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^(99m)TcO4-SPECT/CT甲状腺核素显像联合超声及TSH对甲状腺结节性质的诊断价值 被引量:1
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作者 王静 吴龙云 +5 位作者 郝宏毅 尹彩君 杨勇 倪效波 张荣 王雪霁 《宁夏医学杂志》 CAS 2024年第3期206-209,F0002,共5页
目的通过高锝酸钠-单光子发射计算机断层显像/电子计算机X射线断层扫描技术(^(99m)TcO4-SPECT/CT)核素显像提供甲状腺结节功能状态、结节解剖特点以及超声检查联合血清促甲状腺激素(TSH)水平进一步鉴别诊断甲状腺结节的良恶性,客观评价... 目的通过高锝酸钠-单光子发射计算机断层显像/电子计算机X射线断层扫描技术(^(99m)TcO4-SPECT/CT)核素显像提供甲状腺结节功能状态、结节解剖特点以及超声检查联合血清促甲状腺激素(TSH)水平进一步鉴别诊断甲状腺结节的良恶性,客观评价甲状腺结节的良恶性情况,对甲状腺结节的良恶性做出早期诊断。方法对因甲状腺结节同时行^(99m)TcO4-SPECT/CT甲状腺核素显像、甲状腺B超及TSH水平检查的患者共80例(92个结节)进行回顾性分析,对比不同方法及联合检查对甲状腺结节的诊断效能。结果92个结节中良性74个,恶性18个;^(99m)TcO4-SPECT/CT甲状腺显像与超声检查比较灵敏度(77.8%)高,特异度(70.2%)及准确度(71.7%)低,假阳性率(29.7%)高,假阴性率(22.2%)低,两者之间灵敏度、特异度、准确度、假阳性率、假阴性率差异均具有统计学意义(P<0.05);两者准确度比较差异无统计学意义(P>0.05)。^(99)mTcO4-SPECT/CT甲状腺显像与超声检查比较灵敏度高,特异性及准确度低,假阳性率高,假阴性率低,两者之间灵敏度、特异度、准确度、假阳性率、假阴性率差异均具有统计学意义(P<0.05);两者准确度比较差异无统计学意义(P>0.05);^(99m)TcO4-SPECT/CT甲状腺显像与超声检查联合较单独核素、单独超声检查灵敏度(88.9%)、特异度(87.8%)、准确度(81.5%)高,假阳性率(12.1%)、假阴性率(11.1%)低;联合检查与单独核素特异度、准确度、假阳性率比较差异有统计学意义(P<0.05),灵敏度与假阴性率比较差异无统计学意义(P>0.05);联合检查与单独超声灵敏度、准确度、假阴性率比较差异有统计学意义(P<0.05);特异度与假阳性率比较差异无统计学意义(P>0.05)。结论超声可以作为甲状腺结节的首选检查方法,其特异性高,但灵敏度低。^(99m)TcO4-SPECT/CT甲状腺显像在提供功能和代谢信息的同时,能提供解剖信息;而血清TSH水平则可为甲状腺结节的良恶性鉴别提供重要的参考依据,尤其对于核素冷结节且超声实性结节的患者,更应参考其TSH水平,将三者结合起来判断甲状腺结节的性质,为临床提供恰当的治疗方案,这具有重要意义。 展开更多
关键词 ^(99m)TcO4-SPECT/CT甲状腺核素显像 超声 血清促甲状腺激素 甲状腺结节
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不同剂量TSH抑制疗法对围绝经期甲状腺癌术后患者骨密度及血清Tg、MIP-1α水平的影响
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作者 林庆军 杜丽 +2 位作者 林燕晖 林燕纯 陈业晞 《中国现代医药杂志》 2024年第1期17-21,共5页
目的探究不同剂量促甲状腺激素(Thyroid stimulating hormone,TSH)抑制疗法对围绝经期甲状腺癌术后患者骨密度及血清甲状腺球蛋白(Thyroglobulin,Tg)、巨噬细胞炎性蛋白-1α(Macrophage inflammatory protein-1 alpha,MIP-1α)水平的影... 目的探究不同剂量促甲状腺激素(Thyroid stimulating hormone,TSH)抑制疗法对围绝经期甲状腺癌术后患者骨密度及血清甲状腺球蛋白(Thyroglobulin,Tg)、巨噬细胞炎性蛋白-1α(Macrophage inflammatory protein-1 alpha,MIP-1α)水平的影响。方法回顾性选取2021年9月~2023年7月在我院接受治疗的110例围绝经期甲状腺癌术后患者为研究对象。根据不同的TSH治疗剂量将患者分为高剂量组和低剂量组,每组55例。治疗后观察评估两组治疗疗效;比较两组患者的游离三碘甲状腺原氨酸(Free triiodothyronine,FT3)、游离甲状腺素(Free thyroxine,FT4)、TSH、Tg、癌胚抗原(Carcinoembryonic antigen,CEA)、MIP-1α、钙、磷及骨密度水平。结果高剂量组临床总有效率为87.27%,显著高于低剂量组的70.91%(P<0.05);治疗后,两组TSH水平明显下降,且高剂量组显著低于低剂量组(P<0.05),FT3及FT4水平均上升,且高剂量组高于低剂量组(P<0.05);血清Tg、CEA及MIP-1α水平明显降低,且高剂量组低于低剂量组(P<0.05);治疗后钙、磷及骨密度各指标水平差异无统计学意义(P>0.05)。结论高剂量的TSH抑制疗法相比低剂量的疗效更好,能更有效地抑制患者TSH的分泌,间接降低血清Tg和MIP-1α水平,且两种疗法均对患者的骨代谢不产生明显影响。 展开更多
关键词 tsh抑制疗法 围绝经期 甲状腺癌 骨密度 血清甲状腺球蛋白 巨噬细胞炎性蛋白-1Α
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亚临床甲状腺功能减退症患者血脂和Hcy水平及其与TSH的关系分析
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作者 马望雯 赵燕萍 李文亚 《河北医学》 CAS 2024年第7期1130-1134,共5页
目的:分析亚临床甲状腺功能减退症患者血脂和Hcy水平及其与TSH的关系。方法:择取2020年3月至2023年3月于本院收治的亚临床甲减患者119例(亚临床甲减组)。另选取同期于本院体检,健康体检指标各项正常者121例为正常对照组。比较不同人群... 目的:分析亚临床甲状腺功能减退症患者血脂和Hcy水平及其与TSH的关系。方法:择取2020年3月至2023年3月于本院收治的亚临床甲减患者119例(亚临床甲减组)。另选取同期于本院体检,健康体检指标各项正常者121例为正常对照组。比较不同人群血脂代谢、Hcy、TSH水平。比较亚临床甲减组中亚1组、亚2组血脂代谢、Hcy水平。经偏相关系数、多元线性回归分析血脂代谢、Hcy水平与TSH水平的相关性。结果:亚临床甲减组TC、TG、LDL-C、Hcy、TSH水平均高于正常对照组(P<0.05)。亚临床甲减组、对照组HDL-C、FT3、FT4水平比较,差异无统计学意义(P>0.05)。亚2组TC、LDL-C、Hcy水平均高于亚1组(P<0.05)。亚2组、亚1组TG、HDL-C、FT3、FT4水平比较,差异无统计学意义(P>0.05)。校正性别、年龄、BMI、吸烟史、FPG及TSH因素,结果得知TSH是TC、TG、LDL-C、Hcy水平异常的危险因素,而TSH与HDL-C线性回归关系无统计学意义(P>0.05)。结论:亚临床甲减患者的血脂代谢和Hcy水平发生一定变化,且会受到TSH的影响,故应加强亚临床甲减患者的血脂代谢和Hcy水平监测,为临床医生提供了新的视角来评估和管理亚临床甲减患者的心血管风险。 展开更多
关键词 亚临床甲状腺功能减退症 血脂代谢 HCY tsh
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Design and optimization of a greener sinomenine hydrochloride preparation process considering variations among different batches of the medicinal herb 被引量:1
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作者 Dandan Ren Jiale Xie +2 位作者 Tianle Chen Haibin Qu Xingchu Gong 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第7期77-90,共14页
The current methods used to industrially produce sinomenine hydrochloride involve several issues,including high solvent toxicity,long process flow,and low atomic utilization efficiency,and the greenness scores of the ... The current methods used to industrially produce sinomenine hydrochloride involve several issues,including high solvent toxicity,long process flow,and low atomic utilization efficiency,and the greenness scores of the processes are below 65 points.To solve these problems,a new process using anisole as the extractant was proposed.Anisole exhibits high selectivity for sinomenine and can be connected to the subsequent water-washing steps.After alkalization of the medicinal material,heating extraction,water washing,and acidification crystallization were carried out.The process was modeled and optimized.The design space was constructed.The recommended operating ranges for the critical process parameters were 3.0–4.0 h for alkalization time,60.0–80.0℃ for extraction temperature,2.0–3.0(volume ratio)for washing solution amount,and 2.0–2.4 mol·L^(-1) for hydrochloric acid concentration.The new process shows good robustness because different batches of medicinal materials did not greatly impact crystal purity or sinomenine transfer rate.The sinomenine transfer rate was about 20%higher than that of industrial processes.The greenness score increased to 90 points since the novel process proposed in this research solves the problems of long process flow,high solvent toxicity,and poor atomic economy,better aligning with the concept of green chemistry. 展开更多
关键词 Sinomenine hydrochloride Process optimization ANISOLE
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Carbon-doped CuFe_(2)O_(4) with C-O-M channels for enhanced Fenton-like degradation of tetracycline hydrochloride: From construction to mechanism 被引量:1
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作者 Hong Qin Yangzhuo He +9 位作者 Piao Xu Yuan Zhu Han Wang Ziwei Wang Yin Zhao Haijiao Xie Quyang Tian Changlin Wang Ying Zeng Yicheng Li 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第4期732-747,共16页
Carbon-doped copper ferrite(C–CuFe_(2)O_(4))was synthesized by a simple two-step hydrothermal method,which showed enhanced tetracycline hydrochloride(TCH)removal efficiency as compared to the pure CuFe_(2)O_(4) in Fe... Carbon-doped copper ferrite(C–CuFe_(2)O_(4))was synthesized by a simple two-step hydrothermal method,which showed enhanced tetracycline hydrochloride(TCH)removal efficiency as compared to the pure CuFe_(2)O_(4) in Fenton-like reaction.A removal efficiency of 94%was achieved with 0.2 g L^(-1) catalyst and 20 mmol L^(-1) H_(2)O_(2) within 90 min.We demonstrated that 5%C–CuFe_(2)O_(4) catalyst in the presence of H_(2)O_(2) was significantly efficient for TCH degradation under the near-neutral pH(5–9)without buffer.Multiple techniques,including SEM,TEM,XRD,FTIR,Raman,XPS M€ossbauer and so on,were conducted to investigate the structures,morphologies and electronic properties of as-prepared samples.The introduction of carbon can effectively accelerate electron transfer by cooperating with Cu and Fe to activate H_(2)O_(2) to generate·OH and·O_(2)^(-).Particularly,theoretical calculations display that the p,p,d orbital hybridization of C,O,Cu and Fe can form C–O–Cu and C–O–Fe bonds,and the electrons on carbon can transfer to metal Cu and Fe along the C–O–Fe and C–O–Cu channels,thus forming electron-rich reactive centers around Fe and Cu.This work provides lightful reference for the modification of spinel ferrites in Fenton-like application. 展开更多
关键词 Fenton-like reaction CuFe_(2)O_(4) Tetracycline hydrochloride degradation
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超声引导下细针穿刺联合血清TSH水平对不同直径甲状腺结节的诊断效能分析
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作者 周小峰 陈卉品 +2 位作者 李锐 黎坤俭 林艳端 《现代医用影像学》 2024年第6期1145-1147,1151,共4页
目的:分析不同直径甲状腺结节诊断中超声引导下细针穿刺细胞学检查(ultrasound-guided fine needle aspiration cytology,US-FNAC)联合促甲状腺激素(thyroid stimulating hormone,TSH)的诊断效能。方法:分析于我院进行诊断治疗的68例患... 目的:分析不同直径甲状腺结节诊断中超声引导下细针穿刺细胞学检查(ultrasound-guided fine needle aspiration cytology,US-FNAC)联合促甲状腺激素(thyroid stimulating hormone,TSH)的诊断效能。方法:分析于我院进行诊断治疗的68例患者为例,按照结节直径予以分组,均予以US-FNAC诊断和TSH水平检测,以手术后的病理组织检查结果为金标准,评估US-FNAC联合血清TSH水平在良恶性结节鉴别诊断中的应用价值。结果:Bethesda分类等级越高,恶性率越高;TSH水平>5 IU/L、≤5 IU/L的恶性率分别为83.33%、16.13%;联合检测的符合率和敏感性随着结节直径提升而提升,但是组间数据不存在统计学意义。结论:US-FNAC联合TSH水平检测在不同直径甲状腺结节的鉴别诊断中有良好的应用价值,但是对于≥30mm结节敏感性较低,临床需要按照实际情况针对性予以选择。 展开更多
关键词 超声引导下细针穿刺 血清tsh 甲状腺结节 诊断效能 鉴别诊断
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骨化三醇软胶囊联合碳酸钙D_(3)预防分化型甲状腺癌术后TSH抑制治疗患者骨质疏松的效果
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作者 查官金 段飞 +1 位作者 陈羿 江泰峰 《临床合理用药杂志》 2024年第35期113-116,共4页
目的观察骨化三醇软胶囊联合碳酸钙D_(3)预防分化型甲状腺癌术后促甲状腺激素(TSH)抑制治疗患者骨质疏松的效果。方法选取2022年1月—2023年6月于九江市第一人民医院行分化型甲状腺癌术后TSH抑制治疗的患者100例为研究对象,采用随机数... 目的观察骨化三醇软胶囊联合碳酸钙D_(3)预防分化型甲状腺癌术后促甲状腺激素(TSH)抑制治疗患者骨质疏松的效果。方法选取2022年1月—2023年6月于九江市第一人民医院行分化型甲状腺癌术后TSH抑制治疗的患者100例为研究对象,采用随机数字表法分为观察组和对照组各50例。观察组采用骨化三醇软胶囊联合碳酸钙D_(3)治疗,对照组采用碳酸钙D_(3)治疗,2组均治疗12个月。比较2组治疗效果,术前及术后6、12个月骨质相关指标[甲状旁腺激素(PTH)、血清钙、血清磷、碱性磷酸酶(ALP)、血清25-羟维生素D[25-(OH)D]、甲状腺功能[TSH、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))],骨质疏松发生率及不良反应。结果观察组治疗总有效率为98.00%,高于对照组的62.00%(χ2=20.250,P<0.001)。对照组术后6、12个月PTH、血清钙、血清磷、ALP、25-(OH)D水平均降低(P<0.01);观察组术后6、12个月PTH、ALP水平及术后6个月的血清磷、25-(OH)D水平均降低(P<0.01);观察组术后6、12个月PTH、血清钙、血清磷、ALP、25-(OH)D水平均高于对照组(P<0.01)。对照组术后6、12个月TSH水平高于术前,FT_(3)、FT_(4)水平低于术前(P<0.01);观察组术后6个月TSH水平高于术前,FT_(4)水平低于术前(P<0.01);观察组术后6、12个月TSH水平低于对照组,FT_(3)、FT_(4)水平高于对照组(P<0.05或P<0.01)。术后随访12个月,观察组骨质疏松发生率为2.00%,低于对照组的36.00%(χ2=18.778,P<0.001)。观察组与对照组不良反应总发生率比较差异无统计学意义(8.00%vs.2.00%,χ2=1.895,P=0.169)。结论骨化三醇软胶囊联合碳酸钙D_(3)预防分化型甲状腺癌术后TSH抑制治疗患者骨质疏松的效果更佳,能改善骨质相关指标及甲状腺功能,降低骨质疏松发生率,且用药安全性高。 展开更多
关键词 分化型甲状腺癌 tsh抑制治疗 骨化三醇软胶囊 碳酸钙D 3 骨质疏松 预防
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Use of the “Veda-Lab Easy Reader+” for the Determination of T3, T4 and TSH Hormones in the Mountainous Population of Benin: Case of Natitingou
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作者 Pamphile Thierry Houngbo Natacha Aivodji +1 位作者 Rodrigue Akotegnon Alphonse Sezan 《Advances in Bioscience and Biotechnology》 CAS 2024年第1期39-51,共13页
The thyroid, an endocrine gland located at the base of the neck, produces thyroid hormones (triiodothyronine (T3) and thyroxine (T4)). The production of these hormones is possible by iodine and other nutrients such as... The thyroid, an endocrine gland located at the base of the neck, produces thyroid hormones (triiodothyronine (T3) and thyroxine (T4)). The production of these hormones is possible by iodine and other nutrients such as selenium and certain vitamins. To assess the thyroid disturbances in the mountain population of Benin, a survey was conducted in Natitingou, a mountain town located in the department of Atacora, in the northwest of Benin, on a sample of thirty (30) adults (15 men and 15 women), most of whom are educated. The results of the questionnaire revealed that 43% of the surveyed population acknowledged having knowledge on the mentioned subject and have dietary habits based on the consumption of seafood, and also legumes (20%). The examination of the serum results of the dosage of T3, T4 and TSH hormones revealed cases of thyroid disturbances in the region (36.32% in men and 44.98% in women). The analysis of a comparative table including the “VEDALAB Easy Reader+” and five (05) other readers, presents the performance, reading techniques, principles, advantages and disadvantages of each device. Pending further studies, some recommendations were made at the end of this study to the academic authorities regarding probable cases of dysthyroidism for which additional examinations are required and an awareness for the improvement of dietary habits. 展开更多
关键词 Thyroid tsh T3 T4 “VEDALAB Easy Reader+”
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Benzydamine hydrochloride ameliorates ethanol-induced inflammation in RAW 264.7 macrophages by stabilizing redox homeostasis
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作者 Tiasha Dasgupta Venkatraman Manickam 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2024年第2期73-81,I0006-I0009,共13页
Objective:To evaluate the protective effect of benzydamine hydrochloride against ethanol-induced oxidative stress and inflammation in RAW 264.7 macrophages.Methods:RAW 264.7 macrophages were treated with ethanol(100 m... Objective:To evaluate the protective effect of benzydamine hydrochloride against ethanol-induced oxidative stress and inflammation in RAW 264.7 macrophages.Methods:RAW 264.7 macrophages were treated with ethanol(100 mM)and benzydamine hydrochloride(7.5μM).The imflammatory status was confirmed by measuring pro-(TNF-αand IL-6)and anti-inflammatory(IL-10)cytokines through ELISA and RT-PCR assays.Reactive oxygen species generation and mitochondrial membrane potential were investigated to study the protective role of benzydamine hydrochloride against ethanol-induced oxidative stress.Apoptosis detection was also investigated using flow cytometry and acridine orange/ethidium bromide staining.Results:Benzydamine hydrochloride significantly decreased the secretion of TNF-αand IL-6,as well as the generation of reactive oxygen species inside the cells,thereby stabilizing the mitochondrial membrane potential and reducing DNA fragmentation.The ethanol-induced cellular necrosis was also reversed by the administration of benzydamine hydrochloride.Conclusions:Benzydamine hydrochloride ameliorates ethanol-induced cell apoptosis and inflammation in RAW macrophages. 展开更多
关键词 ALCOHOL Benzydamine hydrochloride INFLAMMATION Oxidative stress Apoptosis
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Degradation of ciprofloxacin hydrochloride in a multiphase mixed system by subaquatic gas-liquid discharge plasma
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作者 Mengyu WANG Jianping LIANG +5 位作者 Ke LU Zikai ZHOU Qinghua LIU Hao YUAN Wenchun WANG Dezheng YANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第11期144-151,共8页
In recent years, antibiotic pollution has become a serious threat to human health. In this study, a gas-liquid discharge plasma is developed to degrade ciprofloxacin hydrochloride in a multiphase mixed system containi... In recent years, antibiotic pollution has become a serious threat to human health. In this study, a gas-liquid discharge plasma is developed to degrade ciprofloxacin hydrochloride in a multiphase mixed system containing inorganic and organic impurities. The discharge characteristics are analyzed by diagnosing the applied voltage and discharge current waveforms, as well as the optical emission spectra. The work investigates how degradation efficiency is affected by applied voltage, gas flow rate, treatment time, initial concentration as well as the addition of γ-Al_(2)O_(3) pellets and peanut straw. After 70 min, the degradation efficiency of ciprofloxacin hydrochloride in the multiphase mixed system reached 99.6%. Its removal efficiency increases as the initial concentration decreases and the applied voltage increases. Besides, there is still a good degradation efficiency of ciprofloxacin hydrochloride with the addition of peanut straw.The degradation mechanism of ciprofloxacin hydrochloride is investigated through the analysis of degraded intermediates and reactive species. 展开更多
关键词 antibiotic gas-liquid discharge multiphase mixed system ciprofloxacin hydrochloride degradation
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Method Verification and Validation of Hydralazine Hydrochloride: Spectrophotometric Analysis in Pure and Pharmaceutical Formulations
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作者 Laila Abdullah Alshatti 《American Journal of Analytical Chemistry》 CAS 2024年第7期219-228,共10页
The new method proposed is based on the formation of hydralazine-Bromophenol blue ion pair simply and without further extraction or heating. The ion pair was prepared in the presence of pH 3 citrate buffer forming a y... The new method proposed is based on the formation of hydralazine-Bromophenol blue ion pair simply and without further extraction or heating. The ion pair was prepared in the presence of pH 3 citrate buffer forming a yellow-colored chromogen. A new maximum UV-visible band formed at 416 nm. The color was stable for more than 10 hours and obeyed Beer’s Law over the concentration range of 10 - 50 µg/mL. The calculated molar absorptivity and Sandell’s sensitivity were 1.01 × 104 L∙mol−1∙cm−1 and 0.0514 µg/mL, respectively. The elements of method validation stipulated by The International Conference on Harmonization [Q2 (R1)] were applied for hydralazine hydrochloride assay in pure and pharmaceutical tablet formulation. The average recoveries of the pure solution and the pharmaceutical formulation were 98.94% and 99.50%, respectively. The results were statistically compared by F-test, which indicates that the method can be precise and repeatable for both pure and pharmaceutical solutions. The method was found to be accurate, reproducible, and cost-effective, and validated for the assay of hydralazine in terms of the routine quality control. 展开更多
关键词 SPECTROPHOTOMETRY Validation Hydralazine hydrochloride International Conference on Harmonization Q2 (R1)
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Clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride on mild-to-moderate depression
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作者 Yi Wang Qun Lu +5 位作者 Ittipalanukul Penpat Juan Wu Dilinuer Abulikemu Fei-Cui Zeng Jia-Ying Huang Zhi-Hai Hu 《World Journal of Psychiatry》 SCIE 2024年第6期848-856,共9页
BACKGROUND Depression is a common,chronic,and recurrent mood disorder that has become a worldwide health hazard.Fluoxetine hydrochloride,a common treatment method,can inhibit 5-hydroxytryptamine(5-HT)recycling in the ... BACKGROUND Depression is a common,chronic,and recurrent mood disorder that has become a worldwide health hazard.Fluoxetine hydrochloride,a common treatment method,can inhibit 5-hydroxytryptamine(5-HT)recycling in the presynaptic membrane;however,the efficacy of a single drug is inadequate.At present,mildto-moderate depression can be treated with acupuncture of ghost caves,but the clinical curative effect of combined therapy with fluoxetine hydrochloride has not been sufficiently reported.AIM To evaluate the clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride in the treatment of mild-to-moderate depression.METHODS This retrospective study included 160 patients with mild-to-moderate depression who were admitted to Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Affiliated to Shanghai University of Traditional Chinese Medicine,between January 2022 and June 2023.Patients were separated into a single-agent group(fluoxetine hydrochloride treatment,n=80)and a coalition group(fluoxetine hydrochloride treatment combined with acupuncture at ghost points,n=80).Pre-treatment symptoms were recorded,and the clinical curative effect and adverse reactions[Asberg Antidepressant Side Effects Scale(SERS)]were assessed.Depression before and after treatment[Hamilton Depression Scale(HAMD)-24],neurotransmitter levels[5-HT,norepinephrine(NE),dopamine(DA)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were compared.RESULTS The total efficacy rate was 97.50%in the coalition group and 86.25%in the single-agent group(P<0.05).After 2,4,6,and 8 wk of treatment,the HAMD,self-rating depression scale,and SERS scores of the coalition and single-agent groups decreased compared with pre-treatment,and the decrease was more significant in the coalition group(P<0.05).After 8 wk of treatment,the levels of NE,DA,5-HT,and SOD in the coalition and single-agent groups increased,while the levels of MDA decreased;the increases and decrease in the coalition group were more significant(P<0.05).The PSQI scores of the coalition and single-agent groups decreased,and the decrease was more significant in the coalition group(P<0.05).CONCLUSION Acupuncture at ghost points combined with paroxetine tablets can safely improve depressive symptoms and sleep disorders,regulate neurotransmitter levels,and reduce stress responses in patients with mild-to-moderate depression. 展开更多
关键词 DEPRESSION PRICK Fluoxetine hydrochloride Curative effect Depressive symptoms Oxidative stress index
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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation
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作者 Yafan Bai Hui Ma +5 位作者 Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li 《Neural Regeneration Research》 SCIE CAS 2025年第8期2325-2336,共12页
Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0... Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain injury.Behavioral experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain edema.Next,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 cells.Finally,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain edema.Furthermore,YL-0919 effectively combated oxidative stress both in vivo and in vitro.The protective effects of YL-0919 were partially inhibited by BD-1047.These results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist BD-1047.YL-0919 may have potential as a new treatment for traumatic brain injury. 展开更多
关键词 antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury
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Analysis of the Efficacy of Atomoxetine Hydrochloride Combined with Psycho-Behavioral Modification Therapy in the Treatment of ADHD in Children
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作者 Nan Li 《Journal of Clinical and Nursing Research》 2024年第4期137-142,共6页
Objective: To evaluate the therapeutic efficacy of atomoxetine hydrochloride (ATX) combined with psychological-behavioral modification therapy for attention-deficit/hyperactivity disorder (ADHD) in children. Methods: ... Objective: To evaluate the therapeutic efficacy of atomoxetine hydrochloride (ATX) combined with psychological-behavioral modification therapy for attention-deficit/hyperactivity disorder (ADHD) in children. Methods: A total of 60 cases of ADHD children admitted to our hospital between November 2021 and November 2022 were selected and randomly grouped into Group I and Group II. There were 30 cases in Group I who were treated with ATX combined with psychological-behavioral modification therapy. There were 30 cases in Group II who were treated with ATX monotherapy, and the therapeutic effects were compared. Results: Before treatment, there was no difference in the behavioral problem scores and cognitive function indexes of the two groups (P>0.05). After treatment, the behavioral problem scores of Group I were lower than those of Group II, and the cognitive function indicators of Group I were lower than those of Group II (P < 0.05). The adverse reaction rate of Group I was lower than that of Group II, and the total effective rate was higher than that of Group II (P < 0.05). Conclusion: ATX combined with psychological-behavioral modification therapy improved the behavioral problems of ADHD children, enhanced their cognitive function, and reduced the adverse reactions to drug treatment. 展开更多
关键词 Atomoxetine hydrochloride Psycho-behavioral modification therapy ADHD in children
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Role of TSH Inhibition Therapy in the Postoperative Management of Patients with Differentiated Thyroid Cancer
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作者 Xudong Gao Bo Zhao +1 位作者 Ya Su Shenglin He 《Proceedings of Anticancer Research》 2024年第2期20-23,共4页
Objective:To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer.Methods:Seventy patients diagnosed with differentiated thyroid cancer were s... Objective:To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer.Methods:Seventy patients diagnosed with differentiated thyroid cancer were selected for the study.TSH inhibition therapy was administered to the research group,while thyroxine replacement therapy was provided to the control group during the postoperative management phase.This allowed for a comparative analysis between the two groups.Results:In comparison with the control group,the research group exhibited significant decreases in serum TSH,T3,and T4 levels after treatment,while FT4 and FT3 levels significantly increased(P<0.05).Additionally,significant decreases in Tg,VEGF,TSGF,CD44V6,and sIL-2R levels were observed in the research group after treatment(P<0.05).No significant differences were found in pre-treatment thyroid function between the two groups(P>0.05).Conclusion:The application of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer demonstrates promising outcomes. 展开更多
关键词 tsh inhibition therapy Differentiated thyroid cancer Postoperative management EFFECT
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0~3岁儿童血清FT3、FT4、TSH间接参考区间分析
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作者 罗海琦 李燕华 刘玉华 《中文科技期刊数据库(文摘版)医药卫生》 2024年第11期0233-0236,共4页
分析儿童(0-3岁)血清FT3、FT4、TSH间接参考区间,为儿童甲状腺功能评估提供支持。方法 选取2022年10月至2023年10月接诊的300例0-3岁儿童血液标本展开分析,在研究中,根据儿童年龄分组,甲组1d-1个月,乙组2个月-12个月,丙组1岁-3岁。在血... 分析儿童(0-3岁)血清FT3、FT4、TSH间接参考区间,为儿童甲状腺功能评估提供支持。方法 选取2022年10月至2023年10月接诊的300例0-3岁儿童血液标本展开分析,在研究中,根据儿童年龄分组,甲组1d-1个月,乙组2个月-12个月,丙组1岁-3岁。在血清标本获取后,检测FT3(游离三碘甲状腺原氨酸)、FT4(游离甲状腺素)、TSH(促甲状腺素激素),并获取指标的区间值。结果 在本研究中,所有儿童FT3、FT4、TSH精密度较高,满足实验室检测要求。基于儿童血清样本检测后的数据,建立0-3岁不同年龄段的儿童血清FT3、FT4、TSH间接参考区间。结论 根据不同年龄的血清FT3、FT4、TSH水平,可建立间接参考区间,为诊断儿童甲状腺疾病提供支持。 展开更多
关键词 儿童 血清FT3 FT4 tsh 间接参考区间
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Clinical Study on the Treatment of Senile Alzheimer’s Dementia with Sodium Oligomannate Combined with Memantine Hydrochloride
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作者 Jian Zhao Xi Li +1 位作者 Xuelian Jia Ganke Gao 《Journal of Clinical and Nursing Research》 2024年第10期208-217,共10页
Objective:To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia.Methods:Sixty-eight cases of Alzheimer’s dementia treated at the... Objective:To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia.Methods:Sixty-eight cases of Alzheimer’s dementia treated at the Second People’s Hospital of Fujian University of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the study subjects.The patients were divided into two groups based on different treatment methods:the control group(treated with memantine hydrochloride,34 cases)and the treatment group(treated with sodium oligomannate+memantine hydrochloride,34 cases).Cognitive function,activities of daily living,neurotransmitters,serum intestinal flora metabolic markers,inflammatory factors,neurotrophic factors,and adverse reactions were compared between the two groups.Results:The treatment group showed better cognitive function,quality of life scores,and levels of relevant metabolic markers in the body compared to the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions between the two groups(treatment group:2%;control group:4%)was not statistically significant(χ^(2)=0.731,P=0.393).Conclusion:Sodium oligomannate combined with memantine hydrochloride has better efficacy than the control group for treating senile Alzheimer’s dementia.It significantly improves and restores cognitive function and daily living abilities,benefits neurotransmitter secretion and internal regulation,upregulates the expression of neurotrophic factors,and has fewer adverse reactions,making it a treatment worthy of further clinical promotion and application. 展开更多
关键词 Senile Alzheimer’s dementia Sodium oligomannate Memantine hydrochloride Cognitive function TREATMENT
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Effect of TSH Suppression Therapy on Sex Hormone Levels after Thyroid Cancer Surgery
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作者 Shenglin He Ya Su +1 位作者 Bo Zhao Xudong Gao 《Proceedings of Anticancer Research》 2024年第1期82-85,共4页
Objective:To analyze the effect of thyroid-stimulating hormone(TSH)suppression therapy on sex hormone levels in patients undergoing postoperative treatment for thyroid cancer.Methods:A total of 40 patients undergoing ... Objective:To analyze the effect of thyroid-stimulating hormone(TSH)suppression therapy on sex hormone levels in patients undergoing postoperative treatment for thyroid cancer.Methods:A total of 40 patients undergoing postoperative thyroid cancer treatment were selected for data analysis.TSH suppression therapy was implemented during the postoperative period.Patients were grouped according to the TSH level:TSH<0.1,0.1≤TSH<0.5,and TSH≥0.5.Results:Among male patients,there were no significant differences in sex hormone levels at different dosing times and TSH levels(P>0.05).For female patients,testosterone levels at different dosing times showed no significant differences under the same circumstances(P>0.05).The comparison of testosterone levels at different TSH levels over 5 years of TSH suppression therapy did not yield significant differences(P>0.05).However,the comparison of testosterone levels within 5 years of TSH suppression therapy yielded significant differences(P<0.05),with the lowest levels observed at 0.1≤TSH<0.5.Conclusion:The use of TSH suppression therapy in postoperative thyroid cancer treatment minimally affects sex hormone levels in male patients.However,it has a significant impact on female patients.Therefore,preoperative sex hormone testing is recommended,and postoperative monitoring should include regular sex hormone testing. 展开更多
关键词 Thyroid cancer Postoperative tsh suppression therapy Sex hormone levels
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亚临床甲状腺功能减退症患者TSH与肾上腺皮质功能的关系 被引量:2
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作者 江帆 刘宁 +4 位作者 翟鑫 管频 冯光球 陈娟 曾敏 《中南医学科学杂志》 CAS 2023年第1期90-92,共3页
目的 分析亚临床甲状腺功能减退症患者促甲状腺激素(TSH)与肾上腺皮质功能的关系。方法 选取150例亚临床甲状腺功能减退症患者为研究组,甲状腺功能正常的健康人群150例为对照组。比较两组TSH、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(F... 目的 分析亚临床甲状腺功能减退症患者促甲状腺激素(TSH)与肾上腺皮质功能的关系。方法 选取150例亚临床甲状腺功能减退症患者为研究组,甲状腺功能正常的健康人群150例为对照组。比较两组TSH、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、皮质醇(CORT)和促肾上腺皮质激素(ACTH)水平。采用Pearson法分析亚临床甲状腺功能减退症患者TSH水平与ACTH、CORT水平的相关性。结果 与对照组比较,研究组患者TSH、ACTH水平升高,CORT水平降低(P<0.05)。Pearson分析结果显示,亚临床甲状腺功能减退症患者TSH水平与ACTH水平呈正相关(P<0.05),与CORT水平呈负相关(P<0.05)。结论 亚临床甲状腺功能减退症患者血清TSH水平与肾上腺皮质功能指标ACTH、CORT水平存在相关性。 展开更多
关键词 亚临床甲状腺功能减退症 肾上腺皮质功能 促甲状腺激素 促肾上腺皮质激素 皮质醇
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超声造影参数联合血清TSH对微小甲状腺结节性质的鉴别效能分析 被引量:3
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作者 程海燕 董刚 《罕少疾病杂志》 2023年第9期38-40,共3页
目的 观察超声造影参数联合血清TSH对微小甲状腺结节性质的鉴别效能。方法 将2019年1月至2019年10月在我院进行住院治疗的94例微小甲状腺结节病例作为研究对象,所有病例均行超声甲状腺结节造影及血清TSH检测,获取超声造影参数(RT、MTT、... 目的 观察超声造影参数联合血清TSH对微小甲状腺结节性质的鉴别效能。方法 将2019年1月至2019年10月在我院进行住院治疗的94例微小甲状腺结节病例作为研究对象,所有病例均行超声甲状腺结节造影及血清TSH检测,获取超声造影参数(RT、MTT、TPH、WIS、TTP、PI、AUC)。全部患者在术中取病理组织并进行病理检查,并将检查结果作为“金标准”,同时对比超声造影联合血清TSH与病理检查结果的良恶性诊断符合率,同时进行超声造影参数联合血清TSH的结节良恶性诊断价值的ROC曲线分析。结果 手术后取病理组织显示,全部94例患者中,共有164个微小甲状腺结节中,其中良性结节有63例共108个结节,恶性结节中有31例共58个。良恶性微小甲状腺结节与血清TSH比较发现,比较差异无统计学意义。良、恶性微小甲状腺结节病例在RT、MTT、TPH、WIS、TTP上比较差异无差异性(P>0.05);恶性微小甲状腺结节病例的PI、AUC高于恶性微小甲状腺结节病例(P<0.05)。超声参数(PI、AUC)联合TSH鉴别诊断符合率(98.79%)高于超声参数PI联合TSH鉴别诊断(87.80%)、超声参数AUC联合TSH鉴别诊断(90.25%)(χ^(2)=13.129,P=0.001<0.05)。超声参数中Pl、AUC两项与血清TSH联合检测诊断的准确率、敏感性、特异性均相较于超声参数PI联合TSH较高(69.43%、72.48%、76.81%)、超声参数AUC联合TSH鉴别诊断(73.18%、85.63%、78.09%)(P<0.05)。结论 血清TSH有助于微小甲状腺结节鉴别,但超声造影参数(PI、AUC)联合血清TSH在微小甲状腺结节性质鉴别诊断中更具应用价值。 展开更多
关键词 超声造影 甲状腺结节 性质鉴别 tsh
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