Epidemiological, Clinical Aspects and Factors Associated with Typical Gastroesophageal Reflux Disease in the General Population of Parakou, Republic of Benin

Introduction: Gastroesophageal reflux disease (GERD) is a benign and chronic disease that can impair the quality of life. Objective: To study the epidemiological, clinical aspects and factors associated with typical GERD in the general population of Parakou in the Republic of Benin. Methods: This was a descriptive and analytical cross-sectional study with prospective data collection which took place from May 1, 2019 to June 30, 2019. The study population consisted of any subject aged at least 15 years and living in Parakou. Subjects aged at least 15 years, present on the day of the survey and having given their free and informed verbal consent were included. The Short form of QRS®(Reflux-Qual Short form) questionnaire and the “Hospital Anxiety and Depression” score were used to assess the quality of life and anxiety/depression, respectively. The sampling was probabilistic through a 2-stage cluster sampling. The variable of interest was the presence of GERD. Results: Out of 390 subjects surveyed, 28 had symptoms of typical GERD, representing a prevalence of 7.18%. The average age of these subjects was 27.11 ± 7.88 years. Fifteen subjects (53.57%) were male, giving a sex ratio of 1.15. Fourteen (50%) had a secondary level of education, 12 (42.86%) were pupils/students, 18 (64.29%) were single. The monthly income of 22 subjects (78.57%) was lower than the guaranteed interprofessional minimum wage (40,000 FCFA). The average duration of progression of symptoms was 15.89 ± 4.97 months. Symptoms occurred less than twice a week in 22 subjects (78.57%). The clinical manifestations were both diurnal and nocturnal in 12 subjects (42.86%). None of the 28 subjects with GERD had clinical warning signs. Asthma, diabetes, consumption of high fat or spice foods, carbonated drinks, non-steroidal anti-inflammatory drugs, alcoholic beverages and tobacco were statistically associated with the occurrence of GERD. Each of the 28 subjects had at least one associated factor. A significant impair in quality of life was observed in 27 patients (96.43%). Conclusion: Typical GERD is relatively common in the general population of Parakou in the Republic of Benin. It often affects young males. Among the risk factors identified, the most common are carbonated drinks, spicy meals and diabetes. GERD significantly impairs quality of life. Raising awareness about the disease and its associated factors is necessary among the general population.

Study on Quality Improvement Effect and Separate Character of Soybean Male Sterile (MS1) Recurrent Selection Population

To solve the problem that soybean has narrow genetic base, we constructed a series of male sterile recurrent selection populations, and studied the effects of quality improvement and practical value. An LD-base population, which fits to our ecology type was constructed by 6 years＇ gene enrichment through the introduction of new genes from 23 local varieties and recurrent selection. The LD-base populations were then improved by making crosses with high protein and high oil genotypes. As a result we obtained a high protein sub-population （db） and a high oil sub-population （gy）, For the db sub-population, the protein content is 1.18% higher than the base population, 22.38% of the individuals contain 45% or more of protein, which is 10.99% higher than the base population. For the gy sub-population, oil content is 0.24% higher than the base population. Individuals with oil content of 20% or more are 11.05% higher than the base population. The quantitative characters such as flowering date, mature date, pod habit, and hilum color, etc., all showed wide range of separation, and the segregation ratio approached balance. The c.v. of branch number of ms1 recurrent population （72.8%） is higher than general cross-population （57.3%）, and the c.v. of 100 seed weight of ms1 （18.1%） is higher than general cross population （16.5%）, the coefficient of variation of plant height, pods per plant, and seeds per pod were not significantly different. It was demonstrated in this paper that the quality character of ms 1 male sterile recurrent selection population was improved by adding new genes. And the segregation of other characters widened, making the populations suitable for the objective of soybean breeding. In this paper, we also discussed the breeding method, key technology, and selection effect of soybean ms 1 population.

QTL and genetic analysis controlling fiber quality traits using paternal backcross population in upland cotton

Background:Genetic improvement in fiber quality is one of the main challenges for cotton breeders.Quantitative trait loci(QTL)mapping provides a powerful approach to dissect the molecular mechanism in fiber quality traits.In present study,F14 recombinant inbred line(RIL)population was backcrossed to paternal parent for a paternal backcross(BC/P)population,deriving from one upland cotton hybrid.Three repetitive BC/P field trials and one maternal backcross(BC/M)field trial were performed including both two BC populations and the original RIL population.Results:In total,24 novel QTLs are detected for fiber quality traits and among which 13 QTLs validated previous results.Thirty-five QTLs in BC/P populations explain 5.01%–22.09%of phenotype variation(PV).Among the 35 QTLs,23 QTLs are detected in BC/P population alone.Present study provides novel alleles of male parent for fiber quality traits with positive genetic effects.Particularly,qFS-Chr3–1 explains 22.09%of PV in BC/P population,which increaseds 0.48 cN·tex−1 for fiber strength.A total of 7,2,8,2 and 6 QTLs explain over 10.00%of PV for fiber length,fiber uniformity,fiber strength,fiber elongation and fiber micronaire,respectively.In RIL population,six common QTLs are detected in more than one environment:qFL-Chr1–2,qFS-Chr5–1,qFS-Chr9–1,qFS-Chr21–1,qFM-Chr9–1 and qFM-Chr9–2.Two common QTLs of qFE-Chr2–2(TMB2386-SWU12343)and qFM-Chr9–1(NAU2873-CGR6771)explain 22.42%and 21.91%of PV.The region between NAU4034 and TMB1296 harbor 30 genes(379 kb)in A05 and 42 genes(49 kb)in D05 for fiber length along the QTL qFL-Chr5–1 in BC/P population,respectively.In addition,a total of 142 and 46 epistatic QTLs and QTL×environments(E-QTLs and QQEs)are identified in recombinant inbred lines in paternal backcross(RIL-P)and paternal backcross(BC/P)populations,respectively.Conclusions:The present studies provide informative basis for improving cotton fiber quality in different populations.

A strategy for population pharmaceutical quality assessment based on quality by design

From a regulatory perspective,drug quality consistency evaluation must concern different processes used for the same drug.In this study,an assessment strategy based on quality by design(QbD)was developed for population pharmaceutical quality evaluation.A descriptive analysis method based on QbD concept was first established to characterize the process by critical evaluation attributes(CEAs).Then quantitative analysis method based on an improved statistical process control(SPC)method was established to investigate the process indicators(PIs)in the process population,such as mean distribution,batch-to-batch difference and abnormal quality probability.After that rules for risk assessment were established based on the SPC limitations and parameters.Both the SPC parameters of the CEAs and the risk of PIs were visualized according to the interaction test results to obtain a better understanding of the population pharmaceutical quality.Finally,an assessment strategy was built and applied to generic drug consistency assessment,process risk assessment and quality trend tracking.The strategy demonstrated in this study could help reveal quality consistency from the perspective of process control and process risk,and further show the recent development status of domestic pharmaceutical production processes.In addition,a process risk assessment and population quality trend tracking provide databased information for approval.Not only can this information serve as a further basis for decisionmaking by the regulatory authority regarding early warnings,but it can also reduce some avoidable adverse reactions.With continuous addition of data,dynamic population pharmaceutical quality is meaningful for emergencies and decision-making regarding drug regulation.

Studies on rice seed quality through analysis of a large- scale T-DNA insertion population

米饭(Oryza sativa ) T-DNA 插入人口，它包括了超过 63 000 根独立的转基因的线和 8 840 识别 flanking 定序被印射到大米染色体上的标签(FST ) ，被开发全身地学习大米种子质量控制。FST 分发的染色体宽的分析证明 T-DNA 插入断然与表示基因被相关，但是否定地与 transposable 元素和小 RNA。另外，恢复 T-DNAs 优先地在表示基因的 untranslated 区域被定位。超过 11 000 根通常认为的同型结合的线通过种的多产生被获得，包括淀粉，直链淀粉，蛋白质和脂肪的内容并且屏蔽的抵抗，和种子质量的测量在他们的一半附近与一个非破坏性的在红外线附近的光谱学方法，与种子质量的唯一或多重的改变的参数识别了 551 异种。相应 FST 的分析证明包括新陈代谢的进程和 transcriptional 规定，参予多样的函数的基因被包含，显示种子质量被一个复杂网络调整。

Effects of "Three Controls" Nutrient Management on Population Quality and Yield Components of Rice

[Objectives]This study was conducted to explore the control mechanism of agricultural non-point source pollution,and investigate the feasibility of promoting rice"three controls"nutrient management in Enping City.[Methods]With high-quality conventional rice as a material,such three treatments as three controls fertilization A(ZHY)and B(ZHY)and farmers conventional fertilization method FFP(ZXL)were set up,and the whole process of the late-season plot experiment was recorded.The agronomic characteristics of rice population quality and yield components during rice growth and development under the"three controls"fertilization technology were analyzed.[Results]Compared with the conventional fertilization method,the three controls A(ZHY)fertilization method improved rice yield by 27.13%,seed setting rate by 2.11%and 1 000-grain weight by 3.30%when reducing N,P and K by 27.13%,10.89%and 27.31%,respectively.In the case of three controls B(ZHY)omitting the last fertilization in the three controls fertilization method(4∶2∶3∶1),which saved the formula fertilizer by 11.25%,no difference was caused in yield,but the seed setting rate and 1 000-grain weight were still improved by 3.47%and 2.79%,respectively.Compared with the conventional fertilization method,the top first,second and third basal nodes of the three controls A(ZHY)fertilization method were shortened by 18.82%,17.06%and 20.52%,respectively,which plays an important role in combating typhoon and resisting lodging.[Conclusions]Compared with the conventional fertilization method,rice"three controls"nutrient management can improve yield and lodging resistance of rice,reduce fertilizer loss and agricultural non-point source pollution,and protect ecological environment.

Physical Quality of Tibet an Population

Physical development of teenagers is an important indicator of overall popu lation health quality.Surveys show the physical quality of children with primary and middle schooling in 1982 improved considerably,com-pared to 1965,with the height of school boys and gi rls increasingby7.81%and6.47%,weightby16.56%and11.02%,chest measurements by 3.87%and 1.67%。and sitting height by 7.14%and 6.32%re-spectively.

Population Quality-based Demographic Dividend,Industrial Transformation and Sustainable Development of the Chinese Economy and Society

China is faced with a decreasing labor supply and therefore is losing its cost advantage.However,benefiting from continuous improvement of population quality,China's population quality-based demographic dividend begins to replace the quantity-based dividend to play a dominant role in economic development.Thus,in supply-side structure,rather than essential factors,it paves the way for the sustainable development of the Chinese economy.With the addition of the successful industrial transformation and upgrading,China still has the advantage to overcome the middle income trap and maintain the momentum of economic growth.

The Impacts of Lower Population Growth on the Quality of Life and Economic Development：China＇s Experience

China is the most populous country in the world.The total Population on the mainland of China has in-creased from 540 million in 1949 to 1.18 billion by the end of 1993.China adopted a population policy by namc of"controlling population growth and im-proving the quality of the human resources',which has been deeply rooted in the hearts of the Chinese pcoplc.The overw helming majority of the Chinese people have recognized the necessity for implementing the family planning programme not only for the sustained devel-opment of the country,but also for the benefits of their own familie cs.

Population,Environment Dynamics,Poverty and Quality of Life in China

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Quality of life and influencing factors between local and itinerant populations during the COVID-19 pandemic

Objective:To determine the difference in quality of life and its influencing factors between local and itinerant populations in Nanjing during COVID-19.Methods:The quality of life questionnaire,which was based on the Brief Scale of WHO Quality of Life and redesigned by the research group,was used to randomly investigate 1150 people in 5 districts of Nanjing.Results:A total of 1112 valid questionnaires were collected(local population,n=558;itinerant population,n=554).The quality of life of the itinerant population was significantly lower than the local population.The itinerant population scores in physiology,psychology,social relationships,and environment were lower than the local population(all P values<0.05).COVID-19 had a greater impact on the itinerant population than on the local population,especially in medical assistance,enjoyment of life,and interpersonal relationships(all P values<0.05).Conclusion:The itinerant population had a lower quality of life than that of the local population during the prevention and control pandemic of COVID-19,thus more social support and help is warranted.

Population Growth,Available Resources,and Quality of Life:China’s Post-Reform Economic Development

Two opposing intellectual traditions and their contem-porary developments regarding the relations among population, available resources, and quality of life as reflected in economic growth are reviewed. What is at issue is whether population growth is detrimental to or beneficial for economic development. Neither of the extreme views gives a complete picture of the interplay among population, resources, and quality of life. Following previous literature on the topic, this paper establishes a more balanced approach that considers the function linking population and quality of life not constant but variable and regards the limitedness of resources as not absolute but relative to regions and societies. The proposed approach is more flexible in better explaining the relation between population and economic growth. China is examined as a case in point to shed light on the interaction of population growth, economic development, and available resources, and its recent post-economic reform experiences showcase the appropriateness of the synthetic approach.

Mapping quantitative trait loci associated with starch paste viscosity attributes by using double haploid populations of rice (Oryza sativa L.)

The paste viscosity attributes of starch,measured by rapid visco analyzer(RVA),are important factors for the evaluation of the cooking and eating qualities of rice in breeding programs.To determine the genetic roots of the paste viscosity attributes of rice grains,quantitative trait loci(QTLs)associated with the paste viscosity attributes were mapped,using a double haploid(DH)population derived from Zhongjiazao 17(YK17),a super rice variety,crossed with D50,a tropic japonica variety.Fifty-four QTLs,for seven parameters of the RVA profiles,were identified in three planting seasons.The 54 QTLs were located on all of the 12 chromosomes,with a single QTL explaining 5.99 to 47.11%of phenotypic variation.From the QTLs identified,four were repeatedly detected under three environmental conditions and the other four QTLs were repeated under two environments.Most of the QTLs detected for peak viscosity(PKV),trough viscosity(TV),cool paste viscosity(CPV),breakdown viscosity(BDV),setback viscosity(SBV),and peak time(PeT)were located in the interval of RM 6775-RM 3805 under all three environmental conditions,with the exception of pasting temperature(PaT).For digenic interactions,eight QTLs with six traits were identified for additivexenvironment interactions in all three planting environments.The epistatic interactions were estimated only for PKV,SBV and PaT.The present study will facilitate further understanding of the genetic architecture of eating and cooking quality(ECQ)in the rice quality improvement program.

The Effect of Brown Coal Mining on the Environment and Health of the Population in Northern Bohemia (Czech Republic)

Coal mining has proven negative impacts on the landscape and health of inhabitants. Solid dust particles and SO2, which are the main polluting substances in coal mining and burning, are the main causes of diseases in areas with intensive coal mining. This contribution deals with areas in the Czech Republic which have the greatest problems in this regard, being North Bohemia (Chomutov, Most, Teplice and ústí nad Labem districts). It is an area with considerable anthropogenic activity, mainly due to the intensive mining of brown coal, which has a direct effect on the health of the inhabitants of the entire ústí nad Labem region. Along with the growing number of inhabitants, energy consumption demands are constantly increasing. Nevertheless, it’s important to focus primarily on renewable energy sources, which will ensure the sustainable development of the environment and society. At the same time, the question arises, which energy sources can potentially be utilized here after mining ends (2052). In terms of geography, wind energy has the greatest potential in this area. This and associated issues are dealt with by the project “Sustainable Forms of Management in an Anthropogenically Burdened Region” at the Faculty of Environment at the University of Jan E. Purkyně in ústí nad Labem.

Safety and Efficacy of a Proprietary Undenatured Beta-Glucan on Different Human Populations

After proving safety in animal and human models, a series of clinical trials were conducted to examine the administration of 1 mg/mL bid of an undenatured beta-glucan on the immune system;and on self-perceived effects on subjects’ quality of life (QoL) using a Visual Analogue Scale (VAS). In one study, a subject population that was self-perceived to be fatigued was administered an undetaured beta-glucan, to determine if this supplementation affected their quality-of-life as a result of an increased immune system response. 44 subjects were administered 1 mg/mL bid of the undenatured beta-glucan (Lentinex®) for four weeks. Prior to the beginning of the administration, and following the four-week administration period, the subjects were asked to fill out a quality-of-life VAS questionnaire. The changes in the two questionnaires revealed differences that occurred as a result of the beta-glucan administration. More than 75% of the subjects scored “better” (more than 1 cm on the VAS) with regard to feeling in a good mood, and feeling rested. More than 60% increased their energy and reduced their tiredness and exhaustion, and 70% felt less stressed. In a second study, subjects aged 40 years and older, believed to be in good general health, seeking therapy for tiredness/exhaustion/fatigue or similar conditions (neurasthenia) which were administered 1 mg/mL bid Lentinex®. The overall results indicated that the subjects felt significantly better (mean VAS = 5.91) after the last week of the study compared to how they felt initially (VAS = 4.73) (p < 0.0001). A statistically significant (p < 0.0001) change in distribution favoring a better situation after 4 weeks intake of supplement, with a remarkable fall in number of subjects scoring below normal (from 61.4% to 18.2%) accompanied by a significant shift in subjects feeling above normal, from 9.2% to 50.0%. These clinical studies, and others, showed that Lentinex® administration improved the perceived quality-of-life of subjects whose immune system was probably not functioning at optimal levels.

以数字技术推动人口高质量发展——基于健康人力资本的跨国实证研究

数字技术在促进经济增长和改善社会福祉方面发挥了积极作用,成为实现经济和社会高质量发展的重要引擎。数字技术是促进健康人力资本积累的重要途径和实现人口高质量发展的关键支撑。本文从理论层面系统阐述了数字技术促进健康人力资本积累的逻辑机制,并采用全球118个国家1990—2020年跨国面板数据,结合不同国家经济发展水平差异,从人口“生命长度和生命质量”两个维度,实证检验数字技术对健康人力资本积累的具体影响。研究发现,数字技术在大健康领域的广泛应用,有助于降低人口死亡率、提高人口健康预期寿命,进而促进健康人力资本积累;其作用途径主要通过提高政府卫生支出效率、提升数字健康素养、增加闲暇时间和促进环境改善四个路径来实现;数字技术在改善健康人力资本方面的差异与国家经济发展水平差距密切相关。基于以上分析,研究认为应加大医疗技术创新,发挥新型举国体制的优势,集中力量技术攻关,实现现代数字技术、医疗健康大数据、医疗全流程、医疗健康行业相关方多要素融合,创新中国式精准医疗发展模式。

青年强则国强:青年人口学前瞻与优化青年人口发展

从当年梁启超发出历史呼号“少年强则国强”、李大钊提出“青春中华之创造”到如今党的二十大报告发出时代强音“青年强,则国家强”,显示了一脉相承的青少年与国家发展联系紧密的认识逻辑。本文回顾和界定了青年及青年人口学的内涵,认为青年可定义为“风险型人口”和“资源型人口”两大类,继而讨论了“青年强”的三重含义,即青年人口储备充足、青年人口素质卓越和青年人口红利丰厚,充分诠释了“青年强,则国家强”时代命题的深刻内涵。概言之,人尽其才则“青年强”,才尽其用则“国家强”。本文从国际比较的视角阐述了我国青年人口发展面临的问题和挑战,突出表现为:中国未来青年人口数量将长期处于缩减状态;青年人口的科学文化素质、身体健康素质和思想素质都有待“提质增效”;就业不充分,青年人口红利没有被充分释放。因此,要优化青年人口发展、进一步增强青年力量,采取相应的对策来强化青年人口储备、优化青年人口素质、极化青年人口红利、激发全人口活力。在人口负增长时代,建设适宜青年生存与发展的青年友好型社会极为必要,把解决青年问题作为解决低生育率等社会人口问题的重要突破口迫在眉睫。

高质量发展视域下的中国人口均衡发展

在人口形势发生重要转折性变化之际,高质量发展要求更加重视人口素质,以“提质”替代“增量”,以“人才”替代“人力”,充分发挥凝结在人口自身的素质要素的作用,使更多民众更好地享受高质量发展的成果,享受高品质生活。长期均衡发展是人口发展的主要目标,也是人口高质量发展的内在要求。人口均衡发展不仅体现在人口系统内部要素间的依存制约以及人口系统与社会经济系统之间的协调适应,还体现在代际间的传承永续。年龄结构失衡是当前人口非均衡发展的突出表现,应聚焦结构失衡,弥补制约人口均衡发展的短板;同时充分发挥作为人口结构中坚力量的劳动年龄人口的作用,通过与经济高质量发展相协调以及推动人口均衡分布,促进人口均衡发展,助力实现人口高质量发展。

人口老龄化与劳动力就业质量

推进就业优先战略、保障高质量充分就业是实现社会经济高质量发展、增进民生福祉的关键举措.与此同时,老龄化程度的加深对经济发展、产业结构与要素投入调整产生了广泛而深远的影响.为此,基于我国2006—2021年省级面板数据,运用熵值法对各省劳动力就业质量进行测算,并采用双向固定效应模型和调节效应模型探究了人口老龄化对高质量就业的影响.研究发现,人口老龄化抑制我国劳动力就业质量提升,人工智能的发展带来的外部环境和技术创新水平的提升可以削弱人口老龄化对就业质量的消极影响.

南方双季稻区水田高留茬秸秆还田机作业效果研究

为考察自行研制的南方双季稻区水田高留茬秸秆还田机大田作业效果,以原谷珍香为供试品种进行大田试验,并设置现有的常规秸秆还田机作业进行对照,通过对早稻不同高度的留茬秸秆进行还田作业,考察了该机具的耕作效果,并研究了对后茬晚稻机插质量、群体质量构建及产量和产量构成等指标的影响。结果显示,较对照,同一留茬高度时,经自行研制的南方双季稻区水田高留茬秸秆还田机处理的效果显著,其耕深、耕深稳定性、埋茬深度、耕后地面平整度和植被覆盖率分别平均提升5.18%、4.64%、20.85%、21.61%和4.43%,漏插率、漂秧率、伤秧率和翻倒率分别平均降低28.79%、23.17%、29.84%和45.02%,均匀度合格率和插秧深度合格率分别平均提高1.40%和1.65%,茎蘖数平均提高2.52%~6.62%,SPAD值(移栽后27d始)平均提高3.59%~6.53%,地上部干物质重(插秧后34 d始)平均提高1.78%~4.81%,穗干重和收获指数分别平均提高3.39%和2.16%,有效穗、穗粒数、千粒重、结实率和理论产量分别平均提高2.52%、1.34%、0.08%、1.41%和5.47%,实际产量平均增产268.86 kg·hm^(-2),平均增产率4.09%。该机具对秸秆的留茬高度适应性强,作业效果好,适宜在南方双季稻区水田进行推广应用。