Deformation,structure and potential hazard of a landslide based on InSAR in Banbar county,Xizang(Tibet)

The Tibetan Plateau is characterized by complex geological conditions and a relatively fragile ecological environment.In recent years,there has been continuous development and increased human activity in the Tibetan Plateau region,leading to a rising risk of landslides.The landslide in Banbar County,Xizang(Tibet),have been perturbed by ongoing disturbances from human engineering activities,making it susceptible to instability and displaying distinct features.In this study,small baseline subset synthetic aperture radar interferometry(SBAS-InSAR)technology is used to obtain the Line of Sight(LOS)deformation velocity field in the study area,and then the slope-orientation deformation field of the landslide is obtained according to the spatial geometric relationship between the satellite’s LOS direction and the landslide.Subsequently,the landslide thickness is inverted by applying the mass conservation criterion.The results show that the movement area of the landslide is about 6.57×10^(4)m^(2),and the landslide volume is about 1.45×10^(6)m^(3).The maximum estimated thickness and average thickness of the landslide are 39 m and 22 m,respectively.The thickness estimation results align with the findings from on-site investigation,indicating the applicability of this method to large-scale earth slides.The deformation rate of the landslide exhibits a notable correlation with temperature variations,with rainfall playing a supportive role in the deformation process and displaying a certain lag.Human activities exert the most substantial influence on the spatial heterogeneity of landslide deformation,leading to the direct impact of several prominent deformation areas due to human interventions.Simultaneously,utilizing the long short-term memory(LSTM)model to predict landslide displacement,and the forecast results demonstrate the effectiveness of the LSTM model in predicting landslides that are in a continuous development and movement phase.The landslide is still active,and based on the spatial heterogeneity of landslide deformation,new recommendations have been proposed for the future management of the landslide in order to mitigate potential hazards associated with landslide instability.

A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that regulate genomic architecture.Here,we present a structural model of the endogenously purified human canonical BAF complex bound to the nucleosome,generated using cryoelectron microscopy(cryo-EM),cross-linking mass spectrometry,and homology modeling.BAF complexes bilaterally engage the nucleosome H2A/H2B acidic patch regions through the SMARCB1 C-terminalα-helix and the SMARCA4/2 C-terminal SnAc/postSnAc regions,with disease-associated mutations in either causing attenuated chromatin remodeling activities.Further,we define changes in BAF complex architecture upon nucleosome engagement and compare the structural model of endogenous BAF to those of related SWI/SNF-family complexes.Finally,we assign and experimentally interrogate cancer-associated hot-spot mutations localizing within the endogenous human BAF complex,identifying those that disrupt BAF subunit-subunit and subunit-nucleosome interfaces in the nucleosome-bound conformation.Taken together,this integrative structural approach provides important biophysical foundations for understanding the mechanisms of BAF complex function in normal and disease states.

Study on the secondary structure and hydration effect of human serum albumin under acidic pH and ethanol perturbation with IR/NIR spectroscopy

Human serum albumin(HSA)is the most abundant protein in plasma and plays an essential physiological role in the human body.Ethanol precipitation is the most widely used way to obtain HSA,and pH and ethanol are crucial factors affecting the process.In this study,infrared(IR)spectroscopy and near-infrared(NIR)spectroscopy in combination with chemometrics were used to investigate the changes in the secondary structure and hydration of HSA at acidic pH(5.6-3.2)and isoelectric pH when ethanol concentration was varied from 0%to 40%as a perturbation.IR spectroscopy combined with the two-dimensional correlation spectroscopy(2DCOS)analysis for acid pH system proved that the secondary structure of HSA changed significantly when pH was around 4.5.What's more,the IR spectroscopy and 2DCOS analysis showed different secondary structure forms under different ethanol concentrations at the isoelectric pH.For the hydration effect analysis,NIR spectroscopy combined with the McCabe-Fisher method and aquaphotomics showed that the free hydrogen-bonded water fluctuates dynamically,with ethanol at 0-20%enhancing the hydrogen-bonded water clusters,while weak hydrogen-bonded water clusters were formed when the ethanol concentration increased continuously from 20%to 30%.These measurements provide new insights into the structural changes and changes in the hydration behavior of HSA,revealing the dynamic process of protein purification,and providing a theoretical basis for the selection of HSA alcoholic precipitation process parameters,as well as for further studies of complex biological systems.

Human Capital Structure and Economic Growth:From the Perspective of New Structural Economics

The Chinese economy has achieved remarkable development over the past 40 years of reform and opening-up.However,with the narrowing of potential for efficiency improvement from resources reallocation and changes in population age structure,the Chinese economy has moved from high-speed growth to high-quality development.In this setting,understanding factor endowment and comparative advantages of the economy from a perspective of human capital structure so as to enhance industrial structure adaptability by riding the trend is of significance for cultivating new driving force for economic development.This paper,following a theoretical paradigm of new structural economics,demonstrates how human capital structure matches industrial structure and the presence of optimal human capital structure using mathematical deduction.On this basis,national level panel data and instrumental variables are adopted for generalized method of moments,the results of which shows that there are varied impacts on economic growth in light of different human capital structure characteristics.The proportions of high-level human capital and medium-level human capital boost economic development,while that of low-level human capital has an inhibitory effect on economic growth.The policy implication of this study is that large economies should diversify efforts as per different human capital structure characteristics in terms of development need of tapping growth impetus from human capital structure improvement.It is of equal importance to raise the proportion of high and medium human capital in order to stimulate economic growth and to cut the proportion of low human capital that hinders economic development.

Effect of human disturbance on the structure and regeneration of forests in the Nevado de Toluca National Park, Mexico

Sample plots were established in the principal forest types in the the Nevado de Toluca National Park, Mexico including those domi- nated by Pinus hartwegii, Abies religiosa, Quercus laurina and Alnus jorullensis. The vertical structure was defined by three strata in the coniferous forests and two strata in the broadleaved forests. Timber harvesting in Abies religiosa and Quercus laurina forests and fires generated by humans in Pinus hartwegii forests impeded the recruitment of saplings. Mature trees were also heavily impacted by logging in Pinus hartwegii forests. On the contrary, Alnusjorullensis forests were increas- ing due to the disturbance of Pinus and Quercus forests, as well aban- doned crop lands within the park. A combination of logging, uncon- trolled fire, and grazing appears to be compromising the recruitment of important tree species in this national park. These factors, together with human settlements, have also increased the proportion of early succes- sional species. Changes in forest structure from human disturbance indicate a need to control these activities if conservation goals are not to be compromised.

RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform

We have previously reported that the human ACAT1 gene produces a chimeric mRNA through the interchromosomal processing of two discontinuous RNAs transcribed from chromosomes 1 and 7. The chimeric mRNA uses AUG1397-1399 and GGC1274-1276 as translation initiation codons to produce normal 50-kDa ACAT1 and a novel enzymatically active 56-kDa isoform, respectively, with the latter being authentically present in human cells, including human monocyte- derived macrophages. In this work, we report that RNA secondary structures located in the vicinity of the GGC1274-1276 codon are required for production of the 56-kDa isoform. The effects of the three predicted stem-loops （nt 1255-1268, 1286-1342 and 1355-1384） were tested individually by transfecting expression plasmids into cells that contained the wild-type, deleted or mutant stem-loop sequences linked to a partial ACAT1 AUG open reading frame （ORF） or to the ORFs of other genes. The expression patterns were monitored by western blot analyses. We found that the upstream stem-loop1255-1268 from chromosome 7 and downstream stem-loop1286-1342 from chromosome 1 were needed for production of the 56-kDa isoform, whereas the last stem-loop135s-1384 from chromosome 1 was dispensable. The results of experi- ments using both monocistronic and bicistronic vectors with a stable hairpin showed that translation initiation from the GGC1274-1276 codon was mediated by an internal ribosome entry site （IRES）. Further experiments revealed that translation initiation from the GGC1274-1276 codon requires the upstream AU-constituted RNA secondary structure and the downstream GC-rich structure. This mechanistic work provides further support for the biological significance of the chimeric nature of the human ACAT1 transcript.

Mapping theme trends and knowledge structures for human neural stem cells:a quantitative and co-word biclustering analysis for the 2013-2018 period

Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells.

Impacts of environmental conditions on woody plant diversity,structure and regeneration in forest patches of Guna Mountain:Este District,South Gondar Zone,Ethiopia

Environmental conditions determine woody plant life such as species diversity,structure and regeneration status.This research aimed to assess the impact of environmental conditions on woody plant species diversity,structure and regeneration in forest patches of Guna Mountain:the case of Este District,South Gondar Zone,north-west Ethiopia.A total of 71 square sample plots(400 m~2 each) were established at 10 transects laid in five forest patches of the study area to collect vegetation data including the abundance of species,height and diameter at breast height(DBH).Environmental data including available potassium,available phosphorus,cation exchange capacity,soil texture,electrical conductivity,soil acidity,total nitrogen,organic matter,organic carbon,sodium adsorption ratio,exchangeable sodium percentage,bulk density,aspect,elevation,slope,latitude and longitude data were collected in the same plots.A correlation analysis between vegetation and environmental data was performed using rcorr(x) function in package Hmisc in R Programming Language.The most pronounced impacts were observed in altitude,grazing and pH,positively and silt,sand,electrical conductivity and cation exchange capacity,negatively.In addition,strong and significant impacts on plant structure were also observed due to the variation in soil texture and p H.The difference in aspect,sand and slope also impacted plant regeneration.The study showed that environmental parameters influence the diversity,structure and regeneration of woody plants.These parameters can be considered in the rehabilitation of the vegetation cover and conservation efforts of the rare woody species.Conservation measures that can minimalize the negative influences of environmental conditions can be applied through collaboration with communities around the forest patches.

A review on the coordinative structure of human walking and the application of principal component analysis

Walking is a complex task which includes hundreds of muscles, bones and joints working together to deliver smooth movements. With the complexity, walking has been widely investigated in order to identify the pattern of multi-segment movement and reveal the control mechanism. The degree of freedom and dimensional properties provide a view of the coordinative structure during walking, which has been extensively studied by using dimension reduction technique. In this paper, the studies related to the coordinative structure, dimensions detection and pattern reorganization during walking have been reviewed. Principal component analysis, as a popular technique, is widely used in the processing of human movement data. Both the principle and the outcomes of principal component analysis were introduced in this paper. This technique has been reported to successfully reduce the redundancy within the original data, identify the physical meaning represented by the extracted principal components and discriminate the different patterns. The coordinative structure during walking assessed by this technique could provide further information of the body control mechanism and correlate walking pattern with injury.

Synthetic Human Embryo-Like Structure: A New Paradigm for Human Embryology

Early human embryonic development remains mysterious due to drastic species divergences between humans and othermammalian models and limited accessibility to human embryo samples. Recent studies from my laboratory and others haveshown that under suitable culture conditions human pluripotent stem cells ( hPSCs) can undergo intricate morphogenetic eventsand self-organize to form patterned human embryo-like structures in vitro. These synthetic human embryonic tissueshold great promises for advancing human embryology and reproductive medicine. In this talk,I will describe a hPSC-based,synthetic 3D model of human post-implantation development that recapitulates key developmental landmarks successively,including pro-amniotic cavity formation,amniotic ectoderm-epiblast patterning,primordial germ cell specification,and developmentof the primitive streak with controlled anteroposterior polarity ( Fig.1) . We further show that the amniotic ectoderm,as the first lineage that segregates from the epiblast upon implantation of the human embryo,functions as a signaling centerto trigger primitive streak development in the epiblast. Together,our research has developed a powerful synthetic embryologicalmodel and provided new understandings of previously inaccessible but critical embryogenic events in human development.

A correlation between pulse diagnosis of human body and health monitoring of structures

The concept of health monitoring is a key aspect of the field of medicine that has been practiced for a long time. A commonly used diagnostic and health monitoring practice is pulse diagnosis, which can be traced back approximately five thousand years in the recorded history of China. With advances in the development of modern technology, the concept of health monitoring of a variety of engineering structures in several applications has begun to attract widespread attention. Of particular interest in this study is the health monitoring of civil structures. It seem natural, and even beneficial, that these two health-monitoring methods, one as applies to the human body and the other to civil structures, should be analyzed and compared. In this paper, the basic concepts and theories of the two monitoring methods are first discussed. Similarities are then summarized and commented upon. It is hoped that this correlation analysis may help provide structural engineers with some insights into the intrinsic concept of using pulse diagnosis in human health monitoring, which may of be some benefit in the development of modern structural health monitoring methods.

Investigation on the differences of four flavonoids with similar structure binding to human serum albumin

Flavonoids are structurally diverse and the most ubiquitous groups of polyphenols distributed in the various plants,which possess intensive biological activities.In this study,the interaction mechanisms between four flavonoids containing one glucose unit with similar molecular weight isolated from the Tibetan medicinal herb Pyrethrum tatsienense,namely.apigenin-7-O-β-D-glucoside（1）,luteolin-7-O-β-D-glucoside（2）.quercetin-7-O-β-D-glucoside（3）.quercetin-3-O-β-D-glycoside（4）.and human serum albumin（HSA）,were investigated by fluorescence.UV-vis absorbance,circular dichroism,and molecular modeling.The effects of biological metal ions Mg2＋,Zn2＋,and Cu2＋ on the binding affinity between flavonoids and HSA were further examined.Structure-activity relationships of four flavonoids binding to HSA were discussed in depth and some meaningful conclusions have been drawn by the experiment data and theoretical simulation.In addition,an interesting phenomenon was observed that the microenvironment of the binding site I in HSA has hardly changed in the presence of 4 differentiating from the other three flavonoids on the basis of conformation investigations.

A graph theory model using human nature structure

A graph theory model of the human nature structure( GMH) for machine vision and image/graphics processing is described in this paper. Independent from the motion and deformation of contours,the human nature structure( HNS) embodies the most basic movement characteristics of the body. The human body can be divided into basic units like head,torso,and limbs. Using these basic units,a graph theory model for the HNS can be constructed. GMH provides a basic model for human posture processing,and the outline in the perspective projection plane is the body contour of an image. In addition,the GMH can be applied to articulated motion and deformable objects,e. g.,in the design and analysis of body posture,by modifying mapping parameters of the GMH.

A Comparison of the Views of Heavenly Principles and Human Desire and the Theory of Personality Structure

This paper makes a comparative study of the theory of heavenly principles and human desires in the Neo-Confucianism of the Song and Ming Dynasties and the theory of personality structure in psychoanalytic theory.From the perspective of the construction of the subject,in the debate between the heavenly principle and the human desire,the person is built into the moral subject.The id,ego,and super-ego in the psychoanalytic theory constitute the unconscious structural subject.In the framework of these two theories,the“maintain the heavenly principles and eradicate human desires”and“the heavenly principles exist in desire”in the theory of heavenly principles and human desires express the unity of opposites between heavenly principles and human desire.The core of personality structure theory is the relationship of obedience and control among the id,ego,and super-ego.As far as the value orientation is concerned,the debate between the heavenly principle and the human desire provides a theoretical basis for the moral practice of Confucianism of“aim at absolute perfection”,while the free will of the id in the unconscious subject is the most essential ethical aspect of psychoanalysis.

A STUDY OF THE STRUCTURE AND THE EXPRESSION OF PROTOONCOGENES IN HUMAN PRIMARY GASTRIC CANCER

The allelic distribution of EcoRI and BamHI fragments of ras family genes between the human primary gastric cancer tissues and the corresponding adjacent normal tissues did not show any differences. Three genotypes of BamHI restriction fragments length polymorphism of c-H-ras were revealed. No significant differences in the RFLPs were observed between normal individuals and gastric cancer patients. Four protooncogenes, c-H-ras, N-ras, c-myc and c-fos, were found to be transcriptionally active in the gastric cancer tissues in some cases examined. The comparison of the expression of these oncogenes between the malignant tissues and the corresponding normal tissues showed differential patterns. The expression of c-H-ras at cellular level was detected with in situ hybridization. The enhanced expression of c-H-ras in the gastric cancer cells was demonstrated, but the degree of the expession among the cancer cells was shown to be heterogeneous. In addition, the enhanced expression of c-H-ras was seen in the inflammatory cells.

A Study on the Impact of China’s Demographic Structure on Human Capital Accumulation-Based on a Panel Data Model

With the development of the times,the role of human capital in economic growth has been highlighted.However,in the current academic world,the research on the topic of demographic structure and human capital accumulation is not closely integrated.China is now in a period of economic transformation and upgrading,and it is urgent to change the traditional economic growth model,increase human capital investment,and cultivate new growth momentum.Therefore,this paper examines the impact of China’s population structure on human capital accumulation by constructing a mathematical model based on relevant panel data of 31 provinces(municipalities and autonomous regions)from 2001 to 2020.The empirical results show that human capital accumulation in China has a certain lagging effect,while population age and urban-rural structure enhance human capital accumulation in both quantitative and qualitative terms,respectively.In addition,industrial transformation,economic growth level,and per capita income all have significant positive effects.The effect of education,on the other hand,is not significant,while the interaction between urbanization and industrial structure may hurt it.Based on this,this paper proposes targeted countermeasures and suggestions in terms of fully developing the population quality dividend,fully tapping the talent knowledge dividend,continuously improving the health dividend,and continually tapping the aging dividend.

The Positive Research of Human Capital Structure and the Disparity Problem of Area in Our Country

The factors that influence the economic growth are various and complicated.This paper has especially probed into calculating and impact on regional economic growth of the human capital structure. First, on the basis of considering human capital quality, we use Gini coefficient law to calculate human capital structure coefficient of our country＇s each province （municipal or district）; Second, according to the result of calculating of human capital structure coefficient, considering input of material capital, average education level and so on at the same time, we set up regional economic growth model and use the panel data to examine the model. The result indicates the human capital structure coefficient of each province （municipal or district）in inverse proportion to economic growth （- 0. 108）. The last is the conclusion of this text.

The Practical Basis and Theoretical Innovation of Human Rights in Contemporary China——Theory of Human Rights Structure Moving towards Developmentalism

The practice of human rights in contemporary China puts forward an urgent demand for the innovation in human rights theories.On the basis of summarizing the practice of human rights in contemporary China,the developmental theory of human rights holds that human rights are the value consensus and social norms fostered by the common crisis faced by all human beings under the background of globalization of market economy.The free,comprehensive and harmonious development of all people is the ultimate goal of human rights.Taking the right to human development"as a purposive right can provide more enlightening explanations for the relational structure of human rights.

The Tension Balance Structure of China's Human Rights Development Path

The human rights white paper has in it the basic concepts of human rights,the form of the human rights system,and the mode of human rights practice in modern China.It is based on the tension balance structure between the historical feature and rationality,the cultural feature and similarity,the realistic feature and the common feature of human rights.Adhering to the historical nature of human rights rather than abstract rationality,and the cultural diversity and equality of human rights rather than one dominant model,and the particularity of human rights rather than universality is the pillar of China’s human rights philosophy,system,and practice.The human rights development path that combines the top-down leadership of China’s ruling party,the capability of the Chinese government in taking a holistic approach and the bottom-up driving force of the people is very different from the natural evolution path of the West.

Chalcone derivatives as novel,potent and selective inhibitors against human Notum:Structure–activity relationships and biological evaluations

Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal cancer.Herein,two series of chalcone derivatives were designed and synthesized aiming to find selective and potent hNotum inhibitors.Structure–activity relationship(SAR)studies showed that 2-methoxyl and 5-bromine substitutions on A-ring significantly enhanced anti-hNotum effect,while 4’-ethoxyl and 3’-alkyl substitutions on B-ring were beneficial for hNotum inhibition.Among all tested chalcones,B11 displayed the most potent anti-Notum effect(IC_(50)=3.6 nmol/L),good selectivity,excellent chemical stability and suitable metabolic stability.Further investigations showed that B11 acted as a competitive inhibitor of hNotum,while this agent(5μmol/L)significantly weaken the migration abilities of colorectal cancer cells.Collectively,this study deciphers the SARs of chalcones as hNotum inhibitors and reports a novel and potent hNotum inhibitor with the anti-migration effect on colorectal cancer cells,which offers a promising lead compound to develop novel anti-cancer agents.