Neuroinflammation has been recognized to play a critical role in the pathogenesis of Alzheimer's disease (AD), which is pathologically characterized by the accumulation of senile plaques containing activated microg...Neuroinflammation has been recognized to play a critical role in the pathogenesis of Alzheimer's disease (AD), which is pathologically characterized by the accumulation of senile plaques containing activated microglia and amyloid β-peptides (Aβ). In the present study, we examined the neuroprotective effects of hydrogen sulfide (H2S) on neuroinflammation in rats with Aβ1-40 hippocampal injection. We found that Aβ-induced rats exhibited a disorder of pyramidal cell layer arrangement, and a decrease of mean pyramidal cell number in the CA1 hippocampal region compared with those in sham operated rats. NaHS (a donor of H2S, 5.6 mg/kg/d, i.p.) treatment for 3 weeks rescued neuronal cell death significantly. Moreover, we found that H2S dramatically suppressed the release of TNF-α, IL-1β and IL-6 in the hippocampus. Consistently, both immunohistochemistry and Western blotting assays showed that H2S inhibited the upregulation of COX-2 and the activation of NF-κB in the hippocampus. In conclusion, our data indicate that H2S suppresses neuroinflammation via inhibition of the NF-κB activation pathway in the Aβ-induced rat model and has potential value for AD therapy.展开更多
Objective To establish the mitral regurgitation swine model and study the change of hydrogen sulfide(H2S)system in chronic heart failure model.Methods Miniature pigs were randomly divided into two groups,the control g...Objective To establish the mitral regurgitation swine model and study the change of hydrogen sulfide(H2S)system in chronic heart failure model.Methods Miniature pigs were randomly divided into two groups,the control group(n=6)and mitral regurgitation group(n=6).Chronic heart failure models were established by pulling mitral chordal through a small incision extracorporeal.展开更多
With the aid of hydrogen permeating devices, the hydrogen permeation behaviors of X52 pipeline steel in NACE A solution with saturated H2S/CO2 were studied under the conditions of different ambient temperatures and pH...With the aid of hydrogen permeating devices, the hydrogen permeation behaviors of X52 pipeline steel in NACE A solution with saturated H2S/CO2 were studied under the conditions of different ambient temperatures and pH values, and the hydrogen permeation behaviors of X52 pipeline steel in weld seam zone were comparatively studied. The experimental results show that the hydrogen permeation coefficient value is directly proportional to the time required for reaching the saturation anode current and inversely proportional to the saturation anode current, and the hydrogen permeation coefficient is influenced by the corrosion scales; the temperature is directly proportional to the saturation anode current, and the hydrogen permeation coefficient is influenced by the temperature and corrosion scales, heat-affected zone and matrix zone in NACE A solution with saturated H2S/CO2 at normal temperature. The hydrogen permeation coefficient in weld seam zone is larger than that in heat-affected zone which is further larger than that in matrix zone.展开更多
A new intelligent amperometric type of electrochemical hydrogen probe to measure hydrogen atom permeation rate in the metals was devised and developed. Combined with MCS51 single slice computer system, specially progr...A new intelligent amperometric type of electrochemical hydrogen probe to measure hydrogen atom permeation rate in the metals was devised and developed. Combined with MCS51 single slice computer system, specially programmed software was designed for data sampling, logging, storing, processing, result judgment and data output controlling. The probe is portable and can be used in both lab and in site automatically.展开更多
为保障工作人员在硫化氢(H_(2)S)泄漏工况下的生命安全,以东南部海域某高含硫油田开发工程为例,结合国内第一艘圆筒形浮式生产储油卸油装置(Floating Production Storage and Offloading,FPSO)的结构特点,设计一种适用于高含H_(2)S油气...为保障工作人员在硫化氢(H_(2)S)泄漏工况下的生命安全,以东南部海域某高含硫油田开发工程为例,结合国内第一艘圆筒形浮式生产储油卸油装置(Floating Production Storage and Offloading,FPSO)的结构特点,设计一种适用于高含H_(2)S油气田的FPSO应急空气呼吸系统。研究表明:该空气呼吸系统安全可靠、占地面积小、使用方便。研究成果可为H_(2)S防护设计提供一定参考。展开更多
Thermochemical sulfate reduction (TSR) in geological deposits can account for the accumulation of H2S in deep sour gas reservoirs. In this paper, thermal simulation experiments on the reaction of CH4-CaSO4 were carri...Thermochemical sulfate reduction (TSR) in geological deposits can account for the accumulation of H2S in deep sour gas reservoirs. In this paper, thermal simulation experiments on the reaction of CH4-CaSO4 were carried out using an autoclave at high temperatures and high pressures. The products were characterized with analytical methods including carbon isotope analysis. It is found that the reaction can proceed to produce H2S, H2O and CaCO3 as the main products. Based on the experimental results, the carbon kinetic isotope fractionation was investigated, and the value of Ki (kinetic isotope effect) was calculated. The results obtained in this paper can provide useful information to explain the occurrence of H2S in deep carbonate gas reservoirs.展开更多
基金supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.Jx10131801095 to HongZhou)
文摘Neuroinflammation has been recognized to play a critical role in the pathogenesis of Alzheimer's disease (AD), which is pathologically characterized by the accumulation of senile plaques containing activated microglia and amyloid β-peptides (Aβ). In the present study, we examined the neuroprotective effects of hydrogen sulfide (H2S) on neuroinflammation in rats with Aβ1-40 hippocampal injection. We found that Aβ-induced rats exhibited a disorder of pyramidal cell layer arrangement, and a decrease of mean pyramidal cell number in the CA1 hippocampal region compared with those in sham operated rats. NaHS (a donor of H2S, 5.6 mg/kg/d, i.p.) treatment for 3 weeks rescued neuronal cell death significantly. Moreover, we found that H2S dramatically suppressed the release of TNF-α, IL-1β and IL-6 in the hippocampus. Consistently, both immunohistochemistry and Western blotting assays showed that H2S inhibited the upregulation of COX-2 and the activation of NF-κB in the hippocampus. In conclusion, our data indicate that H2S suppresses neuroinflammation via inhibition of the NF-κB activation pathway in the Aβ-induced rat model and has potential value for AD therapy.
基金supported by the Natural Science Foundation of Shandong China (No.2009ZRA05107)the Plan of Innovation Team of Ministry of Education China (No.IRT0759)
文摘Objective To establish the mitral regurgitation swine model and study the change of hydrogen sulfide(H2S)system in chronic heart failure model.Methods Miniature pigs were randomly divided into two groups,the control group(n=6)and mitral regurgitation group(n=6).Chronic heart failure models were established by pulling mitral chordal through a small incision extracorporeal.
基金Funded by the Program for National Science Foundation for Distinguished Young Scholars (No.51125019)the National Natural Science Foundation of China (No.50904050)+2 种基金the Basic Projects of Sichuan Province of China(No.2011JY0106)Postdoctoral Science Foundation(No.20110490810)the Special Fund of China's Central Government for the Development of Local Colleges and Universities-the Project of National First-level Discipline in Oil and Gas Engineering
文摘With the aid of hydrogen permeating devices, the hydrogen permeation behaviors of X52 pipeline steel in NACE A solution with saturated H2S/CO2 were studied under the conditions of different ambient temperatures and pH values, and the hydrogen permeation behaviors of X52 pipeline steel in weld seam zone were comparatively studied. The experimental results show that the hydrogen permeation coefficient value is directly proportional to the time required for reaching the saturation anode current and inversely proportional to the saturation anode current, and the hydrogen permeation coefficient is influenced by the corrosion scales; the temperature is directly proportional to the saturation anode current, and the hydrogen permeation coefficient is influenced by the temperature and corrosion scales, heat-affected zone and matrix zone in NACE A solution with saturated H2S/CO2 at normal temperature. The hydrogen permeation coefficient in weld seam zone is larger than that in heat-affected zone which is further larger than that in matrix zone.
文摘A new intelligent amperometric type of electrochemical hydrogen probe to measure hydrogen atom permeation rate in the metals was devised and developed. Combined with MCS51 single slice computer system, specially programmed software was designed for data sampling, logging, storing, processing, result judgment and data output controlling. The probe is portable and can be used in both lab and in site automatically.
文摘为保障工作人员在硫化氢(H_(2)S)泄漏工况下的生命安全,以东南部海域某高含硫油田开发工程为例,结合国内第一艘圆筒形浮式生产储油卸油装置(Floating Production Storage and Offloading,FPSO)的结构特点,设计一种适用于高含H_(2)S油气田的FPSO应急空气呼吸系统。研究表明:该空气呼吸系统安全可靠、占地面积小、使用方便。研究成果可为H_(2)S防护设计提供一定参考。
文摘Thermochemical sulfate reduction (TSR) in geological deposits can account for the accumulation of H2S in deep sour gas reservoirs. In this paper, thermal simulation experiments on the reaction of CH4-CaSO4 were carried out using an autoclave at high temperatures and high pressures. The products were characterized with analytical methods including carbon isotope analysis. It is found that the reaction can proceed to produce H2S, H2O and CaCO3 as the main products. Based on the experimental results, the carbon kinetic isotope fractionation was investigated, and the value of Ki (kinetic isotope effect) was calculated. The results obtained in this paper can provide useful information to explain the occurrence of H2S in deep carbonate gas reservoirs.