Renin and angiotensinogen expression and functions in growth and apoptosis of human glioblastoma

The expression and function in growth and apoptosis of the renin-angiotensin system(RAS)was evaluated inhuman glioblastoma.Renin and angiotensinogen(AGT)mRNAs and proteins were found by in situ hybridisationand immunohistochemistry in glioblastoma cells.Angiotensinogen was present in glioblastoma cystic fluids.Thus,human glioblastoma cells produce renin and AGT and secrete AGT.Human glioblastoma and glioblastoma cellsexpressed renin,AGT,renin receptor,AT(2)and/or AT(1)mRNAs and proteins determined by RT-PCR and/

On the Human Rights Function of the Olympic Movement

The Olympic Movement is an essential contemporary international social movement with a unique ability to transform and promote the human rights.This human rights function of the Olympic Movement is mainly reflected in two aspects:First,the Olympic Movement accelerates the dissemination of the basic concepts and values of human rights and helps build a broader consensus in a wider field;second,the Olympic Movement expands and enriches the rights system of human rights.It has greatly contributed to realizing individual human rights and collective human rights both inside and outside the Olympic field.The human rights function of the Olympics needs be correctly understood and rationally utilized to maximize its effectiveness in promoting the development of and guaranteeing the realization of human rights.

A Rescuer in the Nucleus:Sno-lncRNA SLERT Found Crucial for Nucleolus Function in Humans

In our conversation with Prof.CHEN Lingling on the"dark mat ter"in the genome,namely the non-coding RNAs,we got to know two classes of long non-coding RNAs(lncRNAs)in close association with Prader-Willi syndrome(PWS).Each with a snoRNA cap on its either end,they fall in the sno-lncRNA family,a group of lncRNAs identified by CHEN’s group in their earlier research.Here we are meeting another member of the family,SLERT,a rescuer

To Actively Perform the Judicial Administration Function and Promote the Development of Cause of Human Rights

Respect for human rights and protection of human rights are significant rules in the Constitution of the People’s Republic of China.In 2015,judicial administration departments at all levels legally exercised their duties,implemented the principles and rules in constitution,and kept strengthening propagation of human rights through creation of contents and methods which had acquired great effects.What they have done contributes significantly toward the development of human rights in China.

Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats

Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.

The Expanding Analysis of Enterprise＇s Human Capital Investment Value

Value is the scale that appraises whether the comparison between a certain thing and its realization which we need to consume is rational. The paper appraises the investment value and incomes of human capital by applying value engineering method. It elaborates the investment structure and contents of human capital first, and then analyzes and summarizes various functions of enterprise＇s human capital. It educes the production function and the optimum equilibrium solution of human capital on this basis. Finally, it appraises the investment value of human capital by applying VE method. Thus we will apply a new method in the human capital field.

A GIS-based Study on Sustainable Human Settlements Functional Division in China

在中国1km×1km栅格尺度人居环境自然适宜性分类评价和分县尺度人口空间集聚程度分级评价的基础上,结合中国分县资源环境承载力和区域经济发展水平和发展潜力,确立了中国可持续的人居功能分区评价模型,提出了中国可持续发展的人居功能分区方案。研究表明:中国可持续的人居功能分区空间分布呈现东南半壁优于西北半壁的格局;人居功能强可持续地区面积约139.75×104km2,占国土面积的14.66%,相应人口4.3亿,接近总人口的1/3,主要分布在东南沿海、长江中下游地区、四川盆地、黄淮海平原以及东北平原的部分地区;人居功能较强可持续地区面积约193.61×104km2,占国土面积的1/5,相应人口3.2亿,接近总人口的1/4,主要分布在三江平原、辽河平原、山东半岛等地;可持续地区面积210.19×104km2,约占国土面积的22%,相应人口3.7亿,占总人口的28.24%,主要分布在呼伦贝尔高原、黄土高原和云贵高原等地,零星见于藏东南谷地和柴达木盆地等地区;较弱可持续地区,面积约145.85×104km2,占国土面积的15.30%,人口1.4亿,约占总人口的11%,零散分布于黄土高原、川滇高原和云贵高原的部分地区;弱可持续地区面积约263.86×104km2,约占国土面积的27.68%,相应人口0.4亿,接近总人口的3%,主要分布在青藏高原、西北荒漠以及川滇高原北部地区。

Cortical language activation in aphasia: a functional MRI study

Background Functional neuroimaging has been used in neurolinguistic research on normal subjects and on patients with brain damage. This study was designed to investigate the differences of the neural basis underlying language processing between normal subjects and aphasics.Methods Functional magnetic resonance imaging (fMRI) was used to map the language network in 6 normal subjects and 3 patients with aphasia who were in the stage of recovery from acute stroke. The participants performed a word generation task during multi-slice functional scanning for the measurement of signal change associated with regional neural activity induced by the task. Results In normal subjects, a distributed language network was activated. Activations were present in the frontal, temporal, parietal and occipital regions. In the patient group, however, no activation was detected in the left inferior frontal gyrus whether the patient had a lesion in the left frontal lobe or not. Two patients showed activations in some right hemisphere regions where no activation appeared in normal subjects. Conclusions fMRI with word generation task is feasible for evaluating language function in aphasic patients. Remote effect of focal lesion and functional redistribution or reorganisation can be found in aphasic patients.

Literature and patent analysis of the cloning and identification of human functional genes in China

The Human Genome Project was launched at the end of the 1980s.Since then,the cloning and identification of functional genes has been a major focus of research across the world.In China too,the potentially profound impact of such studies on the life sciences and on human health was realized,and relevant studies were initiated in the 1990s.To advance China's involvement in the Human Genome Project,in the mid-1990s,Committee of Experts in Biology from National High Technology Research and Development Program of China(863 Program) proposed the "two 1%" goal.This goal envisaged China contributing 1% of the total sequencing work,and cloning and identifying 1% of the total human functional genes.Over the past 20 years,tremendous achievement has been accomplished by Chinese scientists.It is well known that scientists in China finished the 1% of sequencing work of the Human Genome Project,whereas,there is no comprehensive report about "whether China had finished cloning and identifying 1% of human functional genes".In the present study,the GenBank database at the National Center of Biotechnology Information,the PubMed search tool,and the patent database of the State Intellectual Property Office,China,were used to retrieve entries based on two screening standards:(i) Were the newly cloned and identified genes first reported by Chinese scientists?(ii) Were the Chinese scientists awarded the gene sequence patent? Entries were retrieved from the databases up to the cut-off date of 30 June 2011 and the obtained data were analyzed further.The results showed that 589 new human functional genes were first reported by Chinese scientists and 159 gene sequences were patented(http:gene.fudan.sh.cn/introduction/database/chinagene/chinagene.html).This study systematically summarizes China's contributions to human functional genomics research and answers the question "has China finished cloning and identifying 1% of human functional genes?" in the affirmative.

EFFECTS OF PARATHYROID HORMONE AND ESTRADIOL ON PROLIFERATION AND FUNCTION OF HUMAN OSTEOBLASTS FROM FETAL LONG BONE AN IN VITRO STUDY

The effect of parathyroid hormone (PTH) (0.01 nM-10 nM) and 17 -estradiol (E2, 1 nmol-10 nM) alone or in combination on 3H thymidine incorporation, alkaline phosphatase and adenylate cyclase activities were investigated in human fetal osteoblasts using serum-free monolayer primary cultures. The results showed that PTH inhibited cell proliferation while E, promoted it. On alkaline phosphatase activity, PTH showed a complex results while E, were slightly inhibitory. PHT-E2 combination suggested that E2 could alter the effect of PTH alone, also potentiated the anabolic and antagonize the catabolic effects of PTH on bone formation.

Evolution and restoration of structures and functions of the human central nervous system—A review

Clinical translational science:Clinical translational science(CTS)is a new discipline bridging laboratory discoveries and clinical applications.It is normally funded by research grants instead of investment major pharmaceutical companies.It is patient-and populationor community-oriented.Repair of the human

Winners and losers among tree species in Xishuangbanna: which traits are most important?

Massive human interference in natural ecosystems is resulting in a few ＂winners＂ and many ＂losers＂. However, the drivers of this winner-loser replacement pattern remain poorly understood. The aim of the study reported here was to identify winners among the tree flora of Xishuangbanna and compare their functional traits, specific leaf area （SLA）, wood density （WD）, seed mass （SM） and maximum height （MH） with previously identified losers （i.e., endangered species）. Fifteen native tree species were identified as winners from expert opinion, plot-based surveys of secondary forests and plotless surveys along roads. Twelve endangered tree species for which trait information could be obtained were used for comparison. Traits were compared with a Wilcoxon rank-sum test. Winners had significantly higher SLA, but lower WD. SM and MH did not differ significantly between groups. When the effects of phylogeny were removed by using phylogenetic generalized least squares, the difference in SLA became marginally insignificant. Principal component analysis resulted in two overlapping groups, showing that the selected traits were insufficient to distinguish winners and losers. Our results suggest that the ＂few winners, many losers＂ paradigm applies to trees in Xishuangbanna, with15 species accounting for most trees in the disturbed habitats sampled.

Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies

Searching for effective biomarkers is one of the most challenging tasks in the research ？eld of Autism Spectrum Disorder（ASD）. Magnetic resonance imaging（MRI） provides a non-invasive and powerful tool for investigating changes in the structure, function, maturation,connectivity, and metabolism of the brain of children with ASD. Here, we review the more recent MRI studies in young children with ASD, aiming to provide candidate biomarkers for the diagnosis of childhood ASD. The review covers structural imaging methods, diffusion tensor imaging, resting-state functional MRI, and magnetic resonance spectroscopy. Future advances in neuroimaging techniques, as well as cross-disciplinary studies and largescale collaborations will be needed for an integrated approach linking neuroimaging, genetics, and phenotypic data to allow the discovery of new, effective biomarkers.

Emotion detection on webpages using biosensors integrated to a window-based dynamic control system

Purpose-Detecting emotion on user experience of web applications and browsing is important in many ways.Web designers and developers find such approach quite useful in enhancing navigational features of webpages,and biomedical personnel regularly use computer simulations to monitor and control the behaviour of patients.On the other hand,law enforcement agents rely on human physiological functions to determine the likelihood of falsehood in interrogations.Quite often,online user experience is studied via tangible measures such as task completion time,surveys and comprehensive tests from which data attributes are generated.Prediction of users’emotion and behaviour in some of these cases depends mostly on task completion time and number of clicks per given time interval.However,such approaches are generally subjective and rely heavily on distributional assumptions making the results prone to recording errors.Design/methodology/approach-The authors propose a novel method-a window dynamic control system that addresses the foregoing issues.Primary data were obtained from laboratory experiments during which forty-four volunteers had their synchronised physiological readings,skin conductance response(SCR),skin temperature(ST),eye movement behaviour and users’activity attributes taken using biosensors.The windowbased dynamic control system(PHYCOB I)is integrated to the biosensor which collects secondary data attributes from these synchronised physiological readings and uses them for two purposes.For both detection of optimal emotional responses and users’stress levels.The method’s novelty derives from its ability to integrate physiological readings and eye movement records to identify hidden correlates on a webpage.Findings-Results show that the control system detects basic emotions and outperforms other conventional models in terms of both accuracy and reliability,when subjected to model comparison that is,the average recoverable natural structures for the three models with respect to accuracy and reliability are more consistent within the window-based control system environment than with the conventional methods.Research limitations/implications-The paper is limited to using a window control system to detect emotions on webpages,while integrated to biosensors and eye-tracker.Originality/value-The originality of the proposed model is its resistance to overfitting and its ability to automatically assess human emotion(stress levels)while dealing with specific web contents.The latter is particularly important in that it can be used to predict which contents of webpages cause stress-induced emotions to users when involved in online activities.