Background: The treatment of hypertensive spontaneous intracranial hemorrhage(ICH) is still controversial. The purpose of the present study was to investigate whether minimally invasive puncture and drainage(MIPD) cou...Background: The treatment of hypertensive spontaneous intracranial hemorrhage(ICH) is still controversial. The purpose of the present study was to investigate whether minimally invasive puncture and drainage(MIPD) could provide improved patient outcome compared with decompressive craniectomy(DC).Methods: Eligible, consecutive patients with ICH(≥30 ml, in basal ganglia, within 24 hours of ictus) were nonrandomly assigned to receive MIPD(group A) or to undergo DC(group B) hematoma evacuation. The primary outcome was death at 30 days after onset. Functional independence was assessed at 1 year using the Glasgow Outcome Scale(GOS, scores range from 1 to 5, score 1 indicating death, ≥4 indicating functional independence, with lower scores indicating greater disability). Results: A total of 198 patients met the per protocol analysis(84 cases in group A and 114 cases in group B), including 9 cases lost during follow-up(2 cases in group A and 7 cases in group B). For these 9 patients, their last observed data were used as their final results for intention-to-treat analysis. The mean age of all patients was 57.1 years(range of 31-95 years), and 114 patients were male. The initial Glasgow Coma Scale(GCS) score was 8.1±3.4, and the National Institutes of Health Stroke Scale(NIHSS) score was 20.8±5.3. The mean hematoma volume(HV) was 56.7±23.0 ml(range of 30-144 ml), and there was extended intraventricular hemorrhage(IVH) in 134 patients(67.7%). There were no significant intergroup differences in the above baseline data, except group A had a higher mean age(59.4±14.5years) than the mean age of group B(55.3±11.1 years, P=0.025). The total cumulative mortalities at 30 days and 1 year were 32.3% and 43.4%, respectively, and there were no significant differences between groups A and B(30 days: 27.4% vs. 36.0%, P=0.203; 1 year: 36.1% vs. 48.2%, P=0.112, respectively). However, the mortality for patients ≤60 years, NIHSS【15 or HV≤60 ml was significantly lower in group A than that in group B(all P【0.05). The total cumulative functional independence at 1 year was 26.8%, and the difference between group A(33/43, 39.3%) and group B(20/144, 17.5%) was significant(absolute difference 21.7%, odds ratio [OR] 0.329, 95% confidence interval [CI] 0.171 to 0.631, P=0.001). For patient with severe IVH, the 30 days and 1 year mortality rates were significant lower in group B than those in group A(P=0.025, P=0.036). However, the number of favorable outcomes had no significant difference between groups at 1 year post ictus. Multivariate logistic regression analysis showed that a favorable outcome after 1 year was associated with the difference in therapies(OR 0.280, 95% CI 0.104–0.752, P=0.012), age(OR 0.215, 95% CI 0.069–0.671, P=0.008), GCS(OR 1.187, 95% CI 1.010–1.395, P=0.037), HV(OR 0.943, 95% CI 0.906–0.982, P=0.005), IVH(OR 0.655, 95% CI 0.506–0.849, P=0.001) and PI(OR 0.211, 95% CI 0.071–0.624, P=0.001). Conclusions: Our results suggest that for patients with hypertensive spontaneous ICH(HV≥30 ml in basal ganglia), MIPD may be a more effective treatment than DC, as assessed by a higher rate of functional independence at 1 year after onset as well as reduced mortality in patients ≤60 years of age, NIHSS【15 or HV≤60 ml. For patients with HV 】60 ml, deep coma and severe IVH, the outcomes of the two therapies were similar.展开更多
目的探讨CT立体定向微创软管道置管配合尿激酶治疗高血压性脑出血的效果。方法回顾性分析北京中医药大学东方医院2012年10月~2017年5月收治的高血压性脑出血80例患者的临床资料,其中采用内科保守治疗的40例患者设为对照组,采用CT立体定...目的探讨CT立体定向微创软管道置管配合尿激酶治疗高血压性脑出血的效果。方法回顾性分析北京中医药大学东方医院2012年10月~2017年5月收治的高血压性脑出血80例患者的临床资料,其中采用内科保守治疗的40例患者设为对照组,采用CT立体定向微创软通道置管配合尿激酶治疗的40例患者设为观察组,对两组的日常生活活动能力(ADL)、格拉斯哥预后评分(GOS)、格拉斯哥昏迷评分(GCS)、Barthel指数进行比较。结果两组治疗30 d ADL分级改善比较,差异无统计学意义(P>0.05)。观察组治疗30、90 d GOS评分和治疗5 d GCS评分均明显高于对照组,治疗前与治疗30 d Barthel指数差值亦高于对照组,差异均有统计学意义(均P<0.05)。观察组并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论 CT立体定向微创软通道置管配合尿激酶治疗高血压性脑出血的效果显著优于内科保守治疗,能够提高患者日常生活活动能力,减少并发症,具有积极的临床使用价值。展开更多
高血压脑出血是所有脑卒中亚型中最严重的一种,占所有卒中的23.8%,具有很高的致死率和致残率,其预后与出血部位、出血量、出血速度、手术时机、手术方式、年龄、是否口服抗凝药物等因素密切相关。在严格掌握手术适应证和手术时机的前提...高血压脑出血是所有脑卒中亚型中最严重的一种,占所有卒中的23.8%,具有很高的致死率和致残率,其预后与出血部位、出血量、出血速度、手术时机、手术方式、年龄、是否口服抗凝药物等因素密切相关。在严格掌握手术适应证和手术时机的前提下,微创手术(Minimal Invasive Surgery,MIS)包括神经内镜血肿清除术和立体定向碎吸加尿激酶溶解术,其与开颅显微血肿清除手术相比较已经显示出了更加微创、疗效更好的趋势。近年来,在我国内镜血肿清除手术开始普遍开展,哪种手术方式是最佳的治疗方法,需要临床多中心前瞻性随机对照实验来回答。现在有一项比较3种手术方式效果的随机对照实验《幕上高血压脑出血微创手术与开颅手术多中心、随机对照试验》(Minimally-invasive Surgery Versus Craniotomy in Patients With Supratentorial Hypertensive Intracerebral Hemorrhage(MISICH))正在我国多个临床中心进行。展开更多
基金supported by grant from the National Natural Science Foundation of China (81070948)
文摘Background: The treatment of hypertensive spontaneous intracranial hemorrhage(ICH) is still controversial. The purpose of the present study was to investigate whether minimally invasive puncture and drainage(MIPD) could provide improved patient outcome compared with decompressive craniectomy(DC).Methods: Eligible, consecutive patients with ICH(≥30 ml, in basal ganglia, within 24 hours of ictus) were nonrandomly assigned to receive MIPD(group A) or to undergo DC(group B) hematoma evacuation. The primary outcome was death at 30 days after onset. Functional independence was assessed at 1 year using the Glasgow Outcome Scale(GOS, scores range from 1 to 5, score 1 indicating death, ≥4 indicating functional independence, with lower scores indicating greater disability). Results: A total of 198 patients met the per protocol analysis(84 cases in group A and 114 cases in group B), including 9 cases lost during follow-up(2 cases in group A and 7 cases in group B). For these 9 patients, their last observed data were used as their final results for intention-to-treat analysis. The mean age of all patients was 57.1 years(range of 31-95 years), and 114 patients were male. The initial Glasgow Coma Scale(GCS) score was 8.1±3.4, and the National Institutes of Health Stroke Scale(NIHSS) score was 20.8±5.3. The mean hematoma volume(HV) was 56.7±23.0 ml(range of 30-144 ml), and there was extended intraventricular hemorrhage(IVH) in 134 patients(67.7%). There were no significant intergroup differences in the above baseline data, except group A had a higher mean age(59.4±14.5years) than the mean age of group B(55.3±11.1 years, P=0.025). The total cumulative mortalities at 30 days and 1 year were 32.3% and 43.4%, respectively, and there were no significant differences between groups A and B(30 days: 27.4% vs. 36.0%, P=0.203; 1 year: 36.1% vs. 48.2%, P=0.112, respectively). However, the mortality for patients ≤60 years, NIHSS【15 or HV≤60 ml was significantly lower in group A than that in group B(all P【0.05). The total cumulative functional independence at 1 year was 26.8%, and the difference between group A(33/43, 39.3%) and group B(20/144, 17.5%) was significant(absolute difference 21.7%, odds ratio [OR] 0.329, 95% confidence interval [CI] 0.171 to 0.631, P=0.001). For patient with severe IVH, the 30 days and 1 year mortality rates were significant lower in group B than those in group A(P=0.025, P=0.036). However, the number of favorable outcomes had no significant difference between groups at 1 year post ictus. Multivariate logistic regression analysis showed that a favorable outcome after 1 year was associated with the difference in therapies(OR 0.280, 95% CI 0.104–0.752, P=0.012), age(OR 0.215, 95% CI 0.069–0.671, P=0.008), GCS(OR 1.187, 95% CI 1.010–1.395, P=0.037), HV(OR 0.943, 95% CI 0.906–0.982, P=0.005), IVH(OR 0.655, 95% CI 0.506–0.849, P=0.001) and PI(OR 0.211, 95% CI 0.071–0.624, P=0.001). Conclusions: Our results suggest that for patients with hypertensive spontaneous ICH(HV≥30 ml in basal ganglia), MIPD may be a more effective treatment than DC, as assessed by a higher rate of functional independence at 1 year after onset as well as reduced mortality in patients ≤60 years of age, NIHSS【15 or HV≤60 ml. For patients with HV 】60 ml, deep coma and severe IVH, the outcomes of the two therapies were similar.
文摘目的探讨CT立体定向微创软管道置管配合尿激酶治疗高血压性脑出血的效果。方法回顾性分析北京中医药大学东方医院2012年10月~2017年5月收治的高血压性脑出血80例患者的临床资料,其中采用内科保守治疗的40例患者设为对照组,采用CT立体定向微创软通道置管配合尿激酶治疗的40例患者设为观察组,对两组的日常生活活动能力(ADL)、格拉斯哥预后评分(GOS)、格拉斯哥昏迷评分(GCS)、Barthel指数进行比较。结果两组治疗30 d ADL分级改善比较,差异无统计学意义(P>0.05)。观察组治疗30、90 d GOS评分和治疗5 d GCS评分均明显高于对照组,治疗前与治疗30 d Barthel指数差值亦高于对照组,差异均有统计学意义(均P<0.05)。观察组并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论 CT立体定向微创软通道置管配合尿激酶治疗高血压性脑出血的效果显著优于内科保守治疗,能够提高患者日常生活活动能力,减少并发症,具有积极的临床使用价值。
文摘高血压脑出血是所有脑卒中亚型中最严重的一种,占所有卒中的23.8%,具有很高的致死率和致残率,其预后与出血部位、出血量、出血速度、手术时机、手术方式、年龄、是否口服抗凝药物等因素密切相关。在严格掌握手术适应证和手术时机的前提下,微创手术(Minimal Invasive Surgery,MIS)包括神经内镜血肿清除术和立体定向碎吸加尿激酶溶解术,其与开颅显微血肿清除手术相比较已经显示出了更加微创、疗效更好的趋势。近年来,在我国内镜血肿清除手术开始普遍开展,哪种手术方式是最佳的治疗方法,需要临床多中心前瞻性随机对照实验来回答。现在有一项比较3种手术方式效果的随机对照实验《幕上高血压脑出血微创手术与开颅手术多中心、随机对照试验》(Minimally-invasive Surgery Versus Craniotomy in Patients With Supratentorial Hypertensive Intracerebral Hemorrhage(MISICH))正在我国多个临床中心进行。
