Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BM...Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BMD’s heritability is more than 60%(Arden et al.,1996).A number of candidate loci for BMD have been previously identified by Genome Wide Association Studies(GWAS)(Xiong et al.,2009;Karasik et al.,2010;Zhang et al.,2013).Nevertheless,many significant signals based on GWAS are展开更多
目的:探讨自然绝经后女性骨代谢标记物:Ⅰ型前胶原氨基端前肽(N-terminal propeptide of typeⅠprecollagen,PINP)和β-胶原降解产物(βcross-linked C-telopeptide of typeⅠcollagen,β-CTX)与骨密度(bone mineral density,BMD)的关...目的:探讨自然绝经后女性骨代谢标记物:Ⅰ型前胶原氨基端前肽(N-terminal propeptide of typeⅠprecollagen,PINP)和β-胶原降解产物(βcross-linked C-telopeptide of typeⅠcollagen,β-CTX)与骨密度(bone mineral density,BMD)的关系。方法:选取147名45~72岁自然绝经2年以上的妇女为研究对象。使用双能X射线吸收测定法(dualenergy X-ray absorptiometry,DXA)测量BMD,并检测血清β-CTX与PINP水平。研究对象按BMD分为骨量正常组(n=55)、骨量减少组(n=56)、骨质疏松组(n=36),比较3组间PINP、β-CTX的差异;腰椎BMD、髋部BMD与一般资料的相关性;β-CTX与PINP、腰椎BMD与髋部BMD的相关性。结果:3组β-CTX水平比较,差异有统计学意义(P<0.05),而PINP比较无明显差异(P>0.05);腰椎BMD与年龄、绝经年龄、身高、体质量、BMI有相关性(P<0.05);髋部BMD与绝经年龄、身高、体质量、BMI、β-CTX有相关性(P<0.05);β-CTX与PINP有相关性(P<0.05),腰椎BMD与髋部BMD有相关性(P<0.05)。结论:骨吸收与骨形成处于高代谢状态,骨质疏松人群骨量流失可能较快。BMD值较PINP、β-CTX更能反映骨量的高低。展开更多
基金partially supported by or benefited from grants from NIH (P50AR055081,R01AG026564,R01AR050496,R01AR059781,D43TW009107,P20GM109036,R01GM109068,R01MH104680,R01MH107354,R01AR057049,and R03TW008221)
文摘Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BMD’s heritability is more than 60%(Arden et al.,1996).A number of candidate loci for BMD have been previously identified by Genome Wide Association Studies(GWAS)(Xiong et al.,2009;Karasik et al.,2010;Zhang et al.,2013).Nevertheless,many significant signals based on GWAS are
文摘目的:探讨自然绝经后女性骨代谢标记物:Ⅰ型前胶原氨基端前肽(N-terminal propeptide of typeⅠprecollagen,PINP)和β-胶原降解产物(βcross-linked C-telopeptide of typeⅠcollagen,β-CTX)与骨密度(bone mineral density,BMD)的关系。方法:选取147名45~72岁自然绝经2年以上的妇女为研究对象。使用双能X射线吸收测定法(dualenergy X-ray absorptiometry,DXA)测量BMD,并检测血清β-CTX与PINP水平。研究对象按BMD分为骨量正常组(n=55)、骨量减少组(n=56)、骨质疏松组(n=36),比较3组间PINP、β-CTX的差异;腰椎BMD、髋部BMD与一般资料的相关性;β-CTX与PINP、腰椎BMD与髋部BMD的相关性。结果:3组β-CTX水平比较,差异有统计学意义(P<0.05),而PINP比较无明显差异(P>0.05);腰椎BMD与年龄、绝经年龄、身高、体质量、BMI有相关性(P<0.05);髋部BMD与绝经年龄、身高、体质量、BMI、β-CTX有相关性(P<0.05);β-CTX与PINP有相关性(P<0.05),腰椎BMD与髋部BMD有相关性(P<0.05)。结论:骨吸收与骨形成处于高代谢状态,骨质疏松人群骨量流失可能较快。BMD值较PINP、β-CTX更能反映骨量的高低。
