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Time-optimal control of multiple unmanned aerial vehicles with human control input
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作者 Tao Han Bo Xiao +2 位作者 Xi-Sheng Zhan Jie Wu Hongling Gao 《International Journal of Intelligent Computing and Cybernetics》 EI 2019年第1期138-152,共15页
Purpose–The purpose of this paper is to investigate time-optimal control problems for multiple unmanned aerial vehicle(UAV)systems to achieve predefined flying shape.Design/methodology/approach–Two time-optimal prot... Purpose–The purpose of this paper is to investigate time-optimal control problems for multiple unmanned aerial vehicle(UAV)systems to achieve predefined flying shape.Design/methodology/approach–Two time-optimal protocols are proposed for the situations with or without human control input,respectively.Then,Pontryagin’s minimum principle approach is applied to deal with the time-optimal control problems for UAV systems,where the cost function,the initial and terminal conditions are given in advance.Moreover,necessary conditions are derived to ensure that the given performance index is optimal.Findings–The effectiveness of the obtained time-optimal control protocols is verified by two contrastive numerical simulation examples.Consequently,the proposed protocolscan successfully achieve the prescribed flying shape.Originality/value–This paper proposes a solution to solve the time-optimal control problems for multiple UAV systems to achieve predefined flying shape. 展开更多
关键词 Unmanned aerial vehicle human control input Time-optimal control Pontryagin’s minimum principle
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HUMAN-SIMULATING VEHICLE STEERING CONTROL ALGORITHM 被引量:1
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作者 XU Youchun LI Keqiang +1 位作者 CHANG Ming CHEN Jun 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2006年第2期233-236,共4页
A new vehicle steering control algorithm is presented. Unlike the traditional methods do, the algorithm uses a sigmoid function to describe the principle of the human driver's steering strategy. Based on this functio... A new vehicle steering control algorithm is presented. Unlike the traditional methods do, the algorithm uses a sigmoid function to describe the principle of the human driver's steering strategy. Based on this function, a human simulating vehicle steering model, human-simulating steering control(HS) algorithm is designed. In order to improve the adaptability to different environments, a parameter adaptive adjustment algorithm is presented. This algorithm can online modify the value of the key parameters of the HS real time. HS controller is used on a vehicle equipped with computer vision system and computer controlled steering actuator system, the result from the automatic vehicle steering experiment shows that the HS algorithm gives good performance at different speed, even at the maximum speed of 172 km/h. 展开更多
关键词 human-simulating control Sigmoid function Steering algorithm
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Human Interaction Dynamics for Its Use in Mobile Robotics:Impedance Control for Leader-follower Formation 被引量:9
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作者 Daniel Herrera Flavio Roberti +1 位作者 Marcos Toibero Ricardo Carelli 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2017年第4期696-703,共8页
A complete characterization of the behavior in human-robot interactions(HRI) includes both: the behavioral dynamics and the control laws that characterize how the behavior is regulated with the perception data. In thi... A complete characterization of the behavior in human-robot interactions(HRI) includes both: the behavioral dynamics and the control laws that characterize how the behavior is regulated with the perception data. In this way, this work proposes a leader-follower coordinate control based on an impedance control that allows to establish a dynamic relation between social forces and motion error. For this, a scheme is presented to identify the impedance based on fictitious social forces, which are described by distance-based potential fields.As part of the validation procedure, we present an experimental comparison to select the better of two different fictitious force structures. The criteria are determined by two qualities: least impedance errors during the validation procedure and least parameter variance during the recursive estimation procedure.Finally, with the best fictitious force and its identified impedance,an impedance control is designed for a mobile robot Pioneer 3AT,which is programmed to follow a human in a structured scenario.According to results, and under the hypothesis that moving like humans will be acceptable by humans, it is believed that the proposed control improves the social acceptance of the robot for this kind of interaction. 展开更多
关键词 human modeling human-machine interaction impedance control robot dynamics social robotics
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Investigations on serviceability control of long-span structures under human-induced excitation 被引量:3
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作者 Chen Xin Ding Youliang +2 位作者 Li Ai-qun Zhang Zhiqiang Sun Peng 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2012年第1期57-71,共15页
The increasing strength of new structural materials and the span of new structures, accompanied by aesthetic requirements for greater slenderness, are resulting in more applications of long-span structures. In this pa... The increasing strength of new structural materials and the span of new structures, accompanied by aesthetic requirements for greater slenderness, are resulting in more applications of long-span structures. In this paper, serviceability control technology and its design theory are studied. First, a novel tuned mass damper (TMD) with controllable stiffness is developed. Second, methods for modeling human-induced loads are proposed, including standing up, walking, jumping and running, and an analysis method for long-span floor response is proposed based on a finite element model. Third, a design method for long-span floors installed with a multiple TMD (MTMD) system considering human comfort is introduced, largely based on a study of existing literature. Finally, a design, analysis and field test is conducted using several large scale buildings in China including the Beijing Olympic Park National Conference Center, Changsha New Railway Station and the Xi'an Northern Railway Station. The analytical and field test results show that the MTMD system designed using the proposed method is capable of effectively mitigating the vertical vibration of long-span floor structures. The study presented in this paper provides an important reference for the analysis of vibration serviceability of similar long-span floors and design of control system for these structures. 展开更多
关键词 long-span floor vibration control TMD human-inducing loads vibration serviceability
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Fuzzy Simulation Human Intelligent Control System Design on Gyratory Breaker
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作者 Wen,Ruchun Zhao,Shuling Zhu,Jianwu Wang,Xiaoyan 《微计算机信息》 北大核心 2005年第1期11-12,共2页
In order to deal with the complex process that incurs serious time delay, enormous inertia and nonlinear problems, fuzzy simulation human intelligent control algorithm rules are established. The fuzzy simulation human... In order to deal with the complex process that incurs serious time delay, enormous inertia and nonlinear problems, fuzzy simulation human intelligent control algorithm rules are established. The fuzzy simulation human intelligent controller and the hardware with the single-chip microcomputer are designed and the anti-interference measures to the whole system are provided. 展开更多
关键词 模糊控制 人工智能模拟控制 旋转断路器 单芯片微计算机
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Human Resource Controlling and Human Resource Management: Practice of Small and Medium-Sized Building Companies in the Czech Republic
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作者 Filip Busina Martin Sikyr 《Journal of Modern Accounting and Auditing》 2014年第9期983-990,共8页
关键词 人力资源管理 捷克共和国 建筑公司 资源控制 中型 调查结果 管理工具 问卷调查
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Human-inspired lighting control in robot systems with the intention of glare avoidance
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作者 Chen Shengyong Guan Qiu +1 位作者 Liu Sheng Bi Dexue 《Engineering Sciences》 EI 2011年第4期16-22,共7页
This paper presents some human-inspired strategies for lighting control in a robot system for best scene interpretation,where the main intention is to avoid possible glares or highlights occurring in images. It firstl... This paper presents some human-inspired strategies for lighting control in a robot system for best scene interpretation,where the main intention is to avoid possible glares or highlights occurring in images. It firstly compares the characteristics of human eyes and robot eyes. Then some evaluation criteria are addressed to assess the lighting conditions. A bio-inspired method is adopted to avoid the visual glare which is caused by either direct illumination from large light sources or indirect illumination reflected by smooth surfaces. Appropriate methods are proposed to optimize the pose and optical parameters of the light source and the vision camera. 展开更多
关键词 机器人系统 照明条件 灯光控制 灵感 意图 眩光 人类 评价标准
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Theoretical and practical exploration of vision building in human influenza pandemic prevention & control
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作者 Peng Kong Yan Kong +1 位作者 Xu Jiang Xiaohua Wang 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2010年第11期913-916,共4页
This article introduced the vision building concept about human influenza pandemic prevention and control.Different visions were built by creating different shapes of building blocks which also represented different o... This article introduced the vision building concept about human influenza pandemic prevention and control.Different visions were built by creating different shapes of building blocks which also represented different organizations and physical facilities,respectively.The around-view reflection is required to be developed in the process of building so as to search for the ideal pattern.The correlation of all sectors and systems are established to combine different kinds of things,from one family to another,from communities,towns,counties,cities,rural areas, provinces to the state to handle trivial problems.These training objectives have been successfully accomplished,which has not only enriched the knowledge about prevention and control of influenza pandemic between different departments but also clarified the roles and responsibility. It lays the firm foundation for next cooperation between different departments,and make a bridge for the objective and choice of channel over human influenza pandemic prevention and control. 展开更多
关键词 VISION BUILDING human INFLUENZA PANDEMIC PREVENTION and control
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Urban flood control strategy based on new relationship of human and flood 被引量:1
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作者 WAN Yan-hua LUO Dan GUO Yong 《Ecological Economy》 2010年第2期187-194,共8页
China is one of the countries with the most serious flooding disasters.In China,above 70% of big cities,50% of population and 75% of industrial and agricultural output value are distributed in eastern coastal areas wi... China is one of the countries with the most serious flooding disasters.In China,above 70% of big cities,50% of population and 75% of industrial and agricultural output value are distributed in eastern coastal areas with serious flooding.Therefore,enhancement of theoretical study and experience summarization of urban flood control is of great theoretical and practical significance.As economy is developing rapidly,urban scale is expanding fast,and urban flood control stand is promoted.Urban flood control calls for new concept and methods.This paper makes a systematic summarization of concept evolution and advanced methods concerning urban flood control at home and abroad.The concept of urban flood control has transformed from simple flood control and drainage to coexistence with and use of flood.Flood control measures have transferred form emphasis upon engineering ones to priority to both engineering and non-engineering ones,with special attention to ecological flood control,such as making full use of ecological revetment,ecological realignment of a river,multi-objective management of urban flood detention region,turning flood into resources and utilization of wetlands. 展开更多
关键词 防洪策略 大城市 城市防洪 洪水 人力 基础 东部沿海地区 生态防洪
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A DNA-binding protein factor in K562 nuclear extract interacts with positive control region (PCR) in the 5'flanking sequence of human β-globin gene
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作者 HU YULONG,YADI CHEN,TONG SUN,RUOLANQIANShanghai Institute of Cell Biology,Academia Sinica,Shanghai 200031,China. 《Cell Research》 SCIE CAS CSCD 1993年第1期102-102,104-111,共9页
It has been known that there are at least three regulatory regions (NCR1. NCR2 and PCR) in the 5'-flanking sequence (from -610 bp to +1 bp) of human β-glohin geneand that the function of PCR is unique to the huma... It has been known that there are at least three regulatory regions (NCR1. NCR2 and PCR) in the 5'-flanking sequence (from -610 bp to +1 bp) of human β-glohin geneand that the function of PCR is unique to the human erythroleukemia (Ksfi2) ceils. Here we have detected a DNA-binding protein factor (termed NFEa) in K562 ceils. which can bind specifically to the PCR of human β-globin gene. The sequence of the binding site is 5'ACTGATG3' (between -222 bp and -216 bp). The NFEa is erythroidspecific and perhaps specific for K562 cells. It seemed that this factor differed from the erythroid-specific transcriptional factor (NFE-1) ,nsing competition assay. The presence of the NFEa further supported that the funciton of the cis-acting element PCR was specitic for K562 cells. and helps us to understand the mechauism of the regulation of the expression of lmman β-globin gene in the human K562 cells. 展开更多
关键词 K562 PCR DNA NCR
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基于模糊控制的上肢康复机器人变导纳控制 被引量:1
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作者 高建设 刘陆骐 +4 位作者 王杰 李雪晓 丁顺良 高亦阳 王轩 《郑州大学学报(工学版)》 北大核心 2024年第1期12-20,共9页
传统固定参数的导纳模型无法对上肢康复机器人的柔顺性实时调节,而现有变参数导纳模型需要结合实际康复需求进行改善。为此,以自主研发的串并混联的末端牵引式上肢康复机器人为研究对象,结合模糊控制与导纳控制,提出了一种面向实际康复... 传统固定参数的导纳模型无法对上肢康复机器人的柔顺性实时调节,而现有变参数导纳模型需要结合实际康复需求进行改善。为此,以自主研发的串并混联的末端牵引式上肢康复机器人为研究对象,结合模糊控制与导纳控制,提出了一种面向实际康复需求的新型变导纳控制策略,制定了4条有利于康复效率与安全的模糊规则。该策略利用交互力误差及其变化率作为模糊控制输入,实时改变导纳模型的参数,实现柔顺性自主调节。仿真和实验结果验证了所提出的变导纳模型控制策略可行性和所制定的4条模糊规则的有效性。在患者可适应训练强度的场景中,相较于固定导纳模型,变导纳模型追踪给定路径时产生的冗余路径最多可降低56.13%,提高了康复训练效率;当康复运动超出患者可承受范围时,变导纳模型可提前0.5 s改变追踪路径,提高了康复的安全性。 展开更多
关键词 导纳控制 模糊控制 人机交互力 上肢康复机器人 康复训练
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Matlab Based Human & Hardware-in-Loop Simulation for the Study on Vehicle Stability Control 被引量:1
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作者 张勇 殷承良 张建武 《Journal of Shanghai Jiaotong university(Science)》 EI 2006年第4期498-505,共8页
This paper described an effective method to implement human & hardware in the loop simulation(HHILS), which is based on MATLAB system and can be used to study human driving actions in the abrupt situation and vehi... This paper described an effective method to implement human & hardware in the loop simulation(HHILS), which is based on MATLAB system and can be used to study human driving actions in the abrupt situation and vehicle stability control(VSC). A hybrid control algorithm, which makes full use of the advantages of robust control and fuzzy logic, was adopted in VSC system. The results of HHILS show that HHILS’ application on the vehicle handling and VSC resarch is feasible. These results also confirm that the handling performance of the vehicle with VSC is improved obviously compared to the vehicle without VSC. 展开更多
关键词 human & HARDWARE-IN-LOOP simulation vehicle stability control robust-fuzzy control MATLAB XPC target virtual REALITY
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考虑人机信任匹配的人机协同控制策略
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作者 孙剑 阳友康 +3 位作者 岳李圣飒 韩嘉懿 王子衿 尹恒 《同济大学学报(自然科学版)》 EI CAS CSCD 北大核心 2024年第6期838-845,855,F0002,共10页
人机互信水平是影响人机协同系统表现的关键因素之一。提出了一种考虑人机信任匹配的主从博弈协同控制策略。建立评估驾驶人和机器相互信任程度的方法,在此基础上根据人机信任匹配程度进行协同驾驶中的权重分配;采用模型预测控制框架并... 人机互信水平是影响人机协同系统表现的关键因素之一。提出了一种考虑人机信任匹配的主从博弈协同控制策略。建立评估驾驶人和机器相互信任程度的方法,在此基础上根据人机信任匹配程度进行协同驾驶中的权重分配;采用模型预测控制框架并结合主从博弈进行最优化求解,得出最优的协同控制策略;通过驾驶人在环实验,验证了所提出的协同控制策略的有效性。结果表明,对于不同信任匹配程度的驾驶人,所提出的策略使得驾驶人路径跟踪精度平均提高了70.91%,驾驶负担平均降低了44.03%。所提出的策略能提升车辆的驾驶表现,减轻驾驶人操作负担。 展开更多
关键词 人机协同控制 人机信任匹配 权重分配 主从博弈
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Human Resource Management:A Case Study of the Air Traffic Controller Strike in 1981
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作者 GAI Ke-ke PAN Jing 《中国管理信息化》 2009年第15期61-65,共5页
The article discusses several hemispheres of human resource management based on a typical case review. The study presents the main problems of the case from both employees and organizations; the issued problems involv... The article discusses several hemispheres of human resource management based on a typical case review. The study presents the main problems of the case from both employees and organizations; the issued problems involve compensations and benefits,restructuring,job design,and training. Based on the analysis of the case,two alternative solutions state that the potential routes for the organizations to avoid serious negative results. The study introduces a number of recommendations that can be used as a reference for other organizations to avoid similar risks. 展开更多
关键词 人力资源管理 信息化建设 流量控制 风险
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基于扇区开合的管制员排班优化
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作者 王莉莉 马也 《科学技术与工程》 北大核心 2024年第4期1707-1714,共8页
为提高管制员的利用效率和工作满意度,制定出更切合实际运行的管制员排班表,从管制工作的实际需要出发,以人员需求数量最少为目标,在符合民航局各种规章要求的基础上,建立管制员排班模型。在初始模型的基础上,又考虑了人员对工作及休息... 为提高管制员的利用效率和工作满意度,制定出更切合实际运行的管制员排班表,从管制工作的实际需要出发,以人员需求数量最少为目标,在符合民航局各种规章要求的基础上,建立管制员排班模型。在初始模型的基础上,又考虑了人员对工作及休息时间的个性化需求,对模型进行改进。最后以某空中交通管理局区域管制室管制员数据为例进行分析,使用LINGO求解器对模型进行求解。结果表明:与手工编制的排班时间表相比,通过排班优化模型制定出的排班方案减少了执勤人数,避免了人员浪费,并能较为充分地满足管制员的个性化需求。 展开更多
关键词 管制员 排班 人力资源管理 优化模型
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基于逆模型预测控制的拟人驾驶控制
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作者 刘辉 张发旺 +3 位作者 聂士达 段京良 郭丛帅 郭凌雄 《汽车工程》 EI CSCD 北大核心 2024年第4期596-604,共9页
本文提出一种基于逆模型预测控制的拟人驾驶控制方法,利用模型预测控制产生的实轴轨迹与真实轨迹的损失函数更新控制模块代价函数的权重系数实现拟人化驾驶控制。将拟人驾驶控制构建成一个双层优化问题,在下层利用模型预测控制求解一个... 本文提出一种基于逆模型预测控制的拟人驾驶控制方法,利用模型预测控制产生的实轴轨迹与真实轨迹的损失函数更新控制模块代价函数的权重系数实现拟人化驾驶控制。将拟人驾驶控制构建成一个双层优化问题,在下层利用模型预测控制求解一个典型的最优控制问题产生实轴驾驶轨迹,在上层最小化所产生的实轴轨迹和真实驾驶轨迹的误差更新下层代价函数的权重系数,基于极大值微分原理构造辅助系统求解实轴轨迹关于代价函数权重系数的梯度。实车采集真实驾驶轨迹并进行模仿测试与泛化验证,结果表明:本文所提出的方法相比于两类基于虚轴轨迹的逆最优控制方法,在3个工况下与真实驾驶轨迹最大误差分别平均降低了73.52%和65.03%,驾驶行为更加拟人化,且具备泛化性能。 展开更多
关键词 自动驾驶 拟人化驾驶 逆最优控制
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企业数字化转型的劳动收入分配效应研究
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作者 刘佳 秦芳 《首都经济贸易大学学报》 北大核心 2024年第4期99-112,共14页
在数字经济和双循环新发展格局大背景下,基于企业数字化转型视角探究收入分配问题具有重要的意义。借助2007—2021年A股上市公司数据实证检验企业数字化转型对劳动收入份额的影响效应,研究结果表明:第一,企业数字化转型有助于提升劳动... 在数字经济和双循环新发展格局大背景下,基于企业数字化转型视角探究收入分配问题具有重要的意义。借助2007—2021年A股上市公司数据实证检验企业数字化转型对劳动收入份额的影响效应,研究结果表明:第一,企业数字化转型有助于提升劳动收入份额,且该结论具有稳健性;第二,融资约束效应、人力资本结构效应及内部控制效应是企业数字化转型提升劳动收入份额的重要渠道;第三,企业数字化转型的劳动收入分配效应存在行业、所有制、科技属性方面的异质性,且对劳动密集型企业、非国有企业及高科技企业产生明显偏好;第四,企业数字化转型存在劳动收入份额提升与企业高质量发展的双重效应,实现了员工福利与企业发展的互利共赢。研究结论可以在微观层面上提供关于技术进步对劳动收入份额影响的证据,为新时期收入分配结构的优化提供了决策参考。 展开更多
关键词 企业数字化转型 劳动收入份额 融资约束 人力资本结构 内部控制
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农用地土壤重金属来源解析与健康风险空间分异特征研究——以重庆市巫山县笃坪乡为例
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作者 刘力 张传华 +3 位作者 王钟书 张凤太 邓炜 代杰 《西南农业学报》 CSCD 北大核心 2024年第5期1099-1107,共9页
【目的】探明长江上游地区农用地土壤重金属来源及生态风险状况,进行人体健康风险空间分析,有助于提出有效的土壤重金属污染防治建议。【方法】以重庆市巫山县笃坪乡为研究对象,采集表层土壤样品(深度0~20 cm)45件,基于主成分分析/绝对... 【目的】探明长江上游地区农用地土壤重金属来源及生态风险状况,进行人体健康风险空间分析,有助于提出有效的土壤重金属污染防治建议。【方法】以重庆市巫山县笃坪乡为研究对象,采集表层土壤样品(深度0~20 cm)45件,基于主成分分析/绝对主成分分数(PCA/APCS)受体模型进行土壤重金属(Cd、Hg、Pb、As和Cr)来源定量分析,通过人体健康风险评价模型进行人体健康风险评价,利用地统计法进行人体健康风险空间分析,得出不同区域的风险等级及影响因素,并针对性地提出风险管控建议。【结果】(1)研究区土壤Cd、Hg、Pb、As、Cr平均含量分别是重庆市土壤背景值的10.67、3.18、1.03、2.05、4.22倍,土壤重金属含量存在显著异常;(2)土壤综合环境质量优先保护类、安全利用类和严格管控类点位占比分别为2.23%、44.44%和53.33%,主要影响因子为Cd和Cr,土壤以酸性为主,对农产品质量安全及土壤生态环境的风险较高;(3)土壤Cd含量主要受到农业活动和成土母质的影响,贡献率分别为58.55%和30.30%,土壤Hg和Cr含量主要受到成土母质的影响,贡献率分别为71.55%和75.41%,土壤As含量主要受到农业活动的影响,贡献率为63.12%,土壤Pb含量主要受到道路交通的影响,贡献率为90.90%;(4)成人非致癌健康风险指数HI>1的点位占比为6.67%,总体健康风险较低,高风险区集中在研究区北部和中部地区,主要影响因子为Cr;农业活动与道路交通贡献率的高值区主要分布在研究区北部。【结论】建议研究区加强对农业投入品的监测,积极开展有机肥代替等化肥减量措施,推广使用电动农用车,减少由于农业活动对土壤重金属的输入。 展开更多
关键词 土壤重金属 地统计法 来源解析 人体健康风险评价 风险管控建议
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河北医科大学人脑组织库样本分析
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作者 杜鹃 米世雄 +8 位作者 靳玉川 杨倩 马敏 赵雪汝 刘风藏 赵长义 张展翅 樊平 崔慧先 《解剖学报》 CAS CSCD 2024年第4期437-444,共8页
目的通过分析河北医科大学人脑组织库样本基本情况,了解河北省人脑组织捐献现状,为后续科学研究提供基本数据支撑。方法对河北医科大学人脑组织库收集样本进行统计(2019年12月~2024年2月),分析性别、年龄、死亡原因等基本资料,以及死亡... 目的通过分析河北医科大学人脑组织库样本基本情况,了解河北省人脑组织捐献现状,为后续科学研究提供基本数据支撑。方法对河北医科大学人脑组织库收集样本进行统计(2019年12月~2024年2月),分析性别、年龄、死亡原因等基本资料,以及死亡后取材时间、脑脊液pH值、RNA完整性等质量控制信息和神经病理学诊断结果等内容。结果截止到2024年2月,河北医科大学人脑组织库共收集保存人脑样本30例,男女比例9∶1,其中80岁以上者占53%,死亡原因为心脑血管疾病36.67%与神经系统疾病23.33%占比较高。脑组织捐献者归属地在石家庄市内的占90%,市外的占10%。死亡后取材延误时间较短,12 h以内的占90%,大于12 h占10%。RNA完整性(RIN)值>6的脑样本占69.23%。脑脊液pH 5.8~7.5,平均值6.60±0.45。成年人脑重906~1496 g,平均值(1210.78±197.84)g。检出3种载脂蛋白E(APOE)亚型、5种APOE基因型(ε2/ε3、ε2/ε4、ε3/ε3、ε3/ε4、ε4/ε4)。涉及神经病理学诊断相关染色11种,均已建立起系统化染色流程并使用。神经病理学诊断为神经退行性疾病样本共计12例(包括阿尔茨海默病、帕金森病、多系统萎缩、皮质基底节变性和进行性核上性麻痹等),占比40%,80岁以上脑样本共病率达100%。结论河北医科大学脑库脑组织捐献者的资料总结与统计学分析,可以反映河北省人脑组织库建设与运行的现状,也可以更有针对性地了解并识别可能捐献的群体,为脑库的建设提供参考,为科学研究使用提供更为可靠的材料和数据支持。 展开更多
关键词 人脑组织库 人脑样本 基本资料 质量控制信息 神经病理学诊断 神经退行性疾病 共病
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重组人生长激素临床应用的安全性思考
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作者 潘慧 杜红伟 《中国当代儿科杂志》 CAS CSCD 北大核心 2024年第5期444-449,共6页
重组人生长激素(recombinant human growth hormone,rhGH)是改善身材矮小的有效治疗药物,目前rhGH可应用于包含生长激素缺乏症在内的多种原因导致的身材矮小,临床应用的扩展使其安全性问题备受关注。基于现有证据,当rhGH规范应用于生理... 重组人生长激素(recombinant human growth hormone,rhGH)是改善身材矮小的有效治疗药物,目前rhGH可应用于包含生长激素缺乏症在内的多种原因导致的身材矮小,临床应用的扩展使其安全性问题备受关注。基于现有证据,当rhGH规范应用于生理性替代治疗时,其安全性较好。临床中,应用rhGH进行治疗期间可结合文献证据和临床经验重点关注短期安全性,长期安全性由于rhGH治疗时间不足尚无准确定论。该文梳理了在rhGH治疗过程中有可能出现的不良事件及其风险控制措施,旨在帮助临床医生了解rhGH治疗的整体安全性,改善临床规范化应用。 展开更多
关键词 重组人生长激素 临床安全性 不良事件 风险控制
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