To develop synthesized coralline hydroxyl apatite (CHA) bone graftsubstitute and measure its physical and chemical characteristics. Methods: The CHA bone graft substitute was synthesized from natural mineral―corallin...To develop synthesized coralline hydroxyl apatite (CHA) bone graftsubstitute and measure its physical and chemical characteristics. Methods: The CHA bone graft substitute was synthesized from natural mineral―coralline through hydrothermal exchange process. This process was designed and developed independently by the authors. Its physical and chemical characteristics have been determined and studied using various techniques including Scanning Electron Microscopy (SEM), electron microscope image processing, scanning electron microscope energy spectrography; chemical analysis, ICP-AES, X-ray diffraction, etc. Clinical trials have been conducted. Results: Independently developed CHA bone graft-substitute is white in color; its porosity is 25.87%–53.58%, which is approximate to that of human bones and original coral. It is larger than 3–4 in hardness by Mohs hardness scale and the compressive strength ranges from 4.87 to 12.31 MPa. The chemical compositions of the CHA are 53.13%–64.09% CaO and 35.52%–46.48% P2O5. CaO/P2O5 is 1.143–1.804. ICP-AES analysis detected twenty-four trace elements including Pb, Co, Ni, Ba, Mn, Cr, Th, V, Cu, Ti, K, Mo, Zn, Mg, Nb, Be, Sc, Al, Sr, Na, Li, etc. Ca, P, K, Na, Al and Sr are relatively high while the rest are less than n–n×10-6, which is acceptable by human body. The REE level in the CHA bone measured by ICP-MS is 1.433×10-9–2.212×10-9, which is within the acceptable range for human beings. Conclusions: The process of synthesized CHA bone graft-substitute is an innovated independently developed method and concept. Its color, porosity and chemical composition are similar to those of human bones; therefore it has very good biocompatibility and excellent conductivity. Sixty clinical cases have proved that CHA bone graft-substitute has a strong bone-forming ability, no toxicity, no side effect, and better sacralization. It is a fine substitute for bone transplantation.展开更多
淀粉基(starch-based)材料是一类重要的生物降解聚合物,羟基磷灰石(HA)是人体骨骼的主要成分,以淀粉基材料为基体、以 HA 为增强材料的 HA/淀粉基复合材料是一类新型的复合生物材料,其具有良好的生物相容性,在骨修复领域具有巨大的应用...淀粉基(starch-based)材料是一类重要的生物降解聚合物,羟基磷灰石(HA)是人体骨骼的主要成分,以淀粉基材料为基体、以 HA 为增强材料的 HA/淀粉基复合材料是一类新型的复合生物材料,其具有良好的生物相容性,在骨修复领域具有巨大的应用潜力。初步对该复合材料进行了归类,并介绍了其制备工艺、性能和应用等方面的研究近况,指出改进复合工艺、采用纳米级 HA 增强并进行表面改性是其发展趋势。展开更多
基金supportedby the funds from both Science-Technology Department of Guangdong and Science-Technology Department of Guangzhou
文摘To develop synthesized coralline hydroxyl apatite (CHA) bone graftsubstitute and measure its physical and chemical characteristics. Methods: The CHA bone graft substitute was synthesized from natural mineral―coralline through hydrothermal exchange process. This process was designed and developed independently by the authors. Its physical and chemical characteristics have been determined and studied using various techniques including Scanning Electron Microscopy (SEM), electron microscope image processing, scanning electron microscope energy spectrography; chemical analysis, ICP-AES, X-ray diffraction, etc. Clinical trials have been conducted. Results: Independently developed CHA bone graft-substitute is white in color; its porosity is 25.87%–53.58%, which is approximate to that of human bones and original coral. It is larger than 3–4 in hardness by Mohs hardness scale and the compressive strength ranges from 4.87 to 12.31 MPa. The chemical compositions of the CHA are 53.13%–64.09% CaO and 35.52%–46.48% P2O5. CaO/P2O5 is 1.143–1.804. ICP-AES analysis detected twenty-four trace elements including Pb, Co, Ni, Ba, Mn, Cr, Th, V, Cu, Ti, K, Mo, Zn, Mg, Nb, Be, Sc, Al, Sr, Na, Li, etc. Ca, P, K, Na, Al and Sr are relatively high while the rest are less than n–n×10-6, which is acceptable by human body. The REE level in the CHA bone measured by ICP-MS is 1.433×10-9–2.212×10-9, which is within the acceptable range for human beings. Conclusions: The process of synthesized CHA bone graft-substitute is an innovated independently developed method and concept. Its color, porosity and chemical composition are similar to those of human bones; therefore it has very good biocompatibility and excellent conductivity. Sixty clinical cases have proved that CHA bone graft-substitute has a strong bone-forming ability, no toxicity, no side effect, and better sacralization. It is a fine substitute for bone transplantation.
文摘淀粉基(starch-based)材料是一类重要的生物降解聚合物,羟基磷灰石(HA)是人体骨骼的主要成分,以淀粉基材料为基体、以 HA 为增强材料的 HA/淀粉基复合材料是一类新型的复合生物材料,其具有良好的生物相容性,在骨修复领域具有巨大的应用潜力。初步对该复合材料进行了归类,并介绍了其制备工艺、性能和应用等方面的研究近况,指出改进复合工艺、采用纳米级 HA 增强并进行表面改性是其发展趋势。
