Accelerated design of high-performance Mg-Mn-based magnesium alloys based on novel bayesian optimization

Magnesium(Mg),being the lightest structural metal,holds immense potential for widespread applications in various fields.The development of high-performance and cost-effective Mg alloys is crucial to further advancing their commercial utilization.With the rapid advancement of machine learning(ML)technology in recent years,the“data-driven''approach for alloy design has provided new perspectives and opportunities for enhancing the performance of Mg alloys.This paper introduces a novel regression-based Bayesian optimization active learning model(RBOALM)for the development of high-performance Mg-Mn-based wrought alloys.RBOALM employs active learning to automatically explore optimal alloy compositions and process parameters within predefined ranges,facilitating the discovery of superior alloy combinations.This model further integrates pre-established regression models as surrogate functions in Bayesian optimization,significantly enhancing the precision of the design process.Leveraging RBOALM,several new high-performance alloys have been successfully designed and prepared.Notably,after mechanical property testing of the designed alloys,the Mg-2.1Zn-2.0Mn-0.5Sn-0.1Ca alloy demonstrates exceptional mechanical properties,including an ultimate tensile strength of 406 MPa,a yield strength of 287 MPa,and a 23%fracture elongation.Furthermore,the Mg-2.7Mn-0.5Al-0.1Ca alloy exhibits an ultimate tensile strength of 211 MPa,coupled with a remarkable 41%fracture elongation.

Simultaneous determination of 27 preservatives in toothpaste by high-performance liquid chromatography

A method of high-performance liquid chromatography(HPLC)was established for simultaneous determination of 27 preservatives in toothpaste.Toothpaste samples were extracted with 50%aqueous methanol solution,ultrasonicated and then filtered.The target compounds were separated on a C_(18) column(250 mm×4.6μm,5μm)with the mobile phase consisting of acetonitrile and aqueous phosphoric acid solution,the column temperature was 30℃,the sample volume was 10μL,the flow rate was 1 mL/min,and diode array detector was used.Under the optimal experimental conditions,good linear relationship was obtained and the correlation coefficient(R^(2))was greater than 0.9995.This method was accurate and sensitive,which was suitable for the qualitative and quantitative analysis of 27 preservatives in toothpaste.

Establishing a protein expression profile database for the normal human pituitary gland using two-dimensional high-performance liquid chromatography combined with LTQ-Orbitrap mass spectrometry

In this study, we selected adult normal pituitary gland tissues from six patients during operations for pituitary microadenomas via the transsphenoidal approach for extended normal pituitary tissue resection around the tumor, and analyzed the protein expression of human normal pituitary using two-dimensional high-performance liquid chromatography combined with LTQ-Orbitrap mass spectrometry proteomics technology. The ten most highly expressed proteins in normal human pituitary were： alpha 3 type VI collagen isoform 5 precursor （abundance among tall pituitary proteins 1.30%）, fibrinogen beta chain preproprotein （0.99%）, vimentin （0.73%）, prolactin （0.69%）, ATP synthase, H~ transporting and mitochondrial F1 complex beta subunit precursor （0.52%）, keratin I （0.49%）, growth hormone （0.45%）, carbonic anhydrase I （0.40%）, heat shock protein 90 kDa I （0.31%）, and annexin V （0.30%）. Based on the biological function classifications of these proteins, the top three categories by content were neuroendocrine proteins （abundance among all pituitary proteins, 40.1%）, catalytic and metabolic proteins （28.3%）, and cell signal transduction proteins （9.8%）. Based on cell positioning classification, the top three categories were cell organelle （24.5%） membrane （20.8%）, and cytoplasm （13.0%）. Based on biological process classification, the top three categories of proteins are involved in physiological processes （42.9%）, cellular processes （40.4%）, and regulation of biological processes （9.1%）. Our experimental findings indicate that a protein expression profile database of normal human pituitary can be precisely and efficiently established by proteomics technology.

FAILURE MODE AND CONSTITUTIVE MODEL OF PLAIN HIGH-STRENGTH HIGH-PERFORMANCE CONCRETE UNDER BIAXIAL COMPRESSION AFTER EXPOSURE TO HIGH TEMPERATURES

An orthotropic constitutive relationship with temperature parameters for plain highstrength high-performance concrete （HSHPC） under biaxial compression is developed. It is based on the experiments performed for characterizing the strength and deformation behavior at two strength levels of HSHPC at 7 different stress ratios including a=σs ： σ3=0.00：-1,-0.20：-1,-0.30 ： -1,-0.40：-1,-0.50：-1,-0.75：-1,-1.00：-1, after the exposure to normal and high temperatures of 20, 200, 300, 400, 500 and 600℃, and using a large static-dynamic true triaxial machine. The biaxial tests were performed on 100 mm×100 mm×100 mm cubic specimens, and friction-reducing pads were used consisting of three layers of plastic membrane with glycerine in-between for the compressive loading plane. Based on the experimental results, failure modes of HSHPC specimens were described. The principal static compressive strengths, strains at the peak stress and stress-strain curves were measured; and the influence of the temperature and stress ratios on them was also analyzed. The experimental results showed that the uniaxial compressive strength of plain HSHPC after exposure to high temperatures does not decrease dramatically with the increase of temperature. The ratio of the biaxial to its uniaxial compressive strength depends on the stress ratios and brittleness-stiffness of HSHPC after exposure to different temperature levels. Comparison of the stress-strain results obtained from the theoretical model and the experimental data indicates good agreement.

Strength Regularity and Failure Criterion of High-Strength High-Performance Concrete under Multiaxial Compression

Multiaxial compression tests were performed on 100 mm×100 mm×100 mm high-strength high-performance concrete （HSI-IPC） cubes and normal strength concrete （NSC） cubes. The failure modes of specimens were presented, the static compressive strengths in principal directions were measured, the influence of the stress ratios was analyzed. The experimental results show that the ultimate strengths for HSHPC and NSC under multiaxial compression are greater than the uniaxial compressive strengths at all stress ratios, and the multiaxial strength is dependent on the brittleness and stiffness of concrete, the stress state and the stress ratios. In addition, the Kupfer-Gersfle and Ottosen＇s failure criteria for plain HSHPC and NSC under multiaxial compressive loading were modified.

Optimization Techniques for GPU-Based Parallel Programming Models in High-Performance Computing

This study embarks on a comprehensive examination of optimization techniques within GPU-based parallel programming models,pivotal for advancing high-performance computing(HPC).Emphasizing the transition of GPUs from graphic-centric processors to versatile computing units,it delves into the nuanced optimization of memory access,thread management,algorithmic design,and data structures.These optimizations are critical for exploiting the parallel processing capabilities of GPUs,addressingboth the theoretical frameworks and practical implementations.By integrating advanced strategies such as memory coalescing,dynamic scheduling,and parallel algorithmic transformations,this research aims to significantly elevate computational efficiency and throughput.The findings underscore the potential of optimized GPU programming to revolutionize computational tasks across various domains,highlighting a pathway towards achieving unparalleled processing power and efficiency in HPC environments.The paper not only contributes to the academic discourse on GPU optimization but also provides actionable insights for developers,fostering advancements in computational sciences and technology.

Measurement and analysis of defects in high-performance concrete with three-dimensional micro-computer tomography

In order to investigate the effects of two mineral admixtures （i. e., fly ash and ground slag）on initial defects existing in concrete microstructures, a high-resolution X-ray micro-CT（ micro-focus computer tomography）is employed to quantitatively analyze the initial defects in four series of highperformance concrete （HPC）specimens with additions of different mineral admixtures. The nigh-resolution 3D images of microstructures and filtered defects are reconstructed by micro- CT software. The size distribution and volume fractions of initial defects are analyzed based on 3D and 2D micro-CT images. The analysis results are verified by experimental results of watersuction tests. The results show that the additions of mineral admixtures in concrete as cementitious materials greatly change the geometrical properties of the microstructures and the spatial features of defects by physical-chemistry actions of these mineral admixtures. This is the major cause of the differences between the mechanical behaviors of HPC with and without mineral admixtures when the water-to-binder ratio and the size distribution of aggregates are constant.

Preliminary Studies on High-performance Liquid Chro-matography Chemiluminescence Determination of theSaturated Fatty Acids(C_(16) C_(18))in Human Serum

The peroxyoxalate chemiluminescence(CL)detection of fatty acids in human se- rum combined with high-performance liquid chromatography (HPLC)is described.Some fatty acids in serum were extracted with a 1 :1(v/v)mixture of chloroform-n-heptane.2-(4-Hydrazinocarbonyl- phenyl)-4,5-diphenylimidazole (HCPI) was used as a fluorescent labelling reagent of the fatty acids. The labelling reaction was carried out at 30℃ for 1 h at pH 6.5 and the resulting reaction mixture was sudjected to HPLC. The labelled fatty acid C_(17)(P-C_(17))was used as the internal standard. The la- belled fatty acids C_(16) and C_(18) were separated within 18 min on an ODS-8OTM column (150 mm× 6 mm ID,5μm,Tosoh Japan).The calibrlation curves of fatty acids from the spiked control serum were Y_1=-0.003 7 + 0.0028X_1,r=0.994 for FA C_( 16) and Y_2=0.00 1 2 + 0.00098X_2,r=0.999 for FA C_( 18),respectively.The average recoveries of facids from the spiked contrl serum were 107.2%(n=8,RSD=4.3%)for FA C_(16) and 97.35%(n=8, RSD=4.0%)for FA C_(18),respectively.The lower detection limits of fatty acids after reaction were 12μmol per 20μl injection for FA C_(16) and 18 μmol per 20μl injection for FA C_(18),respectively(signal to noise ratio, S/N=2).The HPLC/CL method was applied to the determination of FA C_(16) and FA C_(18) in normal human serum and the results showed that the concentrations of fatty acids in normal human serum were 0.134 ± 0.009 μ mol/ml serum(n=5) for FA C_(16) and 0.052±0.028 μmol/ml serum(n=5)for FA C_(18),respectively.

Simultaneous determination of five nucleosides and nucleobases in Panax notoginseng using high-performance liquid chromatography

Aim To quantitatively determine five nucleosides and nucleobases, including cytidine, uridine, guanosine, adenosine and uracil in different parts of Panax notoginseng. Methods Separation was performed on a Zorbax SB-Aq column using a gradient elution with mobile phase of 8 mmol^L-1 ammonium acetate aqueous solution （A） and methanol （B）. The assay was carried out at a flow rate of 1 mL·min^-1 at 25 ℃ with the diode-array detection at 260 nm. Results Cytidine, uridine, guanosine, adenosine and uracil had good linearity in the ranges of 1.79 - 57.40 μg·mL^-1 （r^2 = 1.0000）, 3.30 - 105.60 μg·mL^-1 （r^2 = 1.0000）, 3.09 - 98.80 μg·mL^ -1（r^2 = 0.9999）, 2.77 - 88.60 μg·mL^-1 （r^2 = 1.0000） and 0.38 - 12.30 μg·mL ^-1 （r^2 = 1.0000） with average recoveries of 93.9%, 96.5%, 92.7%, 93.2% and 98.8%, respectively. The content of cytidine, uridine, guanosine, adenosine and uracil in different parts of P. notogingeng were significantly different. Conclusion This is the first report on quantitative determination of nucleosides and nucleobases in P notoginseng.

High-Performance Liquid Chromatographical Analysis of Ginsenosides in Panax ginseng,P.quinquef(?)lium and P.notoginseng

The compositions and contents of ginsenbsides in Panax ginseng,P.quinquefolium and P.notoginseng were determined and compared by reversed-phase High-Performance Liquid Chro- matography(HPLC).The method was performed on an Alltech Adsorbosphere HS C_(18) column,using 5×10^(-3)M NaH_2PO_4-H_3PO_4 buffer solution(pH 3.0)and acetonitrile-water(50:50)as gradient eluents. The baseline separation of ginsenosides Rb_1,Rb_2,Rb_1,Rc,Rd,Rf,Ro,and Re+Rg_1 was obtained in one analytical run.The ginsenosides are directly detected at 203 nm.The detection limit is 40μg at a signal to noise ratio of 3:1.The improved sample preparation and clean-up prior to injection with SEP-PAK C_(18)cartridge strongly reduced the front peaks caused by the impurities in the methanolic extracts of samples to afford a smooth baseline and clear background.The HPLC patterns of methanolic extracts mainly including the ginsenosides were found capable of serving as chemical fingerprints to differentiate the three species from each other.It was also found that there are no significant diffe- rences of the HPLC patterns between the wild Panax ginseng and the cultivated,the white and the red ginsengs,Chinese and Korean red ginsengs,and the tap roots of Panax ginseng collected in four consecutive months,only certain differences in contents of ginsenosides do exist.The contents of the nine major ginsenosides present in the rhizome,tap root and rootlet as well as the leaf of Panax quinquefolium were also determined and compared.

Recent developments and applications on high-performance cast magnesium rare-earth alloys

During the past decades,with the increasing demands in lightweight structural materials,Mg alloys with low density and high performance have been extensively investigated and partly applied in some industries.Especially when rare earth(RE)elements are added as major alloying elements to Mg alloys,the alloy strength and creep resistance are greatly improved,which have promoted several series of Mg-RE alloys.This paper reviews the progress and developments of high-performance Mg-RE alloys in recent years with emphasis on cast alloys.The main contents include the alloy design,melt purification,grain refinement,castability,novel liquid casting and semisolid forming approaches,and the industrial applications or trials made of Mg-RE alloys.The review will provide insights for future developments of new alloys,techniques and applications of Mg alloys.

IPS e.max Press铸瓷与合金嵌体治疗后牙牙体缺损效果对比研究

目的探讨IPS e.max Press铸瓷与合金嵌体治疗后牙牙体缺损的效果。方法前瞻性纳入2020-05—2022-05三门峡市中心医院口腔科收治的后牙牙体缺损患者,根据修复材料分为IPS e.max Press铸瓷嵌体组(铸瓷组)和合金嵌体组(合金组)。比较2组患者的基线资料。治疗前后检测患者的龈沟液中炎性因子、评价牙周健康情况。治疗3个月后评价牙体缺损边缘密合度和美牙效果。结果共纳入86例(132颗牙)患者,每组43例(66颗牙)。2组患者的基线资料差异无统计学意义(P>0.05)。治疗后铸瓷组患者的IL-6、IL-8、CXCL16水平和GI、SBI及PLI评分均低于合金组;牙体缺损边缘密合度优于合金组,美牙效果满意率高于合金组。差异均有统计学意义(P<0.05)。结论与合金嵌体比较,采用IPS e.max Press铸瓷嵌体治疗后牙牙体缺损有利于降低龈沟液中炎性因子水平,改善牙周健康状况和牙体缺损边缘密合度,并可提高患者对美牙效果的满意度。但仍需进行更大样本量的前瞻性随机对照研究予以证实。

High-Performance and Multifunctional Cement-Based Composite Material

Concrete is a continuously evolving material, and even the definition of high-performance concrete has changed over time. In this paper, high-performance characteristics of concrete material are considered to be those that support the desirable durability, resilience, and sustainability of civil infrastructure that directly impact our quality of life. It is proposed that high-performance material characteristics include tensile ductility, autogenous crack-width control, and material “greenness.” Furthermore, smart functionalities should be aimed at enhancing infrastructure durability, resilience, and sustainability by responding to changes in the surrounding environment of the structure in order to perform desirable functions, thus causing the material to behave in a manner more akin to certain biological materials. Based on recent advances in engineered cementitious composites (ECCs), this paper suggests that concrete embodying such high-performance characteristics and smart multifunctionalities can be designed, and holds the potential to fulfill the expected civil infrastructure needs of the 21st century. Highlights of relevant properties of ECCs are provided, and directions for necessary future research are indicated.

Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy

AIM: To perform plasma free amino acid (PFAA) profiling of esophageal squamous cell carcinoma (ESCC) patients at different pathological stages and healthy subjects.

Advancements in the preparation of high-performance liquid chromatographic organic polymer monoliths for the separation of small-molecule drugs

The various advantages of organic polymer monoliths, including relatively simple preparation processes,abundant monomer availability, and a wide application range of pH, have attracted the attention of chromatographers. Organic polymer monoliths prepared by traditional methods only have macropores and mesopores, and micropores of less than 50 nm are not commonly available. These typical monoliths are suitable for the separation of biological macromolecules such as proteins and nucleic acids, but their ability to separate small molecular compounds is poor. In recent years, researchers have successfully modified polymer monoliths to achieve uniform compact pore structures. In particular, microporous materials with pores of 50 nm or less that can provide a large enough surface area are the key to the separation of small molecules. In this review, preparation methods of polymer monoliths for high-performance liquid chromatography, including ultra-high cross-linking technology, post-surface modification, and the addition of nanomaterials, are discussed. Modified monolithic columns have been used successfully to separate small molecules with obvious improvements in column efficiency.

High-performance self-assembly MnCo2O4 nanosheets for asymmetric supercapacitors

In this study,MnCo2O4 nanosheets were proposed to be utilized as an electrode material for supercapacitors.A two-step hydrothermal method with post-annealing treatment was employed in preparation of the nanostructures.MnCo2O4 electrode delivered a high specific capacitance of 2000 F g^-1 at 0.5 A g^-1,remarkable high-rate capability of 1150 F g^-1 at 20 A g^-1,and an excellent cycling stability of 92.3%at 5 A g^-1 after 5000 cycles.It is found that a three-electrode supercapacitor based on MnCo2O4 exhibits a promising electrochemical performance,better than the other similar materials,benefited from the synergistic effects of MnCo2O4 nanosheets.In fact,the self-assembly of nanosheets structure with high specific surface area and mesoporous structure can potentially enhance the electrochemical performance of supercapacitors.

INFLUENCE OF MINERAL ADMIXTURES ON MECHANICAL PROPERTIES OF HIGH-PERFORMANCE CONCRETE

The improvements of the mechanical properties, including bulk density of fresh mixtures, elastic modulus, and compressive strengths of four high-performance concrete mixtures, made with the addition of fly ash, refined ground blast - furnace microslag (microslag) and silica fume are studied. The concrete mixtures were determined based on the dispersion testing results. The study indicates that the elastic modulus at 28 and 91 days, and compressive strengths of the concretes are improved a lot when fly ash and microslag by 25 percent by weight of cement are added into the mixtures individually. The improvement is especially evident when silica fume by 5 percent and fly ash by 25 percent by weight of cement are added together into the mixture, while the fresh concrete mixture keeps a good workability. Through the analysis of chemically combined water ratios of the four mixtures at various hydration ages, it is found that the addition of all these mineral mixtures are beneficial to the hydration process, especially, at later stages, which might be one of the reasons for the improvement of mechanical properties. (Author abstract) 4 Refs.

Determination of gouty arthritis' biomarkers in human urine using reversed-phase high-performance liquid chromatography

Creatinine, uric acid, hypoxanthine and xanthine are important diagnostic biomarkers in human urine for gouty arthritis or renal disease diacrisis. A simple method for simultaneous determination of these biomarkers in urine based on reversed-phase high-performance liquid chromatography （RP-HPLC） with ultraviolet （UV） detector was proposed. After pretreatment by dilution, centrifugation and filtration, the biomarkers in urine samples were separated by ODS-BP column by elution with methanol/50 mM NaH2PO4 buffer solution at pH 5.26 （5：95）. Good linearity between peak areas and concentrations of standards was obtained for the biomarkers with correlation coefficients in the range of 0.9957-0.9993. The proposed analytical method has satisfactory repeatability （the recovery of data in a range of creatinine, uric acid, hypoxanthine and xanthine was 93.49-97.90%, 95.38-96.45%, 112.46-115.78%and 90.82-97.13%with standard deviation of o5%, respectively） and the limits of detection （LODs, S/N Z 3） for creatinine, uric acid, hypoxanthine, and xanthine were 0.010, 0.025, 0.050 and 0.025 mg/L, respectively. The established method was proved to be simple, accurate, sensitive and reliable for the quantitation of gouty arthritis＇ biomarkers in human urine samples. The ratio of creatinine to uric acid was found to be a possible factor for assessment of gouty arthritis.

The effects of 12 weeks of functional strength training on muscle strength,volume and activity upon exposure to elevated Gz forces in high-performance aircraft personnel

Background:Technological advancements in modern military and acrobatic jet planes have resulted in extraordinary psychophysiological loads being exerted upon flying personnel,including inducing neck and back pain.The purpose of this study was to examine the effects of 12 weeks of functional strength training on 1)the volume and strength of the neck and shoulder muscles and 2)muscular activity upon exposure to helmets of different masses and elevated Gz forces in a long-arm centrifuge in high-performance aircraft personnel.Methods:Eighteen participants underwent 12 weeks of functional strength training(n=12)or the control protocol(n=6)without additional strength training.Pre-and post-intervention tests included evaluations of isometric strength of the head extensor muscles,flexion,and lateral flexion and rotation,as well as magnetic resonance imaging(MRI)to measure the volume of the m.sternocleidomastoideus,m.trapezius,and deep neck muscles.Furthermore,during a long-arm centrifuge(+1.4 and+3Gz)protocol,the muscular activity levels of the m.sternocleidomastoideus,m.trapezius and m.erector spinae muscles were assessed without a flight helmet,with a helmet,and with a helmet and night vision goggles.Each participant’s perception of muscular strain was noted immediately after the long-arm centrifuge protocol.Results:The maximal isometric strength in all exercises and muscle volumes increased in the training group but not the control group(P<0.05).Relative muscle activity(%MVC)with a helmet decreased after the intervention in the training but not the control group(P=0.01).Relative muscle activity while wearing a helmet and night vision goggles was higher after intervention in the control group than in the training group(P<0.01).The perceived muscular strain of the neck muscles induced by the long-arm centrifuge did not differ between the groups.Conclusions:Twelve weeks of functional strength training improves the maximal isometric strength and volume of neck and shoulder muscles and leads to lower relative muscle activation upon exposure to elevated Gz forces in a long-arm centrifuge.

SYNTHESIS AND PROPERTIES OF NOVEL POLY(IMINO KETONE)S AS HIGH-PERFORMANCE POLYMERS

Di(4-bromophenyl)ketone and various aromatic diamines as the monomers,a series of novel poly(imino ketone)s (PIKs)have been synthesized via palladium-catalyzed aryl amination,which is Hartwig-Buchwald polycondensation reaction.The structures of PIKs are characterized by means of elemental analysis,FT-IR,~1H-NMR and UV-Vis spectroscopy. The results show a good agreement with the proposed structure.The general properties of PIKs are studied by DSC,TG and wide-angle X-ray diffraction,the solubility behavior is...