The prediction of mild cognitive impairment or Alzheimer’s disease(AD)has gained the attention of huge researchers as the disease occurrence is increasing,and there is a need for earlier prediction.Regrettably,due to...The prediction of mild cognitive impairment or Alzheimer’s disease(AD)has gained the attention of huge researchers as the disease occurrence is increasing,and there is a need for earlier prediction.Regrettably,due to the highdimensionality nature of neural data and the least available samples,modelling an efficient computer diagnostic system is highly solicited.Learning approaches,specifically deep learning approaches,are essential in disease prediction.Deep Learning(DL)approaches are successfully demonstrated for their higher-level performance in various fields like medical imaging.A novel 3D-Convolutional Neural Network(3D-CNN)architecture is proposed to predict AD with Magnetic resonance imaging(MRI)data.The proposed model predicts the AD occurrence while the existing approaches lack prediction accuracy and perform binary classification.The proposed prediction model is validated using the Alzheimer’s disease Neuro-Imaging Initiative(ADNI)data.The outcomes demonstrate that the anticipated model attains superior prediction accuracy and works better than the brain-image dataset’s general approaches.The predicted model reduces the human effort during the prediction process and makes it easier to diagnose it intelligently as the feature learning is adaptive.Keras’experimentation is carried out,and the model’s superiority is compared with various advanced approaches for multi-level classification.The proposed model gives better prediction accuracy,precision,recall,and F-measure than other systems like Long Short Term Memory-Recurrent Neural Networks(LSTM-RNN),Stacked Autoencoder with Deep Neural Networks(SAE-DNN),Deep Convolutional Neural Networks(D-CNN),Two Dimensional Convolutional Neural Networks(2D-CNN),Inception-V4,ResNet,and Two Dimensional Convolutional Neural Networks(3D-CNN).展开更多
为了解决高维小样本的特征选择问题,该文结合文化基因算法(Memetic algorithm,MA)与最小二乘支持向量机(Memetic algorithm and least squares support vector machine,MALSSVM),设计了一种封装式(Wrapper)特征选择算法。该方法将全局...为了解决高维小样本的特征选择问题,该文结合文化基因算法(Memetic algorithm,MA)与最小二乘支持向量机(Memetic algorithm and least squares support vector machine,MALSSVM),设计了一种封装式(Wrapper)特征选择算法。该方法将全局搜索与局部搜索相结合作为求解策略,利用了最小二乘支持向量机易于求解的特点,构造分类器,以分类的准确率作为文化基因算法寻优过程中适应度函数的主要成分。实验表明,MA-LSSVM可以较高效稳定地获取对分类贡献较大的特征,降低数据维度,提高了分类效率。展开更多
Large high-dimensional data have posed great challenges to existing algorithms for frequent itemsets mining.To solve the problem,a hybrid method,consisting of a novel row enumeration algorithm and a column enumeration...Large high-dimensional data have posed great challenges to existing algorithms for frequent itemsets mining.To solve the problem,a hybrid method,consisting of a novel row enumeration algorithm and a column enumeration algorithm,is proposed.The intention of the hybrid method is to decompose the mining task into two subtasks and then choose appropriate algorithms to solve them respectively.The novel algorithm,i.e.,Inter-transaction is based on the characteristic that there are few common items between or among long transactions.In addition,an optimization technique is adopted to improve the performance of the intersection of bit-vectors.Experiments on synthetic data show that our method achieves high performance in large high-dimensional data.展开更多
基于生物免疫系统的自适应学习、记忆、监视等功能,设计适用于高维动态函数优化的自适应免疫算法.算法设计中,利用抗体的学习功能设计抗体动态进化模块;利用基因漂移促成抗体群中非优越抗体重构;利用记忆特性和记忆池动态维持功能,设计...基于生物免疫系统的自适应学习、记忆、监视等功能,设计适用于高维动态函数优化的自适应免疫算法.算法设计中,利用抗体的学习功能设计抗体动态进化模块;利用基因漂移促成抗体群中非优越抗体重构;利用记忆特性和记忆池动态维持功能,设计由记忆子集合构成的动态记忆池,并经由 Average linkage 保存优秀的记忆细胞;利用动态监视功能建立环境判别规则和初始抗体群的生成规则.该算法结构简单、灵活,以及在不同环境下寻优时间可以动态调节.数值实验比较显示出其优越性和在执行效率、执行效果中寻求权衡的有效性,并且对复杂的高维动态环境优化问题具有较大应用潜力.展开更多
It remains a great challenge to achieve sufficient cancer classification accuracy with the entire set of genes, due to the high dimensions, small sample size, and big noise of gene expression data. We thus proposed a ...It remains a great challenge to achieve sufficient cancer classification accuracy with the entire set of genes, due to the high dimensions, small sample size, and big noise of gene expression data. We thus proposed a hybrid gene selection method, Information Gain-Support Vector Machine （IG-SVM） in this study. IG was initially employed to filter irrelevant and redundant genes. Then, further removal of redundant genes was performed using SVM to eliminate the noise in the datasets more effectively. Finally, the informative genes selected by IG-SVM served as the input for the LIBSVM classifier. Compared to other related algorithms, IG-SVM showed the highest classification accuracy and superior performance as evaluated using five cancer gene expression datasets based on a few selected genes. As an example, IG-SVM achieved a classification accuracy of 90.32% for colon cancer, which is difficult to be accurately classified, only based on three genes including CSRP1, MYLg, and GUCA2B.展开更多
Quantile regression links the whole distribution of an outcome to the covariates of interest and has become an important alternative to commonly used regression models.However,the presence of censored data such as sur...Quantile regression links the whole distribution of an outcome to the covariates of interest and has become an important alternative to commonly used regression models.However,the presence of censored data such as survival time,often the main endpoint in cancer studies,has hampered the use of quantile regression techniques because of the incompleteness of data.With the advent of the precision medicine era and availability of high throughput data,quantile regression with high-dimensional predictors has attracted much attention and provided added insight compared to traditional regression approaches.This paper provides a practical guide for using quantile regression for right censored outcome data with covariates of low-or highdimensionality.We frame our discussion using a dataset from the Boston Lung Cancer Survivor Cohort,a hospital-based prospective cohort study,with the goals of broadening the scope of cancer research,maximizing the utility of collected data,and offering useful statistical alternatives.We use quantile regression to identify clinical and molecular predictors,for example CpG methylation sites,associated with high-risk lung cancer patients,for example those with short survival.展开更多
We analyze the convergence of the weighted nonlocal Laplacian(WNLL)on the high dimensional randomly distributed point cloud.Our analysis reveals the importance of the scaling weight,µ∼|P|/|S|with|P|and|S|being t...We analyze the convergence of the weighted nonlocal Laplacian(WNLL)on the high dimensional randomly distributed point cloud.Our analysis reveals the importance of the scaling weight,µ∼|P|/|S|with|P|and|S|being the number of entire and labeled data,respectively,in WNLL.The established result gives a theoretical foundation of the WNLL for high dimensional data interpolation.展开更多
文摘The prediction of mild cognitive impairment or Alzheimer’s disease(AD)has gained the attention of huge researchers as the disease occurrence is increasing,and there is a need for earlier prediction.Regrettably,due to the highdimensionality nature of neural data and the least available samples,modelling an efficient computer diagnostic system is highly solicited.Learning approaches,specifically deep learning approaches,are essential in disease prediction.Deep Learning(DL)approaches are successfully demonstrated for their higher-level performance in various fields like medical imaging.A novel 3D-Convolutional Neural Network(3D-CNN)architecture is proposed to predict AD with Magnetic resonance imaging(MRI)data.The proposed model predicts the AD occurrence while the existing approaches lack prediction accuracy and perform binary classification.The proposed prediction model is validated using the Alzheimer’s disease Neuro-Imaging Initiative(ADNI)data.The outcomes demonstrate that the anticipated model attains superior prediction accuracy and works better than the brain-image dataset’s general approaches.The predicted model reduces the human effort during the prediction process and makes it easier to diagnose it intelligently as the feature learning is adaptive.Keras’experimentation is carried out,and the model’s superiority is compared with various advanced approaches for multi-level classification.The proposed model gives better prediction accuracy,precision,recall,and F-measure than other systems like Long Short Term Memory-Recurrent Neural Networks(LSTM-RNN),Stacked Autoencoder with Deep Neural Networks(SAE-DNN),Deep Convolutional Neural Networks(D-CNN),Two Dimensional Convolutional Neural Networks(2D-CNN),Inception-V4,ResNet,and Two Dimensional Convolutional Neural Networks(3D-CNN).
文摘为了解决高维小样本的特征选择问题,该文结合文化基因算法(Memetic algorithm,MA)与最小二乘支持向量机(Memetic algorithm and least squares support vector machine,MALSSVM),设计了一种封装式(Wrapper)特征选择算法。该方法将全局搜索与局部搜索相结合作为求解策略,利用了最小二乘支持向量机易于求解的特点,构造分类器,以分类的准确率作为文化基因算法寻优过程中适应度函数的主要成分。实验表明,MA-LSSVM可以较高效稳定地获取对分类贡献较大的特征,降低数据维度,提高了分类效率。
基金The work was supported in part by Research Fund for the Doctoral Program of Higher Education of China(No.20060255006)
文摘Large high-dimensional data have posed great challenges to existing algorithms for frequent itemsets mining.To solve the problem,a hybrid method,consisting of a novel row enumeration algorithm and a column enumeration algorithm,is proposed.The intention of the hybrid method is to decompose the mining task into two subtasks and then choose appropriate algorithms to solve them respectively.The novel algorithm,i.e.,Inter-transaction is based on the characteristic that there are few common items between or among long transactions.In addition,an optimization technique is adopted to improve the performance of the intersection of bit-vectors.Experiments on synthetic data show that our method achieves high performance in large high-dimensional data.
文摘基于生物免疫系统的自适应学习、记忆、监视等功能,设计适用于高维动态函数优化的自适应免疫算法.算法设计中,利用抗体的学习功能设计抗体动态进化模块;利用基因漂移促成抗体群中非优越抗体重构;利用记忆特性和记忆池动态维持功能,设计由记忆子集合构成的动态记忆池,并经由 Average linkage 保存优秀的记忆细胞;利用动态监视功能建立环境判别规则和初始抗体群的生成规则.该算法结构简单、灵活,以及在不同环境下寻优时间可以动态调节.数值实验比较显示出其优越性和在执行效率、执行效果中寻求权衡的有效性,并且对复杂的高维动态环境优化问题具有较大应用潜力.
基金supported by the National Natural Science Foundation of China(Grant No.61672386)Humanities and Social Sciences Planning Project of Ministry of Education,China(Grant No.16YJAZH071)+1 种基金Anhui Provincial Natural Science Foundation of China(Grant No.1708085MF142)the Natural Science Research Key Project of Anhui Colleges,China(Grant No.KJ2014A266)
文摘It remains a great challenge to achieve sufficient cancer classification accuracy with the entire set of genes, due to the high dimensions, small sample size, and big noise of gene expression data. We thus proposed a hybrid gene selection method, Information Gain-Support Vector Machine （IG-SVM） in this study. IG was initially employed to filter irrelevant and redundant genes. Then, further removal of redundant genes was performed using SVM to eliminate the noise in the datasets more effectively. Finally, the informative genes selected by IG-SVM served as the input for the LIBSVM classifier. Compared to other related algorithms, IG-SVM showed the highest classification accuracy and superior performance as evaluated using five cancer gene expression datasets based on a few selected genes. As an example, IG-SVM achieved a classification accuracy of 90.32% for colon cancer, which is difficult to be accurately classified, only based on three genes including CSRP1, MYLg, and GUCA2B.
基金This study was supported by the National Institute of Health(U01CA209414).
文摘Quantile regression links the whole distribution of an outcome to the covariates of interest and has become an important alternative to commonly used regression models.However,the presence of censored data such as survival time,often the main endpoint in cancer studies,has hampered the use of quantile regression techniques because of the incompleteness of data.With the advent of the precision medicine era and availability of high throughput data,quantile regression with high-dimensional predictors has attracted much attention and provided added insight compared to traditional regression approaches.This paper provides a practical guide for using quantile regression for right censored outcome data with covariates of low-or highdimensionality.We frame our discussion using a dataset from the Boston Lung Cancer Survivor Cohort,a hospital-based prospective cohort study,with the goals of broadening the scope of cancer research,maximizing the utility of collected data,and offering useful statistical alternatives.We use quantile regression to identify clinical and molecular predictors,for example CpG methylation sites,associated with high-risk lung cancer patients,for example those with short survival.
基金Research supported by NSFC Grant 12071244NSF DMS-1924935.
文摘We analyze the convergence of the weighted nonlocal Laplacian(WNLL)on the high dimensional randomly distributed point cloud.Our analysis reveals the importance of the scaling weight,µ∼|P|/|S|with|P|and|S|being the number of entire and labeled data,respectively,in WNLL.The established result gives a theoretical foundation of the WNLL for high dimensional data interpolation.
