Postpartum Family Planning at the Timbuktu Hospital in Mali

Introduction: Postpartum family planning is the prevention of pregnancies during the 12 months following childbirth. Few studies have been devoted to postpartum family planning in Mali. Our work will contribute to reducing unmet need for family planning. Objective: To study the use of contraceptive methods in the postpartum period in the obstetrics and gynecology unit of Timbuktu hospital. Materials and Methods: This was a descriptive and analytical cross-sectional study with prospective collection of data from January 1, 2022 to December 31, 2023. All women who gave birth having chosen and benefited from a contraceptive method were included. The statistical test used was the Fisher test with a significance threshold fixed at 5%. Results: The frequency of contraception in the postpartum period was 17.03%. The average age of clients was 26.14% with extremes of 14 and 45 years. They were paupiparous at 56.4% with an inter-birth interval of less than 12 months at 12.3%. More than half of the counseling (58.5%) was done during postnatal visits. The methods chosen were implants at 48.1%, injectable progestins at 21.3%, intrauterine device at 14.7%, miro-progestin pills at 13.5%, tubal ligation at 1 .4% and condoms at 1%. The regular follow-up rate was 51.1% of cases and 25.6% had no follow-up. Conclusion: The overall rate of postpartum family planning of 17.08% remains low. Improving FP staff skills will reduce unmet needs and contribute to increasing contraceptive prevalence in Timbuktu.

Acute hospital-community hospital care bundle for elderly orthopedic surgery patients:A propensity score-matched economic analysis

BACKGROUND While Singapore attains good health outcomes,Singapore’s healthcare system is confronted with bed shortages and prolonged stays for elderly people recovering from surgery in acute hospitals.An Acute Hospital-Community Hospital(AHCH)care bundle has been developed to assist patients in postoperative rehabilitation.The core concept is to transfer patients out of AHs when clinically recommended and into CHs,where they can receive more beneficial dedicated care to aid in their recovery,while freeing up bed capacities in AHs.AIM To analyze the AH length of stay(LOS),costs,and savings associated with the AH-CH care bundle intervention initiated and implemented in elderly patients aged 75 years and above undergoing elective orthopedic surgery.METHODS A total of 8621:1 propensity score-matched patients aged 75 years and above who underwent elective orthopedic surgery in Singapore General Hospital(SGH)before(2017-2018)and after(2019-2021)the care bundle intervention period was analyzed.Outcome measures were AH LOS,CH LOS,hospitalization metrics,postoperative 30-d mortality,and modified Barthel Index(MBI)scores.The costs of AH inpatient hospital stay in the matched cohorts were compared using cost data in Singapore dollars.RESULTS Of the 862 matched elderly patients undergoing elective orthopedic surgery before and after the care bundle intervention,the age distribution,sex,American Society of Anesthesiologists classification,Charlson Comorbidity Index,and surgical approach were comparable between both groups.Patients transferred to CHs after the surgery had a shorter median AH LOS(7 d vs 9 d,P<0.001).The mean total AH inpatient cost per patient was 14.9%less for the elderly group transferred to CHs(S$24497.3 vs S$28772.8,P<0.001).The overall AH U-turn rates for elderly patients within the care bundle were low,with a 0%mortality rate following orthopedic surgery.When elderly patients were discharged from CHs,their MBI scores increased significantly(50.9 vs 71.9,P<0.001).CONCLUSION The AH-CH care bundle initiated and implemented in the Department of Orthopedic Surgery appears to be effective and cost-saving for SGH.Our results indicate that transitioning care between acute and community hospitals using this care bundle effectively reduces AH LOS in elderly patients receiving orthopedic surgery.Collaboration between acute and community care providers can assist in closing the care delivery gap and enhancing service quality.

MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axis

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer physiology.However,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of GC.METHODS Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and cells.The ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,respectively.Cell proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow cytometry.Expression of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western blot.Targets of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter system.Serpin family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical staining.The correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot analysis.The association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and miR-145-5p.The mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude mice.RESULTS GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this miRNA.Overexpression of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 expression.Kaplan-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 expression.Nude mouse tumorigenesis experiments confirmed that miR-145-5p targets SERPINE1 to regulate extracellular signal-regulated kinase-1/2(ERK1/2).CONCLUSION This study found that miR-145-5p inhibits tumor progression and is expressed in lower amounts in patients with GC.MiR-145-5p was found to affect GC cell proliferation,migration,and invasion by negatively regulating SERPINE1 levels and controlling the ERK1/2 pathway.

Pressure-induced phase transitions in the ZrXY(X=Si,Ge,Sn;Y=S,Se,Te)family compounds

Pressure is an effective and clean way to modify the electronic structures of materials,cause structural phase transitions and even induce the emergence of superconductivity.Here,we predicted several new phases of the Zr XY family at high pressures using the crystal structures search method together with first-principle calculations.In particular,the Zr Ge S compound undergoes an isosymmetric phase transition from P4/nmm-I to P4/nmm-II at approximately 82 GPa.Electronic band structures show that all the high-pressure phases are metallic.Among these new structures,P4/nmm-II Zr Ge S and P4/mmm Zr Ge Se can be quenched to ambient pressure with superconducting critical temperatures of approximately 8.1 K and 8.0 K,respectively.Our study provides a way to tune the structure,electronic properties,and superconducting behavior of topological materials through pressure.

Burnout and work-family conflict among nurses during the preparation for reevaluation of a grade A tertiary hospital

Objectives： To gain a better understanding of nurse burnout and work-family conflict for nurses and to help the hospital prepare for hospital grade reevaluation.Methods： This study is a cross-sectional study, and 95 nurses participated. The questionnaires included MBI and Carlson work-family conflict questionnaires, and the data were analyzed using SPSS 17.Results： A total of 71.6% of nurses worked over 8 h per day during the last two months before the reevaluation. The total score of burnout of nurses was 66.84 ± 12.60, and the proportion of heavy work burnout was 44.2%. The personal accomplishment takes the heaviest portion（80.0%）. The total score of work-family conflict is 55.19 ± 9.27. The scores of work-to-family conflict are all higher than that of family-to-work conflict. The time dimension had the highest score.Conclusions： During the preparation period, nurses suffered from a heavy workload and intense job burnout, and many aspects of work-family conflict existed.

Application of Variable Strategies in the Low-cost and Energy-saving Rural Residences in Transitional Areas

Changeful and complex rural family structure and climatic features of transitional areas in China make the application of variable strategy in energy-saving rural residence designs possible.Aiming at the low cost,several effective and reasonable variable strategies were proposed for the design of interior spaces,main bedroom,sunshine room,staircase,west wall,door and window design to satisfy changing structure of a family during different periods and their different thermo-technical requirements in winter and summer.In this way,thermal comfort of rural indoor spaces will be improved,more energy saved,useful experience and thoughts provided for the energy-saving residence design in cold regions and regions hot in summer and cold in winter.

Continuity of Care during Care Transition: Nurses’ Experiences and Challenges

The aim of this study was to gain increased knowledge about nurses’ experiences of care transition of older patients from hospital to municipal health care, based on two research questions: How is nurses’ experience continuity during care transition of older patients from hospital to municipal health care? How would nurses describe an optimal care transition? Nurses have a pivotal role during care transitions of older patients. More knowledge about their experiences is necessary to develop favorable improvements for this important period in the older patient’s treatment and care. The study has a qualitative explorative design with follow-up focus group interviews. Nurses (N = 30) working in hospital (n = 16) and municipal (n = 14) health care were organized in five mixed focus groups during the period October-January 2014/2015. The focus groups met twice, answering the research questions following a previously circulated semi-structured interview guide. The interview analysis was inspired by content analysis. The analysis resulted in the themes “Administrative demands challenge terms for collaboration” and “Essentials for nursing determine optimal care transitions for older patients”. Administrative demands may prevent nurses’ professional dialogue and collaboration across health care levels. Older patients’ best interests should be ensured through a collaborative relationship between hospital and municipal nurses, to form continuous care across health care levels. Clinical practice should be aware of essentials for nursing, which could influence and facilitate a more individualized and continuous transition for older patients.

Influence of Model Parameters on Hadron-Quark Phase Transition in Neutron Star Matter

我们在中子星的内部在阶段转变，状态(曙光女神) 的方程，和相应集体半径的关系上学习模型参数的影响。数字分析证明重核子的联合常数在阶段上有细微影响转变和曙光女神，而是对粒子部分的明显的影响当袋子常数 B 和联合经常的 g 在阶段转变， EOS，和集体半径的关系上有重要影响时。我们发现那两个袋子常数 B 和联合的经常的 g 玩在对在混血儿的夸克之间的相互作用的描述的一样的角色担任主角。使用袋子常数计算的最大的团与试验性的数据决定了(从 175 ～ 200 兆电子伏) 在 1.4 ～的间隔的下降 1.7 太阳的质量。相应半径在结果与中子星的观察价值一致的 9.3 和 12 km.These 之间。第三个家庭的存在的可能性被讨论。第三个家庭的察觉可以在中子星内为阶段转变提供签名。

Population and Environment:Necessary Transition Initiatives for Developing Countries

Now environment is an important topic in academic field.Many researches focus on the negative outcomes of nature which are being continually created by human and much attention has been paid to how the environment is protected through integrated research,movement and policy.But few studies are concentrated on population and environment and are to find out the interconnectivity and underlying mechanism that have an effect on people's preferring additional children and perception to environment.Many researchers claim that population growth is a great problem for environment but they do not provide the indepth integrated knowledge and mechanism that influence fertility trend and environmental problems.It is very crucial to develop practical and concrete initiatives to confirm a transition to reduce population growth and redirect the perception on population and environment.

Epidemiologic Transition and Heart Failure in Black African Adults

The objective of this study is to report clinical, electrocardiographic, and echocardiographic data on heart failure for the evaluation of its cardiovascular risk factors and causes at the Institute of Cardiology of Abidjan and the National Police Hospital. Patients and Methods: The 12-month prospective study included 989 patients who were diagnosed with heart failure at the Institute of Cardiology of Abidjan and the Heart Department of the National Police Hospital in Cote d’Ivoire. Results: The mean age of the patients was 55 ± 12 years. Patients ≤ 50 years, aged 50 and 70 years, and ≥ 70 years were 42%, 60%, and 18%, respectively. The major cardiovascular risk factors were high blood pression (60%), smoking (19%), type 2 diabetes (11%), and hypercholesterolemia (8%). The status of 11% of HIV positive patients were ignored upon admission to the Heart Hospitals. Severe kidney failure (25%) was found in all hypertensive patients. Atrial fibrillation patients and sinus rhythm subjects were 20% and 80%, respectively. The average duration of QRS was 102 ± 24 ms. 20% of patients had a complete left bundle branch block. The mean of the left ventricular ejection fraction (LVEF) was 35.8% ± 13%. The LVEF was? ≤ 45% in 57% of cases and ≤ 30% in 30% of cases. The identified causes of heart failure were ischemic heart disease (60%), hypertensive heart disease (20%), and rheumatic valvulopathy (12%). Among the patients with ischemic heart disease, 80% were infarction. The coronarography and the myocardial revascularization were performed in 50% of cases. The primitive cardiomyopathy was diagnosed in 15% of cases. The average follow-up was 12.6 ± 8 months. 18% of patients died, 14% of whom deceased within 1 year after the initial diagnosis and 5% of death occurred in 19 months following the first symptoms of heart failure. The end stage of heart failure (13%) was the most frequent cause of death followed by the sudden death (5%) and the terminal kidney failure (2%). The patients were rehospitalized for heart failure (28 cases) and for ischemic stroke during the follow-up. The functional New York Heart Association score of patients was II in 39%, III in 43%, and IV in 18% at 1 month after admission.Conclusion: The heart failure is a major public health issue in Cote d’Ivoire as in many other African countries. The prevalence of ischemic heart disease as the leading cause of heart failure is certainly the reflection of the epidemiologic transition and the advent of the coronarography in the technical platform of the Abidjan Institute of Cardiology. The rapid evolution of the epidemiologic pattern of the heart failure in association with the increasing frequency of cardiovascular risk factors should contribute to implement study and prevention strategies against cardiovascular diseases in Cote d’Ivoire and in Africa.

育龄收入、子女人力资本与代际经济支持——基于子女“数量—质量替代”视角

中国家庭中子女数量下降伴随着子女人力资本提升,即子女“数量—质量替代”效应,为改善家庭养老经济支持提供了新契机。使用中国家庭追踪调查数据,结合中介效应模型和两阶段最小二乘法,研究以子女“数量—质量替代”为机制,老年父母的育龄收入对子女经济支持数额的影响。研究发现:(1)家庭中子女数量向质量的转换有利于子女经济支持数额的提高;(2)增加父母育龄收入有利于促进子女数量向质量转换,从而提高子女经济支持数额;(3)对于没有参加养老保险、子女数量较少和来自城市的家庭,在子女“数量—质量替代”机制的作用下,育龄收入的增加提高子女经济支持数额的效应更强。因此,畅通并促进子女数量向质量的转换机制是改善家庭养老经济支持水平、缓解社会养老压力的有效途径;更合理的收入分配制度对完善家庭养老功能、促进中国养老事业可持续发展和提升老年人福祉具有重要意义。

中国性别失衡转变与家庭发展:基于人口普查与公开数据的发现

中国出生性别比失衡已经持续40余年,性别失衡后果和风险正在由个体扩散至家庭层面,对家庭发展产生深远影响,但现有研究缺乏基于宏观数据对二者变化态势的基本认识。使用2000—2020年全国人口普查和统计年鉴等公开数据,基于人口和家庭转型背景,从家庭结构-功能构建家庭发展指数,实证分析最近20年性别失衡转变和家庭发展的时空变化情况,探讨性别失衡转变和家庭发展的关系。研究发现,中国性别失衡正在进入出生性别比持续下降、后果开始显现的转变阶段,省际因人口、经济、社会等发展差异呈现不同阶段特征;中国家庭发展整体水平较低,当面临性别失衡转变时,存在结构功能发展不协调、地区间发展不平衡和总体发展不充分的问题。建议继续加强引导出生性别比回归正常以减少各年龄段性别结构失衡累积,积极探索面向家庭的性别失衡后果治理,充分考虑家庭发展的地区差异和所处阶段,兼顾家庭结构和功能协调发展,促进人口长期均衡与可持续发展。

患者及家属医院文化知晓与体验感现况及影响因素分析

目的研究了解患者及家属医院文化知晓与体验感并分析其影响因素,为从需方视角优化医院品牌文化提供实证依据。方法基于课题组研制的患者及家属医院文化知晓与体验感量表调查样本医院患者及家属对医院文化的知晓与体验状况,采用多元线性回归模型分析影响因素,并构建结构方程模型探讨文化知晓、服务感知和价值认可的关系。结果共收集到4783份有效问卷。患者及家属医院文化知晓与体验感总体得分率为80.0%,但文化知晓得分率仅为65.0%;年龄、常住地、最近一次本院住院时间是体验感的影响因素。结构方程模型结果显示:文化知晓正向影响服务感知,但轻微负向影响价值认可,服务感知正向影响价值认可。结论患者及家属对医院文化知晓与体验感良好,但文化知晓程度较差。建议加强以患者需求为导向的医院文化宣传,将医院特色文化融入患者就医全过程,强化患者及家属服务感知,促进医院文化价值认可,提升其医院文化体验感。

广东省二、三级医疗机构延续护理部门设立及运作现况调查

目的:了解广东省二、三级医疗机构延续护理部门的设立及运作情况,为医疗机构建设延续护理部门、开展延续护理提供参考和借鉴。方法:采用便利抽样法于2023年5月4日—19日选取广东省110所二、三级医疗机构的护理管理人员进行调查,调查其所在医疗机构延续护理部门的建立情况、运作情况、阻滞因素及相关建议。结果:110所医疗机构中有35所(31.82%)设立了延续护理部门,58所(52.73%)拟计划开展延续护理服务,17所(15.45%)暂无设立延续护理部门及开展延续护理的计划。已开展延续护理的35所医疗机构中,2010年前设立延续护理部门的有3所(8.57%),2010—2018年有9所(25.71%),2019年至今有23所(65.71%)。35所医疗机构延续护理运作情况良好,但在医疗收费、医院-社区联动及延续护理质量指标设置方面需进一步加强和完善。51所(46.36%)医疗机构认为设立延续护理部门开展延续护理服务无障碍,59所(53.64%)认为存在障碍,障碍因素主要包括人力资源短缺(79.66%)、经济效益受限(76.27%)、实施场地缺乏(54.24%)、不知如何开展(32.20%)、院领导不支持(23.73%)等。结论:因缺乏统一、规范的标准及指南,广东省二、三级医疗机构延续护理部门的设立及运作情况参差不齐且存在多方面争议、困惑及不足。建议从“相关政策制度、部门组织架构、信息共享与协调机制、服务收费与支付机制、延续护理质量评价指标、工作人员绩效”等方面完善延续护理部门的设立及运作,从而推进延续护理的发展,助力实施健康中国战略。

家庭赋权行为干预对中老年肺癌放疗患者及其照顾者出院准备和生活质量的影响

目的探讨家庭赋权行为干预对中老年肺癌放疗患者及其照顾者出院准备和生活质量的影响。方法将90例中老年肺癌放疗患者及90名照顾者采用便利抽样法根据患者入组顺序随机分为对照组和观察组,各45例患者和45名照顾者。两组患者均给予常规干预,观察组在此基础上予以家庭赋权行为干预。干预前后采用出院准备度量表(RHDS)、世界卫生组织生活质量简表(WHOQOL-BREF)评定患者的出院准备情况及生活质量,统计患者的复诊依从情况;干预前后采用照顾者准备度量表(CPS)评定照顾者对患者出院准备情况。结果干预后,两组患者RHDS评分均较干预前升高,且观察组高于对照组(P<0.01)。干预后,两组照顾者CPS评分均较干预前升高,且观察组高于对照组(P<0.01)。观察组患者复诊依从率高于对照组(P<0.01)。干预后,观察组患者WHOQOL-BREF的躯体功能、情绪状态、社会功能维度评分均较干预前升高,且高于对照组(P<0.05或0.01),对照组患者仅躯体功能、社会功能维度评分较干预前升高(P<0.05)。结论对中老年肺癌放疗患者及照顾者予以家庭赋权行为干预,可有效提升患者及照顾者的出院准备度,改善患者复诊依从性,提高患者生活质量。

婴儿家庭病房对新生儿高胆红素血症结局影响的分析

目的分析新生儿高胆红素血症患儿在婴儿家庭病房和普通病房中治疗效果的异同,为推广婴儿家庭病房提供依据。方法选取2022年1—12月佛山市妇幼保健院婴儿家庭病房收治的183例新生儿高胆红素血症患儿为研究对象,随机抽取同期普通病房183例新生儿高胆红素血症患儿做对比,回顾性分析2种类型病房新生儿高胆红素血症的治疗效果。结果婴儿家庭病房收治患儿平均胎龄(38.22±1.21)周,出生体质量(3181±395)g,入院时的日龄(4.51±1.36)d,血清胆红素水平(266.87±35.16)μmol/L;普通病房患儿平均胎龄(38.17±1.39)周,出生体质量(3139±426)g,入院时的日龄(4.26±1.37)d,血清胆红素水平(262.86±37.55)μmol/L,2组比较,差异均无统计学意义(P>0.05)。婴儿家庭病房15 d再入院5例,普通病房12例,2组比较差异无统计学意义(P>0.05)。婴儿家庭病房母乳喂养181例,普通病房13例,2组比较差异有统计学意义(P<0.05)。婴儿家庭病房并发症(皮疹、腹泻)6例,普通病房并发症(皮疹、腹泻)22例,差异有统计学意义(P<0.05)。婴儿家庭病房非常满意179例,普通病房非常满意160例,差异有统计学意义(P<0.05)。结论婴儿家庭病房减少母婴分离,更有利于母乳喂养及母婴康复,可以缩短新生儿高胆红素血症患儿住院时间,减少并发症的发生,对家属满意度产生正性影响。

NSICU过渡期患者家属需求现况调查及影响因素分析

目的调查神经外科重症监护室(NSICU)过渡期患者家属需求现状,并分析其影响因素,为开展下一步的干预措施提供理论依据。方法采用便利抽样法选取2022年11月至2023年4月该院收治的NSICU过渡期患者家属115例作为研究对象。采取一般资料调查问卷、ICU过渡期患者家属需求量表、ICU转出患者家属迁移应激量表分别对患者家属进行调查。结果115例患者家属平均ICU过渡期患者家属需求量表得分为(100.17±8.38)分,与ICU转出患者家属迁移应激量表总分呈正相关,差异有统计学意义(P<0.05)。有无照顾经验、患者入住NSICU方式、迁移应激水平为NSICU过渡期患者家属需求的影响因素,差异均有统计学意义(P<0.05)。结论NSICU过渡期患者家属需求水平较高,医护人员应对患者家属有无照顾经验、患者入住NSICU方式、迁移应激等因素实施个体化干预,以满足患者家属的需求。

医院信息系统切换研究与实践

医院信息系统(HIS)是医院运行中最为关键的部分,它是医院的命脉,关系着医院信息化建设的成败。随着医院信息化建设的不断深入,医院信息工作量逐步增加,对医院信息系统的要求越来越高,在原有信息系统不能满足医院信息化建设与发展需要时,必然面临着新旧信息系统交替,即系统切换问题。医院信息系统切换是一项复杂而细致的工作,必须根据医院自身情况选择好切换方案并认真做好准备工作,才能确保系统切换成功,从而实现新系统建设的目标,保障医院信息化高质量发展。

lncRNA HAGLR促卵巢癌细胞生长和上皮-间充质转化的机制研究

目的研究长链非编码RNA同源盒D基因簇反义生长相关长链非编码RNA(lncRNA HAGLR)通过调控核苷酸结合寡聚化结构域样受体家族pyrin结构域蛋白3(NLRP3)炎症小体对卵巢癌细胞生长和上皮-间充质转化(EMT)的调控作用。方法培养卵巢正常细胞IOSE-80(IOSE-80组)以及卵巢癌细胞A2780(A2780组)。然后将A2780随机分为lncRNA HAGLR沉默组(siHAGLR组)、沉默阴性对照组(siNC组)、siHAGLR联合NLRP3抑制剂MCC950处理组(siHAGLR+MCC950组)。qRT-PCR法检测lncRNA HAGLR的表达。Western blot检测NLRP3炎症小体相关蛋白NLRP3、caspase-1、ASC和EMT相关蛋白Vimentin、Snail1、α-SMA、Twist1的表达。CCK-8法检测A2780细胞的增殖活性。Transwell法检测A2780细胞的迁移和侵袭能力。细胞克隆形成实验检测A2780细胞的生长能力。TUNEL染色检测A2780细胞的凋亡。结果与IOSE-80组相比,A2780组lncRNA HAGLR、Vimentin、Snail1、α-SMA、Twist1表达均上调(P<0.05),但NLRP3、caspase-1、ASC的表达均下调(P<0.05)。与siNC组相比,siHAGLR组的lncRNA HAGLR、Vimentin、Snail1、α-SMA、Twist1表达均下调(P<0.05),但NLRP3、caspase-1、ASC的表达均上调(P<0.05),细胞增殖率、细胞克隆数以及迁移和侵袭数均明显减少(P<0.05),细胞凋亡数则增加(P<0.05)。与siHAGLR组相比,siHAGLR+MCC950组的lncRNA HAGLR表达无明显变化(P>0.05),而Vimentin、Snail1、α-SMA、Twist1表达均上调(P<0.05),但NLRP3、caspase-1、ASC的表达均下调(P<0.05),细胞增殖率、细胞克隆数以及迁移和侵袭数均显著增加(P<0.05),细胞凋亡数则减少(P<0.05)。结论lncRNA HAGLR通过抑制NLRP3炎症小体促进卵巢癌细胞的生长和EMT。