Catalyst plays an important role in the dehydration of N-（hydroxylethyl）pyrrolidone （NHP） to prepare N-vinyl-pyrrolidone （NVP）. At present, NVP yield is only about 30% on commercial ZrO2 catalyst. A coupled prec...Catalyst plays an important role in the dehydration of N-（hydroxylethyl）pyrrolidone （NHP） to prepare N-vinyl-pyrrolidone （NVP）. At present, NVP yield is only about 30% on commercial ZrO2 catalyst. A coupled precipitation and solid dispersion technique was designed to prepare the nano-ZrO2 catalyst, in which rare earth metal oxides （REOx） was used as electronic promoter. The results indicated that the catalyst doped REOx （S-1.0） exhibits the optimum performance of NHP dehydration at moderate conditions. NHP conversion and NVP selectivity are respectively 97.0%, 82.3%. Of special interest is that the indexes of the catalyst （S-1.0-1.0） are up to 98.4% and 89.2% respectively. Furthermore, this catalyst bears the good stability. It means that nano-ZrO2 doped REOx catalyst might be a potential commercial catalyst for the NHP dehydration.展开更多
The surface-grafted poly(hydroxylethyl methacrylate)(PHEMA)molecules were demonstrated to show a brush state regardless of their molecular length(molecular weight).Adsorption of proteins from 10%fetal bovine serum(FBS...The surface-grafted poly(hydroxylethyl methacrylate)(PHEMA)molecules were demonstrated to show a brush state regardless of their molecular length(molecular weight).Adsorption of proteins from 10%fetal bovine serum(FBS),fibronectin(Fn)and bovine serum albumin(BSA)was quantified by ellipsometry,revealing that the amounts of FBS and Fn decreased monotonously along with the increase of PHEMA thickness,whereas not detectable for BSA when the PHEMA thickness was larger than 6 nm.Radio immunoassay found that the adsorption of Fn from 10%FBS had no significant difference regardless of the PHEMA thickness.However,ELISA results showed that the Arg-Gly-Asp(RGD)activity of adsorbed Fn decreased with the increase of PHEMA thickness.By comparison of cellular behaviors of vascular smooth muscle cells(VSMCs)being cultured in vitro in the normal serum-containing medium and the Fn-depleted serum-containing medium,the significant role of Fn on modulating the adhesion and migration of VSMCs was verified.Taking account all the results,the Fn adsorption model and its role on linking the biomaterials surface to the VSMCs behaviors are proposed.展开更多
Two novel one- and two-dimensional network structure bismuth(III) complexes with N,N-di(2-hydroxylethyl)- aminodithiocarboxylate, {Bi[S2CN(C2H4OH)2]2[1,10-Phen]2(NO3)}3H2O (1) and {Bi[S2CN(C2H4OH)2]3}2 (2) were synthe...Two novel one- and two-dimensional network structure bismuth(III) complexes with N,N-di(2-hydroxylethyl)- aminodithiocarboxylate, {Bi[S2CN(C2H4OH)2]2[1,10-Phen]2(NO3)}3H2O (1) and {Bi[S2CN(C2H4OH)2]3}2 (2) were synthesized. Their crystal and molecular structures were determined by X-ray single crystal diffraction analysis. The crystal 1 belongs to monoclinic system with space group C2/c, a=1.6431(7) nm, b=2.4323(10) nm, c=1.2646(5) nm, =126.237(5)o, Z=4, V=4.076(3) nm3, Dc=1.757 Mg/m3, =4.598 mm-1, F(000)=2156, R=0.0211, wR=0.0369. The structure shows a distorted square antiprism configuration with eight-coordination for the central Bi atom. The one-dimensional chain structure was formed by H-bonding interaction between hydroxyl group of N,N-di(2-hydroxylethyl)aminodithiocarboxylate ligands and crystal water. The crystal 2 belongs to monoclinic system with space group P2(1)/c, a=1.1149(4) nm, b=2.1274(8) nm, c=2.2107(8) nm, =98.325(8), Z=4, V=5.188(3) nm3, Dc=1.920 Mg/m3, =7.315 mm-1, F(000)=2944, R=0.0565, wR=0.0772. The structure shows a distorted square antiprism configuration with eight-coordination for the central Bi atoms. The two-dimensional network structure was formed by H-bonding interaction between adjacent molecules.展开更多
文摘Catalyst plays an important role in the dehydration of N-（hydroxylethyl）pyrrolidone （NHP） to prepare N-vinyl-pyrrolidone （NVP）. At present, NVP yield is only about 30% on commercial ZrO2 catalyst. A coupled precipitation and solid dispersion technique was designed to prepare the nano-ZrO2 catalyst, in which rare earth metal oxides （REOx） was used as electronic promoter. The results indicated that the catalyst doped REOx （S-1.0） exhibits the optimum performance of NHP dehydration at moderate conditions. NHP conversion and NVP selectivity are respectively 97.0%, 82.3%. Of special interest is that the indexes of the catalyst （S-1.0-1.0） are up to 98.4% and 89.2% respectively. Furthermore, this catalyst bears the good stability. It means that nano-ZrO2 doped REOx catalyst might be a potential commercial catalyst for the NHP dehydration.
基金This study is financially supported by the National Basic Research Program of China(2011CB606203)the Natural Science Foundation of China(21374097 and 51120135001).
文摘The surface-grafted poly(hydroxylethyl methacrylate)(PHEMA)molecules were demonstrated to show a brush state regardless of their molecular length(molecular weight).Adsorption of proteins from 10%fetal bovine serum(FBS),fibronectin(Fn)and bovine serum albumin(BSA)was quantified by ellipsometry,revealing that the amounts of FBS and Fn decreased monotonously along with the increase of PHEMA thickness,whereas not detectable for BSA when the PHEMA thickness was larger than 6 nm.Radio immunoassay found that the adsorption of Fn from 10%FBS had no significant difference regardless of the PHEMA thickness.However,ELISA results showed that the Arg-Gly-Asp(RGD)activity of adsorbed Fn decreased with the increase of PHEMA thickness.By comparison of cellular behaviors of vascular smooth muscle cells(VSMCs)being cultured in vitro in the normal serum-containing medium and the Fn-depleted serum-containing medium,the significant role of Fn on modulating the adhesion and migration of VSMCs was verified.Taking account all the results,the Fn adsorption model and its role on linking the biomaterials surface to the VSMCs behaviors are proposed.
基金Project supported by the National Natural Science Foundation of China (No. 20271025) and the Natural Science Foundation of Shandong Province (No. L2003B01).
文摘Two novel one- and two-dimensional network structure bismuth(III) complexes with N,N-di(2-hydroxylethyl)- aminodithiocarboxylate, {Bi[S2CN(C2H4OH)2]2[1,10-Phen]2(NO3)}3H2O (1) and {Bi[S2CN(C2H4OH)2]3}2 (2) were synthesized. Their crystal and molecular structures were determined by X-ray single crystal diffraction analysis. The crystal 1 belongs to monoclinic system with space group C2/c, a=1.6431(7) nm, b=2.4323(10) nm, c=1.2646(5) nm, =126.237(5)o, Z=4, V=4.076(3) nm3, Dc=1.757 Mg/m3, =4.598 mm-1, F(000)=2156, R=0.0211, wR=0.0369. The structure shows a distorted square antiprism configuration with eight-coordination for the central Bi atom. The one-dimensional chain structure was formed by H-bonding interaction between hydroxyl group of N,N-di(2-hydroxylethyl)aminodithiocarboxylate ligands and crystal water. The crystal 2 belongs to monoclinic system with space group P2(1)/c, a=1.1149(4) nm, b=2.1274(8) nm, c=2.2107(8) nm, =98.325(8), Z=4, V=5.188(3) nm3, Dc=1.920 Mg/m3, =7.315 mm-1, F(000)=2944, R=0.0565, wR=0.0772. The structure shows a distorted square antiprism configuration with eight-coordination for the central Bi atoms. The two-dimensional network structure was formed by H-bonding interaction between adjacent molecules.
