We have developed a new three dimensional (3-D) conductivity imaging approach and have used it to detect human brain conductivity changes corresponding to acute cerebral stroke. The proposed Magnetic Resonance Electri...We have developed a new three dimensional (3-D) conductivity imaging approach and have used it to detect human brain conductivity changes corresponding to acute cerebral stroke. The proposed Magnetic Resonance Electrical Impedance Tomography (MREIT) approach is based on the J-Substitution algorithm and is expanded to imaging 3-D subject conductivity distribution changes. Computer simulation studies have been conducted to evaluate the present MREIT imaging approach. Simulations of both types of cerebral stroke, hemorrhagic stroke and ischemic stroke, were performed on a four-sphere head model. Simulation results showed that the correlation coefficient (CC) and relative error (RE) between target and estimated conductivity distributions were 0.9245±0.0068 and 8.9997%±0.0084%, for hemorrhagic stroke, and 0.6748±0.0197 and 8.8986%±0.0089%, for ischemic stroke, when the SNR (signal-to-noise radio) of added GWN (Gaussian White Noise) was 40. The convergence characteristic was also evaluated according to the changes of CC and RE with different iteration numbers. The CC increases and RE decreases monotonously with the increasing number of iterations. The present simulation results show the feasibility of the proposed 3-D MREIT approach in hemorrhagic and ischemic stroke detection and suggest that the method may become a useful alternative in clinical diagnosis of acute cerebral stroke in humans.展开更多
Intraventricular hemorrhage(IVH) is one of the most severe medical emergencies in neurosurgery. Early detection or diagnosis would significantly reduce the rate of disability and mortality, and improve the prognosis o...Intraventricular hemorrhage(IVH) is one of the most severe medical emergencies in neurosurgery. Early detection or diagnosis would significantly reduce the rate of disability and mortality, and improve the prognosis of the patients.Although present medical imaging techniques have high sensitivity to identify bleeding, the use of an additional, non-invasive imaging technique capable of continuously monitoring IVH is required to prevent contingent bleeding or re-bleeding. In this study, electrical impedance tomography(EIT) was applied to detect the onset of IVH modeled on 6 piglets in real time, with the subsequent process being monitored continuously. The experimental IVH model was introduced by one-time injection of 2 ml fresh autologous arterial blood into the ventricles of piglets.Results showed that resistivity variations within the brain caused by the added blood could be detected and imaged in vivo using the EIT method, and the magnitude and the size of region of interest on EIT images may be linearly associated with the volume of the blood. In conclusion, EIT has unique potential for use in clinical practice to provide invaluable real-time neuroimaging data for IVH after the improvement of electrode design, anisotropic realistic modeling, and instrumentation.展开更多
目的探讨基于电阻抗成像技术(EIT)实时监测小猪肺出血模型的可行性。方法以小猪肺出血模型为研究对象,采用EIT实时连续监测小猪肺出血过程中的电阻抗变化。结果当注血量每5 m L逐渐增加时,EIT图像的相应区域呈红色显示,并逐渐增强,EIT...目的探讨基于电阻抗成像技术(EIT)实时监测小猪肺出血模型的可行性。方法以小猪肺出血模型为研究对象,采用EIT实时连续监测小猪肺出血过程中的电阻抗变化。结果当注血量每5 m L逐渐增加时,EIT图像的相应区域呈红色显示,并逐渐增强,EIT所显示的出血位置与CT所示的基本一致。定量分析结果表明,当注血量每5 m L逐渐增加时,图像上提示区域的阻抗、面积变化逐渐增大,EIT定量分析指标与注血量存在良好的相关性。结论 EIT技术能够实时有效地检测小猪肺出血引起的电阻抗变换,为临床研究奠定了基础。展开更多
基金Project supported partly by the National Science Foundation (No.BES-0411898) and the National Institues of Health (No. R01EB00178) USA
文摘We have developed a new three dimensional (3-D) conductivity imaging approach and have used it to detect human brain conductivity changes corresponding to acute cerebral stroke. The proposed Magnetic Resonance Electrical Impedance Tomography (MREIT) approach is based on the J-Substitution algorithm and is expanded to imaging 3-D subject conductivity distribution changes. Computer simulation studies have been conducted to evaluate the present MREIT imaging approach. Simulations of both types of cerebral stroke, hemorrhagic stroke and ischemic stroke, were performed on a four-sphere head model. Simulation results showed that the correlation coefficient (CC) and relative error (RE) between target and estimated conductivity distributions were 0.9245±0.0068 and 8.9997%±0.0084%, for hemorrhagic stroke, and 0.6748±0.0197 and 8.8986%±0.0089%, for ischemic stroke, when the SNR (signal-to-noise radio) of added GWN (Gaussian White Noise) was 40. The convergence characteristic was also evaluated according to the changes of CC and RE with different iteration numbers. The CC increases and RE decreases monotonously with the increasing number of iterations. The present simulation results show the feasibility of the proposed 3-D MREIT approach in hemorrhagic and ischemic stroke detection and suggest that the method may become a useful alternative in clinical diagnosis of acute cerebral stroke in humans.
基金the National Natural Science Foundation of Chinagrant number:61571445 and 61071033+3 种基金Key Technologies R&D Program of Chinagrant number:2012BAI19B01Major Basic Research Program of Shanxi Province of Chinagrant number:2016ZDJC-14
文摘Intraventricular hemorrhage(IVH) is one of the most severe medical emergencies in neurosurgery. Early detection or diagnosis would significantly reduce the rate of disability and mortality, and improve the prognosis of the patients.Although present medical imaging techniques have high sensitivity to identify bleeding, the use of an additional, non-invasive imaging technique capable of continuously monitoring IVH is required to prevent contingent bleeding or re-bleeding. In this study, electrical impedance tomography(EIT) was applied to detect the onset of IVH modeled on 6 piglets in real time, with the subsequent process being monitored continuously. The experimental IVH model was introduced by one-time injection of 2 ml fresh autologous arterial blood into the ventricles of piglets.Results showed that resistivity variations within the brain caused by the added blood could be detected and imaged in vivo using the EIT method, and the magnitude and the size of region of interest on EIT images may be linearly associated with the volume of the blood. In conclusion, EIT has unique potential for use in clinical practice to provide invaluable real-time neuroimaging data for IVH after the improvement of electrode design, anisotropic realistic modeling, and instrumentation.
文摘目的探讨基于电阻抗成像技术(EIT)实时监测小猪肺出血模型的可行性。方法以小猪肺出血模型为研究对象,采用EIT实时连续监测小猪肺出血过程中的电阻抗变化。结果当注血量每5 m L逐渐增加时,EIT图像的相应区域呈红色显示,并逐渐增强,EIT所显示的出血位置与CT所示的基本一致。定量分析结果表明,当注血量每5 m L逐渐增加时,图像上提示区域的阻抗、面积变化逐渐增大,EIT定量分析指标与注血量存在良好的相关性。结论 EIT技术能够实时有效地检测小猪肺出血引起的电阻抗变换,为临床研究奠定了基础。
