The human brain is smaller than you might expect:One of them,dripping with formaldehyde,fits in a single gloved hand of a lab supervisor.Soon,this rubbery organ will be frozen solid,coated in glue,and then sliced into...The human brain is smaller than you might expect:One of them,dripping with formaldehyde,fits in a single gloved hand of a lab supervisor.Soon,this rubbery organ will be frozen solid,coated in glue,and then sliced into several thousand wispy slivers,each just 60 micrometers thick.A custom apparatus will scan those sections using 3D polarized light imaging(3DPLI)to measure the spatial orientation of nerve fibers at the micrometer level.The scans will be gathered into展开更多
Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anato...Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast.The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project(CHPP).Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP.The brain imaging sequences included T1-magnetization that prepared rapid gradient echo,T2 fuid-attenuated inversion-recovery,magnetic resonance angiography,difusion MRI,and resting-state functional MRI.The detailed descriptions of image acquisition,interpretation,and post-processing were provided in this article.The measured IDPs included volumes of brain subregions,cerebral vessel geometrical parameters,microstructural tracts,and function connectivity metrics.展开更多
文摘The human brain is smaller than you might expect:One of them,dripping with formaldehyde,fits in a single gloved hand of a lab supervisor.Soon,this rubbery organ will be frozen solid,coated in glue,and then sliced into several thousand wispy slivers,each just 60 micrometers thick.A custom apparatus will scan those sections using 3D polarized light imaging(3DPLI)to measure the spatial orientation of nerve fibers at the micrometer level.The scans will be gathered into
基金the Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01).
文摘Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast.The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project(CHPP).Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP.The brain imaging sequences included T1-magnetization that prepared rapid gradient echo,T2 fuid-attenuated inversion-recovery,magnetic resonance angiography,difusion MRI,and resting-state functional MRI.The detailed descriptions of image acquisition,interpretation,and post-processing were provided in this article.The measured IDPs included volumes of brain subregions,cerebral vessel geometrical parameters,microstructural tracts,and function connectivity metrics.
