof High pre-stress NPR anchor cable
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Anchorage performance of large-diameter FRP bolts and their application in large deformation roadway 被引量:1
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作者 Jun Han Zuoqing Bi +2 位作者 Bing Liang Chen Cao Shuangwen Ma 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2023年第8期1037-1043,共7页
In underground coal mines, fibre reinforced polymer(FRP) bolt is ideal for mined rib reinforcements as it can prevent gas explosions caused by shearer frictional spark. With increasing mining depth, small diameter FRP... In underground coal mines, fibre reinforced polymer(FRP) bolt is ideal for mined rib reinforcements as it can prevent gas explosions caused by shearer frictional spark. With increasing mining depth, small diameter FRP bolts used in shallow underground mining cannot fulfil the rib support requirements. Under the engineering background of deep underground shortwall mining in Wudong coal mine, this paper systematically studies Φ27 mm FRP bolt support for large deformation coal rib. Specimens with a fan-shaped cross-section were used to enable the tensile testing of the bolt rod, the measured average tensile strength of the studied FRP bolt was(486.1 ± 9.6) MPa with a maximum elongation of 5.7%±0.6%.The shear strength of the bolt was measured as approximately 258 MPa using a self-made double shear testing apparatus. Based on the equivalent radial stiffness principle, a laboratory short encapsulation pullout test(SEPT) method for rib bolting has been developed undertaken consideration of the mechanical properties of the coal seam. Results showed that the average peak anchorage forces of the Φ27 mm FRP bolt and Φ20 mm steel rebar bolt were 108.4 and 66.4 k N, respectively, which were agreed with the theoretical calculations and field measurements. Based on theoretical analysis of the loading states of the bolt under site conditions, bolting method of full-length resin grouting was adopted to offset the weaknesses of the FRP bolt. Numerical method was employed to compare the bolting effect using Φ27 mm FRP bolts and steel rebar bolts. Large diameter FRP bolting was determined as the optimum rib support scheme to increase the productivity of the coal mine and to enhance the ground control capability for+425 level mining roadways. This study provides the laboratory testing design and theoretical prediction of large diameter FRP bolts used for rib support in large deformation roadways. 展开更多
关键词 FRP bolt Laboratory SEPT Tensile strength Double shear testing Mined rib support Large deformation roadway
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Traffic Incident Management Performance Measures: Ranking Agencies on Roadway Clearance Time 被引量:1
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作者 Maroa Mumtarin Skylar Knickerbocker +1 位作者 Theresa Litteral Jonathan S. Wood 《Journal of Transportation Technologies》 2023年第3期353-368,共16页
This study develops a procedure to rank agencies based on their incident responses using roadway clearance times for crashes. This analysis is not intended to grade agencies but to assist in identifying agencies requi... This study develops a procedure to rank agencies based on their incident responses using roadway clearance times for crashes. This analysis is not intended to grade agencies but to assist in identifying agencies requiring more training or resources for incident management. Previous NCHRP reports discussed usage of different factors including incident severity, roadway characteristics, number of lanes involved and time of incident separately for estimating the performance. However, it does not tell us how to incorporate all the factors at the same time. Thus, this study aims to account for multiple factors to ensure fair comparisons. This study used 149,174 crashes from Iowa that occurred from 2018 to 2021. A Tobit regression model was used to find the effect of different variables on roadway clearance time. Variables that cannot be controlled directly by agencies such as crash severity, roadway type, weather conditions, lighting conditions, etc., were included in the analysis as it helps to reduce bias in the ranking procedure. Then clearance time of each crash is normalized into a base condition using the regression coefficients. The normalization makes the process more efficient as the effect of uncontrollable factors has already been mitigated. Finally, the agencies were ranked by their average normalized roadway clearance time. This ranking process allows agencies to track their performance of previous crashes, can be used in identifying low performing agencies that could use additional resources and training, and can be used to identify high performing agencies to recognize for their efforts and performance. 展开更多
关键词 Traffic Incident Management roadway Clearance Time Performance Measures and Ranking Agency Performance Evaluation Tobit Regression Model
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Grouting theories and technologies for the reinforcement of fractured rocks surrounding deep roadways 被引量:2
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作者 Hongpu Kang Wenzhou Li +1 位作者 Fuqiang Gao Jianwei Yang 《Deep Underground Science and Engineering》 2023年第1期2-19,共18页
Grouting is an effective method to improve the integrity and stability of fractured rocks that surround deep roadways.After years of research and practice,various theories and a complete set of grouting technologies f... Grouting is an effective method to improve the integrity and stability of fractured rocks that surround deep roadways.After years of research and practice,various theories and a complete set of grouting technologies for deep roadways with fractured rocks have been developed and are widely applied in Chinese coal mining production.This paper systematically summarizes and analyzes the research results concerning the theory,design,materials,processes,and equipment for the grouting and reinforcement of fractured rocks surrounding deep roadways.Specifically,in terms of grouting methods,pregrouting,groutingwhile-excavation,and postgrouting methods are explored;in terms of grouting theory,backfill grouting,compaction grouting,infiltration grouting,and fracture grouting theories are studied.In addition,this paper also studies grouting borehole arrangement,water-cement ratio,grouting pressure,grouting volume,grout diffusion radius,and other grouting parameters and their determination methods.On this basis,this paper explores the physical and mechanical properties of organic and organic-inorganic composite grouting materials,and assess grouting reinforcement quality testing methods and instruments.Taken as the field cases,the application of pregrouting in front of heading faces,groutingwhile-excavation,and postgrouting in the Kouzidong coal mine are then introduced,and the effects of the grouting reinforcements are evaluated.This paper proposes a development direction for grouting technology based on problems existing in the grouting reinforcement of fractured rocks surrounding deep roadways. 展开更多
关键词 deep roadways development direction field study fractured rocks grouting materials grouting methods high-pressure grouting
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Evaluation of roof cutting by directionally single cracking technique in automatic roadway formation for thick coal seam mining
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作者 Yubing Gao Qiukai Gai +2 位作者 Xingxing Zhang Xun Xi Manchao He 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第5期137-157,共21页
Automatic roadway formation by roof cutting is a sustainable nonpillar mining method that has the potential to increase coal recovery,reduce roadway excavation and improve mining safety.In this method,roof cutting is ... Automatic roadway formation by roof cutting is a sustainable nonpillar mining method that has the potential to increase coal recovery,reduce roadway excavation and improve mining safety.In this method,roof cutting is the key process for stress relief,which significantly affects the stability of the formed roadway.This paper presents a directionally single cracking(DSC)technique for roof cutting with considerations of rock properties.The mechanism of the DSC technique was investi-gated by explicit finite element analyses.The DSC technique and roof cutting parameters were evaluated by discrete element simulation and field experiment.On this basis,the optimized DSC technique was tested in the field.The results indicate that the DSC technique could effectively control the blast-induced stress distribution and crack propagation in the roof rock,thus,achieve directionally single cracking on the roadway roof.The DsC technique for roof cutting with optimized parameters could effectively reduce the deformation and improve the stability of the formed roadway.Field engineering application verified the feasibility and effectiveness of the evaluated DSC technique for roof cutting. 展开更多
关键词 No pillar mining Automatic roadway formation Directionally single cracking Roof cutting roadway stability-Thick coal seam mining
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Dynamic behavior of outburst two-phase flow in a coal mine T-shaped roadway:The formation of impact airflow and its disaster-causing effect
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作者 Liang Cheng Jiang Xu +4 位作者 Shoujian Peng Hailin Yang Feng Jiao Bin Zhou Fazhi Yan 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2023年第8期1001-1017,共17页
The study of the dynamic disaster mechanism of coal and gas outburst two-phase flow is crucial for improving disaster reduction and rescue ability of coal mine outburst accidents.An outburst test in a T-shaped roadway... The study of the dynamic disaster mechanism of coal and gas outburst two-phase flow is crucial for improving disaster reduction and rescue ability of coal mine outburst accidents.An outburst test in a T-shaped roadway was conducted using a self-developed large-scale outburst dynamic disaster test system.We investigated the release characteristics of main energy sources in coal seam,and obtained the dynamic characteristics of outburst two-phase flow in a roadway.Additionally,we established a formation model for outburst impact flow and a model for its flow in a bifurcated structure.The results indicate that the outburst process exhibits pulse characteristics,and the rapid destruction process of coal seam and the blocking state of gas flow are the main causes of the pulse phenomenon.The outburst energy is released in stages,and the elastic potential energy is released in the vertical direction before the horizontal direction.In a straight roadway,the impact force oscillates along the roadway.With an increase in the solid–gas ratio,the two-phase flow impact force gradually increases,and the disaster range extends from the middle of the roadway to the coal seam.In the area near the coal seam,the disaster caused by the two-phase flow impact is characterized by intermittent recovery.In a bifurcated roadway,the effect of impact airflow on impact dynamic disaster is much higher than that of two-phase flow,and the impact force tends to weaken with increasing solid-gas ratio.The impact force is asymmetrically distributed;it is higher on the left of the bifurcated roadway.With an increase in the solid-gas ratio,the static pressure rapidly decreases,and the bifurcated structure accelerates the attenuation of static pressure.Moreover,secondary acceleration is observed when the shock wave moves along the T-shaped roadway,indicating that the bifurcated structure increases the shock wave velocity. 展开更多
关键词 Multiphase flow Coal and gas outburst Dynamic disaster Impact airflow T-shaped bifurcated roadway Coal seam
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