Developmental transitions in some parasitic angiosperms are tied directly to host-derived chemical cues (xenognosins). The obligate hemi-parasite Striga asiatica, initiates the root apical meristem population (germina...Developmental transitions in some parasitic angiosperms are tied directly to host-derived chemical cues (xenognosins). The obligate hemi-parasite Striga asiatica, initiates the root apical meristem population (germination), development of the host attachment organ (the haustorium), and shoot apical meristem initiation (seed coat shedding) in response to specific xengonosins. These checkpoints synchronize spatial and temporal tissue development. We have now exploited the external control over these developmental transitions to trace functional expression in haustorial organogenesis. Genes associated with phytohormone regulation, metabolism, vascular tissue development, and reactive oxygen species (ROS) production identified in this study suggest an elaborate and global response closely tied to plant defense and redox chemistry that may also be components of a more general quorum sensing-type mechanism in plants.展开更多
Designing and developing distributed cyber-physical production systems(CPPS)is a time-consuming,complex,and error-prone process.These systems are typically heterogeneous,i.e.,they consist of multiple components implem...Designing and developing distributed cyber-physical production systems(CPPS)is a time-consuming,complex,and error-prone process.These systems are typically heterogeneous,i.e.,they consist of multiple components implemented with different languages and development tools.One of the main problems nowadays in CPPS implementation is enabling security mechanisms by design while reducing the complexity and increasing the system’s maintainability.Adopting the IEC 61499 standard is an excellent approach to tackle these challenges by enabling the design,deployment,and management of CPPS in a model-based engineering methodology.We propose a method for CPPS design based on the IEC 61499 standard.The method allows designers to embed a bio-inspired anomaly-based host intrusion detection system(A-HIDS)in Edge devices.This A-HIDS is based on the incremental Dendritic Cell Algorithm(iDCA)and can analyze OPC UA network data exchanged between the Edge devices and detect attacks that target the CPPS’Edge layer.This study’s findings have practical implications on the industrial security community by making novel contributions to the intrusion detection problem in CPPS considering immune-inspired solutions,and cost-effective security by design system implementation.According to the experimental data,the proposed solution can dramatically reduce design and code complexity while improving application maintainability and successfully detecting network attacks without negatively impacting the performance of the CPPS Edge devices.展开更多
Objective To evaluate the diagnostic performance of galactomannan(GM)detection in serum and BALF for invasive pulmonary aspergillosis(IPA)in non-neutropenic hosts.Methods A prospective study was performed for 1 356 no...Objective To evaluate the diagnostic performance of galactomannan(GM)detection in serum and BALF for invasive pulmonary aspergillosis(IPA)in non-neutropenic hosts.Methods A prospective study was performed for 1 356 non-neutropenic hosts admitted to the Department of Pulmonary and Critical Care Medicine of展开更多
文摘Developmental transitions in some parasitic angiosperms are tied directly to host-derived chemical cues (xenognosins). The obligate hemi-parasite Striga asiatica, initiates the root apical meristem population (germination), development of the host attachment organ (the haustorium), and shoot apical meristem initiation (seed coat shedding) in response to specific xengonosins. These checkpoints synchronize spatial and temporal tissue development. We have now exploited the external control over these developmental transitions to trace functional expression in haustorial organogenesis. Genes associated with phytohormone regulation, metabolism, vascular tissue development, and reactive oxygen species (ROS) production identified in this study suggest an elaborate and global response closely tied to plant defense and redox chemistry that may also be components of a more general quorum sensing-type mechanism in plants.
文摘Designing and developing distributed cyber-physical production systems(CPPS)is a time-consuming,complex,and error-prone process.These systems are typically heterogeneous,i.e.,they consist of multiple components implemented with different languages and development tools.One of the main problems nowadays in CPPS implementation is enabling security mechanisms by design while reducing the complexity and increasing the system’s maintainability.Adopting the IEC 61499 standard is an excellent approach to tackle these challenges by enabling the design,deployment,and management of CPPS in a model-based engineering methodology.We propose a method for CPPS design based on the IEC 61499 standard.The method allows designers to embed a bio-inspired anomaly-based host intrusion detection system(A-HIDS)in Edge devices.This A-HIDS is based on the incremental Dendritic Cell Algorithm(iDCA)and can analyze OPC UA network data exchanged between the Edge devices and detect attacks that target the CPPS’Edge layer.This study’s findings have practical implications on the industrial security community by making novel contributions to the intrusion detection problem in CPPS considering immune-inspired solutions,and cost-effective security by design system implementation.According to the experimental data,the proposed solution can dramatically reduce design and code complexity while improving application maintainability and successfully detecting network attacks without negatively impacting the performance of the CPPS Edge devices.
文摘Objective To evaluate the diagnostic performance of galactomannan(GM)detection in serum and BALF for invasive pulmonary aspergillosis(IPA)in non-neutropenic hosts.Methods A prospective study was performed for 1 356 non-neutropenic hosts admitted to the Department of Pulmonary and Critical Care Medicine of