To explore the behavior of radiolytically produced hydrogen release from the waste resin stored in a high integrated container(HIC), and the mechanism of hydrogen diffusion in a near-surface disposal facility, both ex...To explore the behavior of radiolytically produced hydrogen release from the waste resin stored in a high integrated container(HIC), and the mechanism of hydrogen diffusion in a near-surface disposal facility, both experimental studies and numerical simulations were performed through an accelerated irradiation test and simulated disposal, respectively. Results indicated that,100 years after disposal, the highest hydrogen concentration appeared in the cell where the HICs were placed. The volume fraction for different scenarios postulated in the numerical simulation was 2.64% for Scenario 1, 2.28% for Scenario 2, and 3.965% for Scenario 3, all of which are lower than the hydrogen explosion limit of 4.1%. The results indicated that the simulated HIC disposal scheme is safe.展开更多
On the basis of hydrogen bonding directed layer-by-layer (LbL) assembly we have fabricated two multilayersystems, poly(acrylic acid) bearng spironaphthoxazine (PAA-SO)/poly(4-vinylpyridine) and carboxyl-terminated pol...On the basis of hydrogen bonding directed layer-by-layer (LbL) assembly we have fabricated two multilayersystems, poly(acrylic acid) bearng spironaphthoxazine (PAA-SO)/poly(4-vinylpyridine) and carboxyl-terminated polyetherdendrimer (dendrimer-COOH)/poly(4-vinylpyridine). UV-Vis spectroscopy indicates that either PAA-SO or dendrimer-COOH can be released from the corresponding multilayer assemblies upon immerssion in a basic aqueous solution.Furthermore, the rate of molecule release can be controlled either by changing the pH value or by adjusting the layerstructure.展开更多
We report an approach of high-pressure hydrogenation to improve the performance of crystalline Si(c-Si) solar cells.As-received p-type c-Si wafer-based PN junctions were subjected to high-pressure(2.5 MPa) hydrogen at...We report an approach of high-pressure hydrogenation to improve the performance of crystalline Si(c-Si) solar cells.As-received p-type c-Si wafer-based PN junctions were subjected to high-pressure(2.5 MPa) hydrogen atmosphere at 200 ℃,followed by evaporating antireflection layers,passivation layers,and front and rear electrodes.The efficiency of the so prepared c-Si solar cell was found to increase evidently after high-pressure hydrogenation,with a maximal enhancement of 10%.The incorporation of hydrogen by Si solar cells was identified,and hydrogen passivation of dangling bonds in Si was confirmed.Compared to the regular approach of hydrogen plasma passivation,the approach of high-pressure hydrogenation reported here needs no post-hydrogenation treatment,and can be more convenient and efficient to use in improving the performances of the c-Si and other solar cells.展开更多
Simulations and analyses of experimental data from leaks from high-pressure hydrogen storage systems will require knowledge of the stagnation state time histories and stream properties exiting the orifices.An analytic...Simulations and analyses of experimental data from leaks from high-pressure hydrogen storage systems will require knowledge of the stagnation state time histories and stream properties exiting the orifices.An analytical ideal-gas model based on the ideal gas state equation and a computer program making use of the NIST standard reference database(REFPROP)were developed to model the entire process of leaks from high-pressurized hydrogen gas containers.The results obtained by the two methods agree with each other well.As the gas behavior departs from the ideal gas properties at high pressures,the actual stagnation pressure and temperature decay more rapidly than with the ideal-gas assumption.展开更多
Historically,the rapid degradation and massive gas release from magnesium(Mg)implants resulted in severe emphysema and mechanical failure.With the advent of new alloys and surface treatment methods,optimized Mg implan...Historically,the rapid degradation and massive gas release from magnesium(Mg)implants resulted in severe emphysema and mechanical failure.With the advent of new alloys and surface treatment methods,optimized Mg implants have re-entered clinics since last decade with reliable performance.However,the optimization aims at slowing down the degradation process,rather than exemption of the gas release.This study involved a systematic evaluation of current preclinical and clinical evidence,regarding the physical signs,symptoms,radiological features,pathological findings and complications potentially associated with peri±implant gas accumulation(PIGA)after musculoskeletal Mg implantation.The literature search identified 196 potentially relevant publications,and 51 papers were enrolled for further analysis,including 22 preclinical tests and 29 clinical studies published from 2005 to 2023.Various Mg-based materials have been evaluated in animal research,and the application of pure Mg and Mg alloys have been reported in clinical follow-ups involving multiple anatomical sites and musculoskeletal disorders.Soft tissue and intraosseous PIGA are common in both animal tests and clinical follow-ups,and potentially associated with certain adverse events.Radiological examinations especially micro-CT and clinical CT scans provide valuable information for quantitative and longitudinal analysis.While according to simulation tests involving Mg implantation and chemical processing,tissue fixation could lead to an increase in the volume of gas cavity,thus the results obtained from ex vivo imaging or histopathological evaluations should be interpreted with caution.There still lacks standardized procedures or consensus for both preclinical and clinical evaluation of PIGA.However,by providing focused insights into the topic,this evidence-based study will facilitate future animal tests and clinical evaluations,and support developing biocompatible Mg implants for the treatment of musculoskeletal disorders.展开更多
Hydrogen energy has been recognized as “Ultimate Power Source” in the 21st century, which could be the best solution to the looming energy crisis and climate degeneration in the near future. Due to its high safety, ...Hydrogen energy has been recognized as “Ultimate Power Source” in the 21st century, which could be the best solution to the looming energy crisis and climate degeneration in the near future. Due to its high safety, low price, abundant resources and decent hydrogen storage density, magnesium based solid-state hydrogen storage materials are becoming the leading candidate for onboard hydrogen storage. However,the high operation temperature and slow reaction rate of MgH_(2), as a result of the large formation enthalpy and high reaction activation energy,respectively, are the first and most difficult problems we need to face and overcome to realize its industrialization. Herein, a state-of-the-art review on tailoring the stable thermodynamics and sluggish kinetics of hydrogen storage in MgH_(2), particularly through nanoengnieering and catalysis is presented, aiming to provide references and solutions for its promotion and application. Promising methods to overcome the challenges faced by MgH_(2)/Mg, such as bidirectional catalysts and nanoconfinement with in-situ catalysis are compared and the required improvements are discussed to stimulate further discussions and ideas in the rational design of MgH_(2)/Mg systems with ability for hydrogen release/uptake at lower temperatures and cycle stability in the near future.展开更多
Background:Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal patch.However,the quantitative evaluation of hydrogen bonding strength between drug and polar...Background:Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal patch.However,the quantitative evaluation of hydrogen bonding strength between drug and polar functional group was rarely reported,and the relationship between hydrogen bonding strength and controlled release capacity of pressure sensitive adhesive(PSA)was not well understood.The present study shed light on this relationship.Methods:Acrylate PSAs with amide group were synthesized by a free radical-initiated solution polymerization.Six drugs,i.e.,etodolac,ketoprofen,gemfibrozil,zolmitriptan,propranolol and lidocaine,were selected as model drugs.In vitro drug release and skin permeation experiments and in vivo pharmacokinetic experiment were performed.Partial correlation analysis,fourier-transform infrared spectroscopy and molecular simulation were conducted to provide molecular details of drug-PSA interactions.Mechanical test,rheology study,and modulated differential scanning calorimetry study were performed to scrutinize the free volume and molecular mobility of PSAs.Results:Release rate of all six drugs from amide PSAs decreased with the increase of amide group concentrations;however,only zolmitriptan and propranolol showed decreased skin permeation rate.It was found that drug release was controlled by amide group through hydrogen bonding,and controlled release extent was positively correlated with hydrogen bonding strength.Conclusion:From these results,we concluded that drugs with strong hydrogen bond forming ability and high skin permeation were suitable to use amide PSAs to regulate their release rate from patch.展开更多
The charge valve is an important element in the charging port of a high-pressure hydrogen storage cylinder(HP-HSC).It is normally closed after the HP-HSC is filled with hydrogen.If the seal of the charge valve is dama...The charge valve is an important element in the charging port of a high-pressure hydrogen storage cylinder(HP-HSC).It is normally closed after the HP-HSC is filled with hydrogen.If the seal of the charge valve is damaged,it will seriously affect the stable operation of the hydrogen supply system and may even cause safety problems.Therefore,the seal performance of the charge valve is important.In this paper,finite element analysis(FEA)is carried out to analyze the seal contact performance of hydrogenated nitrile rubber(HNBR)gaskets in the seal pair of a charge valve.The effects of different pre-compressions,seal widths,and hydrogen pressures on the seal contact performance of the charge valve are analyzed.The contact pressure on the seal surface increases with the increase of pre-compression.With a pre-compression of 2.5 mm,the maximum contact pressure without and with hydrogen pressure are 68.51 and 107.38 MPa,respectively.A contact gap appears in the inner ring of the seal surface with pre-compression below 0.15 mm.The contact gap occurs between the entire seal surface with a seal width of1 mm.The contact pressure on the seal surface and the width of the separation area between the seal surfaces increase with the increase of the seal width.The contact gap between the seal surfaces is zero with a width of 2.5 mm.The width of the separation area between the seal surfaces decreases with the decrease of the hydrogen pressure.The width of the separation area is reduced from 0.5 mm at 35 MPa to 0.17 mm at 15 MPa.This work can be useful for improvement of the seal performance and of the design of the charge valve used in the HP-HSC.展开更多
The purpose of achieving the long-lasting fragrance perception leads to nanocarrier-based profragrances in perfume applications.Herein,we report a family of novel profragrance systems based on polyhedral oligomeric si...The purpose of achieving the long-lasting fragrance perception leads to nanocarrier-based profragrances in perfume applications.Herein,we report a family of novel profragrance systems based on polyhedral oligomeric silsesquioxane(POSS)derivatized thioureas(POSS thioureas)that enable linkage of volatile carbonyl fragrances with the spontaneous formation of fragile hydrogen bonds.This profragrance platform addresses the dilemma of the volatile nature of aroma-materials on the one hand,and the desired long-lasting effects on the other.Their releasing performance as profragrances is investigated by headspace solid-phase microextraction(SPME)in combination with gas chromatography(GC)analysis under water as the external humidity stimulus,indicating that the fragrance concentration released from the POSS–thiourea-based profragrance is up to four times higher than the neat reference of the corresponding perfume aldehydes.Furthermore,deposition of the novel profragrance system onto wallpaper results in excellent retentive capacity for volatile aldehydes.Given the low essential toxicity,the POSS–thiourea system has been demonstrated as a suitable profragrance for practical application to perfume delivery.展开更多
A hydrogen storage system was developed via heterogeneous catalysis,employing the dehydrogenative coupling of methanol and N,N′-dimethylethylenediamine to efficiently produce high-purity H_(2).In this process,the Cu/...A hydrogen storage system was developed via heterogeneous catalysis,employing the dehydrogenative coupling of methanol and N,N′-dimethylethylenediamine to efficiently produce high-purity H_(2).In this process,the Cu/ZnO/Al_(2)O_(3) catalyst displayed superior activity in hydrogen production,with Cu+identified as the major active site through comprehensive characterization.展开更多
文摘To explore the behavior of radiolytically produced hydrogen release from the waste resin stored in a high integrated container(HIC), and the mechanism of hydrogen diffusion in a near-surface disposal facility, both experimental studies and numerical simulations were performed through an accelerated irradiation test and simulated disposal, respectively. Results indicated that,100 years after disposal, the highest hydrogen concentration appeared in the cell where the HICs were placed. The volume fraction for different scenarios postulated in the numerical simulation was 2.64% for Scenario 1, 2.28% for Scenario 2, and 3.965% for Scenario 3, all of which are lower than the hydrogen explosion limit of 4.1%. The results indicated that the simulated HIC disposal scheme is safe.
基金The research was funded by the Major State Basic Research Development Program (Grand No. G2000078102), Key Project of Ministry of Education, and the National Natural Science Foundation of China.
文摘On the basis of hydrogen bonding directed layer-by-layer (LbL) assembly we have fabricated two multilayersystems, poly(acrylic acid) bearng spironaphthoxazine (PAA-SO)/poly(4-vinylpyridine) and carboxyl-terminated polyetherdendrimer (dendrimer-COOH)/poly(4-vinylpyridine). UV-Vis spectroscopy indicates that either PAA-SO or dendrimer-COOH can be released from the corresponding multilayer assemblies upon immerssion in a basic aqueous solution.Furthermore, the rate of molecule release can be controlled either by changing the pH value or by adjusting the layerstructure.
基金Project supported by the National Natural Science Foundation of China(Grant No.62075044)the Shanghai Science and Technology Committee,China(Grant No.18JC1411500)the CIOMP–Fudan University Joint Foundation(Grant No.FC2017-001).
文摘We report an approach of high-pressure hydrogenation to improve the performance of crystalline Si(c-Si) solar cells.As-received p-type c-Si wafer-based PN junctions were subjected to high-pressure(2.5 MPa) hydrogen atmosphere at 200 ℃,followed by evaporating antireflection layers,passivation layers,and front and rear electrodes.The efficiency of the so prepared c-Si solar cell was found to increase evidently after high-pressure hydrogenation,with a maximal enhancement of 10%.The incorporation of hydrogen by Si solar cells was identified,and hydrogen passivation of dangling bonds in Si was confirmed.Compared to the regular approach of hydrogen plasma passivation,the approach of high-pressure hydrogenation reported here needs no post-hydrogenation treatment,and can be more convenient and efficient to use in improving the performances of the c-Si and other solar cells.
基金supported by the National Basic Research Program of China(2011CB706904)
文摘Simulations and analyses of experimental data from leaks from high-pressure hydrogen storage systems will require knowledge of the stagnation state time histories and stream properties exiting the orifices.An analytical ideal-gas model based on the ideal gas state equation and a computer program making use of the NIST standard reference database(REFPROP)were developed to model the entire process of leaks from high-pressurized hydrogen gas containers.The results obtained by the two methods agree with each other well.As the gas behavior departs from the ideal gas properties at high pressures,the actual stagnation pressure and temperature decay more rapidly than with the ideal-gas assumption.
基金a grant from the state of Schleswig-Holstein and the European Union ERDF-European Regional Development Fund(Zukunftsprogramm Wirtschaft)。
文摘Historically,the rapid degradation and massive gas release from magnesium(Mg)implants resulted in severe emphysema and mechanical failure.With the advent of new alloys and surface treatment methods,optimized Mg implants have re-entered clinics since last decade with reliable performance.However,the optimization aims at slowing down the degradation process,rather than exemption of the gas release.This study involved a systematic evaluation of current preclinical and clinical evidence,regarding the physical signs,symptoms,radiological features,pathological findings and complications potentially associated with peri±implant gas accumulation(PIGA)after musculoskeletal Mg implantation.The literature search identified 196 potentially relevant publications,and 51 papers were enrolled for further analysis,including 22 preclinical tests and 29 clinical studies published from 2005 to 2023.Various Mg-based materials have been evaluated in animal research,and the application of pure Mg and Mg alloys have been reported in clinical follow-ups involving multiple anatomical sites and musculoskeletal disorders.Soft tissue and intraosseous PIGA are common in both animal tests and clinical follow-ups,and potentially associated with certain adverse events.Radiological examinations especially micro-CT and clinical CT scans provide valuable information for quantitative and longitudinal analysis.While according to simulation tests involving Mg implantation and chemical processing,tissue fixation could lead to an increase in the volume of gas cavity,thus the results obtained from ex vivo imaging or histopathological evaluations should be interpreted with caution.There still lacks standardized procedures or consensus for both preclinical and clinical evaluation of PIGA.However,by providing focused insights into the topic,this evidence-based study will facilitate future animal tests and clinical evaluations,and support developing biocompatible Mg implants for the treatment of musculoskeletal disorders.
基金funded by Chongqing Special Key Project of Technology Innovation and Application Development(Grant No.cstc2019jscx-dxwt BX0016)Guiding Project of Scientific Research Program in Ministry of Education of Hubei Province (No. B2021025)Fundamental Research Funds for the Central Universities (2022CDJXY-010 and 2022CDJQY-013)。
文摘Hydrogen energy has been recognized as “Ultimate Power Source” in the 21st century, which could be the best solution to the looming energy crisis and climate degeneration in the near future. Due to its high safety, low price, abundant resources and decent hydrogen storage density, magnesium based solid-state hydrogen storage materials are becoming the leading candidate for onboard hydrogen storage. However,the high operation temperature and slow reaction rate of MgH_(2), as a result of the large formation enthalpy and high reaction activation energy,respectively, are the first and most difficult problems we need to face and overcome to realize its industrialization. Herein, a state-of-the-art review on tailoring the stable thermodynamics and sluggish kinetics of hydrogen storage in MgH_(2), particularly through nanoengnieering and catalysis is presented, aiming to provide references and solutions for its promotion and application. Promising methods to overcome the challenges faced by MgH_(2)/Mg, such as bidirectional catalysts and nanoconfinement with in-situ catalysis are compared and the required improvements are discussed to stimulate further discussions and ideas in the rational design of MgH_(2)/Mg systems with ability for hydrogen release/uptake at lower temperatures and cycle stability in the near future.
基金supported by the National Natural Science Foundation of China(81773665)Natural Science Foundation of Liaoning Province(20170540861,China)
文摘Background:Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal patch.However,the quantitative evaluation of hydrogen bonding strength between drug and polar functional group was rarely reported,and the relationship between hydrogen bonding strength and controlled release capacity of pressure sensitive adhesive(PSA)was not well understood.The present study shed light on this relationship.Methods:Acrylate PSAs with amide group were synthesized by a free radical-initiated solution polymerization.Six drugs,i.e.,etodolac,ketoprofen,gemfibrozil,zolmitriptan,propranolol and lidocaine,were selected as model drugs.In vitro drug release and skin permeation experiments and in vivo pharmacokinetic experiment were performed.Partial correlation analysis,fourier-transform infrared spectroscopy and molecular simulation were conducted to provide molecular details of drug-PSA interactions.Mechanical test,rheology study,and modulated differential scanning calorimetry study were performed to scrutinize the free volume and molecular mobility of PSAs.Results:Release rate of all six drugs from amide PSAs decreased with the increase of amide group concentrations;however,only zolmitriptan and propranolol showed decreased skin permeation rate.It was found that drug release was controlled by amide group through hydrogen bonding,and controlled release extent was positively correlated with hydrogen bonding strength.Conclusion:From these results,we concluded that drugs with strong hydrogen bond forming ability and high skin permeation were suitable to use amide PSAs to regulate their release rate from patch.
基金supported by the National Natural Science Foundation of China(No.52175067)the Science and Technology Department of Zhejiang Province(No.2021C01021),Chinathe Young Elite Scientist Sponsorship Program by China Association for Science and Technology(No.YESS20200154)。
文摘The charge valve is an important element in the charging port of a high-pressure hydrogen storage cylinder(HP-HSC).It is normally closed after the HP-HSC is filled with hydrogen.If the seal of the charge valve is damaged,it will seriously affect the stable operation of the hydrogen supply system and may even cause safety problems.Therefore,the seal performance of the charge valve is important.In this paper,finite element analysis(FEA)is carried out to analyze the seal contact performance of hydrogenated nitrile rubber(HNBR)gaskets in the seal pair of a charge valve.The effects of different pre-compressions,seal widths,and hydrogen pressures on the seal contact performance of the charge valve are analyzed.The contact pressure on the seal surface increases with the increase of pre-compression.With a pre-compression of 2.5 mm,the maximum contact pressure without and with hydrogen pressure are 68.51 and 107.38 MPa,respectively.A contact gap appears in the inner ring of the seal surface with pre-compression below 0.15 mm.The contact gap occurs between the entire seal surface with a seal width of1 mm.The contact pressure on the seal surface and the width of the separation area between the seal surfaces increase with the increase of the seal width.The contact gap between the seal surfaces is zero with a width of 2.5 mm.The width of the separation area between the seal surfaces decreases with the decrease of the hydrogen pressure.The width of the separation area is reduced from 0.5 mm at 35 MPa to 0.17 mm at 15 MPa.This work can be useful for improvement of the seal performance and of the design of the charge valve used in the HP-HSC.
基金supported by National Key Research and Development Program(2016YFA0200300)NSFC/China(21788102 and 21636002)+3 种基金Shanghai Municipal Science and Technology Major Project(2018SHZDZX03)Shanghai Municipal Science and Technology Major Project(2018SHZDZX03)Innovation Program of Shanghai Municipal Education Commission,Programme of Introducing Talents of Discipline to Universities(B16017)Croucher Foundation(Hong Kong)in the form of a CAS-Croucher Foundation Joint Laboratory Grant,and Fundamental Research Funds for the Central Universities.
文摘The purpose of achieving the long-lasting fragrance perception leads to nanocarrier-based profragrances in perfume applications.Herein,we report a family of novel profragrance systems based on polyhedral oligomeric silsesquioxane(POSS)derivatized thioureas(POSS thioureas)that enable linkage of volatile carbonyl fragrances with the spontaneous formation of fragile hydrogen bonds.This profragrance platform addresses the dilemma of the volatile nature of aroma-materials on the one hand,and the desired long-lasting effects on the other.Their releasing performance as profragrances is investigated by headspace solid-phase microextraction(SPME)in combination with gas chromatography(GC)analysis under water as the external humidity stimulus,indicating that the fragrance concentration released from the POSS–thiourea-based profragrance is up to four times higher than the neat reference of the corresponding perfume aldehydes.Furthermore,deposition of the novel profragrance system onto wallpaper results in excellent retentive capacity for volatile aldehydes.Given the low essential toxicity,the POSS–thiourea system has been demonstrated as a suitable profragrance for practical application to perfume delivery.
基金supported by the National Key R&D Program of China(2021YFA1501100)the National Natural Science Foundation of China(22005007)+1 种基金the New Cornerstone Science Foundation,and Liaoning Binhai Laboratory Project(LBLF-202306)the Tencent Foundation through the XPLORER PRIZE.
文摘A hydrogen storage system was developed via heterogeneous catalysis,employing the dehydrogenative coupling of methanol and N,N′-dimethylethylenediamine to efficiently produce high-purity H_(2).In this process,the Cu/ZnO/Al_(2)O_(3) catalyst displayed superior activity in hydrogen production,with Cu+identified as the major active site through comprehensive characterization.
