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Study on crustal thickness and the prediction of prolific depressions:the Bohai Basin as an example
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作者 Mengke Cai Gongcheng Zhang +1 位作者 Wanyin Wang Dingding Wang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第4期92-104,共13页
The deep crustal structure is closely related to oil and gas reserves.Predicting the oil and gas enrichment of depressions based on the Moho depth and crustal thickness is a promising research topic with significant i... The deep crustal structure is closely related to oil and gas reserves.Predicting the oil and gas enrichment of depressions based on the Moho depth and crustal thickness is a promising research topic with significant implications for guiding exploration in petroliferous basins.In this study,seismic data were used as a constraint on the use of satellite gravity anomaly inversion to obtain the distribution of Moho depth and crustal thickness in the Bohai Basin.Stretching factors were calculated to analyze the differential distribution of deep crustal structural activity.Four indicators,including the minimum Moho depth,minimum crustal thickness,sum of Moho stretching factors,and sum of crustal stretching factors,were selected.Principal component analysis was applied to reduce the dimensionality of the multi-indicator system and obtain an oil and gas enrichment score for quantitative prediction of favorable prolific depressions.The deviation between the inverted Moho depth and seismic constraints was small;thus,the data effectively reflect the variations in the characteristics of each depression.The analysis revealed significant statistical features related to the minimum Moho depth/crustal thickness and the sum of Moho/crustal stretching factors associated with prolific depressions.Based on the oil and gas enrichment score,the depressions were classified into four categories related to their different deep crustal structural characteristics.Highly active ClassⅠ,ClassⅡ,and ClassⅢdepressions are predicted to be favorable prolific depressions.This study expands the research on quantitatively predicting favorable prolific depressions in the Bohai Basin using the deep crustal structure and can contribute to reducing production costs and improving exploration efficiency in future explorations. 展开更多
关键词 Bohai Basin satellite gravity anomaly deep crustal structure Moho depth crustal thickness favorable prolific depression
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Liver surface depressions in the presence of diaphragmatic muscular bands on trans-illumination
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作者 Shamir O Cawich Michael T Gardner +3 位作者 Ramanand Shetty Jean Pierre Louboutin Zenica Dabichan Shaneeta Johnson 《World Journal of Experimental Medicine》 2024年第2期5-10,共6页
Traditional descriptions of liver anatomy refer to a smooth,convex surface contacting the diaphragm.Surface depressions are recognized anatomic variants.There are many theories to explain the cause of the depressions.... Traditional descriptions of liver anatomy refer to a smooth,convex surface contacting the diaphragm.Surface depressions are recognized anatomic variants.There are many theories to explain the cause of the depressions.We discuss the theory that these are caused by hypertrophic muscular bands in the diaphragm. 展开更多
关键词 LIVER Anatomy depressions FISSURE Groove SULCUS Variant
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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior 被引量:1
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作者 Man Han Deyang Zeng +7 位作者 Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng 《Neural Regeneration Research》 SCIE CAS 2025年第1期159-173,共15页
Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice ... Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and hippocampus.Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology.In this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression.We focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine circuit.We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic system.Therefore,BDNF might be a biological indicator regulating stress-related processes in various brain regions. 展开更多
关键词 AMYGDALA chronic mild stress chronic social defeat stress corticolimbic system depressION HIPPOCAMPUS medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area
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Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression
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作者 Min Xu Hai-Ying Jin +1 位作者 Feng-Li Sun Wei-Dong Jin 《World Journal of Psychiatry》 SCIE 2025年第1期32-36,共5页
Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines stil... Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake inhibitors.Previous studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent depression.In the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side effects.This review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI. 展开更多
关键词 Child depression Adolescent depression ANTIdepressANT Switch SUICIDE Non-suicidal self injury
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Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects
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作者 Rui-Ying Fang Xiao-Rui Pan +4 位作者 Xin-Xing Zeng Zheng-Zheng Li Bo-Fan Chen Hai-Min Zeng Jie Peng 《World Journal of Psychiatry》 SCIE 2025年第1期12-20,共9页
A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and depression.The gut-brain axis,which acts as a two-way commu... A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and depression.The gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these conditions.Evidence suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse mechanisms.The interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine system.Modulating the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and depression.Future research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment. 展开更多
关键词 Gut-brain axis OBESITY depressION Gut microbiota Mechanism
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Effect of esketamine on reducing postpartum pain and depression
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作者 Brandon Lucke-Wold Armin Karamian 《World Journal of Clinical Cases》 SCIE 2025年第7期17-20,共4页
In this editorial,we comment on a recent article by Chen et al,that addressed the effect of intraoperative injection of esketamine on postoperative analgesia and postoperative rehabilitation after cesarean section.Poo... In this editorial,we comment on a recent article by Chen et al,that addressed the effect of intraoperative injection of esketamine on postoperative analgesia and postoperative rehabilitation after cesarean section.Poor management of postcesarean pain is associated with decreased maternal care for the baby,longer hospitalization,and higher risk of developing postpartum depression.Esketamine is a more potent S-enantiomer of ketamine which has shown promising analgesic and antidepressant properties for managing post-cesarean pain and depression in clinical studies.However,due to its potential adverse effects on the neurological and hemodynamic status of patients,it is recommended that its usage in low doses should be limited to cesarean candidates experiencing unbearable pain.Before any recommendation for routine perioperative use of esketamine,more standardized clinical trials are needed to strengthen our existing knowledge of its effectiveness in reducing postpartum pain and depression. 展开更多
关键词 Cesarean section Postpartum pain Postpartum depression Postoperative analgesia Esketamine
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Social function scores and influencing factors in patients with residual depressive symptoms
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作者 Zong-Ling Liao Xiao-Li Pu +1 位作者 Zhi-Yi Zheng Jie Luo 《World Journal of Psychiatry》 SCIE 2025年第1期117-127,共11页
BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still unclear.Residual depressive symptoms are highly harmful,leading to low mood in patients,affectin... BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still unclear.Residual depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on families.Studying the influencing factors of their social function is of great significance.AIM To explore the social function score and its influencing factors in patients with residual depressive symptoms.METHODS This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December 2023.Social functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between groups.Factors influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±3.26.Compared with the control group,the SDS scores and all items in the case group were higher.SDS scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥8.Disease history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.CONCLUSION The social function scores of patients with residual symptoms of depression are high.They are affected by disease history,medication compliance,therapy method,degree of somatic symptoms,residual symptoms,and anxiety. 展开更多
关键词 depressIVE Residual symptoms Social function Influence factors
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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
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作者 Jinmei Ye Cong Duan +5 位作者 Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng 《Neural Regeneration Research》 SCIE CAS 2025年第6期1541-1554,共14页
In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release f... In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder. 展开更多
关键词 BIOMARKER cytokine EXOSOMES INFLAMMASOME major depressive disorder MICROGLIA mitochondrial DNA mitochondrial dysfunction NEUROINFLAMMATION Toll-like receptor
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Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression
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作者 Juan Liu Yan-Ping Guo +1 位作者 Yan-Mei Lu Bei-Lin Wang 《World Journal of Psychiatry》 SCIE 2025年第1期54-62,共9页
BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer prognosis.While epirubicin(EPI)is r... BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer prognosis.While epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical burden.Therefore,an appropriate intervention mode is necessary.METHODS This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July 2023.Patients were divided into conventional(n=55)and joint inter-vention(n=55)groups.The conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness intervention.Both groups underwent three cycles of chemotherapy.Immune function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were assessed.Adverse reactions and nursing satisfaction were recorded and evaluated.RESULTS Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(P<0.05).Tumor marker levels(NMP22,BTA,and UBC)were lower in the joint intervention group compared to the conventional group(P<0.05).The joint intervention group also showed a greater reduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinary system tumors and depression and is worthy of clinical application. 展开更多
关键词 Urinary system tumor Bladder cancer Prostate cancer depressION EPIRUBICIN
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Correlation between anxiety, depression, and social stress in young patients with thoracolumbar spine fractures
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作者 Bo Wang Da Shi +1 位作者 Yin-Di Sun Bo Dong 《World Journal of Psychiatry》 SCIE 2025年第1期83-92,共10页
BACKGROUND Traumatic injuries,such as falling,car accidents,and crushing mostly cause spinal fractures in young and middle-aged people,and>50%of them are thoracolumbar fractures.This kind of fracture is easily comb... BACKGROUND Traumatic injuries,such as falling,car accidents,and crushing mostly cause spinal fractures in young and middle-aged people,and>50%of them are thoracolumbar fractures.This kind of fracture is easily combined with serious injuries to peripheral nerves and soft tissues,which causes paralysis of the lower limbs if there is no timely rehabilitation treatment.Young patients with thoracolumbar fractures find it difficult to recover after the operation,and they are prone to depression,low self-esteem,and other negative emotions.AIM To investigate the association between anxiety,depression,and social stress in young patients with thoracolumbar spine fractures and the effect on rehabilitation outcomes.METHODS This study retrospectively analyzed 100 patients admitted to the orthopedic department of Honghui Hospital,Xi’an Jiaotong University who underwent thoracolumbar spine fracture surgery from January 2022 to June 2023.The general data of the patients were assessed with the Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),life events scale,and social support rating scale(SSRS)to identify the correlation between anxiety,depression scores,and social stress and social support.The Japanese Orthopedic Association(JOA)was utilized to evaluate the rehabilitation outcomes of the patients and to analyze the effects of anxiety and depression scores on rehabilitation.RESULTS According to the scores of HAMD and HAMA in all patients,the prevalence of depression in patients was 39%(39/100),and the prevalence of anxiety was 49%(49/100).Patients were categorized into non-depression(n=61)and depression(n=39),non-anxiety(n=51),and anxiety(n=49)groups.Statistically significant differences in gender,occupation,Pittsburgh Sleep Quality Index(PSQI)score,and monthly family income were observed between the non-depression and depression groups(P<0.05).A significant difference in occupation and PSQI score was found between the non-anxiety and anxiety groups.Both depression(r=0.207,P=0.038)and anxiety scores(r=0.473,P<0.001)were significantly and positively correlated with negative life events.The difference in negative life event scores as well as SSRS total and item scores was statist-ically significant between patients in the non-depression and depression groups(P<0.05).The difference between the non-anxiety and anxiety groups was statistically significant(P<0.05)in the negative life event scores as well as the total SSRS scores.Additionally,JOA scores were significantly lower in both anxious and depressed patients.CONCLUSION Young patients with thoracolumbar fractures are prone to anxiety and depression.Patients’anxiety and depression are closely associated with social pressure,which reduces the life pressure of young patients with thoracolumbar fractures,enhances social support,and improves the psychology of anxiety and depression.,which affects patients’recovery. 展开更多
关键词 Patients with thoracolumbar fractures ANXIETY depressION Social pressure Social support
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Differential Hydrocarbon Enrichment and its Main Controlling Factors in Depressions of the Bohai Bay Basin Differential Hydrocarbon Enrichment and its Main Controlling Factors in Depressions of the Bohai Bay Basin 被引量:15
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作者 JIANG Youlu LIU Hua +4 位作者 SONG Guoqi WANG Yongshi LIU Jingdong ZHAO Kai LYU Xueying 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第5期1855-1872,共18页
Significant differential hydrocarbon enrichment occurs in depressions in a petroliferous basin.There are multiple depressions in the Bohai Bay Basin, and each depression as a relatively independent unit of hydrocarbon... Significant differential hydrocarbon enrichment occurs in depressions in a petroliferous basin.There are multiple depressions in the Bohai Bay Basin, and each depression as a relatively independent unit of hydrocarbon generation, migration and accumulation, contains significantly different hydrocarbon generation conditions and enrichment degree. On the basis of previous documents and a large number of statistical data, this work comparatively analyzed the differential hydrocarbon enrichment and its major controlling factors in depressions of the Bohai Bay Basin. The results show that depressions in the Bohai Bay Basin have various hydrocarbon enrichment degrees, and can be categorized into four types, namely enormously oil-rich, oil-rich, oily and oil-poor depressions. In general, the enormously oil-rich and oil-rich depressions are distributed in the eastern part of the basin along the Tan-Lu and Lan-Liao faults, whereas depressions in the western part of the basin are poor in hydrocarbons. Moreover, the vertical distribution of hydrocarbons is also highly heterogeneous, with Pre-Paleogene strata rich in hydrocarbons in the northern and western depressions, Paleogene strata rich in hydrocarbons in the entire basin, and Neogene strata rich in hydrocarbons in the off-shore areas of the Bohai Bay Basin. From early depressions in onshore areas to the late depressions in offshore areas of the Bohai Bay Basin, the source rocks and source-reservoir-cap rock assemblages gradually become younger and shallower, and the hydrocarbon resource abundance gradually increases. Hydrocarbon supplying condition is the key factor constraining the hydrocarbon enrichment for different depressions,while the main source-reservoir-cap rock assemblage, sufficient hydrocarbons and the transportation capacity of faults control the vertical distribution of hydrocarbons. The main factors controlling hydrocarbon enrichment are different for different layers. The hydrocarbon supplying condition of source rocks is the key controlling factor, whereas the source-reservoir configuration, the main sourcereservoir-cap rock assemblages, and the fault transportation are the main factors of hydrocarbon enrichment in the Paleogene, Paleogene and Neogene, respectively. 展开更多
关键词 differential hydrocarbon enrichment hydrocarbon distribution hydrocarbon-rich depression fault transportation main controlling factors Bohai Bay Basin
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Relationship between Geological Structures and Hydrocarbon Enrichment of Different Depressions in the Bohai Bay Basin 被引量:13
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作者 JIANG Youlu LIU Hua +3 位作者 SONG Guoqi WANG Yongshi LIU Pei Lü Xueying 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2015年第6期1998-2011,共14页
The Bohai Bay Basin contains many depressions with varying degrees of hydrocarbon enrichment associated with the geological structures of different depressions. This study discussed the relationship between the geolog... The Bohai Bay Basin contains many depressions with varying degrees of hydrocarbon enrichment associated with the geological structures of different depressions. This study discussed the relationship between the geological structures and hydrocarbon enrichment of the depressions in the Bohai Bay Basin. Based on the Paleogene strata distribution and the length to width ratio of different depressions, their geological structures are divided into three types in plan-view: open(length/width 〈 2), narrow(length/width 〉 4) and transitional types(length/width 2-4). In cross section, the geological structures can be divided into dustpan I, dustpan II and double-faulted types. Based on tectonic evolution and sedimentary characteristics, the depressions are classified into early-formed, inherited and late-formed categories. Generally, narrow depressions are mainly located in the northeast and southwest of the Bohai Bay Basin, while open depressions are dominantly distributed in the central area of the basin; late-formed depressions are mainly around the Bohai sea area, and early-formed depressions are mostly located in the periphery of the basin. Geological structures of the depressions control the formation of the source, reservoir and cap rocks as well as hydrocarbon accumulation setting, and further influence the pay zones and oil-bearing sequence. In detail, dustpan II and doublefaulted depressions mainly have A-type sags, which often possess better hydrocarbon generation conditions than dustpan I ones; hydrocarbons in open dustpan II depressions tend to accumulate in the central uplift areas or buried hill, while those in narrow dustpan I depressions always accumulate in gentle slope belts. The oil-bearing sequence for different evolutional depressions corresponds well with the sedimentary strata of the main development stages of depressions. In early-formed depressions, hydrocarbons are mainly enriched in deeply buried reservoirs, while in late-formed depressions hydrocarbons are abundant in the relatively shallow traps. In summary, most inherited and late-formed dustpan II depressions are enriched in hydrocarbons due to their extensive source rocks and good source-reservoir-seal assemblages, whereas dustpan I and early-formed depressions are relatively poor in hydrocarbons. 展开更多
关键词 geological structure of depression hydrocarbon enrichment fault migration system dustpan-shaped depression Bohai Bay Basin
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Formation Mechanism of "Drag Depressions" and Irregular Boundaries in Intraplate Deformation 被引量:11
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作者 DENGJun HUANGDinghua +6 位作者 WANGQingfei HOUZengqian LüQingtian YAOLingqing XINHongbo ZHANGQiang WEIYanguang 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2004年第1期267-272,共6页
Almost all intraplate caprocks experienced strong deformation during the convergence of microplates, and then disintegrated into many secondary geologic units with the special characters, such as irregular boundaries ... Almost all intraplate caprocks experienced strong deformation during the convergence of microplates, and then disintegrated into many secondary geologic units with the special characters, such as irregular boundaries and particular structural assemblages. In order to understand the formation mechanism of these special phenomena, a rheological experiment on the structural scenery of the Tongling area is carried out. The result shows that the primary regular and uniform boundaries of the Tongling area becomes irregular because of the enclosing and confinement of surrounding geological units in the process of 'compression-shearing-rotation-drag'; simultaneously, two specific 'drag depressions' developed at two opposite corners of the block. The former and the later phenomena can be regarded as a typical regional-scale rheological effect and necessary outcome of intraplate deformation respectively. 展开更多
关键词 intraplate deformation simulation experiment drag depression irregular boundaries Tongling area
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The Character and Formation of Elongated Depressions on the Upper Bulgarian Slope 被引量:2
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作者 XU Cuiling GREINERT Jens +3 位作者 HAECKEL Matthias BIALAS Jorg DIMITROV Lyubomir ZHAO Guangtao 《Journal of Ocean University of China》 SCIE CAS CSCD 2018年第3期555-562,共8页
Seafloor elongated depressions are indicators of gas seepage or slope instability. Here we report a sequence of slopeparallel elongated depressions that link to headwalls of sediment slides on upper slope. The depress... Seafloor elongated depressions are indicators of gas seepage or slope instability. Here we report a sequence of slopeparallel elongated depressions that link to headwalls of sediment slides on upper slope. The depressions of about 250 m in width and several kilometers in length are areas of focused gas discharge indicated by bubble-release into the water column and methane enriched pore waters. Sparker seismic profiles running perpendicular and parallel to the coast, show gas migration pathways and trapped gas underneath these depressions with bright spots and seismic blanking. The data indicate that upward gas migration is the initial reason for fracturing sedimentary layers. In the top sediment where two young stages of landslides can be detected, the slopeparallel sediment weakening lengthens and deepens the surficial fractures, creating the elongated depressions in the seafloor supported by sediment erosion due to slope-parallel water currents. 展开更多
关键词 methane seepage elongated depression POCKMARK LANDSLIDE Black Sea
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Evaluation of abundant hydrocarbon-generation depressions in the deepwater area of Qiongdongnan Basin,South China Sea 被引量:1
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作者 LIU Zhen SUN Zhipeng +7 位作者 WANG Zisong ZHANG Wei LI Tingan HE Weijun LI Fengxia CAO Shang LIU Jingjing LIN Lu 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2016年第2期137-144,共8页
It has been confirmed that the key source rocks of Qiongdongnan Basin are associated with the Yacheng Formation, which was deposited in a transitional marine-continental environment. Because the distribution and evolu... It has been confirmed that the key source rocks of Qiongdongnan Basin are associated with the Yacheng Formation, which was deposited in a transitional marine-continental environment. Because the distribution and evolution patterns of the source rocks in the major depressions are different, it is important to determine the most abundant hydrocarbon-generation depressions in terms of exploration effectiveness. Based on an analysis of organic matter characteristics of the source rocks, in combination with drilling data and seismic data, this paper establishes a model to evaluate the hydrocarbon-generation depressions in the deepwater area of Qiongdongnan Basin. First of all, by using the method of seismic-facies model analysis, the distribution of sedimentary facies was determined. Then, the sedimentary facies were correlated with the organic facies, and the distribution of organic facies was predicted. Meanwhile, the thickness of source rocks for all the depressions was calculated on the basis of a quantitative analysis of seismic velocity and lithology. The relationship between mudstone porosity and vitrinite reflectance(Ro) was used to predict the maturity of source rocks. Second, using the parameters such as thickness and maturity of source rocks, the quantity and intensity of gas generation for Yacheng and Lingshui Formations were calculated. Finally, in combination with the identified hydrocarbon resources, the quantity and intensity of gas generation were used as a guide to establish an evaluation standard for hydrocarbon-generation depressions, which was optimized for the main depressions in the Central Depression Belt. It is proposed that Lingshui, Ledong, Baodao and Changchang Depressions are the most abundant hydrocarbon depressions, whilst Songnan and Beijiao Depressions are rich hydrocarbon depressions. Such an evaluation procedure is beneficial to the next stage of exploration in the deep-water area of Qiongdongnan Basin. 展开更多
关键词 comprehensive evaluation hydrocarbon-generation depressions source rocks deepwater area Qiongdongnan Basin
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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression 被引量:4
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作者 Qiuqin Han Wenhui Li +5 位作者 Peiqing Chen Lijuan Wang Xiwen Bao Renyan Huang Guobin Liu Xiaorong Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1890-1898,共9页
Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containin... Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological diseases.In patients with major depressive disorder,NLRP3 inflammasome levels are significantly elevated.Understanding the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic strategies.In this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 inflammasome.Moreover,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating depression.Additionally,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to depression.Currently,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression treatment.The modulation of NLRP3 inflammasomes in microglia holds promise for the management of depression.Further investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments. 展开更多
关键词 depressION MICROGLIA NEUROINFLAMMATION NLRP3 inflammasome
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Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment 被引量:3
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作者 Chika Fujii Charles F.Zorumski Yukitoshi Izumi 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第10期2202-2211,共10页
The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functio... The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving cellular stress and are possible targets for the pathophysiology and treatment of psychiatric and neurologic illnesses. An increasing number of studies indicate the involvement of endoplasmic reticulum stress and autophagy in the control of neuroinflammation, a contributing factor to multiple neuropsychiatric illnesses. Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. Subsequently, induction of autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinflammation. The aim of this review is to summarize our current understanding of the molecular mechanisms governing the induction of endoplasmic reticulum stress, autophagy, and neuroinflammation in the central nervous system. Studies focused on innate immune factors, including neurosteroids with anti-inflammatory roles will be reviewed. In the context of depression, animal models that led to our current understanding of molecular mechanisms underlying depression will be highlighted, including the roles of sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinflammation. 展开更多
关键词 ALLOPREGNANOLONE fluvoxamine KETAMINE NEUROSTEROIDS postpartum depression QUERCETIN
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EFFECT OF FUTURE SEA LEVEL RISE ON DISASTROUS FLOODS IN THE TAIHU LAKE LOWER REACH DEPRESSIONS AND COUNTERMEASURES
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作者 毛锐 许朋柱 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 1994年第4期377-380,共4页
Use of numerical simulation of the tidal flow of the Changjiang River Estuary and the HuangpuRiver to forecast flood in the Taihu Lake lower reach drainage system for the case of future sea level riseof 0.4 m and 0.8 ... Use of numerical simulation of the tidal flow of the Changjiang River Estuary and the HuangpuRiver to forecast flood in the Taihu Lake lower reach drainage system for the case of future sea level riseof 0.4 m and 0.8 m,and floods preventing and reducing methods are discussed in this paper. 展开更多
关键词 Taihu LAKE lower REACH depressions sea level RISE mathematical model of TIDAL current
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Advances in depressants for flotation separation of Cu–Fe sulfide minerals at low alkalinity:A critical review 被引量:1
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作者 Qicheng Feng Wenhang Yang +3 位作者 Maohan Chang Shuming Wen Dianwen Liu Guang Han 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CSCD 2024年第1期1-17,共17页
The flotation separation of Cu–Fe sulfide minerals at low alkalinity can be achieved using selective depressants.In the flotation system of Cu–Fe sulfide minerals,depressants usually preferentially interact with the... The flotation separation of Cu–Fe sulfide minerals at low alkalinity can be achieved using selective depressants.In the flotation system of Cu–Fe sulfide minerals,depressants usually preferentially interact with the pyrite surface to render the mineral surface hydrophilic and hinder the adsorption of the collector.This review summarizes the advances in depressants for the flotation separation of Cu–Fe sulfide minerals at low alkalinity.These advances include use of inorganic depressants (oxidants and sulfur–oxygen compounds),natural polysaccharides (starch,dextrin,konjac glucomannan,and galactomannan),modified polymers (carboxymethyl cellulose,polyacrylamide,lignosulfonate,and tricarboxylate sodium starch),organic acids (polyglutamic acid,sodium humate,tannic acid,pyrogallic acid,salicylic acid,and lactic acid),sodium dimethyl dithiocarbamate,and diethylenetriamine.The potential application of specific inorganic and organic depressants in the flotation separation of Cu–Fe sulfide minerals at low alkalinity is reviewed.The advances in the use of organic depressants with respect to the flotation separation of Cu–Fe sulfide minerals are comprehensively detailed.Additionally,the depression performances and mechanisms of different types of organic depressants on mineral surfaces are summarized.Finally,several perspectives on depressants vis-à-vis flotation separation of Cu–Fe sulfide minerals at low alkalinity are proposed. 展开更多
关键词 Cu–Fe sulfide minerals flotation separation selective depressants depression mechanism
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Geological Analogy Expert System of Oil-Generating Depressions
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作者 Ye Jiaren Lu Mingde Wang FeiqiaoChina University of Geosciences , Wuhan 430074 《Journal of Earth Science》 SCIE CAS CSCD 1993年第1期94-99,共6页
The geologic analogy expert system of oil-generating depressions (GAESOD) constructed on IBM 386 by using GCLISP language is a tool-type expert system for geologic analogy .GAESOD consists of eight parts: (1) illustra... The geologic analogy expert system of oil-generating depressions (GAESOD) constructed on IBM 386 by using GCLISP language is a tool-type expert system for geologic analogy .GAESOD consists of eight parts: (1) illustrating module of system; (2) general controlling module; (3) knowledge base; (4 (reasoning module; (5 )data base; (6)explanation module; (7)gaining and managing module of knowledge; (8) managing module of data base .There are 36 known models of oil-generating depressions of the eastern part and the continental shelf of China in the knowledge base .Three values,such as resemblance coefficient ,certainty factor and fine-poor coefficient ,will be acquired if this system is applied to any two on-generating depressions .Finally,GAESOD are applied to the analysis of some data from Xichang depression ,Hepu basin and the conclusions from this system are consistent with the results from geologic experts. 展开更多
关键词 geologic analogy expert system knowledge oil-generating depressions .reasoning .
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