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Wear Behavior of PTFE–Hydroxyapatite Composite Fabricated by Hot-Press Sintering Process
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作者 H.R.Zafarani M.Abdi M.E.Bahrololoom 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2014年第2期347-351,共5页
In the present work, a new biocompatible composite was fabricated by hot-press sinter-bonding of polytet- rafluoroethylene (PTFE)-hydroxyapatite composite. Furthermore, the wear properties of this composite were stu... In the present work, a new biocompatible composite was fabricated by hot-press sinter-bonding of polytet- rafluoroethylene (PTFE)-hydroxyapatite composite. Furthermore, the wear properties of this composite were studied by computer-controlled pin-on-disk type tribometer in reporting volume loss per distance. The investigation was performed in three different fractions of hydroxyapatite (10, 20 and 30 wt%). In order to improve the bonding between hydroxyapatite and PTFE, and thus to increase the wear properties of the composite, the effect of adding silane-coupling agent was investigated. Furthermore, to simulate the environment of human body, some of the wear tests were carried out in the ringer's solution. It was found that the wear resistance is improved at high load. Moreover, an optimum fraction of hydroxyapatite (20 wt%) was found in which the best wear resistance is achieved, especially at dry sliding condition. At last, the roles of the factors such as wear load, ringer's solution, and silane-coupling agent are described with respect to their influences on the Lancaster wear coefficient. 展开更多
关键词 hydroxyapatite composite POLYMERS Silane-coupling agent Wear resistance
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In vitro corrosion-fatigue behavior of biodegradable Mg/HA composite in simulated body fluid 被引量:2
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作者 E.Ghazizadeh A.H.Jabbari M.Sedighi 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2021年第6期2169-2184,共16页
Magnesium and its composites as biodegradable materials offer especial capabilities to be used as bio-absorbable implants.However,their poor corrosion and fatigue properties in the physiological environment can restri... Magnesium and its composites as biodegradable materials offer especial capabilities to be used as bio-absorbable implants.However,their poor corrosion and fatigue properties in the physiological environment can restrict their applications.In this study,corrosion-fatigue tests have been performed on the extruded magnesium and magnesium/hydroxyapatite(Mg/HA)composites in a high cycle regime.To produce the composites,pure magnesium was reinforced by 2.5 wt.%and 5 wt.%of hydroxyapatite submicron particles using an electromagneticmechanical stirring method and hot extrusion process.The experimental density measurement exhibits that the porosity increases in the extruded samples with more hydroxyapatite particles.To investigate the corrosion and corrosion-fatigue behavior of the specimens,simulated body fluid(SBF)was used during in vitro tests.The results of the potentiodynamic polarization corrosion test show that the composite with 2.5 wt.%of hydroxyapatite(Mg/2.5 wt.%HA)and the pure magnesium specimen exhibit the highest and the lowest corrosion resistance,respectively.Regarding the elemental mapping analysis of the corroded samples,this behavior could be due to the formation of strong phosphorus-calcium based layers on the composite surface.The results obtained from the mechanical tests indicate that Mg/5 wt.%HA offered the highest tensile and compressive yield strengths,as well as the most promising high cycle fatigue behavior.During the corrosionfatigue test,the simultaneous effects of fatigue and corrosion damages led to a similar corrosion-fatigue behavior in both composites.The fracture surfaces of the corrosion-fatigue samples suggest that the cracks are initiated in the corroded regions of the samples surface,which reduces the crack initiation step and subsequently decreases the fatigue life.In comparison with the pure magnesium,both composites exhibit more promising corrosion and corrosion-fatigue behaviors with a significant fatigue life improvement in the physiological environment. 展开更多
关键词 MAGNESIUM Magnesium/hydroxyapatite composite CORROSION BIODEGRADATION High cycle fatigue Corrosion-fatigue
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An in-vitro Investigation of Iron-Containing Hydroxyapatite/Titanium Composites
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作者 Q. Chang H.Q. Ru +3 位作者 D.L. Chen X.Y. Yue L. Yu C.P. Zhang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2011年第6期546-552,共7页
The in-vitro biological behavior of a newly-developed iron-containing hydroxyapatite/titanium(HA/Ti) composite was investigated by immersing the composites in the simulated body fluid(SBF) for up to 5 weeks.The ad... The in-vitro biological behavior of a newly-developed iron-containing hydroxyapatite/titanium(HA/Ti) composite was investigated by immersing the composites in the simulated body fluid(SBF) for up to 5 weeks.The addition of iron was observed to have a significant influence on the in-vitro biological behavior of the composites.The obtained results revealed that the stability of the composites in the physiological solution was markedly improved.The solubility decreased in the order of pure HA,HA/5(Ti-33Fe),and HA/15(Ti33Fe).Precipitation occurred on the surface of HA/5(Ti-33Fe) composite,showing a good combination of physiostability with bioactivity,while HA/15(Ti-33Fe) composite exhibited superior physiostability since there was no obvious change on the surface of HA/15(Ti-33Fe). 展开更多
关键词 hydroxyapatite composite IRON TITANIUM Simulated body fluid Biological behavior
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Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation
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作者 Monika Zielinska Ewa Chmielewska +2 位作者 Tomasz Buchwald Adam Voelkel PawełKafarski 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2021年第3期364-373,共10页
There is a strong need to search for more effective compounds with bone anti-resorptive properties,which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to sear... There is a strong need to search for more effective compounds with bone anti-resorptive properties,which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to search for new techniques to characterize the interactions between bone and drug. By studying their interaction with hydroxyapatite(HA), this study used three forms of ceramic materials,two of which are bone-stimulating materials, to assess the suitability of new active substances with antiresorptive properties. In this study, three methods based on HA in loose form, polycaprolactone/HA(a polymer-ceramic materials containing HA), and polymer-ceramic monolithic in-needle extraction(MINE) device(a polymer inert skeleton), respectively, were used. The affinity of risedronate(a standard compound) and sixteen aminomethylenebisphosphonates(new compounds with potential antiresorptive properties) to HA was defined according to the above-mentioned methods. Ten monolithic materials based on 2-hydroxyethyl methacrylate/ethylene dimethacrylate are prepared and studied, of which one was selected for more-detailed further research. Simulated body fluids containing bisphosphonates were passed through the MINE device. In this way, sorptionedesorption of bisphosphonates was evaluated using this MINE device. The paper presents the advantages and disadvantages of each technique and its suitability for assessing new active substances. All three methods allow for the selection of several compounds with potentially higher anti-resorptive properties than risedronate, in hope that it reflects their higher bone affinity and release ability. 展开更多
关键词 Monolithic column Polymer composites BISPHOSPHONATES hydroxyapatite coatings hydroxyapatite composite
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Effect of nano-hydroxyapatite/collagen composite and bone morphogenetic protein-2 on lumbar intertransverse fusion in rabbits 被引量:11
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作者 孙天胜 关凯 +5 位作者 时述山 朱兵 郑永军 崔福斋 张伟 廖素三 《Chinese Journal of Traumatology》 CAS 2004年第1期18-24,共7页
Objective: To investigate the effect of nano hydroxyapatite/collagen (nHA/collagen) composite as a graft extender and enhancer when combined with recombinant human bone morphogenetic protein 2 (rhBMP 2) on lumbar inte... Objective: To investigate the effect of nano hydroxyapatite/collagen (nHA/collagen) composite as a graft extender and enhancer when combined with recombinant human bone morphogenetic protein 2 (rhBMP 2) on lumbar intertransverse fusion in rabbits. Methods: Sixty four adult female New Zealand white rabbits, aged 1 year and weighing 3.5 4.5 kg, underwent similar posterolateral intertransverse process arthrodesis and were randomly divided into 4 groups based on different grafts: autogenous cancellous bone alone (ACB group), nHA/collagen alone (HAC group), half autogenous cancellous bone and half nHA/collagen (ACB+HAC group) and nHA/collagen combined with rhBMP 2 (HAC+BMP group). The fusion masses were analyzed by manual palpation, radiography, biomechanical testing and histological examination. Results: Fusion was observed in 4 cases in the 6th week and in 5 cases in the 10th week after surgery in ACB group. No case showed fusion in HAC group. In ACB+HAC group, there was fusion in 3 cases in the 6th week and in 4 cases in the 10th week after surgery. In HAC+BMP group, fusion in 1 case was found in the 4th week, in 5 cases in the 6th week and in 6 cases in the 10th week after surgery. It suggested that ACB, ACB+HAC and HAC+BMP groups showed similar fusion ratio and mechanical strength in the 6th and 10th week after surgery. According to the microstructure analysis of the samples, nHA/collagen had no negative effect when implanted together with ilium autograft. In HAC+BMP group, new bone like tissue was observed in the 2nd week postoperatively, and nearly all of the implanted composites were replaced by mature bone matrix and new bones in 10th week postoperatively. Conclusions: The nHA/collagen, especially combined with rhBMP 2, is a promising bone substitute, for it has quick biodegradation, fine bone bending ability, and high osteoconductivity on posterolateral spinal fusion in rabbits. 展开更多
关键词 Lumbar vertebrae Spinal fusion Bone morphogenetic protein 2 Nano hydroxyapatite/collagen composite
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Novel Mesoporous Hydroxyapatite/Chitosan Composite for Bone Repair 被引量:4
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作者 Jingzhe Zhang Guangyao Liu Qiong Wu Jianlin Zuo Yanguo Qin Jincheng Wang 《Journal of Bionic Engineering》 SCIE EI CSCD 2012年第2期243-251,共9页
The objective of the present investigation was to evaluate the osteogenic properties of mesoporous Hydroxyapatite/Chitosan (HAJCS) composite in vitro and in vivo. HA/CS composite was successfully prepared and synthe... The objective of the present investigation was to evaluate the osteogenic properties of mesoporous Hydroxyapatite/Chitosan (HAJCS) composite in vitro and in vivo. HA/CS composite was successfully prepared and synthesized using a freeze-drying method, and then characterized by Scanning Electron Microscope (SEM). Results show that the mesoporous HA/CS composite presents high surface area and porosity. The effects of mesoporous HA/CS on early adhesion, proliferation and differentiation of osteoblast cells in vitro were measured. MTT cytotoxicity test and cell adhesion test show that the composite has good biocompatibility and promotes cell viability and proliferation. In vitro tests show that osteoblast-like cells on the composite surfaces are able to adhere, proliferate, and migrate through the pores. These cells maintained similar expression levels of osteoblastic-associated markers namely Collagen type I (COL-I), Bone Morphogenetic Protein 2(BMP-2). Histologic analysis and radiological analysis in vivo also prove that mesoporous HA/CS composite can be used to repair bone defect as a new kind of bone grafting materials. 展开更多
关键词 hydroxyapatite/chitosan composite bone repair BIOCOMPATIBILITY FREEZE-DRYING
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Synthesis of carbon nanotubes loaded hydroxyapatite: Potential for controlled drug release from bone implants 被引量:2
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作者 Lisa COSTANTINI Nikolaos BOUROPOULOS +2 位作者 Dimitrios G.FATOUROS Ioanna KONTOPOULOU Marta ROLDO 《Journal of Advanced Ceramics》 CSCD 2016年第3期232-243,共12页
关键词 carbon nanotubes (CNTs) hydroxyapatite (HA) composites bone regeneration CHITOSAN
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