Study on Optimizing High-Gradient Magnetic Separation—Part 2: Experimental Evaluation of the Performance of a New Designed Magnetic Filter

The introduction of functionalized magnetizable particles and high-gradient magnetic separation represents a time and money saving alternative to conventional purification and separation unit operations in the biotechnical sector. This technique has some advantages especially for the recycling of immobilized enzymes. A new magnetic filter with sight glasses was constructed and produced to study the performance of high-gradient magnetic separation at varied parameters. By optical analysis the buildup of a clogging was identified as the major parameter which affected the separation performance. For the cleaning procedure, a two-phase flow of water with highly dispersed air bubbles was tested which led to a nearly complete cleaning of the filter chamber.

Study on Optimizing High-Gradient Magnetic Separation—Part 1: Improvement of Magnetic Particle Retention Based on CFD Simulations

The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological process design. The selective separation of the magnetizable particles is performed for example by a high-gradient magnetic separator. In this study FEM and CFD simulations of the magnetic field and the fluid flow field within a filter chamber of a magnetic separator were carried out, to find an optimal separator design. The motion of virtual magnetizable particles was calculated with a one-way coupled Lagrangian approach in order to test many geometric and parametric variations in reduced time. It was found that a flow homogenisator smoothed the fluid flow, so that the linear velocity became nearly equal over the cross section in the direction of flow. Furthermore the retention of magnetizable particles increases with a high total edge length within the filter matrix.

Radio frequency conditioning of an S-band accelerating structure prototype for compact proton therapy facility

The development of a high-gradient accelerating structure is underway to construct a compact proton linear accelerator for cancer treatment.Extensive experiments and numerous studies are being conducted to develop compact linear accelerators for proton therapy.Optimization of the electromagnetic and mechanical design has been performed to simplify the manufacturing process and reduce costs.A novel high-gradient structure with a low relativistic proton velocity(β),v/c=0.38,was designed,fabricated,and tested at high power.The first full-scale prototype was also successfully tested with high radio frequency(RF)power,a repetition rate of 50 Hz,and pulse length of 3μs to reach a high-gradient of 46 MV/m using a 50 MW S-band klystron power supply obtained from the Shanghai Soft X-ray Free Electron Laser Facility.This is the first high-power test in China,which is in line with the expected experimental goal.This study presents preliminary high-power testing of S-band standing wave accelerating structures with 11 cells.This work aims to verify the feasibility of using a high-gradient RF accelerating structure in compact proton therapy facilities.The cold test of the prototype cavity was completed in advance.Details of the high-power RF test setup,the process of RF conditioning,and the high-power results are described.

Structure study of a dielectric laser accelerator with discrete translational symmetry

The dielectric laser accelerator(DLA) is a promising technology for achieving high-gradient acceleration in a compact design. Its advantages include ease of cascading and an energy gain per unit distance which can exceed that of conventional accelerators by two orders of magnitude. This paper establishes rules for efficient particle acceleration using dielectric structures based on basic equations, proposes a design principle for DLA structures with clear physical images and verifies the accuracy of the corresponding formula for energy gain. DLA structures with different specifications, materials and geometric shapes are constructed, and the achievable acceleration gradient is calculated. Our results demonstrate that effective acceleration can be achieved when the electric field sensed by particles in the acceleration cavity has zero frequency,which provides a powerful method for designing such devices. Furthermore, we demonstrate that the simplified formula for calculating energy gain presented in this paper can accurately determine the energy gain of particles during the design of acceleration structures using a dielectric accelerator.

Effect of a high-gradient magnetic field on grain refinement of a hypoeutectic Mn-Sb alloy during directional solidification

The obvious grain refinement of the primary MnSb phase has been observed in the Mn-89.7 wt%Sb alloy directionally solidified under a high-gradient magnetic field.With the application of a high-gradient magnetic field,the morphology of the primary MnSb phase transformed from developed dendritic-like to equiaxed-like,and the grain size decreased by approximately 93%.Refinement of the primary MnSb phase can be attributed to the constituent supercooling in front of the solidification interface,which promoted nucleation of the primary MnSb phase.The constituent supercooling can be linked to the enrichment of the Mn solute induced by the magnetic force and the Lorentz force that drove Mn solute migration and suppressed convection.

Development of X-band accelerating structures for high gradients

Short copper standing wave （SW） structures operating at an X-band frequency have been recently designed and manufactured at the Laboratori Nazionali di Frascati of the Istituto Nazionale di Fisica Nucleare （INFN） using the vacuum brazing technique. High power tests of the structures have been performed at the SLAC National Accelerator Laboratory. In this manuscript we report the results of these tests and the activity in progress to enhance the high gradient performance of the next generation of structures, particularly the technological characterization of high performance coatings obtained via molybdenum sputtering.