Background Cardiovascular disease(CVD)is a common cause of death in China.There have been many evidences that inflammatory factors and acute phase reactants play an important role in the pathogenesis of coronary heart...Background Cardiovascular disease(CVD)is a common cause of death in China.There have been many evidences that inflammatory factors and acute phase reactants play an important role in the pathogenesis of coronary heart disease and acute coronary syndromes,and their related factors may become indicators for predicting and diagnosing early cardiovascular disease.Recent evidence has shown that human cartilage glycoprotein 39(YKL-40)is related to metabolic disorders caused by inflammatory diseases and heart diseases.YKL-40 is a new type of inflammation marker.Studies have shown that YKL-40 can further aggravate vascular damage and can be used as a biomarker for assessing the severity of cardiovascular disease and judging the prognosis.This article reviewed the biological characteristics of YKL-40 and its relationship with cardiovascular diseases.[S Chin J Cardiol 2021;22(1):57-64]展开更多
Objective:To study the relationship of serum human epididymis protein (HE4), cancer protein-2 (CP2) and human cartilage glycoprotein-39 (HCgp-39) levels with tumor malignancy in patients with endometrial carcinoma.Met...Objective:To study the relationship of serum human epididymis protein (HE4), cancer protein-2 (CP2) and human cartilage glycoprotein-39 (HCgp-39) levels with tumor malignancy in patients with endometrial carcinoma.Methods:A total of 90 patients with endometrial carcinoma treated in our hospital between May 2012 and August 2015 were collected and divided into early-to-mid (Ⅰ-Ⅲ stage) endometrial carcinoma group (n=59) and advanced (Ⅳ stage) endometrial carcinoma group (n=31) according to the pathological staging, and 34 patients with endometrial thickening who received uterine curettage in our hospital during the same period were selected as control group. The levels of HE4, CP2, HCgp-39 and tumor markers in serum as well as the mRNA expression of proliferation genes and invasion genes in tumor tissue were determined.Results:HE4, CP2, HCgp-39, CA125, CA19-9 and CEA levels in serum as well as Bcl2, Chk1, PIK1, HER2 and GDF-15 mRNA expression in tumor tissues of early-to-mid endometrial carcinoma group and advanced endometrial carcinoma group were significantly higher than those of control group while the miRNA-199a-3p, Bax, caspase3, BRCA1, Kiss-1 and KAI1 mRNA expression were lower than those of control group;HE4, CP2, HCgp-39, CA125, CA19-9 and CEA levels in serum as well as Bcl2, Chk1, PIK1, HER2 and GDF-15 mRNA expression in tumor tissues of advanced endometrial carcinoma group were significantly higher than those of early-to-mid endometrial carcinoma group while the miRNA-199a-3p, Bax, caspase3, BRCA1, Kiss-1 and KAI1 mRNA expression were lower than those of early-to-mid endometrial carcinoma group;serum HE4, CP2 and HCgp-39 levels were positively correlated with CA125, CA19-9, CEA, Bcl2, Chk1, PIK1, HER2 and GDF-15, and negatively correlated with miRNA-199a-3p, Bax, caspase3, BRCA1, Kiss-1 and KAI1. Conclusion:Serum HE4, CP2 and HCgp-39 levels can directly reflect the tumor malignancy in patients with endometrial carcinoma, and are expected to become the reliable means for tumor screening and treatment guidelines.展开更多
【目的】观察加味温胆汤联合耳穴压豆治疗痰湿壅盛型高血压患者的临床疗效。【方法】将116例痰湿壅盛型高血压患者随机分为观察组和对照组,每组各58例,2组患者均给予常规检查与健康宣教,对照组给予硝苯地平控释片口服治疗,观察组在对照...【目的】观察加味温胆汤联合耳穴压豆治疗痰湿壅盛型高血压患者的临床疗效。【方法】将116例痰湿壅盛型高血压患者随机分为观察组和对照组,每组各58例,2组患者均给予常规检查与健康宣教,对照组给予硝苯地平控释片口服治疗,观察组在对照组治疗的基础上给予口服加味温胆汤联合耳穴压豆治疗。2组均连续治疗6周。治疗6周后,评价2组临床疗效,观察2组患者治疗前后血清人软骨糖蛋白-39(YKL-40)与人纤维胶凝蛋白3(ficolin-3)表达的变化情况,以及中医证候积分的变化情况。比较2组患者治疗前后动态血压及血压变异性的变化情况,包括24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、24 h平均舒张压变异性(24 h DBPV)和24 h平均收缩压变异性(24 h SBPV)。并评价2组的安全性及并发症的发生情况。【结果】(1)治疗后,2组患者的血清YKL-40、ficolin-3水平均明显改善(P<0.05),且观察组在改善血清YKL-40、ficolin-3水平方面均明显优于对照组,差异均有统计学意义(P<0.05)。(2)治疗后,2组患者的中医证候积分均明显改善(P<0.05),且观察组在改善中医证候积分方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的24 h SBP、24 h DBP、24 h DBPV与24 h SBPV均明显改善(P<0.05),且观察组在改善24 h SBP、24 h DBP、24 h DBPV与24 h SBPV方面均明显优于对照组,差异均有统计学意义(P<0.05)。(4)观察组总有效率为94.83%(55/58),对照组为82.76%(48/58)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(5)观察组并发症总发生率为8.62%(5/58),对照组为6.90%(4/58)。观察组并发症总发生率稍高于对照组,但差异无统计学意义(P>0.05)。【结论】加味温胆汤联合耳穴压豆治疗痰湿壅盛型高血压,能够明显地改善患者血压变异性,降低血清YKL-40、ficolin-3水平,改善患者的临床症状,临床疗效显著。展开更多
基金supported by Science and Technology Key Research Project in Jining(No.2018SMNS006)Teaching Case Library Project of 2018 Professional Degree Graduate Student in Shandong Province(No.SDYAL18100)
文摘Background Cardiovascular disease(CVD)is a common cause of death in China.There have been many evidences that inflammatory factors and acute phase reactants play an important role in the pathogenesis of coronary heart disease and acute coronary syndromes,and their related factors may become indicators for predicting and diagnosing early cardiovascular disease.Recent evidence has shown that human cartilage glycoprotein 39(YKL-40)is related to metabolic disorders caused by inflammatory diseases and heart diseases.YKL-40 is a new type of inflammation marker.Studies have shown that YKL-40 can further aggravate vascular damage and can be used as a biomarker for assessing the severity of cardiovascular disease and judging the prognosis.This article reviewed the biological characteristics of YKL-40 and its relationship with cardiovascular diseases.[S Chin J Cardiol 2021;22(1):57-64]
文摘Objective:To study the relationship of serum human epididymis protein (HE4), cancer protein-2 (CP2) and human cartilage glycoprotein-39 (HCgp-39) levels with tumor malignancy in patients with endometrial carcinoma.Methods:A total of 90 patients with endometrial carcinoma treated in our hospital between May 2012 and August 2015 were collected and divided into early-to-mid (Ⅰ-Ⅲ stage) endometrial carcinoma group (n=59) and advanced (Ⅳ stage) endometrial carcinoma group (n=31) according to the pathological staging, and 34 patients with endometrial thickening who received uterine curettage in our hospital during the same period were selected as control group. The levels of HE4, CP2, HCgp-39 and tumor markers in serum as well as the mRNA expression of proliferation genes and invasion genes in tumor tissue were determined.Results:HE4, CP2, HCgp-39, CA125, CA19-9 and CEA levels in serum as well as Bcl2, Chk1, PIK1, HER2 and GDF-15 mRNA expression in tumor tissues of early-to-mid endometrial carcinoma group and advanced endometrial carcinoma group were significantly higher than those of control group while the miRNA-199a-3p, Bax, caspase3, BRCA1, Kiss-1 and KAI1 mRNA expression were lower than those of control group;HE4, CP2, HCgp-39, CA125, CA19-9 and CEA levels in serum as well as Bcl2, Chk1, PIK1, HER2 and GDF-15 mRNA expression in tumor tissues of advanced endometrial carcinoma group were significantly higher than those of early-to-mid endometrial carcinoma group while the miRNA-199a-3p, Bax, caspase3, BRCA1, Kiss-1 and KAI1 mRNA expression were lower than those of early-to-mid endometrial carcinoma group;serum HE4, CP2 and HCgp-39 levels were positively correlated with CA125, CA19-9, CEA, Bcl2, Chk1, PIK1, HER2 and GDF-15, and negatively correlated with miRNA-199a-3p, Bax, caspase3, BRCA1, Kiss-1 and KAI1. Conclusion:Serum HE4, CP2 and HCgp-39 levels can directly reflect the tumor malignancy in patients with endometrial carcinoma, and are expected to become the reliable means for tumor screening and treatment guidelines.
文摘【目的】观察加味温胆汤联合耳穴压豆治疗痰湿壅盛型高血压患者的临床疗效。【方法】将116例痰湿壅盛型高血压患者随机分为观察组和对照组,每组各58例,2组患者均给予常规检查与健康宣教,对照组给予硝苯地平控释片口服治疗,观察组在对照组治疗的基础上给予口服加味温胆汤联合耳穴压豆治疗。2组均连续治疗6周。治疗6周后,评价2组临床疗效,观察2组患者治疗前后血清人软骨糖蛋白-39(YKL-40)与人纤维胶凝蛋白3(ficolin-3)表达的变化情况,以及中医证候积分的变化情况。比较2组患者治疗前后动态血压及血压变异性的变化情况,包括24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、24 h平均舒张压变异性(24 h DBPV)和24 h平均收缩压变异性(24 h SBPV)。并评价2组的安全性及并发症的发生情况。【结果】(1)治疗后,2组患者的血清YKL-40、ficolin-3水平均明显改善(P<0.05),且观察组在改善血清YKL-40、ficolin-3水平方面均明显优于对照组,差异均有统计学意义(P<0.05)。(2)治疗后,2组患者的中医证候积分均明显改善(P<0.05),且观察组在改善中医证候积分方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的24 h SBP、24 h DBP、24 h DBPV与24 h SBPV均明显改善(P<0.05),且观察组在改善24 h SBP、24 h DBP、24 h DBPV与24 h SBPV方面均明显优于对照组,差异均有统计学意义(P<0.05)。(4)观察组总有效率为94.83%(55/58),对照组为82.76%(48/58)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(5)观察组并发症总发生率为8.62%(5/58),对照组为6.90%(4/58)。观察组并发症总发生率稍高于对照组,但差异无统计学意义(P>0.05)。【结论】加味温胆汤联合耳穴压豆治疗痰湿壅盛型高血压,能够明显地改善患者血压变异性,降低血清YKL-40、ficolin-3水平,改善患者的临床症状,临床疗效显著。
