The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic st...The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic status.Not all individuals of T1DM progress in that specific sequence.We hereby present a case of T1DM with a classical third phase(honeymoon phase)and discuss the intri-cacies of this interesting phase along with a possible future promise of“cure”with the use of immunotherapies.We now know that the course of T1DM may not be in only one direction towards further progression;rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being discussed.The third phase popularly called the“honeymoon phase”,is of special interest as this phase is complex in its pathogenesis.The honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive“diabetes reversal”in T1DM.Identifying this phase is therefore the key,with a lot of varying criteria having been proposed.展开更多
人们习惯上把新婚度假或到外地旅行称之为“度蜜月”(to spend a hon-eymoon)。其实蜜月一词来自于英语。honeymoon 一词大约产生于公元前500年的英国近海地区。当时在 England 境内的条顿族中流行“抢婚”的习俗。任何一个条顿未婚青...人们习惯上把新婚度假或到外地旅行称之为“度蜜月”(to spend a hon-eymoon)。其实蜜月一词来自于英语。honeymoon 一词大约产生于公元前500年的英国近海地区。当时在 England 境内的条顿族中流行“抢婚”的习俗。任何一个条顿未婚青年男子都可以抢一个中意的女子为妻。但有时不慎已抢得的女子又会被其它男子抢去,为此不少男子一把女子抢到手,就迫不及待地携妻外逃,过一段不易被人发现的隐居生活。然而外逃并不是一件美事,许多夫妻浪迹于荒山野岭之间,因食宿无着落,生存条件恶劣等原因,大多抛尸荒野。展开更多
Despite recent trade frictions, the latest EU report suggests China and the European Union will experience more opportunities in 2007 Though it wasn’t always the case, China is an increasingly important part of Eur...Despite recent trade frictions, the latest EU report suggests China and the European Union will experience more opportunities in 2007 Though it wasn’t always the case, China is an increasingly important part of European business and eco- nomic展开更多
文摘The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic status.Not all individuals of T1DM progress in that specific sequence.We hereby present a case of T1DM with a classical third phase(honeymoon phase)and discuss the intri-cacies of this interesting phase along with a possible future promise of“cure”with the use of immunotherapies.We now know that the course of T1DM may not be in only one direction towards further progression;rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being discussed.The third phase popularly called the“honeymoon phase”,is of special interest as this phase is complex in its pathogenesis.The honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive“diabetes reversal”in T1DM.Identifying this phase is therefore the key,with a lot of varying criteria having been proposed.
文摘人们习惯上把新婚度假或到外地旅行称之为“度蜜月”(to spend a hon-eymoon)。其实蜜月一词来自于英语。honeymoon 一词大约产生于公元前500年的英国近海地区。当时在 England 境内的条顿族中流行“抢婚”的习俗。任何一个条顿未婚青年男子都可以抢一个中意的女子为妻。但有时不慎已抢得的女子又会被其它男子抢去,为此不少男子一把女子抢到手,就迫不及待地携妻外逃,过一段不易被人发现的隐居生活。然而外逃并不是一件美事,许多夫妻浪迹于荒山野岭之间,因食宿无着落,生存条件恶劣等原因,大多抛尸荒野。
文摘Despite recent trade frictions, the latest EU report suggests China and the European Union will experience more opportunities in 2007 Though it wasn’t always the case, China is an increasingly important part of European business and eco- nomic
