First, the high-rise building structure design process is divided into three relevant steps, that is, scheme generation and creation, performance evaluation, and scheme optimization. Then with the application of relat...First, the high-rise building structure design process is divided into three relevant steps, that is, scheme generation and creation, performance evaluation, and scheme optimization. Then with the application of relational database, the case database of high-rise structures is constructed, the structure form-selection designing methods such as the smart algorithm based on CBR, DM, FINS, NN and GA is presented, and the original forms system of this method and its general structure are given. CBR and DM are used to generate scheme candidates; FINS and NN to evaluate and optimize the scheme performance; GA to create new structure forms. Finally, the application cases are presented, whose results fit in with the real project. It proves by combining and using the expert intelligence, algorithm intelligence and machine intelligence that this method makes good use of not only the engineering project knowledge and expertise but also much deeper knowledge contained in various engineering cases. In other words, it is because the form selection has a strong background support of vast real cases that its results prove more reliable and more acceptable. So the introduction of this method provides an effective approach to improving the quality, efficiency, automatic and smart level of high-rise structures form selection design.展开更多
With the rapid development of China's economy, the modernization drive and the process of urbanization continue to advance, land for urban construction is becoming more and tenser and land prices are rising steadily,...With the rapid development of China's economy, the modernization drive and the process of urbanization continue to advance, land for urban construction is becoming more and tenser and land prices are rising steadily, there are more and more high-rise buildings, its density is also increasing. With the increasing number trend of high-rise building development, anti-seismic building requirement as an important part of architectural design is worthy of our exploration and study. Seismic resistance has become an important subject of engineering design. This paper will discuss the technical principle of seismic design in building structure design, so as to optimize the seismic design of high-rise building structure better.展开更多
Layer-structured Ruddlesden–Popper(RP)perovskites(RPPs)with decent stability have captured the imagination of the photovoltaic research community and bring hope for boosting the development of perovskite solar cell(P...Layer-structured Ruddlesden–Popper(RP)perovskites(RPPs)with decent stability have captured the imagination of the photovoltaic research community and bring hope for boosting the development of perovskite solar cell(PSC)technology.However,two-dimensional(2D)or quasi-2D RP PSCs are encountered with some challenges of the large exciton binding energy,blocked charge transport and poor film quality,which restrict their photovoltaic performance.Fortunately,these issues can be readily resolved by rationally designing spacer cations of RPPs.This review mainly focuses on how to design the molecular structures of organic spacers and aims to endow RPPs with outstanding photovoltaic applications.We firstly elucidated the important roles of organic spacers in impacting crystallization kinetics,charge transporting ability and stability of RPPs.Then we brought three aspects to attention for designing organic spacers.Finally,we presented the specific molecular structure design strategies for organic spacers of RPPs aiming to improve photovoltaic performance of RP PSCs.These proposed strategies in this review will provide new avenues to develop novel organic spacers for RPPs and advance the development of RPP photovoltaic technology for future applications.展开更多
Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design...Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design targets,or are difficult to suit for different types of structures,e.g.,designing for different materials at each layer.These methods also cannot accommodate versatile design situations under different angles and polarizations.In addition,how to benefit practical fabrications and manufacturing has not been extensively considered yet.In this work,we introduce OptoGPT(Opto Generative Pretrained Transformer),a decoder-only transformer,to solve all these drawbacks and issues simultaneously.展开更多
γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface receptors.Mutations inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as well.However,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-secretase.In this review,we focus on recent studies of structural dynamic mechanisms ofγ-secretase.Different mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics simulations.While an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental findings.The approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-secretase.In addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is discussed.Finally,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations of theγ-secretase-substrate complexes.Comprehensive understanding of the functional mechanisms ofγ-secretase will greatly facilitate the rational design of effective drug molecules for treating familial Alzheimer’s disease and perhaps Alzheimer’s disease in general.展开更多
Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas...Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightweight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightweight, high-strength large cavity structures.展开更多
Different bilayer structures of HfO_(x)/Ti(TiO_(x)) are designed for hafnium-based memory to investigate the switching characteristics. The chemical states in the films and near the interface are characterized by x-ra...Different bilayer structures of HfO_(x)/Ti(TiO_(x)) are designed for hafnium-based memory to investigate the switching characteristics. The chemical states in the films and near the interface are characterized by x-ray photoelectron spectroscopy,and the oxygen vacancies are analyzed. Highly improved on/off ratio(~104) and much uniform switching parameters are observed for bilayer structures compared to single layer HfO_(x) sample, which can be attributed to the modulation of oxygen vacancies at the interface and better control of the growth of filaments. Furthermore, the reliability of the prepared samples is investigated. The carrier conduction behaviors of HfO_(x)-based samples can be attributed to the trapping and de-trapping process of oxygen vacancies and a filamentary model is proposed. In addition, the rupture of filaments during the reset process for the bilayer structures occur at the weak points near the interface by the recovery of oxygen vacancies accompanied by the variation of barrier height. The re-formation of fixed filaments due to the residual filaments as lightning rods results in the better switching performance of the bilayer structure.展开更多
Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely comme...Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely commercial application and development of LSB is mainly hindered by serious“shuttle effect”of lithium polysulfides(Li PSs),slow reaction kinetics,notorious lithium dendrites,etc.In various structures of LSB materials,array structured materials,possessing the composition of ordered micro units with the same or similar characteristics of each unit,present excellent application potential for various secondary cells due to some merits such as immobilization of active substances,high specific surface area,appropriate pore sizes,easy modification of functional material surface,accommodated huge volume change,enough facilitated transportation for electrons/lithium ions,and special functional groups strongly adsorbing Li PSs.Thus many novel array structured materials are applied to battery for tackling thorny problems mentioned above.In this review,recent progresses and developments on array structured materials applied in LSBs including preparation ways,collaborative structural designs based on array structures,and action mechanism analyses in improving electrochemical performance and safety are summarized.Meanwhile,we also have detailed discussion for array structured materials in LSBs and constructed the structure-function relationships between array structured materials and battery performances.Lastly,some directions and prospects about preparation ways,functional modifications,and practical applications of array structured materials in LSBs are generalized.We hope the review can attract more researchers'attention and bring more studying on array structured materials for other secondary batteries including LSB.展开更多
With the continuous advancement in topology optimization and additive manufacturing(AM)technology,the capability to fabricate functionally graded materials and intricate cellular structures with spatially varying micr...With the continuous advancement in topology optimization and additive manufacturing(AM)technology,the capability to fabricate functionally graded materials and intricate cellular structures with spatially varying microstructures has grown significantly.However,a critical challenge is encountered in the design of these structures–the absence of robust interface connections between adjacent microstructures,potentially resulting in diminished efficiency or macroscopic failure.A Hybrid Level Set Method(HLSM)is proposed,specifically designed to enhance connectivity among non-uniform microstructures,contributing to the design of functionally graded cellular structures.The HLSM introduces a pioneering algorithm for effectively blending heterogeneous microstructure interfaces.Initially,an interpolation algorithm is presented to construct transition microstructures seamlessly connected on both sides.Subsequently,the algorithm enables the morphing of non-uniform unit cells to seamlessly adapt to interconnected adjacent microstructures.The method,seamlessly integrated into a multi-scale topology optimization framework using the level set method,exhibits its efficacy through numerical examples,showcasing its prowess in optimizing 2D and 3D functionally graded materials(FGM)and multi-scale topology optimization.In essence,the pressing issue of interface connections in complex structure design is not only addressed but also a robust methodology is introduced,substantiated by numerical evidence,advancing optimization capabilities in the realm of functionally graded materials and cellular structures.展开更多
In this paper,to present a lightweight-developed front underrun protection device(FUPD)for heavy-duty trucks,plain weave carbon fiber reinforced plastic(CFRP)is used instead of the original high-strength steel.First,t...In this paper,to present a lightweight-developed front underrun protection device(FUPD)for heavy-duty trucks,plain weave carbon fiber reinforced plastic(CFRP)is used instead of the original high-strength steel.First,the mechanical and structural properties of plain carbon fiber composite anti-collision beams are comparatively analyzed from a multi-scale perspective.For studying the design capability of carbon fiber composite materials,we investigate the effects of TC-33 carbon fiber diameter(D),fiber yarn width(W)and height(H),and fiber yarn density(N)on the front underrun protective beam of carbon fiber compositematerials.Based on the investigation,a material-structure matching strategy suitable for the front underrun protective beam of heavy-duty trucks is proposed.Next,the composite material structure is optimized by applying size optimization and stack sequence optimization methods to obtain the higher performance carbon fiber composite front underrun protection beam of commercial vehicles.The results show that the fiber yarn height(H)has the greatest influence on the protective beam,and theH1matching scheme for the front underrun protective beamwith a carbon fiber composite structure exhibits superior performance.The proposed method achieves a weight reduction of 55.21% while still meeting regulatory requirements,which demonstrates its remarkable weight reduction effect.展开更多
In this research work, it has been designed a bionic robot fish structure, can swim underwater. The active compact body is powered by eight sets of symmetric PVC gel actuators with a caudal fin. The robot’s 200 mm-lo...In this research work, it has been designed a bionic robot fish structure, can swim underwater. The active compact body is powered by eight sets of symmetric PVC gel actuators with a caudal fin. The robot’s 200 mm-long, fish structure design incorporates a 55.52 angle to optimize the fish dynamics movement. It’s a fast and smooth operation and can swim. The robot can swim fast and quietly by using the right positions and the appropriate actuators on PVC gel actuators. This design entails a unique architecture that enables the robot to move safely and unobtrusively at the same time, which makes it suitable equipment for different exploration and surveillance missions in the water with speed and silent operation as the foremost concern.展开更多
This paper analyzes the structural design of an urban interchange ramp bridge from four aspects,which are the superstructure,pier structure,foundation structure,and deck structure design to summarize the structural de...This paper analyzes the structural design of an urban interchange ramp bridge from four aspects,which are the superstructure,pier structure,foundation structure,and deck structure design to summarize the structural design ideas of this urban interchange ramp bridge,which can be used as a reference for future construction of the same bridge.展开更多
Artificial fish reef is a kind of artificial structure in water,which provides a necessary and safe place for aquatic life such as fish to inhabit,grow,and breed,and creates an environment suitable for fish growth,so ...Artificial fish reef is a kind of artificial structure in water,which provides a necessary and safe place for aquatic life such as fish to inhabit,grow,and breed,and creates an environment suitable for fish growth,so as to protect and multiply fishery resources.In a large time scale,the physical process of sea area can deeply affect the chemical process and biological process,so the structure characteristics of artificial reef are the key factors affecting the flow field effect around the reef.In this study,through the hydrodynamic experiments of four kinds of reef models,including big windows box reef,big and small windows box reef,"(卐)"shaped reef and double-layer shellfish breeding reef,the influence of single reef structure on the flow field effect is analyzed,and the force conditions of different reefs under the same incoming current velocity are obtained.According to the simulation results,the safety research and calculation of five kinds of reef models are carried out,and the volumes of vortex area and upwelling area behind four kinds of reef are obtained.Using hydrodynamic model to simulate the flow field effect of reef area,optimizing the reef structure design,improving the maximum biological trapping and proliferation effect of reef,can provide theoretical guidance and scientific and technological support for the construction of reef area.展开更多
Adequacy of structural fire design in uncommon structures is conceptually ensured through cost-benefit analysis where the future costs are balanced against the benefits of safety investment.Cost-benefit analyses,howev...Adequacy of structural fire design in uncommon structures is conceptually ensured through cost-benefit analysis where the future costs are balanced against the benefits of safety investment.Cost-benefit analyses,however,are complicated and computationally challenging,and hence impractical for application to individual projects.To address this issue,design guidance proposes target reliability indices for normal design conditions,but no target reliability indices are defined for structural fire design.We revisit the background of the cost-optimization based approach underlying normal design target reliability indices then we extend this approach for the case of fire design of structures.We also propose a modified objective function for cost-optimization which simplifies the evaluation of target reliability indices and reduces the number of assumptions.The optimum safety level is expressed as a function of a new dimensionless variable named“Damage-to-investment indicator”(DII).The cost optimization approach is validated for the target reliability indices for normal design condition.The method is then applied for evaluating DII and the associated optimum reliability indices for fire-exposed structures.Two case studies are presented:(i)a one-way loaded reinforced concrete slab and(ii)a steel column under axial loading.This study thus provides a framework for deriving optimum(target)reliability index for structural fire design which can support the development of rational provisions in codes and standards.展开更多
Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmit...Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmits professional knowledge for students,enhances the students’professional ability,and further carries out in-depth research on the course to bring a better teaching effect for students.The article mainly focuses on the research of the principles of concrete structure design course,conducts an analysis of the teaching characteristics of the principles of concrete structure design course,and reasonably sets the teaching content from the optimization of the course teaching objectives;innovative course teaching methods can deepen the effect of knowledge understanding;reform of experimental practice teaching can lay down the effect of the internalization of knowledge,etc.The in-depth description and discussion of the relevant aspects of the research aim to provide guidelines for related research.展开更多
This paper reviews the applications of the multi degree-of-freedom(MDOF)equivalent linear system in seismic analysis and design of planar steel and reinforced concrete framed structures.An equivalent MDOF linear struc...This paper reviews the applications of the multi degree-of-freedom(MDOF)equivalent linear system in seismic analysis and design of planar steel and reinforced concrete framed structures.An equivalent MDOF linear structure,analogous to the original MDOF nonlinear structure,is constructed,which has the same mass and elastic stiffness as the original structure and modal damping ratios that account for the effects of geometrical and material nonlinearities.The equivalence implies a balance between the viscous damping work of the equivalent linear structure and that of the nonlinearities in the original nonlinear structure.This work balance is established with the aid of a transfer function in the frequency domain.Thus,equivalent modal damping ratios can be explicitly determined in terms of the period and deformation levels of the structure as well as the soil types.Use of these equivalent modal damping ratios can help address a variety of seismic analysis and design problems associated with planar steel and reinforced concrete framed structures in a rational and accurate manner.These include force-based seismic design with the aid of acceleration response spectra characterized by high amounts of damping,improved direct displacement-based seismic design and the development of advanced seismic intensity measures.The equivalent modal damping ratios are also utilized in the context of linear modal analysis for the definition and construction of the MDOF response spectrum.Furthermore,the equivalent modal damping ratios are employed in a seismic retrofit method for steel-framed structures with viscous dampers.Finally,it is demonstrated that modal behavior(or strength reduction)factors can be easily constructed based on these modal damping ratios for a more rational and accurate force-based seismic design,including the determination of inelastic displacement profiles.展开更多
In this study,an innovative solution is developed for vibration suppression of the high-rise building.The infinite dimensional system model has been presented for describing high-rise building structures which have a ...In this study,an innovative solution is developed for vibration suppression of the high-rise building.The infinite dimensional system model has been presented for describing high-rise building structures which have a large inertial load with the help of the Hamilton’s principle.On the basis of this system model and with the use of the Lyapunov’s direct method,a boundary controller is proposed and the closed-loop system is uniformly bounded in the time domain.Finally,by using the Smart Structure laboratory platform which is produced by Quancer,we conduct a set of experiments and find that the designed method is resultful.展开更多
This paper presents the restraining moments of outriggers acting on the core wall and the equation of the horizontal top deflection based on a simplified outrigger model. The deformation compatibility conditions betwe...This paper presents the restraining moments of outriggers acting on the core wall and the equation of the horizontal top deflection based on a simplified outrigger model. The deformation compatibility conditions between outriggers and core wall as well as the finite rigidities of outriggers are also considered. One case study was carried out to analyze the horizontal top deflection and the mutation of the restraining moments caused by the variation of outrigger location. The results showed that the method adopted in the paper is simple and reasonable. Some conclusions are valuable to the safety design of high-rise building structures.展开更多
Many studies have been undertaken to predict local scour around offshore high-rise structure foundations(HRSFs),which have been used in constructing the Donghai Wind Farm in China.However,there have been few works on ...Many studies have been undertaken to predict local scour around offshore high-rise structure foundations(HRSFs),which have been used in constructing the Donghai Wind Farm in China.However,there have been few works on the turbulent flow that drives the scour process.In this study,the characteristics of the turbulent flow fields around an HRSF were investigated using the particle image velocimetry technique.The mean flow,vorticity,and turbulence intensity were analyzed in detail.The relationship between the flow feature and scour development around an HRSF was elaborated.The results showed that the flow velocity increased to its maximum value near the third row of the pile group.The shear layer and wake vortices could not be fully developed downstream of the last row of the piles at small Reynolds numbers.The strong flow and turbulent fluctuation near the third piles explained the existence of a longtail scour pattern starting from the HRSF shoulders and a trapezoidal deposition region directly downstream of HRSF.This laboratory experiment gains insight into the mechanism of the turbulent flow around HRSFs and provides a rare dataset for numerical model verifications.展开更多
When evaluating the seismic safety and reliability of complex engineering structures,it is a critical problem to reasonably consider the randomness and multi-dimensional nature of ground motions.To this end,a proposed...When evaluating the seismic safety and reliability of complex engineering structures,it is a critical problem to reasonably consider the randomness and multi-dimensional nature of ground motions.To this end,a proposed modeling strategy of multi-dimensional stochastic earthquakes is addressed in this study.This improved seismic model has several merits that enable it to better provide seismic analyses of structures.Specifically,at first,the ground motion model is compatible with the design response spectrum.Secondly,the evolutionary power spectrum involved in the model and the design response spectrum are constructed accordingly with sufficient consideration of the correlation between different seismic components.Thirdly,the random function-based dimension-reduction representation is applied,by which seismic modeling is established,with three elementary random variables.Numerical simulations of multi-dimensional stochastic ground motions in a specific design scenario indicate the effectiveness of the proposed modeling strategy.Moreover,the multi-dimensional seismic response and the global reliability of a high-rise frame-core tube structure is discussed in detail to further illustrate the engineering applicability of the proposed method.The analytical investigations demonstrate that the suggested stochastic model of multi-dimensional ground motion is available for accurate seismic response analysis and dynamic reliability assessment of complex engineering structures for performance-based seismic resistance design.展开更多
文摘First, the high-rise building structure design process is divided into three relevant steps, that is, scheme generation and creation, performance evaluation, and scheme optimization. Then with the application of relational database, the case database of high-rise structures is constructed, the structure form-selection designing methods such as the smart algorithm based on CBR, DM, FINS, NN and GA is presented, and the original forms system of this method and its general structure are given. CBR and DM are used to generate scheme candidates; FINS and NN to evaluate and optimize the scheme performance; GA to create new structure forms. Finally, the application cases are presented, whose results fit in with the real project. It proves by combining and using the expert intelligence, algorithm intelligence and machine intelligence that this method makes good use of not only the engineering project knowledge and expertise but also much deeper knowledge contained in various engineering cases. In other words, it is because the form selection has a strong background support of vast real cases that its results prove more reliable and more acceptable. So the introduction of this method provides an effective approach to improving the quality, efficiency, automatic and smart level of high-rise structures form selection design.
文摘With the rapid development of China's economy, the modernization drive and the process of urbanization continue to advance, land for urban construction is becoming more and tenser and land prices are rising steadily, there are more and more high-rise buildings, its density is also increasing. With the increasing number trend of high-rise building development, anti-seismic building requirement as an important part of architectural design is worthy of our exploration and study. Seismic resistance has become an important subject of engineering design. This paper will discuss the technical principle of seismic design in building structure design, so as to optimize the seismic design of high-rise building structure better.
基金funding from National Science Foundation of China(52202337 and 22178015)the Young Taishan Scholars Program of Shandong Province(tsqn202211082)+1 种基金Natural Science Foundation of Shandong Province(ZR2023MB051)Independent Innovation Research Project of China University of Petroleum(East China)(22CX06023A).
文摘Layer-structured Ruddlesden–Popper(RP)perovskites(RPPs)with decent stability have captured the imagination of the photovoltaic research community and bring hope for boosting the development of perovskite solar cell(PSC)technology.However,two-dimensional(2D)or quasi-2D RP PSCs are encountered with some challenges of the large exciton binding energy,blocked charge transport and poor film quality,which restrict their photovoltaic performance.Fortunately,these issues can be readily resolved by rationally designing spacer cations of RPPs.This review mainly focuses on how to design the molecular structures of organic spacers and aims to endow RPPs with outstanding photovoltaic applications.We firstly elucidated the important roles of organic spacers in impacting crystallization kinetics,charge transporting ability and stability of RPPs.Then we brought three aspects to attention for designing organic spacers.Finally,we presented the specific molecular structure design strategies for organic spacers of RPPs aiming to improve photovoltaic performance of RP PSCs.These proposed strategies in this review will provide new avenues to develop novel organic spacers for RPPs and advance the development of RPP photovoltaic technology for future applications.
基金the National Science Foundation(PFI-008513 and FET-2309403)for the support of this work.
文摘Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design targets,or are difficult to suit for different types of structures,e.g.,designing for different materials at each layer.These methods also cannot accommodate versatile design situations under different angles and polarizations.In addition,how to benefit practical fabrications and manufacturing has not been extensively considered yet.In this work,we introduce OptoGPT(Opto Generative Pretrained Transformer),a decoder-only transformer,to solve all these drawbacks and issues simultaneously.
基金supported in part by Award 2121063 from National Science Foundation(to YM)AG66986 from the National Institutes of Health(to MSW).
文摘γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface receptors.Mutations inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as well.However,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-secretase.In this review,we focus on recent studies of structural dynamic mechanisms ofγ-secretase.Different mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics simulations.While an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental findings.The approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-secretase.In addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is discussed.Finally,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations of theγ-secretase-substrate complexes.Comprehensive understanding of the functional mechanisms ofγ-secretase will greatly facilitate the rational design of effective drug molecules for treating familial Alzheimer’s disease and perhaps Alzheimer’s disease in general.
基金the National Natural Science Foundation of China and the Natural Science Foundation of Jiangsu Province.It was also supported in part by Young Elite Scientists Sponsorship Program by CAST.
文摘Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightweight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightweight, high-strength large cavity structures.
基金financially supported by the National Natural Science Foundation of China (Grant No.51802025)the Natural Science Basic Research Plan in Shaanxi Province of China (Grant No.2020JQ-384)。
文摘Different bilayer structures of HfO_(x)/Ti(TiO_(x)) are designed for hafnium-based memory to investigate the switching characteristics. The chemical states in the films and near the interface are characterized by x-ray photoelectron spectroscopy,and the oxygen vacancies are analyzed. Highly improved on/off ratio(~104) and much uniform switching parameters are observed for bilayer structures compared to single layer HfO_(x) sample, which can be attributed to the modulation of oxygen vacancies at the interface and better control of the growth of filaments. Furthermore, the reliability of the prepared samples is investigated. The carrier conduction behaviors of HfO_(x)-based samples can be attributed to the trapping and de-trapping process of oxygen vacancies and a filamentary model is proposed. In addition, the rupture of filaments during the reset process for the bilayer structures occur at the weak points near the interface by the recovery of oxygen vacancies accompanied by the variation of barrier height. The re-formation of fixed filaments due to the residual filaments as lightning rods results in the better switching performance of the bilayer structure.
基金This work was supported by the National Natural Science Foundation of China(52203066,51973157,61904123)the Tianjin Natural Science Foundation(18JCQNJC02900)+3 种基金the National innovation and entrepreneurship training program for college students(202310058007)the Tianjin Municipal college students’innovation and entrepreneurship training program(202310058088)the Science&Technology Development Fund of Tianjin Education Commission for Higher Education(Grant No.2018KJ196)the State Key Laboratory of Membrane and Membrane Separation,Tiangong University.
文摘Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely commercial application and development of LSB is mainly hindered by serious“shuttle effect”of lithium polysulfides(Li PSs),slow reaction kinetics,notorious lithium dendrites,etc.In various structures of LSB materials,array structured materials,possessing the composition of ordered micro units with the same or similar characteristics of each unit,present excellent application potential for various secondary cells due to some merits such as immobilization of active substances,high specific surface area,appropriate pore sizes,easy modification of functional material surface,accommodated huge volume change,enough facilitated transportation for electrons/lithium ions,and special functional groups strongly adsorbing Li PSs.Thus many novel array structured materials are applied to battery for tackling thorny problems mentioned above.In this review,recent progresses and developments on array structured materials applied in LSBs including preparation ways,collaborative structural designs based on array structures,and action mechanism analyses in improving electrochemical performance and safety are summarized.Meanwhile,we also have detailed discussion for array structured materials in LSBs and constructed the structure-function relationships between array structured materials and battery performances.Lastly,some directions and prospects about preparation ways,functional modifications,and practical applications of array structured materials in LSBs are generalized.We hope the review can attract more researchers'attention and bring more studying on array structured materials for other secondary batteries including LSB.
基金the National Key Research and Development Program of China(Grant Number 2021YFB1714600)the National Natural Science Foundation of China(Grant Number 52075195)the Fundamental Research Funds for the Central Universities,China through Program No.2172019kfyXJJS078.
文摘With the continuous advancement in topology optimization and additive manufacturing(AM)technology,the capability to fabricate functionally graded materials and intricate cellular structures with spatially varying microstructures has grown significantly.However,a critical challenge is encountered in the design of these structures–the absence of robust interface connections between adjacent microstructures,potentially resulting in diminished efficiency or macroscopic failure.A Hybrid Level Set Method(HLSM)is proposed,specifically designed to enhance connectivity among non-uniform microstructures,contributing to the design of functionally graded cellular structures.The HLSM introduces a pioneering algorithm for effectively blending heterogeneous microstructure interfaces.Initially,an interpolation algorithm is presented to construct transition microstructures seamlessly connected on both sides.Subsequently,the algorithm enables the morphing of non-uniform unit cells to seamlessly adapt to interconnected adjacent microstructures.The method,seamlessly integrated into a multi-scale topology optimization framework using the level set method,exhibits its efficacy through numerical examples,showcasing its prowess in optimizing 2D and 3D functionally graded materials(FGM)and multi-scale topology optimization.In essence,the pressing issue of interface connections in complex structure design is not only addressed but also a robust methodology is introduced,substantiated by numerical evidence,advancing optimization capabilities in the realm of functionally graded materials and cellular structures.
基金supported by the Guangxi Science and Technology Plan and Project(Grant Numbers 2021AC19131 and 2022AC21140)Guangxi University of Science and Technology Doctoral Fund Project(Grant Number 20Z40).
文摘In this paper,to present a lightweight-developed front underrun protection device(FUPD)for heavy-duty trucks,plain weave carbon fiber reinforced plastic(CFRP)is used instead of the original high-strength steel.First,the mechanical and structural properties of plain carbon fiber composite anti-collision beams are comparatively analyzed from a multi-scale perspective.For studying the design capability of carbon fiber composite materials,we investigate the effects of TC-33 carbon fiber diameter(D),fiber yarn width(W)and height(H),and fiber yarn density(N)on the front underrun protective beam of carbon fiber compositematerials.Based on the investigation,a material-structure matching strategy suitable for the front underrun protective beam of heavy-duty trucks is proposed.Next,the composite material structure is optimized by applying size optimization and stack sequence optimization methods to obtain the higher performance carbon fiber composite front underrun protection beam of commercial vehicles.The results show that the fiber yarn height(H)has the greatest influence on the protective beam,and theH1matching scheme for the front underrun protective beamwith a carbon fiber composite structure exhibits superior performance.The proposed method achieves a weight reduction of 55.21% while still meeting regulatory requirements,which demonstrates its remarkable weight reduction effect.
文摘In this research work, it has been designed a bionic robot fish structure, can swim underwater. The active compact body is powered by eight sets of symmetric PVC gel actuators with a caudal fin. The robot’s 200 mm-long, fish structure design incorporates a 55.52 angle to optimize the fish dynamics movement. It’s a fast and smooth operation and can swim. The robot can swim fast and quietly by using the right positions and the appropriate actuators on PVC gel actuators. This design entails a unique architecture that enables the robot to move safely and unobtrusively at the same time, which makes it suitable equipment for different exploration and surveillance missions in the water with speed and silent operation as the foremost concern.
文摘This paper analyzes the structural design of an urban interchange ramp bridge from four aspects,which are the superstructure,pier structure,foundation structure,and deck structure design to summarize the structural design ideas of this urban interchange ramp bridge,which can be used as a reference for future construction of the same bridge.
基金supported by the National Key R&D Plan(No.2023YFD2401104)Tianjin Agricultural Development Service Center Science and Technology Innovation Project for Youth(No.ZXKJ202429 and No.ZXKJ202454).
文摘Artificial fish reef is a kind of artificial structure in water,which provides a necessary and safe place for aquatic life such as fish to inhabit,grow,and breed,and creates an environment suitable for fish growth,so as to protect and multiply fishery resources.In a large time scale,the physical process of sea area can deeply affect the chemical process and biological process,so the structure characteristics of artificial reef are the key factors affecting the flow field effect around the reef.In this study,through the hydrodynamic experiments of four kinds of reef models,including big windows box reef,big and small windows box reef,"(卐)"shaped reef and double-layer shellfish breeding reef,the influence of single reef structure on the flow field effect is analyzed,and the force conditions of different reefs under the same incoming current velocity are obtained.According to the simulation results,the safety research and calculation of five kinds of reef models are carried out,and the volumes of vortex area and upwelling area behind four kinds of reef are obtained.Using hydrodynamic model to simulate the flow field effect of reef area,optimizing the reef structure design,improving the maximum biological trapping and proliferation effect of reef,can provide theoretical guidance and scientific and technological support for the construction of reef area.
基金funded by the Ghent University Special Research Fund under grant 01N01219“Multi-objective societal optimization of structural fire safety investments for uncommon projects using advanced regression techniques”.
文摘Adequacy of structural fire design in uncommon structures is conceptually ensured through cost-benefit analysis where the future costs are balanced against the benefits of safety investment.Cost-benefit analyses,however,are complicated and computationally challenging,and hence impractical for application to individual projects.To address this issue,design guidance proposes target reliability indices for normal design conditions,but no target reliability indices are defined for structural fire design.We revisit the background of the cost-optimization based approach underlying normal design target reliability indices then we extend this approach for the case of fire design of structures.We also propose a modified objective function for cost-optimization which simplifies the evaluation of target reliability indices and reduces the number of assumptions.The optimum safety level is expressed as a function of a new dimensionless variable named“Damage-to-investment indicator”(DII).The cost optimization approach is validated for the target reliability indices for normal design condition.The method is then applied for evaluating DII and the associated optimum reliability indices for fire-exposed structures.Two case studies are presented:(i)a one-way loaded reinforced concrete slab and(ii)a steel column under axial loading.This study thus provides a framework for deriving optimum(target)reliability index for structural fire design which can support the development of rational provisions in codes and standards.
文摘Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmits professional knowledge for students,enhances the students’professional ability,and further carries out in-depth research on the course to bring a better teaching effect for students.The article mainly focuses on the research of the principles of concrete structure design course,conducts an analysis of the teaching characteristics of the principles of concrete structure design course,and reasonably sets the teaching content from the optimization of the course teaching objectives;innovative course teaching methods can deepen the effect of knowledge understanding;reform of experimental practice teaching can lay down the effect of the internalization of knowledge,etc.The in-depth description and discussion of the relevant aspects of the research aim to provide guidelines for related research.
文摘This paper reviews the applications of the multi degree-of-freedom(MDOF)equivalent linear system in seismic analysis and design of planar steel and reinforced concrete framed structures.An equivalent MDOF linear structure,analogous to the original MDOF nonlinear structure,is constructed,which has the same mass and elastic stiffness as the original structure and modal damping ratios that account for the effects of geometrical and material nonlinearities.The equivalence implies a balance between the viscous damping work of the equivalent linear structure and that of the nonlinearities in the original nonlinear structure.This work balance is established with the aid of a transfer function in the frequency domain.Thus,equivalent modal damping ratios can be explicitly determined in terms of the period and deformation levels of the structure as well as the soil types.Use of these equivalent modal damping ratios can help address a variety of seismic analysis and design problems associated with planar steel and reinforced concrete framed structures in a rational and accurate manner.These include force-based seismic design with the aid of acceleration response spectra characterized by high amounts of damping,improved direct displacement-based seismic design and the development of advanced seismic intensity measures.The equivalent modal damping ratios are also utilized in the context of linear modal analysis for the definition and construction of the MDOF response spectrum.Furthermore,the equivalent modal damping ratios are employed in a seismic retrofit method for steel-framed structures with viscous dampers.Finally,it is demonstrated that modal behavior(or strength reduction)factors can be easily constructed based on these modal damping ratios for a more rational and accurate force-based seismic design,including the determination of inelastic displacement profiles.
基金supported in part by the National Natural Science Foundation of China(61933001,62061160371,62003029)Beijing Natural Science Foundation(JQ20026)Beijing Top Discipline for Artificial Intelligent Science and Engineering,University of Science and Technology Beijing。
文摘In this study,an innovative solution is developed for vibration suppression of the high-rise building.The infinite dimensional system model has been presented for describing high-rise building structures which have a large inertial load with the help of the Hamilton’s principle.On the basis of this system model and with the use of the Lyapunov’s direct method,a boundary controller is proposed and the closed-loop system is uniformly bounded in the time domain.Finally,by using the Smart Structure laboratory platform which is produced by Quancer,we conduct a set of experiments and find that the designed method is resultful.
基金Project supported by the National Natural Science Foundation of China (No. 50378041) and the Specialized Research Fund for theDoctoral Program of Higher Education (No. 20030487016), China
文摘This paper presents the restraining moments of outriggers acting on the core wall and the equation of the horizontal top deflection based on a simplified outrigger model. The deformation compatibility conditions between outriggers and core wall as well as the finite rigidities of outriggers are also considered. One case study was carried out to analyze the horizontal top deflection and the mutation of the restraining moments caused by the variation of outrigger location. The results showed that the method adopted in the paper is simple and reasonable. Some conclusions are valuable to the safety design of high-rise building structures.
基金supported by the National Key Research and Development Program of China(Grant No.2016YFC0402605)the National Natural Science Foundation of China(Grant No.51779080)+2 种基金the Fok Ying Tung Education Foundation(Grant No.20190094210001)the Natural Science Foundation of Jiangsu Province(Grant No.BK20191299)the 111 Project of the Ministry of Education and State Administration of Foreign Expert Affairs of China(Grant No.B17015).
文摘Many studies have been undertaken to predict local scour around offshore high-rise structure foundations(HRSFs),which have been used in constructing the Donghai Wind Farm in China.However,there have been few works on the turbulent flow that drives the scour process.In this study,the characteristics of the turbulent flow fields around an HRSF were investigated using the particle image velocimetry technique.The mean flow,vorticity,and turbulence intensity were analyzed in detail.The relationship between the flow feature and scour development around an HRSF was elaborated.The results showed that the flow velocity increased to its maximum value near the third row of the pile group.The shear layer and wake vortices could not be fully developed downstream of the last row of the piles at small Reynolds numbers.The strong flow and turbulent fluctuation near the third piles explained the existence of a longtail scour pattern starting from the HRSF shoulders and a trapezoidal deposition region directly downstream of HRSF.This laboratory experiment gains insight into the mechanism of the turbulent flow around HRSFs and provides a rare dataset for numerical model verifications.
基金National Natural Science Foundation of China under Grant Nos.51978543,52108444,and 51778343Plan of Outstanding Young and Middle-aged Scientific and Technological Innovation Team in the Universities of Hubei Province with Project No.T2020010Natural Science Foundation of Hebei Province under Grant No.E2021512001。
文摘When evaluating the seismic safety and reliability of complex engineering structures,it is a critical problem to reasonably consider the randomness and multi-dimensional nature of ground motions.To this end,a proposed modeling strategy of multi-dimensional stochastic earthquakes is addressed in this study.This improved seismic model has several merits that enable it to better provide seismic analyses of structures.Specifically,at first,the ground motion model is compatible with the design response spectrum.Secondly,the evolutionary power spectrum involved in the model and the design response spectrum are constructed accordingly with sufficient consideration of the correlation between different seismic components.Thirdly,the random function-based dimension-reduction representation is applied,by which seismic modeling is established,with three elementary random variables.Numerical simulations of multi-dimensional stochastic ground motions in a specific design scenario indicate the effectiveness of the proposed modeling strategy.Moreover,the multi-dimensional seismic response and the global reliability of a high-rise frame-core tube structure is discussed in detail to further illustrate the engineering applicability of the proposed method.The analytical investigations demonstrate that the suggested stochastic model of multi-dimensional ground motion is available for accurate seismic response analysis and dynamic reliability assessment of complex engineering structures for performance-based seismic resistance design.