Objective To evaluate the biomechanics of hollow-compression-screw in the osteoporotic femoral neck with composite c alcium phosphate cement (CCPC).Methods Sixteen femurs of superior segment were randomly divided into...Objective To evaluate the biomechanics of hollow-compression-screw in the osteoporotic femoral neck with composite c alcium phosphate cement (CCPC).Methods Sixteen femurs of superior segment were randomly divided into two groups:augmentation group and non-augmentation group.CCPC was used in augmentation group.Result Augmentation with CCPC would improve the initial mobile force of hollow-compression-screw,the ini tial mobile force and the maximal axial pull-out strength for augmentation group,non-augmentation group in-creased from(192.7±14.0)N and(202.8±14.0)N to(328.5±34.7)N and(347.8±31.2)N.There was significant difference of two groups(P <0.01).Conclusion CCPC can enhance hollow-compressio n-screw fixation in osteoporotic fe moral neck.展开更多
Cancer is one of the major causes of human death. There are many types of cancer treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy. Combining different therapies can synergistically enh...Cancer is one of the major causes of human death. There are many types of cancer treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy. Combining different therapies can synergistically enhance the therapeutic effect. We developed porous hollow palladium nanoparticles （PHPdNPs） to co-deliver ^131I （a radioisotope that is commonly used in radiotherapy） and doxorubicin （DOX; a chemotherapy drug）. Compared with other mesoporous nanocarriers, our PHPdNPs exhibited impressive photothermal conversion efficiency and stability. Drug loading is high and drug release is controllable by repeated laser irradiation and acidic pH in tumor microenvironments. Owing to the specific interaction between palladium and iodine, the PHPdNPs serve as effective ^131I delivery vehicles with excellent radiochemical stability. A single dose of [^131I]PHPdNPs-DOX has superior antitumor efficacy because it enables a combination of chemo-, photothermal-, and radio-therapy. Moreover, the nanocomplex has no obvious side-effects in mice. Therefore, we believe that PHPdNPs are excellent candidates for multimodal imaging-guided therapy.展开更多
文摘Objective To evaluate the biomechanics of hollow-compression-screw in the osteoporotic femoral neck with composite c alcium phosphate cement (CCPC).Methods Sixteen femurs of superior segment were randomly divided into two groups:augmentation group and non-augmentation group.CCPC was used in augmentation group.Result Augmentation with CCPC would improve the initial mobile force of hollow-compression-screw,the ini tial mobile force and the maximal axial pull-out strength for augmentation group,non-augmentation group in-creased from(192.7±14.0)N and(202.8±14.0)N to(328.5±34.7)N and(347.8±31.2)N.There was significant difference of two groups(P <0.01).Conclusion CCPC can enhance hollow-compressio n-screw fixation in osteoporotic fe moral neck.
基金This research was supported in part by the National Key Research and Development Program of China （No. 2016YFA0203600）, National Natural Science Foundation of China （Nos. 81571743, 51502251, and 81571707）, Fundamental Research Funds for Xiamen University （No. 20720160067） and Natural Science Foundation of Fujian Province （Nos. 2015J01519 and 2014Y2004）.
文摘Cancer is one of the major causes of human death. There are many types of cancer treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy. Combining different therapies can synergistically enhance the therapeutic effect. We developed porous hollow palladium nanoparticles （PHPdNPs） to co-deliver ^131I （a radioisotope that is commonly used in radiotherapy） and doxorubicin （DOX; a chemotherapy drug）. Compared with other mesoporous nanocarriers, our PHPdNPs exhibited impressive photothermal conversion efficiency and stability. Drug loading is high and drug release is controllable by repeated laser irradiation and acidic pH in tumor microenvironments. Owing to the specific interaction between palladium and iodine, the PHPdNPs serve as effective ^131I delivery vehicles with excellent radiochemical stability. A single dose of [^131I]PHPdNPs-DOX has superior antitumor efficacy because it enables a combination of chemo-, photothermal-, and radio-therapy. Moreover, the nanocomplex has no obvious side-effects in mice. Therefore, we believe that PHPdNPs are excellent candidates for multimodal imaging-guided therapy.
