Integrated energy systems(lESs)represent a promising energy supply model within the energy internet.However,multi-energy flow coupling in the optimal configuration of IES results in a series of simplifications in the ...Integrated energy systems(lESs)represent a promising energy supply model within the energy internet.However,multi-energy flow coupling in the optimal configuration of IES results in a series of simplifications in the preliminary planning,affecting the cost,efficiency,and environmental performance of IES.A novel optimal planning method that considers the part-load characteristics and spatio-temporal synergistic effects of IES components is proposed to enable a rational design of the structure and size of IES.An extended energy hub model is introduced based on the“node of energy hub”concept by decomposing the IES into different types of energy equipment.Subsequently,a planning method is applied as a two-level optimization framework-the upper level is used to identify the type and size of the component,while the bottom level is used to optimize the operation strategy based on a typical day analysis method.The planning problem is solved using a two-stage evolutionary algorithm,combing the multiple-mutations adaptive genetic algorithm with an interior point optimization solver,to minimize the lifetime cost of the IES.Finally,the feasibility of the proposed planning method is demonstrated using a case study.The life cycle costs of the IES with and without consideration of the part-load characteristics of the components were$4.26 million and$4.15 million,respectively,in the case study.Moreover,ignoring the variation in component characteristics in the design stage resulted in an additional 11.57%expenditure due to an energy efficiency reduction under the off-design conditions.展开更多
To improve polishing quality and cope with the shortage of skilled workers for aluminum wheel-hub surface polishing, an automatic surface polishing system with hierarchical control based on the teaching-playback metho...To improve polishing quality and cope with the shortage of skilled workers for aluminum wheel-hub surface polishing, an automatic surface polishing system with hierarchical control based on the teaching-playback method was presented. Multi-axis cutter location data (CL data) were generated with the teaching method. First, a helical tool path and a flexible polishing tool were adopted to achieve high quality and high efficiency; next, the initial irregular data were processed into continuous polishing CL data. The important factor affecting polishing quality, namely the interpolation cycle in the multi-axis CL data was calculated based on a constant removal rate. Results from polishing experiments show that the quality of automatic machine polishing is better and stabler than manual polishing.展开更多
The first-order approximation coupling （FOAC） model was proposed recently for dynamics and control of flexible hub-beam systems. This model may deal with system dynamics for both low and high rotation speed, while t...The first-order approximation coupling （FOAC） model was proposed recently for dynamics and control of flexible hub-beam systems. This model may deal with system dynamics for both low and high rotation speed, while the classical zeroth-order approximation coupling （ZOAC） model is only available for low rotation speed. This paper assumes the FOAC model to present experimental study of active positioning control of a flexible hub-beam system. Linearization and nonlinear control strategies are both considered. An experiment system based on a DSP TMS320F2812 board is introduced. The difference between linearization and nonlinear control strategies are studied both numerically and experimentally. Simulation and experimental results indicate that, linearized controller can make the system reach an expected position with suppressed vibration of flexible beam, but the time taken to position is longer than expected, whereas nonlinear controller works well with precise positioning, suppression of vibration and time control.展开更多
Hypoxia preconditioning （HPC） is associated with many complicated pathophysiological and biochemical processes that integrated and regulated via molecular levels. HPC could protect cells, tissues, organs and systems...Hypoxia preconditioning （HPC） is associated with many complicated pathophysiological and biochemical processes that integrated and regulated via molecular levels. HPC could protect cells, tissues, organs and systems from hypoxia injury, but up to date, the molecular mechanism still remained unclear. The acute and repetitive hy- poxia preconditioning model was constructed and the related parameters were observed. The high-throughput mi- croarray analysis and multiple bioinformatics were used to explore the differentially expressed genes in HPC mice brain and the related gene network, pathways and biological processes related to HPC. The 2D-DIGE coupled with MALDI-TOF/TOF-MS was performed to identify these proteins that were differentially expressed during HPC. The UPLC-HRMS based metabolomics method was utilized to explore the key endogenous metabolites and metabolic pathways related to HPC. The results showed that （1） 1175 differentially expressed genes in HPC mice brain were identified. Fourteen of these genes were the related hub genes for HPC, including Cacna2dl, Grin2a, Npylr, Mef2c, Epha4, Rxfpl, Chrm3, Pdela, Atp2b4, Glral, Idil , Fgfl, Grin2b and Cda. The change trends of all the detected genes by RT-PCR were consistent with the data of gene chips. There were 113 significant functions up- regulated and 138 significant functions down-regulated in HPC mice. （2） About 2100 proteins were revealed via the gel imaging and spot detection. 66, 45 and 70 of proteins were found to have significantly difference between the control group and three times of HPC group, the control and six times of HPC, and the three times of HPC and six times of HPC group. （3）Some endogenous metabolites such as phenylalanine, valine, proline, leucine and glu- tamine were increased, while ereatine was decreased, both in HPC brain and heart; in addition, y-aminobutyric acid was markedly decreased in brain. The sphingolipid metabolic pathways were noticed due to the low p-value and high pathway impact. Especially, the sphingolipid compound sphingomyelin, ceramide, glucosyleeramide, galactosylceramide and laetosylceramide were mapping in this metabolic pathway. Interestingly, these sphingolipid metabolites with olefinic bond in the long fatty chain were up-regulated, while those sphingolipids without olefinic bond were down-regulated. The functions of these differentially expressed genes mainly involved the cellular proces- ses including MAPK pathway, ion transport, neurotransmitter transport and neuropeptide signal pathway. The pro- tein levels related the ATP synthesis and citric acid cycle decreased while the proteins with the glycolysis and oxy- gen-binding increased. Glutathione, GNBP-1 and GPD1L were related to preventing hypoxic damage. The results indicated that C24：l-Cers played a critical role in HPC and had potential in endogenous protective mechanism. The combinations of the system omies data of the different molecules were sufficient to give a further understanding of the molecular pathways affected by HPC. Our data provided an important insight to reveal the protection mechanism of HPC.展开更多
Coordinated scheduling of multimode plays a pivotal role in the rapid gathering and dissipating of passengers in transport hubs. Based on the survey data, the whole-day reaching time distribution at transfer points of...Coordinated scheduling of multimode plays a pivotal role in the rapid gathering and dissipating of passengers in transport hubs. Based on the survey data, the whole-day reaching time distribution at transfer points of passengers from the dominant mode to the connecting mode was achieved. A GI/M K/1 bulk service queuing system was constituted by putting the passengers' reaching time distribution as the input and the connecting mode as the service institution. Through queuing theory, the relationship between average queuing length under steady-state and headway of the connecting mode was achieved. By putting the minimum total cost of system as optimization objective, the headway as decision variable, a coordinated scheduling model of multimode in intermodal transit hubs was established. At last, a dynamic scheduling strategy was generated to cope with the unexpected changes of the dominant mode. The instance analysis indicates that this model can significantly reduce passengers' queuing time by approximately 17% with no apparently increase in departure frequency, which provides a useful solution for the coordinated scheduling of different transport modes in hubs.展开更多
BACKGROUND Helicobacter pylori(H.pylori)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting H.pylori infection and T2DM remain unkn...BACKGROUND Helicobacter pylori(H.pylori)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting H.pylori infection and T2DM remain unknown.AIM To explore potential molecular connections between H.pylori infection and T2DM.METHODS We extracted gene expression arrays from three online datasets(GSE60427,GSE27411 and GSE115601).Differentially expressed genes(DEGs)commonly present in patients with H.pylori infection and T2DM were identified.Hub genes were validated using human gastric biopsy samples.Correlations between hub genes and immune cell infiltration,miRNAs,and transcription factors(TFs)were further analyzed.RESULTS A total of 67 DEGs were commonly presented in patients with H.pylori infection and T2DM.Five significantly upregulated hub genes,including TLR4,ITGAM,C5AR1,FCER1G,and FCGR2A,were finally identified,all of which are closely related to immune cell infiltration.The gene-miRNA analysis detected 13 miRNAs with at least two gene cross-links.TF-gene interaction networks showed that TLR4 was coregulated by 26 TFs,the largest number of TFs among the 5 hub genes.CONCLUSION We identified five hub genes that may have molecular connections between H.pylori infection and T2DM.This study provides new insights into the pathogenesis of H.pylori-induced onset of T2DM.展开更多
BACKGROUND The identification of specific gene expression patterns is crucial for understanding the mechanisms underlying primary biliary cholangitis(PBC)and finding relevant biomarkers for diagnosis and therapeutic e...BACKGROUND The identification of specific gene expression patterns is crucial for understanding the mechanisms underlying primary biliary cholangitis(PBC)and finding relevant biomarkers for diagnosis and therapeutic evaluation.AIM To determine PBC-associated hub genes and assess their clinical utility for disease prediction.METHODS PBC expression data were obtained from the Gene Expression Omnibus database.Overlapping genes from differential expression analysis and weighted gene coexpression network analysis(WGCNA)were identified as key genes for PBC.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses were performed to explore the potential roles of key genes.Hub genes were identified in protein-protein interaction(PPI)networks using the Degree algorithm in Cytoscape software.The relationship between hub genes and immune cells was investigated.Finally,a Mendelian randomization study was conducted to determine the causal effects of hub genes on PBC.RESULTS We identified 71 overlapping key genes using differential expression analysis and WGCNA.These genes were primarily enriched in pathways related to cytokinecytokine receptor interaction,and Th1,Th2,and Th17 cell differentiation.We utilized Cytoscape software and identified five hub genes(CD247,IL10,CCL5,CCL3,and STAT3)in PPI networks.These hub genes showed a strong correlation with immune cell infiltration in PBC.However,inverse variance weighting analysis did not indicate the causal effects of hub genes on PBC risk.CONCLUSION Hub genes can potentially serve as valuable biomarkers for PBC prediction and treatment,thereby offering significant clinical utility.展开更多
The external rotor hub motor adopts direct drive mode,no deceleration drive device,and has a compact structure.Its axial size is smaller than that of a deceleration-driven hub motor,which greatly reduces the weight of...The external rotor hub motor adopts direct drive mode,no deceleration drive device,and has a compact structure.Its axial size is smaller than that of a deceleration-driven hub motor,which greatly reduces the weight of the vehicle and increases the cruising range of the vehicle.Because of the limited special working environment and performance requirements,the hub motor has a small internal space and a large heat generation,so it puts forward higher requirements for heat dissipation capacity.For the external rotor hub motor,a new type of in-tank watercooled structure of hub motor was proposed to improve its cooling effect and performance.Firstly,the threedimensional finite element model of the motor is established to analyze the characteristics of motor loss and temperature field distribution.Secondly,the cooling performance of different cooling structures in the tank was studied.Finally,the thermal network model and three-dimensional finite element analysis were used to optimize the water-cooled structure in the tank,and the power density of themotor was improved by improving the cooling performance under the condition of volume limitation of the hub motor.The results show that the cooling effect of the proposed water-cooled structure in the tank is significant under the condition of constant power density.Compared to natural ventilation,the maximum temperature was reduced by 33.13°C and the cooling effect was increased by about 27.7%.展开更多
The target of integrated construction of comprehensive transportation hub is to integrate the traffic resources,achieve butt joint of pan-regional transportation mode,and finally realize the"seamless connection&q...The target of integrated construction of comprehensive transportation hub is to integrate the traffic resources,achieve butt joint of pan-regional transportation mode,and finally realize the"seamless connection"of the goods and"zero transfer"of the passenger traffic.Relying on the particularity of the geographical location and the convenience of the Yangtze River channel,Luzhou puts forth effort to build a comprehensive transport hub in Southern Sichuan and has made great efforts in traffic infrastructure construction.However,there are still some problems.Combining practice of Luzhou,using the advanced experience of foreign and domestic cities for reference,the paper pointed out that for the sake of constructing a comprehensive transportation hub,we need to build the traffic integration on the basis of the efficiency.Besides,the paper proposed the strategies for construction.展开更多
This article discusses the roadbed splicing for hub interchanges.The article starts with a description of the characteristics of junction roadbed splicing.The application of splicing technology is explained using a su...This article discusses the roadbed splicing for hub interchanges.The article starts with a description of the characteristics of junction roadbed splicing.The application of splicing technology is explained using a subgrade splicing scheme of a project.Roadbed splicing involves stepwise excavation and preparative measures like surface cleaning and backfilling.This article serves to provide a valuable reference for road and bridge construction and improve the quality of China’s road and bridge projects,so as to achieve sustainable development of the road and bridge engineering industry.展开更多
基金the National Natural Science Foundation of China(Grant No.51821004)supported by the Major Program of the National Natural Science Foundation of China(Grant No.52090062)The author Chengzhou Li also thank the China Scholarship Council(CSC)for the financial support.
文摘Integrated energy systems(lESs)represent a promising energy supply model within the energy internet.However,multi-energy flow coupling in the optimal configuration of IES results in a series of simplifications in the preliminary planning,affecting the cost,efficiency,and environmental performance of IES.A novel optimal planning method that considers the part-load characteristics and spatio-temporal synergistic effects of IES components is proposed to enable a rational design of the structure and size of IES.An extended energy hub model is introduced based on the“node of energy hub”concept by decomposing the IES into different types of energy equipment.Subsequently,a planning method is applied as a two-level optimization framework-the upper level is used to identify the type and size of the component,while the bottom level is used to optimize the operation strategy based on a typical day analysis method.The planning problem is solved using a two-stage evolutionary algorithm,combing the multiple-mutations adaptive genetic algorithm with an interior point optimization solver,to minimize the lifetime cost of the IES.Finally,the feasibility of the proposed planning method is demonstrated using a case study.The life cycle costs of the IES with and without consideration of the part-load characteristics of the components were$4.26 million and$4.15 million,respectively,in the case study.Moreover,ignoring the variation in component characteristics in the design stage resulted in an additional 11.57%expenditure due to an energy efficiency reduction under the off-design conditions.
基金Funded by the Science and Technology Department of Zhejiang Province,China (No. 2005D60SA700351)
文摘To improve polishing quality and cope with the shortage of skilled workers for aluminum wheel-hub surface polishing, an automatic surface polishing system with hierarchical control based on the teaching-playback method was presented. Multi-axis cutter location data (CL data) were generated with the teaching method. First, a helical tool path and a flexible polishing tool were adopted to achieve high quality and high efficiency; next, the initial irregular data were processed into continuous polishing CL data. The important factor affecting polishing quality, namely the interpolation cycle in the multi-axis CL data was calculated based on a constant removal rate. Results from polishing experiments show that the quality of automatic machine polishing is better and stabler than manual polishing.
基金supported by the National Natural Science Foundation of China(10772112 and 10472065)the Key Project of Ministry of Education of China(107043)+2 种基金the Key Scientific Project of Shanghai Municipal Education Commission(09ZZ 17)the Specialized Research Fund for the Doctoral Program of Higher Education of China(20070248032)the Research Project of State Key Laboratory of Ocean Engineering of China(GKZD010807)
文摘The first-order approximation coupling （FOAC） model was proposed recently for dynamics and control of flexible hub-beam systems. This model may deal with system dynamics for both low and high rotation speed, while the classical zeroth-order approximation coupling （ZOAC） model is only available for low rotation speed. This paper assumes the FOAC model to present experimental study of active positioning control of a flexible hub-beam system. Linearization and nonlinear control strategies are both considered. An experiment system based on a DSP TMS320F2812 board is introduced. The difference between linearization and nonlinear control strategies are studied both numerically and experimentally. Simulation and experimental results indicate that, linearized controller can make the system reach an expected position with suppressed vibration of flexible beam, but the time taken to position is longer than expected, whereas nonlinear controller works well with precise positioning, suppression of vibration and time control.
文摘Hypoxia preconditioning （HPC） is associated with many complicated pathophysiological and biochemical processes that integrated and regulated via molecular levels. HPC could protect cells, tissues, organs and systems from hypoxia injury, but up to date, the molecular mechanism still remained unclear. The acute and repetitive hy- poxia preconditioning model was constructed and the related parameters were observed. The high-throughput mi- croarray analysis and multiple bioinformatics were used to explore the differentially expressed genes in HPC mice brain and the related gene network, pathways and biological processes related to HPC. The 2D-DIGE coupled with MALDI-TOF/TOF-MS was performed to identify these proteins that were differentially expressed during HPC. The UPLC-HRMS based metabolomics method was utilized to explore the key endogenous metabolites and metabolic pathways related to HPC. The results showed that （1） 1175 differentially expressed genes in HPC mice brain were identified. Fourteen of these genes were the related hub genes for HPC, including Cacna2dl, Grin2a, Npylr, Mef2c, Epha4, Rxfpl, Chrm3, Pdela, Atp2b4, Glral, Idil , Fgfl, Grin2b and Cda. The change trends of all the detected genes by RT-PCR were consistent with the data of gene chips. There were 113 significant functions up- regulated and 138 significant functions down-regulated in HPC mice. （2） About 2100 proteins were revealed via the gel imaging and spot detection. 66, 45 and 70 of proteins were found to have significantly difference between the control group and three times of HPC group, the control and six times of HPC, and the three times of HPC and six times of HPC group. （3）Some endogenous metabolites such as phenylalanine, valine, proline, leucine and glu- tamine were increased, while ereatine was decreased, both in HPC brain and heart; in addition, y-aminobutyric acid was markedly decreased in brain. The sphingolipid metabolic pathways were noticed due to the low p-value and high pathway impact. Especially, the sphingolipid compound sphingomyelin, ceramide, glucosyleeramide, galactosylceramide and laetosylceramide were mapping in this metabolic pathway. Interestingly, these sphingolipid metabolites with olefinic bond in the long fatty chain were up-regulated, while those sphingolipids without olefinic bond were down-regulated. The functions of these differentially expressed genes mainly involved the cellular proces- ses including MAPK pathway, ion transport, neurotransmitter transport and neuropeptide signal pathway. The pro- tein levels related the ATP synthesis and citric acid cycle decreased while the proteins with the glycolysis and oxy- gen-binding increased. Glutathione, GNBP-1 and GPD1L were related to preventing hypoxic damage. The results indicated that C24：l-Cers played a critical role in HPC and had potential in endogenous protective mechanism. The combinations of the system omies data of the different molecules were sufficient to give a further understanding of the molecular pathways affected by HPC. Our data provided an important insight to reveal the protection mechanism of HPC.
基金Projects(51278221,51378076)supported by the National Natural Science Foundation of China
文摘Coordinated scheduling of multimode plays a pivotal role in the rapid gathering and dissipating of passengers in transport hubs. Based on the survey data, the whole-day reaching time distribution at transfer points of passengers from the dominant mode to the connecting mode was achieved. A GI/M K/1 bulk service queuing system was constituted by putting the passengers' reaching time distribution as the input and the connecting mode as the service institution. Through queuing theory, the relationship between average queuing length under steady-state and headway of the connecting mode was achieved. By putting the minimum total cost of system as optimization objective, the headway as decision variable, a coordinated scheduling model of multimode in intermodal transit hubs was established. At last, a dynamic scheduling strategy was generated to cope with the unexpected changes of the dominant mode. The instance analysis indicates that this model can significantly reduce passengers' queuing time by approximately 17% with no apparently increase in departure frequency, which provides a useful solution for the coordinated scheduling of different transport modes in hubs.
基金Supported by National Natural Science Foundation of China,No.82100594.
文摘BACKGROUND Helicobacter pylori(H.pylori)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting H.pylori infection and T2DM remain unknown.AIM To explore potential molecular connections between H.pylori infection and T2DM.METHODS We extracted gene expression arrays from three online datasets(GSE60427,GSE27411 and GSE115601).Differentially expressed genes(DEGs)commonly present in patients with H.pylori infection and T2DM were identified.Hub genes were validated using human gastric biopsy samples.Correlations between hub genes and immune cell infiltration,miRNAs,and transcription factors(TFs)were further analyzed.RESULTS A total of 67 DEGs were commonly presented in patients with H.pylori infection and T2DM.Five significantly upregulated hub genes,including TLR4,ITGAM,C5AR1,FCER1G,and FCGR2A,were finally identified,all of which are closely related to immune cell infiltration.The gene-miRNA analysis detected 13 miRNAs with at least two gene cross-links.TF-gene interaction networks showed that TLR4 was coregulated by 26 TFs,the largest number of TFs among the 5 hub genes.CONCLUSION We identified five hub genes that may have molecular connections between H.pylori infection and T2DM.This study provides new insights into the pathogenesis of H.pylori-induced onset of T2DM.
基金Supported by School-Level Key Projects at Bengbu Medical College,No.2021byzd109。
文摘BACKGROUND The identification of specific gene expression patterns is crucial for understanding the mechanisms underlying primary biliary cholangitis(PBC)and finding relevant biomarkers for diagnosis and therapeutic evaluation.AIM To determine PBC-associated hub genes and assess their clinical utility for disease prediction.METHODS PBC expression data were obtained from the Gene Expression Omnibus database.Overlapping genes from differential expression analysis and weighted gene coexpression network analysis(WGCNA)were identified as key genes for PBC.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses were performed to explore the potential roles of key genes.Hub genes were identified in protein-protein interaction(PPI)networks using the Degree algorithm in Cytoscape software.The relationship between hub genes and immune cells was investigated.Finally,a Mendelian randomization study was conducted to determine the causal effects of hub genes on PBC.RESULTS We identified 71 overlapping key genes using differential expression analysis and WGCNA.These genes were primarily enriched in pathways related to cytokinecytokine receptor interaction,and Th1,Th2,and Th17 cell differentiation.We utilized Cytoscape software and identified five hub genes(CD247,IL10,CCL5,CCL3,and STAT3)in PPI networks.These hub genes showed a strong correlation with immune cell infiltration in PBC.However,inverse variance weighting analysis did not indicate the causal effects of hub genes on PBC risk.CONCLUSION Hub genes can potentially serve as valuable biomarkers for PBC prediction and treatment,thereby offering significant clinical utility.
基金supported by National Science Foundation of China(Grant No.51705306).
文摘The external rotor hub motor adopts direct drive mode,no deceleration drive device,and has a compact structure.Its axial size is smaller than that of a deceleration-driven hub motor,which greatly reduces the weight of the vehicle and increases the cruising range of the vehicle.Because of the limited special working environment and performance requirements,the hub motor has a small internal space and a large heat generation,so it puts forward higher requirements for heat dissipation capacity.For the external rotor hub motor,a new type of in-tank watercooled structure of hub motor was proposed to improve its cooling effect and performance.Firstly,the threedimensional finite element model of the motor is established to analyze the characteristics of motor loss and temperature field distribution.Secondly,the cooling performance of different cooling structures in the tank was studied.Finally,the thermal network model and three-dimensional finite element analysis were used to optimize the water-cooled structure in the tank,and the power density of themotor was improved by improving the cooling performance under the condition of volume limitation of the hub motor.The results show that the cooling effect of the proposed water-cooled structure in the tank is significant under the condition of constant power density.Compared to natural ventilation,the maximum temperature was reduced by 33.13°C and the cooling effect was increased by about 27.7%.
文摘The target of integrated construction of comprehensive transportation hub is to integrate the traffic resources,achieve butt joint of pan-regional transportation mode,and finally realize the"seamless connection"of the goods and"zero transfer"of the passenger traffic.Relying on the particularity of the geographical location and the convenience of the Yangtze River channel,Luzhou puts forth effort to build a comprehensive transport hub in Southern Sichuan and has made great efforts in traffic infrastructure construction.However,there are still some problems.Combining practice of Luzhou,using the advanced experience of foreign and domestic cities for reference,the paper pointed out that for the sake of constructing a comprehensive transportation hub,we need to build the traffic integration on the basis of the efficiency.Besides,the paper proposed the strategies for construction.
文摘This article discusses the roadbed splicing for hub interchanges.The article starts with a description of the characteristics of junction roadbed splicing.The application of splicing technology is explained using a subgrade splicing scheme of a project.Roadbed splicing involves stepwise excavation and preparative measures like surface cleaning and backfilling.This article serves to provide a valuable reference for road and bridge construction and improve the quality of China’s road and bridge projects,so as to achieve sustainable development of the road and bridge engineering industry.
