An Investigative Study for Smart Home Security: Issues, Challenges and Countermeasures

Home security should be a top concern for everyone who owns or rents a home. Moreover, safe and secure residential space is the necessity of every individual as most of the family members are working. The home is left unattended for most of the day-time and home invasion crimes are at its peak as constantly monitoring of the home is difficult. Another reason for the need of home safety is specifically when the elderly person is alone or the kids are with baby-sitter and servant. Home security system i.e. HomeOS is thus applicable and desirable for resident’s safety and convenience. This will be achieved by turning your home into a smart home by intelligent remote monitoring. Smart home comes into picture for the purpose of controlling and monitoring the home. It will give you peace of mind, as you can have a close watch and stay connected anytime, anywhere. But, is common man really concerned about home security? An investigative study was done by conducting a survey to get the inputs from different people from diverse backgrounds. The main motivation behind this survey was to make people aware of advanced HomeOS and analyze their need for security. This paper also studied the necessity of HomeOS investigative study in current situation where the home burglaries are rising at an exponential rate. In order to arrive at findings and conclusions, data were analyzed. The graphical method was employed to identify the relative significance of home security. From this analysis, we can infer that the cases of having kids and aged person at home or location of home contribute significantly to the need of advanced home security system. At the end, the proposed system model with its flow and the challenges faced while implementing home security systems are also discussed.

17β-Estradiol,through activating the G protein-coupled estrogen receptor,exacerbates the complication of benign prostatic hyperplasia in type 2 diabetes mellitus patients by inducing prostate proliferation

Benign prostatic hyperplasia(BPH)is one of the major chronic complications of type 2 diabetes mellitus(T2DM),and sex steroid hormones are common risk factors for the occurrence of T2DM and BPH.The profiles of sex steroid hormones are simultaneously quantified by LC-MS/MS in the clinical serum of patients,including simple BPH patients,newly diagnosed T2DM patients,T2DM complicated with BPH patients and matched healthy individuals.The G protein-coupled estrogen receptor(GPER)inhibitor G15,GPER knockdown lentivirus,the YAP1 inhibitor verteporfin,YAP1 knockdown/overexpression lentivirus,targeted metabolomics analysis,and Co-IP assays are used to investigate the molecular mechanisms of the disrupted sex steroid hormones homeostasis in the pathological process of T2DM complicated with BPH.The homeostasis of sex steroid hormone is disrupted in the serum of patients,accompanying with the proliferated prostatic epithelial cells(PECs).The sex steroid hormone metabolic profiles of T2DM patients complicated with BPH have the greatest degrees of separation from those of healthy individuals.Elevated 17β-estradiol(E2)is the key contributor to the disrupted sex steroid hormone homeostasis,and is significantly positively related to the clinical characteristics of T2DM patients complicated with BPH.Activating GPER by E2 via Hippo-YAP1 signaling exacerbates high glucose(HG)-induced PECs proliferation through the formation of the YAP1-TEAD4 heterodimer.Knockdown or inhibition of GPER-mediated Hippo-YAP1 signaling suppresses PECs proliferation in HG and E2 co-treated BPH-1 cells.The anti-proliferative effects of verteporfin,an inhibitor of YAP1,are blocked by YAP1 overexpression in HG and E2 co-treated BPH-1 cells.Inactivating E2/GPER/Hippo/YAP1 signaling may be effective at delaying the progression of T2DM complicated with BPH by inhibiting PECs proliferation.