Impact of dietary nutrition regimens based on body composition analysis on bone metabolism in Alzheimer’s disease patients

BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine disorders.However,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively unexplored.AIM To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD patients.METHODS This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December 2024.Based on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human BCA.The intervention period lasted for 12 weeks.Bone mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the intervention.RESULTS No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(P<0.05).After the intervention,BMI in the PN group did not differ significantly from that of the RD group,but muscle mass and mineral content were significantly higher in the PN group(P<0.05).After the intervention,a higher proportion of patients in the PN group had a T score>-1 compared to the RD group(P<0.05).The mini-mental state examination(MMSE)score was similar in both groups before the intervention.However,12 weeks after the intervention,the MMSE score in the PN group was significantly higher than that in the RD group(P<0.05).In both groups,the MMSE score significantly increased 12 weeks post-intervention compared to pre-intervention levels(P<0.05).Before the intervention,the levels of osteocalcin,serum calcium,PINP,β-CTX,and 25-hydroxyvitamin D were not significantly different between the two groups(P>0.05).After 12 weeks of intervention,the PN group exhibited higher levels of osteocalcin,serum calcium,and 25-hydroxyvitamin D,as well as lower levels of PINP andβ-CTX,compared to the RD group(P<0.05).In both groups,osteocalcin,serum calcium,and 25-hydroxyvitamin D levels were significantly higher,while PINP andβ-CTX levels were significantly lower after 12 weeks of intervention compared to baseline(P<0.05).CONCLUSION The human BCA-based dietary nutrition regimen plays a crucial role in improving BMD and bone metabolism,with effects that surpass those of conventional nutrition strategies.The findings of this study provide strong evidence for the nutritional management of AD patients.

Contamination and human health risk assessment of heavy metal(loid)s in topsoil and groundwater around mining and dressing factories in Chifeng,North China

Chifeng is a concentrated mining area for non-ferrous metal minerals,as well as a key prevention and control area for heavyduty enterprises.This situation necessitates an efective ecological and human health risk assessment of heavy metal(loid)s driven by the wide distribution of metal ore processing,mining,and smelting factories in Hexigten Banner and Bairin Left Banner.We conducted surveys to assess the levels of heavy metal(loid)s(Cr,As,Pb,Cd,and Hg)in the topsoil and groundwater of the areas.The results indicated that the concentrations of As,Cd,and Pb in partial soil samples exceeded the environmental quality standards of Grade II.Based on contamination assessments,such as geoaccumulation indices and pollution indices,we inferred that Cd,Pb,and As were primary pollutants in topsoil.Potential ecological risks when considered as part of the average risk indices(RI)are up to 1626.40 and 2818.76,respectively,in the two areas.Comparative analysis revealed that Cd posed a very high potential ecological risk,followed by As.Moreover,the evaluation showed that the three exposure pathways of carcinogenic and non-carcinogenic risk followed a descending order:inhalation>ingestion>dermal contact,except for Pb.Arsenic in topsoil posed a potential non-carcinogenic risk to human health,while there were no adverse efects of As in groundwater.In addition,the average total carcinogenic risk for As in the two areas,as well as the risk of Pb in the topsoil of Bairin Left Banner and all the fve heavy metal(loid)s in groundwater,exceeded human tolerance.Pb–Zn mines caused higher human health risks.In addition,the tandem contamination of heavy metal(loid)s in soil and groundwater was not obvious.This research study provides a basis for pollution remediation to control heavy industry-induced ecological and health risks of heavy metal(loid)s.

The two-way feedback and passing-way of human body

Two-way feedback of human body was published in 1992. The sensation of two-way feedback of body is a special system of human reaction, which maintains and regulates symmetry and balance of human body. The human two-way feedback reacts to human health. For human overall health and delay decrepitude, it is necessary to pay attention to the stimulations (passive acceptance and initiative interventions) and relevant influences in human body and the stimulative effect. In this paper, the experimental research of stimulation and an example of two-way feedback in human body are given. And lay a foundation of prevention, medical treatment and hygiene of human overall health.

Development of China's Public Health as an Essential Element of Human Rights

September 2017 Contents Preface Ensuring People’s Right to Health Based on China’s Conditions Continuous Improvement of Health Environment and Conditions Public Health Service Capability Improving Steadily Great Improvement in the Quality of Medical and Health Services Improvement of the National Medical Security System

For People's Right to Safety Of Lives and Health——On development of health-related human rights in China

Medical and health work constitutes the prerequisite to protection of the people's right to safety of lives and health. Over the past decades, the Chinese Government has spared no effort in this regard and, as a result, the Chinese people's health has significantly improved. In the nationwide fight against the SARS (severe acute respiratory syndrome) epidemic in the first half of 2003, the Government placed the health of the Chinese people and the safety of their lives above everything else. With a huge input of human, financial and material resources, the country won a decisive victory over the epidemic. Following is the full text of an interview by Human Rights with Gao Qiang, executive vice-minister of the Ministry of Health, on China's medical and health work and how it is related to protection of human rights.

High level of deoxycholic acid in human bile does not promote cholesterol gallstone formation

AIM:To study whether patients with excess deoxycholic acid (DCA) differ from those with normal percentage of DCA with respect to biliary lipid composition and cholesterol saturation of gallbladder bile. METHODS:Bile was collected during operation through puncturing into the gallbladder from 122 cholesterol gallstone patients and 46 gallstone-free subjects undergoing cholecystectomy.Clinical data,biliary lipids,bile add composition, presence of crystals and nucleation time were analyzed. RESULTS:A subgroup of gallstone patients displayed a higher proportion of DCA in bile than gallstone free subjects. By choosing a cut-off level of the 90th percentile,a group of 13 gallstone patients with high DCA levels (mean 50 percent of total bile acids) and a large group of 109 patients with normal DCA levels (mean 21 percent of total bile acids) were obtained.The mean age of the patients with high DCA levels was higher than that of the group with normal levels (mean age:62 years vs45 years) and so was the mean BMI (28.3 vs.24.7).Plasma levels of cholesterol and triglycerides were slightly higher in the DCA excess groups compared with those in the normal DCA group.There was no difference in biliary lipid composition,cholesterol saturation,nucleation time or occurrence of cholesterol crystals in bile between patients with high and normal levels of DCA. CONCLUSION:Gallstone patients with excess DCA were of older age and had higher BMI than patients with normal DCA.The two groups of patients did not differ with respect to biliary lipid composition,cholesterol saturation,nucleation time or occurrence of cholesterol crystals.It is concluded that DCA in bile does not seem to contribute to gallstone formation in cholesterol gallstone patients.

Communicating Different and Higher across the Praxis of Bloom’s Taxonomy While Shifting toward Health at Every Size (HAES)

The majority of recent studies on prevention and control of childhood obesity focus on methods for achieving weight loss. In contrast, the Health at Every Size (HAES) paradigm fosters improved health behaviors for people of all sizes by emphasizing natural diversity of body type and attention to social, emotional, and spiritual factors in addition to physical ones. This study examined introduction of the HAES paradigm to student teachers using different communication models while moving across the learning domains of Bloom’s Taxonomy. The qualitative research tested a face-to-face verbal communication model and a Computer-Mediated Communication (CMC) module and its blog. It was also based upon reflection diaries recorded by participants using both models. Participants included Druze, Jewish, and Bedouin students at a teacher training program in northern Israel. The student teachers succeeded in developing the HAES concepts further while demonstrating the higher domain levels across Bloom’s Taxonomy. These higher levels emerged when engaging with theoretical concepts and practical dilemmas relating to the HAES concepts of health promotion, body image, well-being, and self-worth. Challenging the appreciation of HAES using different communication models can be translated into diverse contexts of Health Education Practices.

A New Page for Women's Reproductive Health in Integrated Traditional Chinese and Western Medicine

The integrated traditional Chinese and western medicine (ICWM) of obstetrics and gynecology (OBS/GYN) emerged eventually with more than 40 years’ hard struggle, and one of the most promising articles is the integration of the masterpieces of menstrual disorder and infertility in TCM and the virtual explosion of new knowledge and methods in

The Way Food, Diet, and Exercise Are Communicated in Women’s Health Magazine: From a Critical Perspective

Women’s Health Magazine creates a fantasy world for many women,in which they can attach themselves to the ideal beauty standards,and work towards reaching those ideals by engaging in diet and exercise.The advertisements in this magazine mostly give value to the Western ideal of white beauty,which is about the slenderness of the feminine physical body.However,the white beauty ideal makes women in different cultures such as the Turkish and Latin women to resemble this ideal by changing their darker hair colors to blonde,changing their darker eye colors to blue,and changing their curvy body types to slim;even though,their curviness represents sexual desire in their specific culture,and thus it leads these women to lose their cultural characteristics that make them more feminine(Mendible,2007,pp.3-8).In other words,the white ideal beauty causes many women in other cultures to have some kind of cultural assimilation in terms of their own beauty standards,and instead cause them to embrace an international standard of beauty that is Western,and many women such as the Turkish and Hispanic,as well as,the Korean,Chinese,and Japanese,undergo some kind of a process of cultural assimilation related to their cultural body characteristics,as a result(Yan&Bissell,2014,p.197).In other words,these women lose their indigenous body characteristics and they instead try to resemble the slender ideal body of the West with the spread of globalization,which has a major influence on that(Hoskins,2014,p.110).The aim of this paper is to show how the Women’s Health Magazine,a popular contemporary magazine,crates a discourse on food,diet,and exercise,which have a major influence in shaping and assimilating the body type of Turkish women from a critical perspective.

Path Breakthrough of Medical Humanities Education From the Perspective of“All-Staff,Whole-Process,and All-Round Education”

Medical education is an important cornerstone for the development of healthcare,and medical humanities education,as an integral part of medical education,plays an irreplaceable role in cultivating people’s health guardians with high medical ethics.We adopted the method of stratified random sampling to select 309 students and 107 faculty members from three independent medical colleges in Sichuan province as the research subjects and distributed questionnaire surveys investigating in three dimensions:overall cognition of medical humanities,evaluation of medical humanistic qualities,and the current situation of medical humanities education,supplemented by an in-depth literature review and interviews with subject matter experts.We found that“tech-centrism”still has a great influence,the self-evaluation of medical students’humanistic quality is generally not high,the educational concept of“emphasizing professional skills over morality”of faculty and staff is still quite prevalent,and there is still the“last mile”phenomenon in medical humanities education.In order to promote the integrated development of“new medicine”and“new liberal arts”and break the barriers of“tech-centrism”and“instrumental rationality,”it is necessary to change the educational concept and strengthen the education of all employees,break through the bottleneck of internships and strengthen the whole process of education,integrate educational resources and strengthen all-round education,improve the incentive mechanisms,strengthen the assessment methods,and provide Chinese wisdom and Chinese solutions for the development of medical humanities education.

ICP-AES测定5种澳洲进口保健品中的元素

采用微波消解法对5种样品进行消解处理,应用ICP-AES法测定保健药品中Na、Ni、Mg、Sn、Zn、Mo、Si、Se、Sr、Ge、Ca、Au、Al、Hg、Pb、Ag、Fe等17种微量和中量元素的含量。方法回收率在91.3%~102.9%之间,相对标准偏差小于4.89%。此实验方法测定速度快、容易操作、灵敏度极好、准确性高,还能够实现同时测定多种元素。结果表明,所测药品中均含有丰富的人体所需的微量和中量元素,但个别保健品中含有的不益于人体健康的元素的含量也较高。

Effect of insulin on hyperkalemia during anhepatic stage of liver transplantation

AIM:To investigate the effectiveness of insulin on decreasing serum potassium concentration during anhepatic stage of orthotopic liver transplantation. METHODS:Sixteen patients with serum potassium concentrations greater than 4.0 mmol/L at the onset of anhepatic stage were randomized into two groups.The patients in control group (n=8) received no treatment, while those in treatment group (n=8) received an intravenous bolus injection of regular insulin (20U) 10 min into the anhepatic stage,followed by a glucose infusion (500mL 50g/L dextrose) over 15 min. RESULTS:In control group,potassium concentration underwent no changes whereas in treatment group,it decreased from 4.8±0.48 mmol/L to 4.19±0.55 mmol/L (mean±SD) within 15 min and to 3.62±0.45 mmol/L 60 min after the therapy.The potassium concentration was lower in treatment group than in control group within 30 min of treatment (3.94±0.57 vs 4.47±0.42 mmol/L, respectively;P<0.05),and increased similarly 30 s after graft reperfusion in both groups of patients,but remained lower in treatment group (5.81±2.78 vs 7.44±1.75 mmol/L, respectively;P<0.05).The potassium concentration returned to pre-reperfusion levels within 5 min after graft reperfusion. CONCLUSION:In patients undergoing orthotopic liver transplantation,the administration of insulin rapidly decreases serum potassium concentration even in the absence of the liver,suggesting an important contribution by extrahepatic tissues in insulin-stimulated uptake of potassium.

Enterobius vermicularis infection among population of General Mansilla,Argentina

AIM:To evaluate the relationships between the personal, sociocultural,and environmental characteristics,and the presence or absence of symptoms with the detection of Enterobius vermicularis(E.vermicularis)in a population sample in our region(General Mansilla,Province of Buenos Aires,Argentina),by individual and familiar analyses. METHODS:E.verrnicularis was diagnosed in 309 people from 70 family units residing in the urban area and the rural area of the city of General Mansilla.Each of them was surveyed so as to register personal,environmental and sociocultural data.Questions about the presence or absence of anal itch,abdominal pain and sleeping disorder were also asked.Significant associations were determined by square chi tests.Logistic regression models were adjusted by using a backward conditional stepwise method to determine the presence of this parasite in the individuals and in the families. RESULTS:The parasites were found in 29.12%(90/309) of the individuals,with a frequency of 14.28%(20/140) among the heads of the families and of 41.42%(70/169) among the children.The only variables showing a significant association were affiliation,where the risk category was “being the son/daughter of”,and the symptoms were abdominal pain,sleeping disorder,and anal itch.Families with a member infected with parasite were considered Positive Families(PF)and they were 40/70(57.14%),only 5%(2/40)of the PF had 100% of their members infected with the parasite.The logistic regression models applied showed that the risk categories were mainly affiliation(son/daughter) and housing(satisfactory)among others. CONCLUSION:The presence of E.vermiculariswas proved in one third of the studied population.The frequency of families with all their members infected with the parasite was very low.Most of the studied personal,sociocultural, and environmental variables did not turn out to be significantly associated with the presence of the parasite.An association with the category of“son/daughter”and housing classified as“satisfactory”was determined.The latter may be due to the fact that the people living in that category of housing have hygienic practices at home that favour the distribution of the eggs in the environment.The presence of the analysed symptoms was associated with the presence of the parasite, thus strengthening the need of periodical control of the population showing at least one of these symptoms.

Transition to adulthood: A critical role for exercise in building overall well-being

A growing number of multidisciplinary studies have reported the beneficial effects of physical activities towards the development of overall well-being and the reduction of chronic illnesses. Physical inactivity is a serious worldwide problem and is considered the key lifestyle factor that negatively influences health and function of individuals. Here we propose that growth kinetics of body and mind and associated disproportionate physical activity may have considerable effects on the increased physical and mental illnesses and premature death rates currently observed in mid to late adulthood people. Children and young adults, being in exponential growth phase and self-motivated to engage in physical activity, possess more cognition, resilience, and mind-body-emotion-spirit integration. In contrast, as our body transitions into adulthood, there is a decline in the growth of body and mind. Furthermore, in this period, adults experience the increased stressors of career and financial demands, time pressure, and family responsibilities. The decline in growth combined with prolonged stress appears to result in reduced cognition, resilience, and mind-body-emotion-spirit integration, leading to sedentary and other faulty lifestyles, which could further lead to a predisposition to maladaptive behaviours and various chronic diseases at a later stage. In agreement with this, currently more than two thirds of the adult population across the world are physically inactive and are failing to perform the daily recommended guidelines of moderate to vigorous exercise. As negative changes and faulty lifestyles begin to occur during and after adulthood transition, creating awareness in people between 29 to 35 years of age about mindful exercise should be considered a national priority. This would allow adults to achieve overall well-being, and increased productivity and life expectancy, reducing health care-associated economic burden placed on the nation.

赵氏雷火灸神阙穴治疗痰湿质肥胖的临床及人体成分研究

目的以人体测量学指标和人体成分为观察指标,评估赵氏雷火灸神阙穴治疗对痰湿质肥胖患者的疗效。方法采用单盲随机对照试验研究方法,将符合纳入标准的肥胖患者随机分配到观察组(采用赵氏雷火灸神阙穴+认知-行为和精神-心理支持干预)、对照组(采用认知-行为和精神-心理支持干预),疗程4周,观察组隔天1次治疗,每周3次治疗,随访4周。观察组分别于治疗前,治疗后1、2、3、4周,4周后随访6个时间点收集患者的体重、体质指数(BMI)、腰围(WC)、臀围、腰臀比(WHR)等人体测量学指标,于治疗前、治疗后4周、4周后随访采用生物电阻抗法进行人体成分信息采集;对照组分别于治疗前、治疗后4周、4周后随访3个时间点采集人体测量学指标和人体成分分析。结果观察组在体重、BMI、WC、臀围四项指标均较治疗前改善(P<0.05),其中WHR多个时点下降有反弹;体重、BMI、WC、臀围在第二个时点与基线差异无统计学意义(P>0.05),其他多个时点与基线比,均较治疗前下降,差异有统计学意义(P<0.05),两组的体脂百分比治疗后4周观察组相较对照组改善好(P<0.05);与基线对比,两组在治疗4周后的差值分析中可见,观察组在体重、BMI、WC、臀围、WHR下降的差值均较对照组好(P<0.01);4周后随访,观察组的WC、臀围改善比对照组好(P<0.05);人体成分分析的结果提示4周后,观察组的骨骼肌重量、脂肪重量、体质百分比及基础代谢率均较治疗前改善(P<0.05);但两组比较差异无统计学意义(P>0.05)。两组在整个治疗过程中均未出现不良反应和不良事件。结论赵氏雷火灸神阙穴治疗痰湿质肥胖,能有效减重(体重、BMI)、减脂(体脂百分比)、塑形(WC、臀围),有较好的近远期疗效,操作简单,安全无不良反应,患者易于接受,具有简、便、廉、验特点,易于社区、家庭推广,为治疗肥胖提供一种可向社会面推广的干预手段。

牛乳β-酪蛋白基因分型及A1β-酪蛋白对人体健康的潜在影响

长期以来,牛奶为人们提供优质蛋白质和钙等微量元素。β-酪蛋白作为牛乳蛋白质的重要组成部分,具有多种分型,其中最常见的是A1型和A2型,且因与人体健康密切相关而受到广泛关注。BCM-7是A1β-酪蛋白消化产生的一种生物活性肽,具有阿片样性质,推测其可能与胃肠功能紊乱、I型糖尿病、心血管疾病和神经系统疾病等慢性非传染性疾病密切相关,而也有少数文献报道,A1β-酪蛋白对机体是有益的。因此,该文从β-酪蛋白的基因分型及其与人体健康的关系等方面进行阐述,为阐明A1和A2型β-酪蛋白牛奶对人体健康的具体影响以及各自发挥作用的机理奠定基础,并为A1和A2型β-酪蛋白牛奶的消费选择提供一定的理论参考。

Health service needs of women with reproductive tract infections in selected areas of China

OBJECTIVE: To provide insight into the psychosocial factors underlying the utilisation of health services by women with reproductive tract infection (RTI) symptoms. METHODS: A cross-sectional study, adopting Aday and Andersen' s Social Behaviour Model, was conducted between 1998 and 1999 in Chinese Hebei province and Beijing. A total of 864 eligible married women (age 21 to 60 years) were face to face interviewed. RESULTS: The percentage of self-reported symptoms of RTIs in urban and rural women was 35.6 and 46.8, respectively; the proportion of women with RTIs who utilised health services was 27.5% and 26.7%, respectively. Compared to urban women, rural women had less knowledge on RTIs and more traditional beliefs, and were more satisfied with local health services. The results of logistic regression analysis showed that the common factor influencing health service utilisation in women with RTIs was current experience of RTIs. Knowledge about self-medication, perceived social stigma attached to RTIs, prior experience of RTIs, family income and perceived severity of RTIs were also predictors of utilisation of health services in rural women with RTIs. Satisfaction with health providers, information received from health providers, prior experience of RTIs, occupation and medical care coverage were predictors of utilisation of health services in urban women with RTIs. CONCLUSION: The prevalence of RTIs is high, but the rate of seeking health services is low. There is a great need for emphasizing culturally acceptable reproductive health education in different places to improve women' s ability for self-care. Regular medical check-ups for women are also important. It is necessary to improve the quality of health service, complete the reform of health insurance and alleviate women' s social stigma related to RTIs, giving women social and moral support.

上海城市公共开放空间夏季小气候及舒适度

基于2006年5—8月上海城区5种类型公共开放空间(广场、喷泉、草坪、廊道、林地)的空气温度、相对湿度、风速和辐射强度等小气候指标,分析了各空间类型对小气候的调节作用,并采用体感气象指数(discomfortindex,DI)作为评价指标,比较了各空间类型对人体舒适程度影响的差异.结果表明:上海市5种类型公共开放空间的平均温度、相对湿度等小气候因子存在一定差异;平均气温依次为广场>草坪>喷泉>廊道>林地;平均空气相对湿度依次为林地>廊道>喷泉>草坪>广场;广场面积、喷泉水体附近的风速及风向、草坪的草种类型、廊道的宽度及乔木盖度、林地的盖度及乔木林冠层高度等非气候指标分别与各自空间的气候指标呈显著相关.与其他3种空间类型相比,林地和廊道具有明显的遮荫、降温、增湿作用,对小气候的调节能力更佳.

口服麦苗粉对人体健康效应的观察

麦苗营养在维护人体健康方面具有神奇的效果,研究在动物试验和临床试验的基础上,开展日常口服麦苗粉对人体健康的影响观察,结果显示:每天口服少量麦苗粉能有效改善睡眠、修复记忆力、提高免疫功能、促进伤口愈合、增强体力、缓解人体各种不适反应、维护心脏、维持体内正常的血象指标、增进机体排毒、延缓人体衰老;尤其对于年龄较大、亚健康体质或身体健康出现问题的人群,效果更加明显。长期坚持每天口服少量麦苗粉未发现对人体产生毒副作用。

陕西省区域环境地球化学分区

为了利用地壳元素分布特征与动植物微量元素含量间的关系,指导生态环境综合治理,借助已有的基础地球化学资料,进行陕西省地球化学分区,确定各分区的环境背景值、污染起始值、缺乏临界值、过剩值临界值,并将陕西省分为陕北、关中、陕南3个地球化学区,圈定了1个元素贫化区和2个元素富集区。提出应该在元素的缺乏和过剩的异常区内进行生物体内微量元素含量的定期检测。做到对地球化学疾病及时发现及时寻找对策,以保证人类生存环境的安全,提高生存质量。