The changes of glucocorticoid receptor （GR） and the reactivity of target cells toglucocorticoids （GC） were studied experimentally.The results showed that GC resistance,which wascaused mainly by the decrease of GR,...The changes of glucocorticoid receptor （GR） and the reactivity of target cells toglucocorticoids （GC） were studied experimentally.The results showed that GC resistance,which wascaused mainly by the decrease of GR,developed in burned and shocked rats and dogs.Thesechanges may exacerbate the shock state,and even lead to the development of multiple organfailuue.The protection of GC against intestinal ischemic shock of dogs was demonstrated after theconcentration of dexamethasone （Dex） in plasma was elevated to 10<sup>-6</sup> mol/L by iv injection of 5mgDex/kg body weight.展开更多
文摘The changes of glucocorticoid receptor （GR） and the reactivity of target cells toglucocorticoids （GC） were studied experimentally.The results showed that GC resistance,which wascaused mainly by the decrease of GR,developed in burned and shocked rats and dogs.Thesechanges may exacerbate the shock state,and even lead to the development of multiple organfailuue.The protection of GC against intestinal ischemic shock of dogs was demonstrated after theconcentration of dexamethasone （Dex） in plasma was elevated to 10<sup>-6</sup> mol/L by iv injection of 5mgDex/kg body weight.
